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The map label for this gene is betA [H]

Identifier: 23501442

GI number: 23501442

Start: 548896

End: 550545

Strand: Reverse

Name: betA [H]

Synonym: BR0553

Alternate gene names: 23501442

Gene position: 550545-548896 (Counterclockwise)

Preceding gene: 23501443

Following gene: 23501441

Centisome position: 26.12

GC content: 59.64

Gene sequence:

>1650_bases
ATGGAAGCAGATTTCGTCATCATCGGCTCCGGCTCTGCCGGTTCGGCCATGGCCTATCGCCTTTCAGAAAACGGGCGCTA
TTCGGTGATCGTCATCGAATATGGCGTGCCCGATGTGGGCCCGCTGATCCAGATGCCCGCCGCCCTCTCCTTTCCCATGA
ACATGGAAACCTACGACTGGGGCTTTTCCAGCGAGCCGGAACCGCATATTGGCGGGCGCAGCCTCGTCACCCCCCGCGGC
AAGGTGCTGGGCGGGTCGTCTTCCATCAATGGCATGGTTTATGTGCGCGGCCATGCGTGCGATTTCGACCATTGGTCACA
AAGCGGTGCGCGAGGCTGGGCCTATGCCGATGTGCTGCCCTATTTCAAGCGGATGGAAAATTCGCAAGGCGGACAGGAAG
GCTGGCGCGGCACCAATGGCCCGCTTTATGTCCAGCGCGGCAAGCGCGACAATCCGCTGTTCCATGCCTTTGTCGAGGCT
GGCCATCAGGCAGGCTTTGAAGTCACCGATGATTATAACGGTGAGAAGCAGGAAGGCTTCGGCCCGATGGAGCAGACAAT
TCATAATGGCCGCCGCTGGTCAGCCGCCAATGCCTATCTGAAACCGGCTCTCAAGCGCCCGAATGTCAAGCTGGTCAAAG
GGTTTGCGCGCAAGATCGTGCTGGAAGGAAAACGCGCCGTCGGGGTGGAAATCGAGGCGGGCCGCACCTTTTCCACCATC
CGCGCGCGGCGCGAAGTGATTATTGCCGCCTCTTCCATCAACTCGCCCAAACTGTTGATGCTTTCCGGCATCGGGCCTGC
CGCGCATTTGAAGGAACACGGCATCGACCTGGTGGCCGACCGCCCCGGCGTGGGCCAGAACCTGCAAGACCATCTGGAAG
TCTATATCCAGCAGGAATGCACCCAGCCTATCACGCTTTATTCCGAGCTGAACCTGTTTTCAAAAGCCAGGATTGGCGTG
GAATGGCTGCTCTTCAAAACCGGCGACGGTGCAACAAACCATTTTGAATCCGCCGCCTTCGTCCGCTCCAAGGCGGGTGT
GGAATATCCCGATATCCAGTATCACTTCCTGCCGGTTGCCATCCGCTATGACGGCAAGGCGGCAGCGCAGTCGCATGGGT
TCCAGGCCCATGTAGGCCCCATGCGCTCGAAATCGCGCGGCAGCGTCACGCTTCGCTCAGCCAACCCGCGTGAAAAGCCT
GTCATCAAGTTCAATTATATGTCGCATGAAGACGATTGGGCCGATTTTCGCCATTGCGTGCGGCTGACGCGGGAAATCTT
CGGGCAGGCCGCGTTCGATCCCTATCGCGGAGCGGAAATCCAGCCGGGCGCCCATGTGCAGACGGACGATGAAATCGACA
ATTTCATCCGCGAGCATGTCGAAAGCGCGTTCCATCCATGCGGCACCTGCAAAATGGGGGCGGTTGACGATCCGATGGCC
GTGGTCGATCCTGAATGCCGCGTCATCGGCGTCGAAGGCTTGCGCGTTGCGGATTCATCCATCTTCCCGCGCATCACCAA
CGGCAATCTCAACGGCCCATCAATCATGGTGGGCGAAAAGGCGTCCGACCACATTCTGGGCCGCACGCCGCTCGCCCGCT
CCAATCAGGAGCCGTGGATCAATCCGCGGTGGCAGGTGTCGGACCGCTAA

Upstream 100 bases:

>100_bases
CGCTCGGGGCCGACGCACCCGATGCGGCCTCAGCGATTGCATTGGTGGAAGACTATATCGCCATTCAACTTTCAGGACAG
CCTTCGGCGGAGAATTGAGC

Downstream 100 bases:

>100_bases
CGCGGTCCAGCGGAATAGGGCAGTAAGGCAGTAGGGCAATATGTTAGAGCATGTCTCCCGAAAGTGGGAACCGGTTTCGG
GCTAAAGACATGCGTAAAAA

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 549; Mature: 549

Protein sequence:

>549_residues
MEADFVIIGSGSAGSAMAYRLSENGRYSVIVIEYGVPDVGPLIQMPAALSFPMNMETYDWGFSSEPEPHIGGRSLVTPRG
KVLGGSSSINGMVYVRGHACDFDHWSQSGARGWAYADVLPYFKRMENSQGGQEGWRGTNGPLYVQRGKRDNPLFHAFVEA
GHQAGFEVTDDYNGEKQEGFGPMEQTIHNGRRWSAANAYLKPALKRPNVKLVKGFARKIVLEGKRAVGVEIEAGRTFSTI
RARREVIIAASSINSPKLLMLSGIGPAAHLKEHGIDLVADRPGVGQNLQDHLEVYIQQECTQPITLYSELNLFSKARIGV
EWLLFKTGDGATNHFESAAFVRSKAGVEYPDIQYHFLPVAIRYDGKAAAQSHGFQAHVGPMRSKSRGSVTLRSANPREKP
VIKFNYMSHEDDWADFRHCVRLTREIFGQAAFDPYRGAEIQPGAHVQTDDEIDNFIREHVESAFHPCGTCKMGAVDDPMA
VVDPECRVIGVEGLRVADSSIFPRITNGNLNGPSIMVGEKASDHILGRTPLARSNQEPWINPRWQVSDR

Sequences:

>Translated_549_residues
MEADFVIIGSGSAGSAMAYRLSENGRYSVIVIEYGVPDVGPLIQMPAALSFPMNMETYDWGFSSEPEPHIGGRSLVTPRG
KVLGGSSSINGMVYVRGHACDFDHWSQSGARGWAYADVLPYFKRMENSQGGQEGWRGTNGPLYVQRGKRDNPLFHAFVEA
GHQAGFEVTDDYNGEKQEGFGPMEQTIHNGRRWSAANAYLKPALKRPNVKLVKGFARKIVLEGKRAVGVEIEAGRTFSTI
RARREVIIAASSINSPKLLMLSGIGPAAHLKEHGIDLVADRPGVGQNLQDHLEVYIQQECTQPITLYSELNLFSKARIGV
EWLLFKTGDGATNHFESAAFVRSKAGVEYPDIQYHFLPVAIRYDGKAAAQSHGFQAHVGPMRSKSRGSVTLRSANPREKP
VIKFNYMSHEDDWADFRHCVRLTREIFGQAAFDPYRGAEIQPGAHVQTDDEIDNFIREHVESAFHPCGTCKMGAVDDPMA
VVDPECRVIGVEGLRVADSSIFPRITNGNLNGPSIMVGEKASDHILGRTPLARSNQEPWINPRWQVSDR
>Mature_549_residues
MEADFVIIGSGSAGSAMAYRLSENGRYSVIVIEYGVPDVGPLIQMPAALSFPMNMETYDWGFSSEPEPHIGGRSLVTPRG
KVLGGSSSINGMVYVRGHACDFDHWSQSGARGWAYADVLPYFKRMENSQGGQEGWRGTNGPLYVQRGKRDNPLFHAFVEA
GHQAGFEVTDDYNGEKQEGFGPMEQTIHNGRRWSAANAYLKPALKRPNVKLVKGFARKIVLEGKRAVGVEIEAGRTFSTI
RARREVIIAASSINSPKLLMLSGIGPAAHLKEHGIDLVADRPGVGQNLQDHLEVYIQQECTQPITLYSELNLFSKARIGV
EWLLFKTGDGATNHFESAAFVRSKAGVEYPDIQYHFLPVAIRYDGKAAAQSHGFQAHVGPMRSKSRGSVTLRSANPREKP
VIKFNYMSHEDDWADFRHCVRLTREIFGQAAFDPYRGAEIQPGAHVQTDDEIDNFIREHVESAFHPCGTCKMGAVDDPMA
VVDPECRVIGVEGLRVADSSIFPRITNGNLNGPSIMVGEKASDHILGRTPLARSNQEPWINPRWQVSDR

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=556, Percent_Identity=51.0791366906475, Blast_Score=562, Evalue=1e-160,
Organism=Escherichia coli, GI1786503, Length=543, Percent_Identity=51.1970534069982, Blast_Score=552, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI17532301, Length=547, Percent_Identity=45.5210237659963, Blast_Score=517, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24642042, Length=590, Percent_Identity=36.6101694915254, Blast_Score=322, Evalue=5e-88,
Organism=Drosophila melanogaster, GI45551458, Length=565, Percent_Identity=36.8141592920354, Blast_Score=319, Evalue=3e-87,
Organism=Drosophila melanogaster, GI45549471, Length=565, Percent_Identity=36.8141592920354, Blast_Score=318, Evalue=5e-87,
Organism=Drosophila melanogaster, GI24642048, Length=575, Percent_Identity=35.6521739130435, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI24642059, Length=564, Percent_Identity=34.3971631205674, Blast_Score=289, Evalue=4e-78,
Organism=Drosophila melanogaster, GI24642055, Length=569, Percent_Identity=33.7434094903339, Blast_Score=284, Evalue=9e-77,
Organism=Drosophila melanogaster, GI24650267, Length=577, Percent_Identity=34.4887348353553, Blast_Score=282, Evalue=3e-76,
Organism=Drosophila melanogaster, GI17137792, Length=566, Percent_Identity=34.6289752650177, Blast_Score=279, Evalue=3e-75,
Organism=Drosophila melanogaster, GI18859995, Length=573, Percent_Identity=34.2059336823735, Blast_Score=269, Evalue=3e-72,
Organism=Drosophila melanogaster, GI24642039, Length=573, Percent_Identity=33.5078534031414, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24642037, Length=575, Percent_Identity=33.7391304347826, Blast_Score=248, Evalue=6e-66,
Organism=Drosophila melanogaster, GI24642051, Length=567, Percent_Identity=31.0405643738977, Blast_Score=248, Evalue=1e-65,
Organism=Drosophila melanogaster, GI24642035, Length=570, Percent_Identity=33.5087719298246, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI18859993, Length=563, Percent_Identity=31.2611012433393, Blast_Score=238, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24645930, Length=583, Percent_Identity=28.4734133790738, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24642057, Length=599, Percent_Identity=26.0434056761269, Blast_Score=136, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 60624; Mature: 60624

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEADFVIIGSGSAGSAMAYRLSENGRYSVIVIEYGVPDVGPLIQMPAALSFPMNMETYDW
CCCCEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHCCCCCCCCCCCCEECC
GFSSEPEPHIGGRSLVTPRGKVLGGSSSINGMVYVRGHACDFDHWSQSGARGWAYADVLP
CCCCCCCCCCCCCEEECCCCCEECCCCCCCEEEEEEECCCCCHHHCCCCCCCEEHHHHHH
YFKRMENSQGGQEGWRGTNGPLYVQRGKRDNPLFHAFVEAGHQAGFEVTDDYNGEKQEGF
HHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCEEECCCCCCHHCCC
GPMEQTIHNGRRWSAANAYLKPALKRPNVKLVKGFARKIVLEGKRAVGVEIEAGRTFSTI
CHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHEECCCCEEEEEEECCCCHHHH
RARREVIIAASSINSPKLLMLSGIGPAAHLKEHGIDLVADRPGVGQNLQDHLEVYIQQEC
HHCEEEEEEEECCCCCCEEEEECCCCHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHC
TQPITLYSELNLFSKARIGVEWLLFKTGDGATNHFESAAFVRSKAGVEYPDIQYHFLPVA
CCCEEEHHHHCHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEE
IRYDGKAAAQSHGFQAHVGPMRSKSRGSVTLRSANPREKPVIKFNYMSHEDDWADFRHCV
EEECCCHHHHCCCCEEECCCCCCCCCCCEEEECCCCCCCCEEEEEECCCCCCHHHHHHHH
RLTREIFGQAAFDPYRGAEIQPGAHVQTDDEIDNFIREHVESAFHPCGTCKMGAVDDPMA
HHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCE
VVDPECRVIGVEGLRVADSSIFPRITNGNLNGPSIMVGEKASDHILGRTPLARSNQEPWI
EECCCEEEEECCCEEEECCCCCCEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCC
NPRWQVSDR
CCCEEECCC
>Mature Secondary Structure
MEADFVIIGSGSAGSAMAYRLSENGRYSVIVIEYGVPDVGPLIQMPAALSFPMNMETYDW
CCCCEEEEECCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHCCCCCCCCCCCCEECC
GFSSEPEPHIGGRSLVTPRGKVLGGSSSINGMVYVRGHACDFDHWSQSGARGWAYADVLP
CCCCCCCCCCCCCEEECCCCCEECCCCCCCEEEEEEECCCCCHHHCCCCCCCEEHHHHHH
YFKRMENSQGGQEGWRGTNGPLYVQRGKRDNPLFHAFVEAGHQAGFEVTDDYNGEKQEGF
HHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCEEECCCCCCHHCCC
GPMEQTIHNGRRWSAANAYLKPALKRPNVKLVKGFARKIVLEGKRAVGVEIEAGRTFSTI
CHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHEECCCCEEEEEEECCCCHHHH
RARREVIIAASSINSPKLLMLSGIGPAAHLKEHGIDLVADRPGVGQNLQDHLEVYIQQEC
HHCEEEEEEEECCCCCCEEEEECCCCHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHC
TQPITLYSELNLFSKARIGVEWLLFKTGDGATNHFESAAFVRSKAGVEYPDIQYHFLPVA
CCCEEEHHHHCHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEE
IRYDGKAAAQSHGFQAHVGPMRSKSRGSVTLRSANPREKPVIKFNYMSHEDDWADFRHCV
EEECCCHHHHCCCCEEECCCCCCCCCCCEEEECCCCCCCCEEEEEECCCCCCHHHHHHHH
RLTREIFGQAAFDPYRGAEIQPGAHVQTDDEIDNFIREHVESAFHPCGTCKMGAVDDPMA
HHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCE
VVDPECRVIGVEGLRVADSSIFPRITNGNLNGPSIMVGEKASDHILGRTPLARSNQEPWI
EECCCEEEEECCCEEEECCCCCCEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCC
NPRWQVSDR
CCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA