Click here to switch to the map view.

The map label for this gene is thrC [H]

Identifier: 23501385

GI number: 23501385

Start: 482770

End: 484161

Strand: Reverse

Name: thrC [H]

Synonym: BR0484

Alternate gene names: 23501385

Gene position: 484161-482770 (Counterclockwise)

Preceding gene: 23501386

Following gene: 23501384

Centisome position: 22.97

GC content: 58.76

Gene sequence:

>1392_bases
ATGAAATATGTAAGTACGCGTGGGGAAGCACCGGTTCTGGAATTCAGCGATGCATTGCTCGCAGGCCTCGCCCGTGATGG
CGGTCTTTATCTGCCGCAGGAATATCCGCAATTCACAGCCGAACAGATCCGCGCCCTGCGTGGAAAATCCTATGTCGAAG
TCGCGCTGGCCGTCCTCACGCCCTTTACCGGCGGTGAAATTCCGGCAGCCGATTTCGAGCGCATGGTCCGCGAAGCTTAC
GGAACCTTCCGTCACGATGCCGTCTGCCCGTTGGTGCAGACCGACGCGAACGAATTCGTGCTGGAGCTTTTCCATGGCCC
CACCCTTGCCTTCAAGGATGTCGCCATGCAGCTTCTGGCCCGCATGATGGATTATGTTCTGGCACAGCGCGGCGAGCGCG
CAACGATCGTCGGCGCTACATCCGGCGATACGGGCGGCGCAGCCATCGAAGCCTTTGGCGGGCGCGACAACACAGACATT
TTCATCCTGTTCCCCAATGGGCGGGTCTCGCCGGTACAGCAACGCCAGATGACGTCTTCCGGCTTTTCCAATGTCCATGC
GCTTTCCATCGAGGGCAATTTCGACGATTGCCAGAACCTCGTAAAAGGCATGTTCAATGATCTGGAATTCCGTGACGCCC
TGTCGCTTTCCGGCGTGAACTCGATCAACTGGGCGCGCATCATGCCGCAGGTTGTCTATTATTTCACGGCAGCACTCAGC
CTCGGCGCACCGGACCGCGCCGTGTCCTTCACGGTGCCCACCGGCAATTTCGGCGATATTTTCGCAGGCTACGTCGCCAA
GCGCATGGGCCTGCCCATCGAGCAACTCATCATCGCCACCAACGACAACGATATTCTTTCGCGCACGCTGGAAAGCGGGG
CCTATGAGATGCGCGGCGTAGCGCAGACCACTTCGCCCTCAATGGATATCCAGATTTCCTCCAATTTCGAGCGGCTTCTG
TTCGAGGCACACGGGCGCGATGCGGCGGCCGTGCGCGGGCTGATGCAGGGCCTGAAGCAATCTGGCGGATTTACGATTTC
CGAAAAGCCGCTTTCGGCCATCCGCAGCGAATTTTCGGCTGGCCGCTCCACCGTCGATGAGACGGCGGCGACTATCGAAT
CGGTTCTTTCCAAAGACGGCTATCTGCTTGATCCGCATTCGGCGATCGGTGTGAAGGTCGCGCGTGAAAAAGCATCCGGC
ACCGCCCCGATGGTGGTTCTGGCGACCGCCCATCCGGCCAAATTCCCGGATGCGGTGAAGGCTGCATGTGGGGTCGAGCC
GCAATTGCCGGCATGGCTTTGCGACCTGATGCAACGAAAAGAAAGCTTCACAGTTCTTCACAACGAGCTGAAAATCGTGG
AAGAATATGTGCGCCACCATTCCCGAGCCTGA

Upstream 100 bases:

>100_bases
CATTGGGGATGTTTTAAATAGTTGCGGCTTTTTTGGGGACGCCCTATTGCATTTACACAGCTTTGAATGGGCAGCCGCTC
TGGAATGAAGGCCTGACGAA

Downstream 100 bases:

>100_bases
ATAGAGCAGGCACGAAAGGGAACCAGGGTGAGAATGCAGGGAGCAATTTGCTAATGGGTGTTGAAGTAACGCGTCTTCCC
AACGGGTTGACAATAGCCAC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MKYVSTRGEAPVLEFSDALLAGLARDGGLYLPQEYPQFTAEQIRALRGKSYVEVALAVLTPFTGGEIPAADFERMVREAY
GTFRHDAVCPLVQTDANEFVLELFHGPTLAFKDVAMQLLARMMDYVLAQRGERATIVGATSGDTGGAAIEAFGGRDNTDI
FILFPNGRVSPVQQRQMTSSGFSNVHALSIEGNFDDCQNLVKGMFNDLEFRDALSLSGVNSINWARIMPQVVYYFTAALS
LGAPDRAVSFTVPTGNFGDIFAGYVAKRMGLPIEQLIIATNDNDILSRTLESGAYEMRGVAQTTSPSMDIQISSNFERLL
FEAHGRDAAAVRGLMQGLKQSGGFTISEKPLSAIRSEFSAGRSTVDETAATIESVLSKDGYLLDPHSAIGVKVAREKASG
TAPMVVLATAHPAKFPDAVKAACGVEPQLPAWLCDLMQRKESFTVLHNELKIVEEYVRHHSRA

Sequences:

>Translated_463_residues
MKYVSTRGEAPVLEFSDALLAGLARDGGLYLPQEYPQFTAEQIRALRGKSYVEVALAVLTPFTGGEIPAADFERMVREAY
GTFRHDAVCPLVQTDANEFVLELFHGPTLAFKDVAMQLLARMMDYVLAQRGERATIVGATSGDTGGAAIEAFGGRDNTDI
FILFPNGRVSPVQQRQMTSSGFSNVHALSIEGNFDDCQNLVKGMFNDLEFRDALSLSGVNSINWARIMPQVVYYFTAALS
LGAPDRAVSFTVPTGNFGDIFAGYVAKRMGLPIEQLIIATNDNDILSRTLESGAYEMRGVAQTTSPSMDIQISSNFERLL
FEAHGRDAAAVRGLMQGLKQSGGFTISEKPLSAIRSEFSAGRSTVDETAATIESVLSKDGYLLDPHSAIGVKVAREKASG
TAPMVVLATAHPAKFPDAVKAACGVEPQLPAWLCDLMQRKESFTVLHNELKIVEEYVRHHSRA
>Mature_463_residues
MKYVSTRGEAPVLEFSDALLAGLARDGGLYLPQEYPQFTAEQIRALRGKSYVEVALAVLTPFTGGEIPAADFERMVREAY
GTFRHDAVCPLVQTDANEFVLELFHGPTLAFKDVAMQLLARMMDYVLAQRGERATIVGATSGDTGGAAIEAFGGRDNTDI
FILFPNGRVSPVQQRQMTSSGFSNVHALSIEGNFDDCQNLVKGMFNDLEFRDALSLSGVNSINWARIMPQVVYYFTAALS
LGAPDRAVSFTVPTGNFGDIFAGYVAKRMGLPIEQLIIATNDNDILSRTLESGAYEMRGVAQTTSPSMDIQISSNFERLL
FEAHGRDAAAVRGLMQGLKQSGGFTISEKPLSAIRSEFSAGRSTVDETAATIESVLSKDGYLLDPHSAIGVKVAREKASG
TAPMVVLATAHPAKFPDAVKAACGVEPQLPAWLCDLMQRKESFTVLHNELKIVEEYVRHHSRA

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=468, Percent_Identity=36.3247863247863, Blast_Score=282, Evalue=4e-76,
Organism=Homo sapiens, GI153792148, Length=436, Percent_Identity=36.697247706422, Blast_Score=276, Evalue=2e-74,
Organism=Escherichia coli, GI1786185, Length=451, Percent_Identity=34.1463414634146, Blast_Score=241, Evalue=6e-65,
Organism=Saccharomyces cerevisiae, GI6319901, Length=456, Percent_Identity=44.2982456140351, Blast_Score=364, Evalue=1e-101,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 50265; Mature: 50265

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYVSTRGEAPVLEFSDALLAGLARDGGLYLPQEYPQFTAEQIRALRGKSYVEVALAVLT
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHC
PFTGGEIPAADFERMVREAYGTFRHDAVCPLVQTDANEFVLELFHGPTLAFKDVAMQLLA
CCCCCCCCHHHHHHHHHHHHCCHHCCCCCCHHHCCHHHHHHHHHCCCCHHHHHHHHHHHH
RMMDYVLAQRGERATIVGATSGDTGGAAIEAFGGRDNTDIFILFPNGRVSPVQQRQMTSS
HHHHHHHHCCCCCEEEEEECCCCCCCCEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHC
GFSNVHALSIEGNFDDCQNLVKGMFNDLEFRDALSLSGVNSINWARIMPQVVYYFTAALS
CCCCEEEEEEECCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LGAPDRAVSFTVPTGNFGDIFAGYVAKRMGLPIEQLIIATNDNDILSRTLESGAYEMRGV
CCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHHCCHHHCCC
AQTTSPSMDIQISSNFERLLFEAHGRDAAAVRGLMQGLKQSGGFTISEKPLSAIRSEFSA
CCCCCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHC
GRSTVDETAATIESVLSKDGYLLDPHSAIGVKVAREKASGTAPMVVLATAHPAKFPDAVK
CCHHHHHHHHHHHHHHCCCCEEECCCCHHHHEEEHHCCCCCCCEEEEEECCCCCCCHHHH
AACGVEPQLPAWLCDLMQRKESFTVLHNELKIVEEYVRHHSRA
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKYVSTRGEAPVLEFSDALLAGLARDGGLYLPQEYPQFTAEQIRALRGKSYVEVALAVLT
CCCCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHC
PFTGGEIPAADFERMVREAYGTFRHDAVCPLVQTDANEFVLELFHGPTLAFKDVAMQLLA
CCCCCCCCHHHHHHHHHHHHCCHHCCCCCCHHHCCHHHHHHHHHCCCCHHHHHHHHHHHH
RMMDYVLAQRGERATIVGATSGDTGGAAIEAFGGRDNTDIFILFPNGRVSPVQQRQMTSS
HHHHHHHHCCCCCEEEEEECCCCCCCCEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHC
GFSNVHALSIEGNFDDCQNLVKGMFNDLEFRDALSLSGVNSINWARIMPQVVYYFTAALS
CCCCEEEEEEECCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LGAPDRAVSFTVPTGNFGDIFAGYVAKRMGLPIEQLIIATNDNDILSRTLESGAYEMRGV
CCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHHCCHHHCCC
AQTTSPSMDIQISSNFERLLFEAHGRDAAAVRGLMQGLKQSGGFTISEKPLSAIRSEFSA
CCCCCCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHC
GRSTVDETAATIESVLSKDGYLLDPHSAIGVKVAREKASGTAPMVVLATAHPAKFPDAVK
CCHHHHHHHHHHHHHHCCCCEEECCCCHHHHEEEHHCCCCCCCEEEEEECCCCCCCHHHH
AACGVEPQLPAWLCDLMQRKESFTVLHNELKIVEEYVRHHSRA
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]