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The map label for this gene is yeiA [H]

Identifier: 23501189

GI number: 23501189

Start: 290088

End: 291398

Strand: Reverse

Name: yeiA [H]

Synonym: BR0282

Alternate gene names: 23501189

Gene position: 291398-290088 (Counterclockwise)

Preceding gene: 23501190

Following gene: 23501186

Centisome position: 13.82

GC content: 60.87

Gene sequence:

>1311_bases
ATGGCTGATCTTTCAACGAATTTCCTCGGCATCAAATCACCCAATCCGTTCTGGCTCGCCTCGGCCCCGCCGACCGACAA
GGCCTATAATGTCGAGCGCGCTTTCAAGGCAGGCTGGGGCGGCGTAGTCTGGAAAACGCTCGGCGCGGAAGGCCCGCCGG
TGGTCAACGTAAACGACCCGCGCTATGGCGCGATCCACGGCGCGGACCGGCGGCTTCTCGGCCTCAACAATATAGAACTC
ATCACCGACCGGCCGCTGGAGATAAACCTGCGCGAGATGAAAGAGGTGAAAATGCGCTGGCCGGACCGCGCATTGATCGC
CTCGATCATGGTGCCCTGCGAGGAGGAGGCATGGAAGGCGATCCTGCCGCTGGTGGAGGAAACCGGCGCGGACGGGATCG
AACTCAATTTCGGCTGCCCGCACGGCATGAGCGAGCGCGGCATGGGGGCAGCGGTTGGTCAGGTGCCGGAATATGTCGGC
ATGGTCGTCAAATGGTGCAAGCAATACAGCCGTATGCCGGTTATCACCAAGCTGACGCCCAATATCACCGATATCCGCAA
GCCTGCCCGTGCGGCTTTTGCCAATGGCACGGATGCGGTGTCACTCATCAATACGATCAATTCCATCGTGTCTGTCGATC
TCGACACGATGTCGCCCGTGCCTTCCATCGACGGGCGCGGCAGCCATGGCGGCTATTGCGGCCCGGCGGTCAAGCCGATT
GCGCTCAACATGGTGGCGGAGATTGCCCGCGACGCGGAAACGGCGGGTCTGCCGATTTCAGGCATTGGCGGCATCACCAC
CTGGCGGGATGCGGCTGAGTTTATCGCGCTTGGCTGCGGCACGGTGCAGGTCTGCACCGCCGCGATGACCTATGGCTTCA
AGGTCGTGCAGGAGATGATCGACGGTCTTTCCGACTGGATGGACAGCAAGGGCTATCAGACACTCGACGACTTCCAGGGC
TGCGCCGTTTCCCATGTGACCGACTGGCAATATCTCAACCTCAACTATGTCACCAAGGCCCGCATCAATCAGGACCTCTG
CATCCAATGCGGCCGCTGCCACATTGCCTGTGAGGACACCTCGCATCAGGCCATCACGGCCATGGTGAATGGCGCGCGTC
ATTTCGAGGTGATCGACGAGGAATGCGTCGGCTGCAATCTCTGTGTCAATGTCTGCCCGGTGGAGAACTGCATCACCATG
GAGCAGATTTCCGGCGTAGACCCGCGCACGAAGGCGCCCATCATGCCCGCTTACGCCAACTGGACCACGCATCCGAACAA
TCCGGCGGCCATGAAGGAGGCCGCCGAATAA

Upstream 100 bases:

>100_bases
CGAAGCCGTTCTTTCCGGTGCCGCGCATTATGCGCCCGCAGCGCCATCCCGTCACGCAACCGTTCAACCTGGCAGCGAAC
AGGGTTTGGGAGATTGAAAA

Downstream 100 bases:

>100_bases
AAGACTTTCGCAATAGAGCATTTCCAAAAAAGTGCGAAGCGCGTTCAGGCAAACCGTGCCTGAATGGCCTGCGACAGAAG
GGCGACAGGCCGCGTGGTGT

Product: dihydropyrimidine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MADLSTNFLGIKSPNPFWLASAPPTDKAYNVERAFKAGWGGVVWKTLGAEGPPVVNVNDPRYGAIHGADRRLLGLNNIEL
ITDRPLEINLREMKEVKMRWPDRALIASIMVPCEEEAWKAILPLVEETGADGIELNFGCPHGMSERGMGAAVGQVPEYVG
MVVKWCKQYSRMPVITKLTPNITDIRKPARAAFANGTDAVSLINTINSIVSVDLDTMSPVPSIDGRGSHGGYCGPAVKPI
ALNMVAEIARDAETAGLPISGIGGITTWRDAAEFIALGCGTVQVCTAAMTYGFKVVQEMIDGLSDWMDSKGYQTLDDFQG
CAVSHVTDWQYLNLNYVTKARINQDLCIQCGRCHIACEDTSHQAITAMVNGARHFEVIDEECVGCNLCVNVCPVENCITM
EQISGVDPRTKAPIMPAYANWTTHPNNPAAMKEAAE

Sequences:

>Translated_436_residues
MADLSTNFLGIKSPNPFWLASAPPTDKAYNVERAFKAGWGGVVWKTLGAEGPPVVNVNDPRYGAIHGADRRLLGLNNIEL
ITDRPLEINLREMKEVKMRWPDRALIASIMVPCEEEAWKAILPLVEETGADGIELNFGCPHGMSERGMGAAVGQVPEYVG
MVVKWCKQYSRMPVITKLTPNITDIRKPARAAFANGTDAVSLINTINSIVSVDLDTMSPVPSIDGRGSHGGYCGPAVKPI
ALNMVAEIARDAETAGLPISGIGGITTWRDAAEFIALGCGTVQVCTAAMTYGFKVVQEMIDGLSDWMDSKGYQTLDDFQG
CAVSHVTDWQYLNLNYVTKARINQDLCIQCGRCHIACEDTSHQAITAMVNGARHFEVIDEECVGCNLCVNVCPVENCITM
EQISGVDPRTKAPIMPAYANWTTHPNNPAAMKEAAE
>Mature_435_residues
ADLSTNFLGIKSPNPFWLASAPPTDKAYNVERAFKAGWGGVVWKTLGAEGPPVVNVNDPRYGAIHGADRRLLGLNNIELI
TDRPLEINLREMKEVKMRWPDRALIASIMVPCEEEAWKAILPLVEETGADGIELNFGCPHGMSERGMGAAVGQVPEYVGM
VVKWCKQYSRMPVITKLTPNITDIRKPARAAFANGTDAVSLINTINSIVSVDLDTMSPVPSIDGRGSHGGYCGPAVKPIA
LNMVAEIARDAETAGLPISGIGGITTWRDAAEFIALGCGTVQVCTAAMTYGFKVVQEMIDGLSDWMDSKGYQTLDDFQGC
AVSHVTDWQYLNLNYVTKARINQDLCIQCGRCHIACEDTSHQAITAMVNGARHFEVIDEECVGCNLCVNVCPVENCITME
QISGVDPRTKAPIMPAYANWTTHPNNPAAMKEAAE

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=335, Percent_Identity=37.3134328358209, Blast_Score=209, Evalue=5e-54,
Organism=Escherichia coli, GI87082059, Length=412, Percent_Identity=40.7766990291262, Blast_Score=318, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI71984108, Length=481, Percent_Identity=31.8087318087318, Blast_Score=224, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6322633, Length=327, Percent_Identity=26.605504587156, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24640763, Length=316, Percent_Identity=38.9240506329114, Blast_Score=215, Evalue=6e-56,
Organism=Drosophila melanogaster, GI18858217, Length=316, Percent_Identity=38.9240506329114, Blast_Score=215, Evalue=6e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: NA

Molecular weight: Translated: 47276; Mature: 47144

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00198 4FE4S_FERREDOXIN ; PS00307 LECTIN_LEGUME_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLSTNFLGIKSPNPFWLASAPPTDKAYNVERAFKAGWGGVVWKTLGAEGPPVVNVNDP
CCCCCCCEEEECCCCCEEEECCCCCCCCCCHHHHHHCCCCCHHHHHCCCCCCCEEECCCC
RYGAIHGADRRLLGLNNIELITDRPLEINLREMKEVKMRWPDRALIASIMVPCEEEAWKA
CCCEEECCCCEEECCCCEEEEECCCCEECHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHH
ILPLVEETGADGIELNFGCPHGMSERGMGAAVGQVPEYVGMVVKWCKQYSRMPVITKLTP
HHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
NITDIRKPARAAFANGTDAVSLINTINSIVSVDLDTMSPVPSIDGRGSHGGYCGPAVKPI
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCHHH
ALNMVAEIARDAETAGLPISGIGGITTWRDAAEFIALGCGTVQVCTAAMTYGFKVVQEMI
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
DGLSDWMDSKGYQTLDDFQGCAVSHVTDWQYLNLNYVTKARINQDLCIQCGRCHIACEDT
HHHHHHHHCCCCCCHHHHCCCEEEECCCEEEEEEEEEEHHHCCCCHHEECCCEEEEECCC
SHQAITAMVNGARHFEVIDEECVGCNLCVNVCPVENCITMEQISGVDPRTKAPIMPAYAN
CCHHHHHHHCCCHHHEEHHHHHCCCEEEEEECCCCHHEEHHHHCCCCCCCCCCCCCCCCC
WTTHPNNPAAMKEAAE
CCCCCCCCHHHHHCCC
>Mature Secondary Structure 
ADLSTNFLGIKSPNPFWLASAPPTDKAYNVERAFKAGWGGVVWKTLGAEGPPVVNVNDP
CCCCCCEEEECCCCCEEEECCCCCCCCCCHHHHHHCCCCCHHHHHCCCCCCCEEECCCC
RYGAIHGADRRLLGLNNIELITDRPLEINLREMKEVKMRWPDRALIASIMVPCEEEAWKA
CCCEEECCCCEEECCCCEEEEECCCCEECHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHH
ILPLVEETGADGIELNFGCPHGMSERGMGAAVGQVPEYVGMVVKWCKQYSRMPVITKLTP
HHHHHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
NITDIRKPARAAFANGTDAVSLINTINSIVSVDLDTMSPVPSIDGRGSHGGYCGPAVKPI
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCHHH
ALNMVAEIARDAETAGLPISGIGGITTWRDAAEFIALGCGTVQVCTAAMTYGFKVVQEMI
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
DGLSDWMDSKGYQTLDDFQGCAVSHVTDWQYLNLNYVTKARINQDLCIQCGRCHIACEDT
HHHHHHHHCCCCCCHHHHCCCEEEECCCEEEEEEEEEEHHHCCCCHHEECCCEEEEECCC
SHQAITAMVNGARHFEVIDEECVGCNLCVNVCPVENCITMEQISGVDPRTKAPIMPAYAN
CCHHHHHHHCCCHHHEEHHHHHCCCEEEEEECCCCHHEEHHHHCCCCCCCCCCCCCCCCC
WTTHPNNPAAMKEAAE
CCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]