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The map label for this gene is dhT [H]

Identifier: 23501185

GI number: 23501185

Start: 285987

End: 287456

Strand: Reverse

Name: dhT [H]

Synonym: BR0278

Alternate gene names: 23501185

Gene position: 287456-285987 (Counterclockwise)

Preceding gene: 23501186

Following gene: 23501182

Centisome position: 13.64

GC content: 59.86

Gene sequence:

>1470_bases
ATGGCCAAGACCGGGGCAAGCAAAGTCATCAAGGGCGGCACCGTCATCACGGCTGACCGCACGTTCAGGGCAGATATTCT
TATCGAAGACGGCAAGATCGCCGCCATTGGCGATAGCCTTGAAGGCGATGAGGTCATCGACGCATCCGGCTGCTATGTCA
TGCCGGGCGGCATCGACCCGCACACCCACCTGCAAATGCCCTTCATGGGCACATATTCCTCCGACGATTTCGACACGGGC
ACGGCGGCAGCACTTGCCGGCGGCACGACGATGGTGGTCGATTTCGTCCTGCCGGATTCCGAGGGCAATCTTCTGGATGC
GCTTCAGGAATGGTTTCAGAAGGCGGGCAAGGCGCGCACCGATTATTCGTTCCACATGGCGATCACCGGCTGGAACGAGC
GCACTTTCAACGAAATGGCCGAAGTGGTGAAGCGCGGCATCAACACGTTCAAGCATTTCATGGCCTATAAGGGCGCGCTG
ATGGTGAATGACGATGAGATGTTCGCCTCGTTCCAGCGTTGTGCGGAACTGGGTGCCATGCCGCTCGTCCATGCGGAAAA
CGGCGATATCGTCGCGCAATTGCAGGCGAAACTCATGGCCGAAGGCAATGACGGGCCGGAAGCCCATGCCTATTCCCGCC
CGCCGGAAGTGGAAGGAGAAGCCACCAATCGCGCCATCATGATCGCCGATCAGGCGGGCGTACCGCTTTATGTGGTGCAT
GTCTCCTGCGAGCAAAGCCATGAAGCAATCCGCCGCGCGCGCCAGAAGGGTATGCGTGTTTTCGGCGAGCCGCTGATCCA
GCATCTGACGCTCGATGAAAGCGAATATCACAATCGCGACTGGGACTATGCCGCGCGGCGCGTGATGTCGCCGCCGTTCC
GCGACAAGCTCAATCAGGACAGCCTCTGGGCGGGCCTTGCGGCTGGAAGCCTGCAATGCGTGGCGACCGATCATTGCGCC
TTCACCACCGAGCAGAAACGCTATGGCATCGGCAATTTCACCAAGATTCCGAACGGCACCGGCGGGCTGGAGGAACGTAT
GCCGGTTCTGTGGACGCGCGGCGTGCGAACGGGCCGCCTGACACCTAATGAGTTCGTGGCCGTCACTTCCACGAACATCG
CGAAAATCCTCAACATCTATCCGCAGAAAGGTGCCGTGGTGCCAGGCGCGGACGCCGATCTTGTTATATGGGATCCGGAG
ACGACCAAGAAGATTTCCGCCAAGACGCAGCATTCCTCCATCGATTACAACGTGTTCGAGGGTTTCGAGCTGAAGGGGCT
GCCGATCATGACGCTGTCGCGCGGGCGGATCGCCTTCGACAAGGGACAGGTGACAGCAAAACCGGGCGACGGGCGCTTCA
TCGAGCGTGAGCCGAATGGCGCGGTCAATCGCGCGCTATCGCAATGGAAGGAAATTGTCGCGCCGCGCAAGGTGGAGCGC
AGTGCCGAACATATGCCGATAGGAGTCTGA

Upstream 100 bases:

>100_bases
CGACGTGCTTCTGCATGCTGTATTGGAGACTGCTGAAATTGTAAGCTGAACTTCCCAATACCGCTGTTCGCAACAAAACC
AACAAGGGGAACGACGAACA

Downstream 100 bases:

>100_bases
TGCGATGACCATGGCTCAGCTTCGGGAAGTGCATATGATGAACGTCAATAGCATGGCCCCGGAGCGGGGCCCGAAAGCAG
ACGGGAAGCGTGCTTCCGGG

Product: phenylhydantoinase

Products: NA

Alternate protein names: DHPase [H]

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MAKTGASKVIKGGTVITADRTFRADILIEDGKIAAIGDSLEGDEVIDASGCYVMPGGIDPHTHLQMPFMGTYSSDDFDTG
TAAALAGGTTMVVDFVLPDSEGNLLDALQEWFQKAGKARTDYSFHMAITGWNERTFNEMAEVVKRGINTFKHFMAYKGAL
MVNDDEMFASFQRCAELGAMPLVHAENGDIVAQLQAKLMAEGNDGPEAHAYSRPPEVEGEATNRAIMIADQAGVPLYVVH
VSCEQSHEAIRRARQKGMRVFGEPLIQHLTLDESEYHNRDWDYAARRVMSPPFRDKLNQDSLWAGLAAGSLQCVATDHCA
FTTEQKRYGIGNFTKIPNGTGGLEERMPVLWTRGVRTGRLTPNEFVAVTSTNIAKILNIYPQKGAVVPGADADLVIWDPE
TTKKISAKTQHSSIDYNVFEGFELKGLPIMTLSRGRIAFDKGQVTAKPGDGRFIEREPNGAVNRALSQWKEIVAPRKVER
SAEHMPIGV

Sequences:

>Translated_489_residues
MAKTGASKVIKGGTVITADRTFRADILIEDGKIAAIGDSLEGDEVIDASGCYVMPGGIDPHTHLQMPFMGTYSSDDFDTG
TAAALAGGTTMVVDFVLPDSEGNLLDALQEWFQKAGKARTDYSFHMAITGWNERTFNEMAEVVKRGINTFKHFMAYKGAL
MVNDDEMFASFQRCAELGAMPLVHAENGDIVAQLQAKLMAEGNDGPEAHAYSRPPEVEGEATNRAIMIADQAGVPLYVVH
VSCEQSHEAIRRARQKGMRVFGEPLIQHLTLDESEYHNRDWDYAARRVMSPPFRDKLNQDSLWAGLAAGSLQCVATDHCA
FTTEQKRYGIGNFTKIPNGTGGLEERMPVLWTRGVRTGRLTPNEFVAVTSTNIAKILNIYPQKGAVVPGADADLVIWDPE
TTKKISAKTQHSSIDYNVFEGFELKGLPIMTLSRGRIAFDKGQVTAKPGDGRFIEREPNGAVNRALSQWKEIVAPRKVER
SAEHMPIGV
>Mature_488_residues
AKTGASKVIKGGTVITADRTFRADILIEDGKIAAIGDSLEGDEVIDASGCYVMPGGIDPHTHLQMPFMGTYSSDDFDTGT
AAALAGGTTMVVDFVLPDSEGNLLDALQEWFQKAGKARTDYSFHMAITGWNERTFNEMAEVVKRGINTFKHFMAYKGALM
VNDDEMFASFQRCAELGAMPLVHAENGDIVAQLQAKLMAEGNDGPEAHAYSRPPEVEGEATNRAIMIADQAGVPLYVVHV
SCEQSHEAIRRARQKGMRVFGEPLIQHLTLDESEYHNRDWDYAARRVMSPPFRDKLNQDSLWAGLAAGSLQCVATDHCAF
TTEQKRYGIGNFTKIPNGTGGLEERMPVLWTRGVRTGRLTPNEFVAVTSTNIAKILNIYPQKGAVVPGADADLVIWDPET
TKKISAKTQHSSIDYNVFEGFELKGLPIMTLSRGRIAFDKGQVTAKPGDGRFIEREPNGAVNRALSQWKEIVAPRKVERS
AEHMPIGV

Specific function: Catalyzes the hydrolysis of dihydropyrimidines and of the structurally related DL-5-mono-substituted hydantoins, to produce N-carbamoyl-D-amino acids [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=484, Percent_Identity=46.2809917355372, Blast_Score=451, Evalue=1e-127,
Organism=Homo sapiens, GI4503379, Length=456, Percent_Identity=47.1491228070175, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI190194363, Length=455, Percent_Identity=47.6923076923077, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI4503377, Length=456, Percent_Identity=46.7105263157895, Blast_Score=418, Evalue=1e-117,
Organism=Homo sapiens, GI4503051, Length=455, Percent_Identity=44.8351648351648, Blast_Score=406, Evalue=1e-113,
Organism=Homo sapiens, GI62422571, Length=455, Percent_Identity=44.8351648351648, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI19923821, Length=480, Percent_Identity=43.125, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI18105007, Length=414, Percent_Identity=26.5700483091787, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI87082175, Length=457, Percent_Identity=40.7002188183807, Blast_Score=339, Evalue=3e-94,
Organism=Escherichia coli, GI1786722, Length=456, Percent_Identity=31.7982456140351, Blast_Score=188, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI17539558, Length=482, Percent_Identity=47.5103734439834, Blast_Score=442, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI71989490, Length=482, Percent_Identity=45.850622406639, Blast_Score=433, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI86575075, Length=458, Percent_Identity=33.4061135371179, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI193204318, Length=438, Percent_Identity=25.5707762557078, Blast_Score=92, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6322218, Length=410, Percent_Identity=26.3414634146341, Blast_Score=126, Evalue=6e-30,
Organism=Drosophila melanogaster, GI221377917, Length=455, Percent_Identity=46.5934065934066, Blast_Score=413, Evalue=1e-115,
Organism=Drosophila melanogaster, GI17137462, Length=453, Percent_Identity=46.1368653421634, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24644287, Length=308, Percent_Identity=44.4805194805195, Blast_Score=255, Evalue=5e-68,
Organism=Drosophila melanogaster, GI24644289, Length=258, Percent_Identity=44.9612403100775, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24642586, Length=408, Percent_Identity=29.4117647058824, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI18859883, Length=463, Percent_Identity=22.4622030237581, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.2 [H]

Molecular weight: Translated: 53612; Mature: 53481

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTGASKVIKGGTVITADRTFRADILIEDGKIAAIGDSLEGDEVIDASGCYVMPGGIDP
CCCCCCCCEECCCEEEEECCEEEEEEEEECCEEEEECCCCCCCCEEECCCCEEECCCCCC
HTHLQMPFMGTYSSDDFDTGTAAALAGGTTMVVDFVLPDSEGNLLDALQEWFQKAGKART
CCEEECCEEECCCCCCCCCCCHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCC
DYSFHMAITGWNERTFNEMAEVVKRGINTFKHFMAYKGALMVNDDEMFASFQRCAELGAM
CEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHCCC
PLVHAENGDIVAQLQAKLMAEGNDGPEAHAYSRPPEVEGEATNRAIMIADQAGVPLYVVH
CEEECCCCCEEEEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEE
VSCEQSHEAIRRARQKGMRVFGEPLIQHLTLDESEYHNRDWDYAARRVMSPPFRDKLNQD
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHCCCCHHHHCCCC
SLWAGLAAGSLQCVATDHCAFTTEQKRYGIGNFTKIPNGTGGLEERMPVLWTRGVRTGRL
HHHHHHCCCCEEEEEECCEEECCCHHHCCCCCCCCCCCCCCCHHHCCCEEEECCCCCCCC
TPNEFVAVTSTNIAKILNIYPQKGAVVPGADADLVIWDPETTKKISAKTQHSSIDYNVFE
CCCCEEEEECCCHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCHHHCCCCCCCCCEEEEC
GFELKGLPIMTLSRGRIAFDKGQVTAKPGDGRFIEREPNGAVNRALSQWKEIVAPRKVER
CCEECCCEEEEECCCEEEEECCEEEECCCCCCEEEECCCHHHHHHHHHHHHHHCCHHHHH
SAEHMPIGV
CCCCCCCCC
>Mature Secondary Structure 
AKTGASKVIKGGTVITADRTFRADILIEDGKIAAIGDSLEGDEVIDASGCYVMPGGIDP
CCCCCCCEECCCEEEEECCEEEEEEEEECCEEEEECCCCCCCCEEECCCCEEECCCCCC
HTHLQMPFMGTYSSDDFDTGTAAALAGGTTMVVDFVLPDSEGNLLDALQEWFQKAGKART
CCEEECCEEECCCCCCCCCCCHHHHCCCCEEEEEEEEECCCCCHHHHHHHHHHHHCCCCC
DYSFHMAITGWNERTFNEMAEVVKRGINTFKHFMAYKGALMVNDDEMFASFQRCAELGAM
CEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHCCC
PLVHAENGDIVAQLQAKLMAEGNDGPEAHAYSRPPEVEGEATNRAIMIADQAGVPLYVVH
CEEECCCCCEEEEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEE
VSCEQSHEAIRRARQKGMRVFGEPLIQHLTLDESEYHNRDWDYAARRVMSPPFRDKLNQD
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHCCCCHHHHCCCC
SLWAGLAAGSLQCVATDHCAFTTEQKRYGIGNFTKIPNGTGGLEERMPVLWTRGVRTGRL
HHHHHHCCCCEEEEEECCEEECCCHHHCCCCCCCCCCCCCCCHHHCCCEEEECCCCCCCC
TPNEFVAVTSTNIAKILNIYPQKGAVVPGADADLVIWDPETTKKISAKTQHSSIDYNVFE
CCCCEEEEECCCHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCHHHCCCCCCCCCEEEEC
GFELKGLPIMTLSRGRIAFDKGQVTAKPGDGRFIEREPNGAVNRALSQWKEIVAPRKVER
CCEECCCEEEEECCCEEEEECCEEEECCCCCCEEEECCCHHHHHHHHHHHHHHCCHHHHH
SAEHMPIGV
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]