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The map label for this gene is nrdA [H]

Identifier: 23100544

GI number: 23100544

Start: 3211759

End: 3213993

Strand: Reverse

Name: nrdA [H]

Synonym: OB3089

Alternate gene names: 23100544

Gene position: 3213993-3211759 (Counterclockwise)

Preceding gene: 23100545

Following gene: 23100543

Centisome position: 88.53

GC content: 36.82

Gene sequence:

>2235_bases
ATGACAATGGACATTGGAACAACGTTGGAAGCATCAGCTTGGCAAAAGGTAGAAAGAGCAAGTCAAAACCTAAATATAAA
CAAAAATGAATGGTATGAGAAAGCGGAGAAAATCATTCCTACAAATAGCTCGGAAGCTAAGTTAGAGGATGCGCTTATTA
ATGTTGCTTTAGAAAACATGGATGAAGCTACTCCTAACTGGGGATTTGCAGCTGCACGTATATATGTAGAAAAATTGTAC
CGCGAAGCTAGCAATAATAGAGGTTATACGCAAGGATCTTACGGTTCTTTCTACGCATTATTAGAACAATTAACTGAAAA
AGGTATCTATACGCCTGCCCTTCTACAAAAATATACTAAAGAAGACATTGAAGAATTTGGAAAAGCTATTCAACCTGAGC
GAGATCAACTATTTAATTATCTAGGTATATACACTGTGGCGACTCGTTACTTGGCTACTGATCATGAAAAAAATGTTTAT
GAACTACCCCAGGAAAGATGGATGGTCATTGCTATGCATATTATGCAAGATGAGCCTGCCGATCAACGTCAAGAGAATGT
TTTAGAAGCATATTGGGCGTTAAGTAATTTATATATGACGGTTGCTACACCAACACTGACAAATGCTGGAAAAACACATG
GTCAATTATCTAGTTGTTTCATAGATACTGTGGATGATAGCTTACAATCAATATATGATAGTAATTCCGATATTGCGAAG
TTATCTAAAAACGGTGGCGGTATTGGAGTTTACATGGGCAAAATTCGTGCAAGAGGAAGTTCCATTAAGGGATTCAAAGG
AATGTCTAGTGGCGTTGTACCATGGATAAAACAATTGAATAATACAGCGGTAAGTGTTGACCAACTTGGTACTCGAAAAG
GCGCAATTGCGATTTATTTAGATGTTTGGCATCAAGATATTGAATCATTCCTTGATTTAAAGTTAAACAACGGTGACGAT
CGTATGCGAGCTCACGACATCTTTACAGGTGTATGTTTGCCAGATTACTTTATGGAACAAGTAGAAAATCGTGGAGATTG
GTACCTGTTTGACCCGCATGAAGTAAGACAAGTAATGGGATATTCCTTAGAAGACTTCTATGACGAACAAAAAGGTAGCG
GAAGTTTTAGAACAAGATATGAAGAATGTATAGCAAATGAAGCGTTGTCGAAACGCAAAGTTCCAGCAATTGAGATTATG
AAACGCTTAATGAAATCACAATTAGAGTCTGGTACACCGTTTATGTTCTATCGTGACGAAGTTAACCGTCAAAATGCAAA
CGCACATGAAGGTTTAATCTATTGTTCAAATCTGTGTACAGAGATTACGCAAAACCAGTCTCCAACTGAGTTTGTAGAAG
AGTTCTTAGAAAATGAAAATACAATCGTAAAGAAATTTAAATCTGGAGATTACGTAGTTTGTAACTTAAGCTCTGTAAAT
TTAGGTAGAGCTGTGAAAAACGATGTACTAGAAAGACTTATTCCGATTCAAGTACGTATGTTAGATAATGTGATTGATAT
AAATACCTTACCAATCAAACAAGCGGAGATTACGAATAGAAAATACCGTGCGATTGGATTAGGAACGTTTGGATGGCATC
ATTTATTGGCGCTAAAAGGTATTGCTTGGGAGTCAGATGAAGCAGTTGCGTATGCAGATGAATTATACGAAAAAATTGCA
TATCTAACTATTCAAAGCAGCATGGAATTAAGTAAAGAAAAAGGTCATTATCCAGTATATGAGGGAAGTAAATGGCAAAC
TGGGGAGTATTTTGACCAAAAAGGATACACAGGAAACAAATGGGACGAATTAAAAGCTGAAGTCAAACAGCATGGTATGC
GTAATGGATATCTTATGGCGGTAGCTCCAAATTCAACTACAGCAATGATTGCTGGTTCAACGGCTAGTATCGATCCGATC
TTCCAAGTATTCTATTATGAAGAGAAAAAAGACTTCAAGATTCCTGTGACTGCACCTGAGTTAGATCATCATACGTATAA
TGTCTATCGTCGATCTGCGTATATTGTAGACCAACGCTTTTCTGTGAAGCAAAATGCGAAACGTCAGAAGCACATTGATC
AAAGTATTTCTTTTAACTTCTATGTTCCTAATACAATAAAAGCATCTGTATTGTTAGACCTCCATACGCAAGCATGGAGA
GAAGGTTTAAAAACAACTTACTATGTACGTTCTACATCCAATGATATTGAAGAATGTGAGTGGTGTTCAAGTTGA

Upstream 100 bases:

>100_bases
AAGATAGAGTAAATTATCTATCATTGAAGAACCAATCTCTGGATTAGGAGATTGGTTTTTTTATTTATACATATTTTTTA
TATTTTTGGGAGGCAAAACT

Downstream 100 bases:

>100_bases
GGATGATCATAGCTTATCTAACCTATAGTGGTAATACAGAGGAAGTTGCCTTTATGATCCAAGATTATTTACAAAAGGAT
GGAGTTGAAGTGGATTTGCA

Product: ribonucleotide-diphosphate reductase alpha subunit

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 744; Mature: 743

Protein sequence:

>744_residues
MTMDIGTTLEASAWQKVERASQNLNINKNEWYEKAEKIIPTNSSEAKLEDALINVALENMDEATPNWGFAAARIYVEKLY
REASNNRGYTQGSYGSFYALLEQLTEKGIYTPALLQKYTKEDIEEFGKAIQPERDQLFNYLGIYTVATRYLATDHEKNVY
ELPQERWMVIAMHIMQDEPADQRQENVLEAYWALSNLYMTVATPTLTNAGKTHGQLSSCFIDTVDDSLQSIYDSNSDIAK
LSKNGGGIGVYMGKIRARGSSIKGFKGMSSGVVPWIKQLNNTAVSVDQLGTRKGAIAIYLDVWHQDIESFLDLKLNNGDD
RMRAHDIFTGVCLPDYFMEQVENRGDWYLFDPHEVRQVMGYSLEDFYDEQKGSGSFRTRYEECIANEALSKRKVPAIEIM
KRLMKSQLESGTPFMFYRDEVNRQNANAHEGLIYCSNLCTEITQNQSPTEFVEEFLENENTIVKKFKSGDYVVCNLSSVN
LGRAVKNDVLERLIPIQVRMLDNVIDINTLPIKQAEITNRKYRAIGLGTFGWHHLLALKGIAWESDEAVAYADELYEKIA
YLTIQSSMELSKEKGHYPVYEGSKWQTGEYFDQKGYTGNKWDELKAEVKQHGMRNGYLMAVAPNSTTAMIAGSTASIDPI
FQVFYYEEKKDFKIPVTAPELDHHTYNVYRRSAYIVDQRFSVKQNAKRQKHIDQSISFNFYVPNTIKASVLLDLHTQAWR
EGLKTTYYVRSTSNDIEECEWCSS

Sequences:

>Translated_744_residues
MTMDIGTTLEASAWQKVERASQNLNINKNEWYEKAEKIIPTNSSEAKLEDALINVALENMDEATPNWGFAAARIYVEKLY
REASNNRGYTQGSYGSFYALLEQLTEKGIYTPALLQKYTKEDIEEFGKAIQPERDQLFNYLGIYTVATRYLATDHEKNVY
ELPQERWMVIAMHIMQDEPADQRQENVLEAYWALSNLYMTVATPTLTNAGKTHGQLSSCFIDTVDDSLQSIYDSNSDIAK
LSKNGGGIGVYMGKIRARGSSIKGFKGMSSGVVPWIKQLNNTAVSVDQLGTRKGAIAIYLDVWHQDIESFLDLKLNNGDD
RMRAHDIFTGVCLPDYFMEQVENRGDWYLFDPHEVRQVMGYSLEDFYDEQKGSGSFRTRYEECIANEALSKRKVPAIEIM
KRLMKSQLESGTPFMFYRDEVNRQNANAHEGLIYCSNLCTEITQNQSPTEFVEEFLENENTIVKKFKSGDYVVCNLSSVN
LGRAVKNDVLERLIPIQVRMLDNVIDINTLPIKQAEITNRKYRAIGLGTFGWHHLLALKGIAWESDEAVAYADELYEKIA
YLTIQSSMELSKEKGHYPVYEGSKWQTGEYFDQKGYTGNKWDELKAEVKQHGMRNGYLMAVAPNSTTAMIAGSTASIDPI
FQVFYYEEKKDFKIPVTAPELDHHTYNVYRRSAYIVDQRFSVKQNAKRQKHIDQSISFNFYVPNTIKASVLLDLHTQAWR
EGLKTTYYVRSTSNDIEECEWCSS
>Mature_743_residues
TMDIGTTLEASAWQKVERASQNLNINKNEWYEKAEKIIPTNSSEAKLEDALINVALENMDEATPNWGFAAARIYVEKLYR
EASNNRGYTQGSYGSFYALLEQLTEKGIYTPALLQKYTKEDIEEFGKAIQPERDQLFNYLGIYTVATRYLATDHEKNVYE
LPQERWMVIAMHIMQDEPADQRQENVLEAYWALSNLYMTVATPTLTNAGKTHGQLSSCFIDTVDDSLQSIYDSNSDIAKL
SKNGGGIGVYMGKIRARGSSIKGFKGMSSGVVPWIKQLNNTAVSVDQLGTRKGAIAIYLDVWHQDIESFLDLKLNNGDDR
MRAHDIFTGVCLPDYFMEQVENRGDWYLFDPHEVRQVMGYSLEDFYDEQKGSGSFRTRYEECIANEALSKRKVPAIEIMK
RLMKSQLESGTPFMFYRDEVNRQNANAHEGLIYCSNLCTEITQNQSPTEFVEEFLENENTIVKKFKSGDYVVCNLSSVNL
GRAVKNDVLERLIPIQVRMLDNVIDINTLPIKQAEITNRKYRAIGLGTFGWHHLLALKGIAWESDEAVAYADELYEKIAY
LTIQSSMELSKEKGHYPVYEGSKWQTGEYFDQKGYTGNKWDELKAEVKQHGMRNGYLMAVAPNSTTAMIAGSTASIDPIF
QVFYYEEKKDFKIPVTAPELDHHTYNVYRRSAYIVDQRFSVKQNAKRQKHIDQSISFNFYVPNTIKASVLLDLHTQAWRE
GLKTTYYVRSTSNDIEECEWCSS

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=725, Percent_Identity=33.1034482758621, Blast_Score=329, Evalue=5e-90,
Organism=Escherichia coli, GI1789030, Length=677, Percent_Identity=29.9852289512555, Blast_Score=284, Evalue=2e-77,
Organism=Escherichia coli, GI2367133, Length=702, Percent_Identity=26.7806267806268, Blast_Score=248, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI17555242, Length=770, Percent_Identity=30.2597402597403, Blast_Score=316, Evalue=3e-86,
Organism=Saccharomyces cerevisiae, GI6320914, Length=742, Percent_Identity=30.3234501347709, Blast_Score=306, Evalue=1e-83,
Organism=Saccharomyces cerevisiae, GI6322123, Length=781, Percent_Identity=29.3213828425096, Blast_Score=305, Evalue=2e-83,
Organism=Drosophila melanogaster, GI17352481, Length=720, Percent_Identity=31.1111111111111, Blast_Score=318, Evalue=8e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 85119; Mature: 84988

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMDIGTTLEASAWQKVERASQNLNINKNEWYEKAEKIIPTNSSEAKLEDALINVALENM
CCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
DEATPNWGFAAARIYVEKLYREASNNRGYTQGSYGSFYALLEQLTEKGIYTPALLQKYTK
HCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHH
EDIEEFGKAIQPERDQLFNYLGIYTVATRYLATDHEKNVYELPQERWMVIAMHIMQDEPA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHCCCCC
DQRQENVLEAYWALSNLYMTVATPTLTNAGKTHGQLSSCFIDTVDDSLQSIYDSNSDIAK
CHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHH
LSKNGGGIGVYMGKIRARGSSIKGFKGMSSGVVPWIKQLNNTAVSVDQLGTRKGAIAIYL
HHCCCCEEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEEHHHHCCCCCCEEEEE
DVWHQDIESFLDLKLNNGDDRMRAHDIFTGVCLPDYFMEQVENRGDWYLFDPHEVRQVMG
HHHHHHHHHHHCEEECCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCEEEECHHHHHHHHC
YSLEDFYDEQKGSGSFRTRYEECIANEALSKRKVPAIEIMKRLMKSQLESGTPFMFYRDE
CCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCC
VNRQNANAHEGLIYCSNLCTEITQNQSPTEFVEEFLENENTIVKKFKSGDYVVCNLSSVN
CCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEHHCCCCCEEEEEECCCC
LGRAVKNDVLERLIPIQVRMLDNVIDINTLPIKQAEITNRKYRAIGLGTFGWHHLLALKG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCEEEEEEECCHHHHHHHHHHC
IAWESDEAVAYADELYEKIAYLTIQSSMELSKEKGHYPVYEGSKWQTGEYFDQKGYTGNK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCCH
WDELKAEVKQHGMRNGYLMAVAPNSTTAMIAGSTASIDPIFQVFYYEEKKDFKIPVTAPE
HHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCCHHHHEEEEECCCCEEECCCCCC
LDHHTYNVYRRSAYIVDQRFSVKQNAKRQKHIDQSISFNFYVPNTIKASVLLDLHTQAWR
CCCCHHHHHHHEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCEEHHEEEHHHHHHH
EGLKTTYYVRSTSNDIEECEWCSS
CCCCEEEEEECCCCCHHHHHCCCC
>Mature Secondary Structure 
TMDIGTTLEASAWQKVERASQNLNINKNEWYEKAEKIIPTNSSEAKLEDALINVALENM
CCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
DEATPNWGFAAARIYVEKLYREASNNRGYTQGSYGSFYALLEQLTEKGIYTPALLQKYTK
HCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHH
EDIEEFGKAIQPERDQLFNYLGIYTVATRYLATDHEKNVYELPQERWMVIAMHIMQDEPA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHCCCCC
DQRQENVLEAYWALSNLYMTVATPTLTNAGKTHGQLSSCFIDTVDDSLQSIYDSNSDIAK
CHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHH
LSKNGGGIGVYMGKIRARGSSIKGFKGMSSGVVPWIKQLNNTAVSVDQLGTRKGAIAIYL
HHCCCCEEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCEEEHHHHCCCCCCEEEEE
DVWHQDIESFLDLKLNNGDDRMRAHDIFTGVCLPDYFMEQVENRGDWYLFDPHEVRQVMG
HHHHHHHHHHHCEEECCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCEEEECHHHHHHHHC
YSLEDFYDEQKGSGSFRTRYEECIANEALSKRKVPAIEIMKRLMKSQLESGTPFMFYRDE
CCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCC
VNRQNANAHEGLIYCSNLCTEITQNQSPTEFVEEFLENENTIVKKFKSGDYVVCNLSSVN
CCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEHHCCCCCEEEEEECCCC
LGRAVKNDVLERLIPIQVRMLDNVIDINTLPIKQAEITNRKYRAIGLGTFGWHHLLALKG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCEEEEEEECCHHHHHHHHHHC
IAWESDEAVAYADELYEKIAYLTIQSSMELSKEKGHYPVYEGSKWQTGEYFDQKGYTGNK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCCH
WDELKAEVKQHGMRNGYLMAVAPNSTTAMIAGSTASIDPIFQVFYYEEKKDFKIPVTAPE
HHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCCHHHHEEEEECCCCEEECCCCCC
LDHHTYNVYRRSAYIVDQRFSVKQNAKRQKHIDQSISFNFYVPNTIKASVLLDLHTQAWR
CCCCHHHHHHHEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCEEHHEEEHHHHHHH
EGLKTTYYVRSTSNDIEECEWCSS
CCCCEEEEEECCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876 [H]