Click here to switch to the map view.

The map label for this gene is tlpA [H]

Identifier: 23100442

GI number: 23100442

Start: 3097818

End: 3099218

Strand: Reverse

Name: tlpA [H]

Synonym: OB2987

Alternate gene names: 23100442

Gene position: 3099218-3097818 (Counterclockwise)

Preceding gene: 23100443

Following gene: 23100441

Centisome position: 85.37

GC content: 36.97

Gene sequence:

>1401_bases
ATGAAGAAAAAGTATCGGTTCAGTCTACGCTTGAAGCTTGTTGTTTTAATAACTGTATTAGCAATGATTACTTATGGATT
TAGCGCGCTATTTATTTATGTTGTAAATGACTATGTACAGCAATTTTGGAGTGTTTCCGATGAGTTGTACTTGACAATCA
TATTACTATTAGGAATCTTTTGGTCAGGATTACTCGCATTTTTTGCGGCTAAATGGATTACGAAGCCAATGGAAAATCTA
GAAAAAGTTGCAACGGAAGCTTCTCTAGGGAATTTGGATCAACACGTGCATATACCACGCTCGGACGATGAAATTCGTTC
TCTTTCTTTAGCAGTCAATGGTATGCTGCTAAATCTGAACCGCATGGTACATAATATTGATACACATTTTGAAAAAACGA
ATGAGACGGTAGTTCAATTAAAGAATGCATCTCATAAAGCATCTCAACATTCTACAGCGATTGGTCACTCTATCGTTGAT
ATTTCAAATGGTGCAGAGAGCTCTTCAGAAGCTACCCAACAAACGGCTGCTTCGGTTGAATTAGCTACAGATTTAGCTCG
AAAAGTACAAGGAAAAGCAGAACAGTCTACAGATAAATCGAAATCAATGCTTGTTACCTTACAGGAAGGCCAACGCGTTG
TTGGACAGTTAGTAGCTGGTATTCAAAAATTGACAAATGAACAAGAATTATCACTTAAAGATGTTAATCATTTAAAGCAG
AATGCAAAACAAGTGGAAACAATCATTACGTTAGTCGGAGAAATTGCGGAACAGACGAATCTTCTAGCTTTAAATGCATC
AATAGAAGCAGCACGGGCTGGTGAACATGGAAAAGGTTTTGCTGTTGTTGCTGAGGAAATTCGTAAACTTGCTGATCAAA
GTGCCCAAGCAGTGCAGCAGATATCGGAATTAATTGGAGCGATACAGCATGATGTTACTCAAGTTGTTGAAAAAATAAAT
GAAAATGTGCAGTATGCAAAGGAAGAAGCAAAACAAGGAGAAGGAACAAACCGCACAATTGAAGAGATGGCTGATTCCAT
CACCGATGTTGCGAATGAAATTGAAACGATTCATCAGTTAGTAGATCAGCAACTTCATTCTATTCAAGATACTGTACAGC
AATCACAAGAAGTTGCGGCTATTGCAGAAGAAACATCAGCAGGAACAGAGGAAGTTAACGCTGCTATTCAAGAACAAGTA
ATAACAATGGAGCAAGTCGATCAATTAGCTTATGAAATGGAACAACATGCAACTAATTTAAAATCACAAATTAACCAATT
TAAGGTAAGAAAACAAGAGGAAGAAAGCAATGTTGAGCCTTTTAAGGCAGAGCAGGAACAATCTTTTCTTGAAAAAAGTG
AATCTACTTCTGAAAAAAATAGGAATAAAGAAGTTTCGTAA

Upstream 100 bases:

>100_bases
CATTTGGAGGTGGATTAGATCAATATCGTAATACGATGAAAGAAATTGAAGACTGCATAGACCTTTTTGTTCAAAAACAT
ACGTAATGCAGGAGGAAATT

Downstream 100 bases:

>100_bases
ATTAACAAAAATCATGGTATGCTTATAATGAAGGCGCAAGCACCCGTTTTACAACGTATAAACGTCAGTGAAGCAATGTA
AAAACTTTATTTAATAGTGT

Product: methyl-accepting chemotaxis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MKKKYRFSLRLKLVVLITVLAMITYGFSALFIYVVNDYVQQFWSVSDELYLTIILLLGIFWSGLLAFFAAKWITKPMENL
EKVATEASLGNLDQHVHIPRSDDEIRSLSLAVNGMLLNLNRMVHNIDTHFEKTNETVVQLKNASHKASQHSTAIGHSIVD
ISNGAESSSEATQQTAASVELATDLARKVQGKAEQSTDKSKSMLVTLQEGQRVVGQLVAGIQKLTNEQELSLKDVNHLKQ
NAKQVETIITLVGEIAEQTNLLALNASIEAARAGEHGKGFAVVAEEIRKLADQSAQAVQQISELIGAIQHDVTQVVEKIN
ENVQYAKEEAKQGEGTNRTIEEMADSITDVANEIETIHQLVDQQLHSIQDTVQQSQEVAAIAEETSAGTEEVNAAIQEQV
ITMEQVDQLAYEMEQHATNLKSQINQFKVRKQEEESNVEPFKAEQEQSFLEKSESTSEKNRNKEVS

Sequences:

>Translated_466_residues
MKKKYRFSLRLKLVVLITVLAMITYGFSALFIYVVNDYVQQFWSVSDELYLTIILLLGIFWSGLLAFFAAKWITKPMENL
EKVATEASLGNLDQHVHIPRSDDEIRSLSLAVNGMLLNLNRMVHNIDTHFEKTNETVVQLKNASHKASQHSTAIGHSIVD
ISNGAESSSEATQQTAASVELATDLARKVQGKAEQSTDKSKSMLVTLQEGQRVVGQLVAGIQKLTNEQELSLKDVNHLKQ
NAKQVETIITLVGEIAEQTNLLALNASIEAARAGEHGKGFAVVAEEIRKLADQSAQAVQQISELIGAIQHDVTQVVEKIN
ENVQYAKEEAKQGEGTNRTIEEMADSITDVANEIETIHQLVDQQLHSIQDTVQQSQEVAAIAEETSAGTEEVNAAIQEQV
ITMEQVDQLAYEMEQHATNLKSQINQFKVRKQEEESNVEPFKAEQEQSFLEKSESTSEKNRNKEVS
>Mature_466_residues
MKKKYRFSLRLKLVVLITVLAMITYGFSALFIYVVNDYVQQFWSVSDELYLTIILLLGIFWSGLLAFFAAKWITKPMENL
EKVATEASLGNLDQHVHIPRSDDEIRSLSLAVNGMLLNLNRMVHNIDTHFEKTNETVVQLKNASHKASQHSTAIGHSIVD
ISNGAESSSEATQQTAASVELATDLARKVQGKAEQSTDKSKSMLVTLQEGQRVVGQLVAGIQKLTNEQELSLKDVNHLKQ
NAKQVETIITLVGEIAEQTNLLALNASIEAARAGEHGKGFAVVAEEIRKLADQSAQAVQQISELIGAIQHDVTQVVEKIN
ENVQYAKEEAKQGEGTNRTIEEMADSITDVANEIETIHQLVDQQLHSIQDTVQQSQEVAAIAEETSAGTEEVNAAIQEQV
ITMEQVDQLAYEMEQHATNLKSQINQFKVRKQEEESNVEPFKAEQEQSFLEKSESTSEKNRNKEVS

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1787690, Length=415, Percent_Identity=26.7469879518072, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788195, Length=179, Percent_Identity=35.195530726257, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI2367378, Length=270, Percent_Identity=30.3703703703704, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1789453, Length=400, Percent_Identity=25.25, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1788194, Length=353, Percent_Identity=24.3626062322946, Blast_Score=89, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 51795; Mature: 51795

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS50885 HAMP ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKYRFSLRLKLVVLITVLAMITYGFSALFIYVVNDYVQQFWSVSDELYLTIILLLGIF
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
WSGLLAFFAAKWITKPMENLEKVATEASLGNLDQHVHIPRSDDEIRSLSLAVNGMLLNLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCEECCCCCHHHHHHHHHHHHHHHHHH
RMVHNIDTHFEKTNETVVQLKNASHKASQHSTAIGHSIVDISNGAESSSEATQQTAASVE
HHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LATDLARKVQGKAEQSTDKSKSMLVTLQEGQRVVGQLVAGIQKLTNEQELSLKDVNHLKQ
HHHHHHHHHHCCHHHCCCCHHHEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
NAKQVETIITLVGEIAEQTNLLALNASIEAARAGEHGKGFAVVAEEIRKLADQSAQAVQQ
HHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ISELIGAIQHDVTQVVEKINENVQYAKEEAKQGEGTNRTIEEMADSITDVANEIETIHQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VDQQLHSIQDTVQQSQEVAAIAEETSAGTEEVNAAIQEQVITMEQVDQLAYEMEQHATNL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSQINQFKVRKQEEESNVEPFKAEQEQSFLEKSESTSEKNRNKEVS
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKKKYRFSLRLKLVVLITVLAMITYGFSALFIYVVNDYVQQFWSVSDELYLTIILLLGIF
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
WSGLLAFFAAKWITKPMENLEKVATEASLGNLDQHVHIPRSDDEIRSLSLAVNGMLLNLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCEECCCCCHHHHHHHHHHHHHHHHHH
RMVHNIDTHFEKTNETVVQLKNASHKASQHSTAIGHSIVDISNGAESSSEATQQTAASVE
HHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LATDLARKVQGKAEQSTDKSKSMLVTLQEGQRVVGQLVAGIQKLTNEQELSLKDVNHLKQ
HHHHHHHHHHCCHHHCCCCHHHEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
NAKQVETIITLVGEIAEQTNLLALNASIEAARAGEHGKGFAVVAEEIRKLADQSAQAVQQ
HHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ISELIGAIQHDVTQVVEKINENVQYAKEEAKQGEGTNRTIEEMADSITDVANEIETIHQL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VDQQLHSIQDTVQQSQEVAAIAEETSAGTEEVNAAIQEQVITMEQVDQLAYEMEQHATNL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSQINQFKVRKQEEESNVEPFKAEQEQSFLEKSESTSEKNRNKEVS
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]