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The map label for this gene is atpB

Identifier: 23100436

GI number: 23100436

Start: 3090751

End: 3091473

Strand: Reverse

Name: atpB

Synonym: OB2981

Alternate gene names: 23100436

Gene position: 3091473-3090751 (Counterclockwise)

Preceding gene: 23100437

Following gene: 23100435

Centisome position: 85.15

GC content: 36.93

Gene sequence:

>723_bases
TTGGATCACGAAAATCCAATAGTGCATGATATCTTTGGGATACCGGGTGCGAATCTTAACCTTTCTAACCTCATGATGAC
ATTTATCGTGTGTCTTATTGTCTTTGTTTTCTGTGTGTGGGGAAGCAGAAAGTTACAGATGAAACCTAAGGGAATACAGA
ACTTCATGGAATGGGCTGTAGAATTCGTTAGGGGTATCATCCAAGACAACATGGATTGGAAAACAGGAAGAATATTTCTT
CCGCTTGGACTAACTCTAATATTCTATATTTTAGTTAGTAACTTAATAGGTGTTGCAACGGTTGGGGTAGTTGAACATGA
CTTATGGTGGAAATCACCTACAGCAGATGCGGTTATGACATTAACACTATCAACAATGATCATTGCATTAACACACTATT
ATGGTATTAAGTTAAGAGGTACAAAAGCTTATTTAAAAACATATGTAAGCCCAGTACCACTGATGTTACCGTTTAAAATA
GTAGAGGAATTCACCAACACATTAACGTTGGGTCTTCGTTTGTTTGGTAATATTTATGCAGGTGAAATTTTATTAAGTTT
ATTAGTAGGACTAGCAACAACAAGTATTTTTGGATTCTTCGGAGCAGCACTTCCGATGCTGGCATGGCAAACTTTTAGTG
TGTTTATTGGAGCCATCCAGTCCTACGTATTCGTAATGTTAACAATGGTTTATATGTCTCACAAAGTGAGCAGTGACCAT
TAA

Upstream 100 bases:

>100_bases
TCATTGTGTATCAATTATCTTTACGCAAGCAGGAAGAAGACTAATCTTTTCCAGTATTCCATTTTTACTTACAAATAGTT
TTAGTAAAGGGGTGATAATC

Downstream 100 bases:

>100_bases
TAAAAAATAATTTATTAGGTTTATTATAAAAGGAGGAAATTATCAATGGGAGCTTTAGCAGCAGCAATAGCAATCGGTTT
AGCAGCATTAGGAGCAGGTC

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MDHENPIVHDIFGIPGANLNLSNLMMTFIVCLIVFVFCVWGSRKLQMKPKGIQNFMEWAVEFVRGIIQDNMDWKTGRIFL
PLGLTLIFYILVSNLIGVATVGVVEHDLWWKSPTADAVMTLTLSTMIIALTHYYGIKLRGTKAYLKTYVSPVPLMLPFKI
VEEFTNTLTLGLRLFGNIYAGEILLSLLVGLATTSIFGFFGAALPMLAWQTFSVFIGAIQSYVFVMLTMVYMSHKVSSDH

Sequences:

>Translated_240_residues
MDHENPIVHDIFGIPGANLNLSNLMMTFIVCLIVFVFCVWGSRKLQMKPKGIQNFMEWAVEFVRGIIQDNMDWKTGRIFL
PLGLTLIFYILVSNLIGVATVGVVEHDLWWKSPTADAVMTLTLSTMIIALTHYYGIKLRGTKAYLKTYVSPVPLMLPFKI
VEEFTNTLTLGLRLFGNIYAGEILLSLLVGLATTSIFGFFGAALPMLAWQTFSVFIGAIQSYVFVMLTMVYMSHKVSSDH
>Mature_240_residues
MDHENPIVHDIFGIPGANLNLSNLMMTFIVCLIVFVFCVWGSRKLQMKPKGIQNFMEWAVEFVRGIIQDNMDWKTGRIFL
PLGLTLIFYILVSNLIGVATVGVVEHDLWWKSPTADAVMTLTLSTMIIALTHYYGIKLRGTKAYLKTYVSPVPLMLPFKI
VEEFTNTLTLGLRLFGNIYAGEILLSLLVGLATTSIFGFFGAALPMLAWQTFSVFIGAIQSYVFVMLTMVYMSHKVSSDH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family

Homologues:

Organism=Escherichia coli, GI1790176, Length=207, Percent_Identity=28.5024154589372, Blast_Score=80, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ATP6_OCEIH (Q8EM77)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_693903.1
- ProteinModelPortal:   Q8EM77
- GeneID:   1017922
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB2981
- NMPDR:   fig|221109.1.peg.2984
- HOGENOM:   HBG734175
- OMA:   NIFAGEM
- ProtClustDB:   PRK05815
- BioCyc:   OIHE221109:OB2981-MONOMER
- HAMAP:   MF_01393
- InterPro:   IPR000568
- InterPro:   IPR023011
- Gene3D:   G3DSA:1.20.120.220
- PANTHER:   PTHR11410
- PRINTS:   PR00123
- TIGRFAMs:   TIGR01131

Pfam domain/function: PF00119 ATP-synt_A; SSF81336 ATPase_F0_A

EC number: 3.6.3.14

Molecular weight: Translated: 26960; Mature: 26960

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1197f07c)-; HASH(0x11288310)-; HASH(0xb69de28)-; HASH(0x114925bc)-; HASH(0xee7a580)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHENPIVHDIFGIPGANLNLSNLMMTFIVCLIVFVFCVWGSRKLQMKPKGIQNFMEWAV
CCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHH
EFVRGIIQDNMDWKTGRIFLPLGLTLIFYILVSNLIGVATVGVVEHDLWWKSPTADAVMT
HHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LTLSTMIIALTHYYGIKLRGTKAYLKTYVSPVPLMLPFKIVEEFTNTLTLGLRLFGNIYA
HHHHHHHHHHHHHHCEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEILLSLLVGLATTSIFGFFGAALPMLAWQTFSVFIGAIQSYVFVMLTMVYMSHKVSSDH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
>Mature Secondary Structure
MDHENPIVHDIFGIPGANLNLSNLMMTFIVCLIVFVFCVWGSRKLQMKPKGIQNFMEWAV
CCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHH
EFVRGIIQDNMDWKTGRIFLPLGLTLIFYILVSNLIGVATVGVVEHDLWWKSPTADAVMT
HHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LTLSTMIIALTHYYGIKLRGTKAYLKTYVSPVPLMLPFKIVEEFTNTLTLGLRLFGNIYA
HHHHHHHHHHHHHHCEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEILLSLLVGLATTSIFGFFGAALPMLAWQTFSVFIGAIQSYVFVMLTMVYMSHKVSSDH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12235376