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The map label for this gene is atpA

Identifier: 23100432

GI number: 23100432

Start: 3087762

End: 3089273

Strand: Reverse

Name: atpA

Synonym: OB2977

Alternate gene names: 23100432

Gene position: 3089273-3087762 (Counterclockwise)

Preceding gene: 23100433

Following gene: 23100431

Centisome position: 85.09

GC content: 39.68

Gene sequence:

>1512_bases
ATGAGCATTAATGCTGAAGAAATTAGCACACTGATTAAACAGCAAATTGAAAACTTTGATTCTGACATCGAAGTAAGTGA
TGTTGGGACAGTTATTGAAGTCGGTGACGGTATCGCGCGTGCTCATGGTCTTGATAATGCTATGGCTGGAGAATTACTTG
AATTCTCAAATGGTGTTATGGGATTAGCACAGAACTTAGAAGAAAGTAATGTAGGTATCGTTATCCTTGGACCTTATACG
GAAATTAAAGAAGGCGATGAAGTTCGTCGTACTGGTCGTATCATGCAAGTACCTGTAGGAGAGGAATTGTTAGGACGTGT
GGTAAACCCACTAGGTCAACCAATTGATGGCAAAGGCCCAATTGAAACATCTAAAACTCGTCCAATCGAAGCGGCTGCTC
CAGGAGTTATGGATCGTAAATCCGTTGATGAGCCACTTCAAACAGGTATTAAAGCAATTGATGCATTAGTTCCAATTGGT
CGTGGTCAACGTGAGTTAATCATCGGAGACCGTCAAACTGGGAAAACTACTGTAGCAGTAGATACAATCTTGAACCAAAA
AGATCAAGATATGATTTGTATTTATGTAGCTATCGGACAAAAAGAATCAACTGTGCGTAATACAGTAGAAACTTTCCGTA
AGCACGGTGCACTTGAAAACACAATTGTAGTTACTGCAGGTGCTTCAGATCCTGCACCACTATTGTACTTATCTCCGTAT
GCTGGTGTAGCAATGGGTGAAGAGTTCATGTATAACGGAAAACACGTTTTAGTTATATATGATGATTTATCTAAACAAGC
AGTAGCATATCGTGAACTTTCCTTATTATTACGTCGTCCACCGGGCCGTGAAGCATTCCCTGGGGATGTATTCTACCTAC
ACTCTCGTTTATTAGAGCGTGCAGCTAAATTAAGTGATGCAAAAGGTGGCGGTTCATTAACTGCATTACCATTTGTTGAA
ACACAAGCTGGTGATATTGCAGCTTACATTCCAACGAACGTAATTTCCATTACTGATGGACAGATTTTCTTACAATCGGA
TCTATTTTTCTCTGGGGTTCGTCCAGCGATCAACCCTGGTTTATCTGTATCACGTGTAGGGGGATCTGCACAAATCAAAG
CAATGAAAAAAGTAGCAGGGACATTGCGTCTTGATCTTGCATCTTTCCGTGAATTAGAAGCATTCTCTCAATTTGGTTCA
GACTTGGATAAATCTACACAAGCGAAACTAAATCGCGGTCAACGTACAGTTGAAGTGTTGAAGCAAGGTCTTCATAAACC
GATGGTAGTTGAAAAACAGGTAGCTATTATCTACTCATTAACGCGTGGTTTCCTAGATGATATCCCTGTAGAAGATATCC
AACGTTTTGAAGAAGAATTGAACATTTGGTTAGAAAGCAATCGTAATGAATTACTTACTTCTATTCGTGAAACTGGTAAT
TTACCAGACGAGAGCGAGTTTAATGATGCGATTGATTCATTCAAGAAAACATTTCTACCATCTAATAACTAA

Upstream 100 bases:

>100_bases
AGTCGGAAATACGATATACGATGGAACGGTAAGTAATAAGTTAAACCGAATTTCACGTAGTATCGTGTCTGCTAACAAAT
GATGATAGGGGTGAAATGGT

Downstream 100 bases:

>100_bases
TAAGTGAAATGATGAAGTTCGGTATAGAGTATAATGGGTCGAATAATTATTCTCGACCCTCACTCCTGACAGGAAAGTGT
GGTGAAAGAGCTTGGCATCA

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MSINAEEISTLIKQQIENFDSDIEVSDVGTVIEVGDGIARAHGLDNAMAGELLEFSNGVMGLAQNLEESNVGIVILGPYT
EIKEGDEVRRTGRIMQVPVGEELLGRVVNPLGQPIDGKGPIETSKTRPIEAAAPGVMDRKSVDEPLQTGIKAIDALVPIG
RGQRELIIGDRQTGKTTVAVDTILNQKDQDMICIYVAIGQKESTVRNTVETFRKHGALENTIVVTAGASDPAPLLYLSPY
AGVAMGEEFMYNGKHVLVIYDDLSKQAVAYRELSLLLRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGGGSLTALPFVE
TQAGDIAAYIPTNVISITDGQIFLQSDLFFSGVRPAINPGLSVSRVGGSAQIKAMKKVAGTLRLDLASFRELEAFSQFGS
DLDKSTQAKLNRGQRTVEVLKQGLHKPMVVEKQVAIIYSLTRGFLDDIPVEDIQRFEEELNIWLESNRNELLTSIRETGN
LPDESEFNDAIDSFKKTFLPSNN

Sequences:

>Translated_503_residues
MSINAEEISTLIKQQIENFDSDIEVSDVGTVIEVGDGIARAHGLDNAMAGELLEFSNGVMGLAQNLEESNVGIVILGPYT
EIKEGDEVRRTGRIMQVPVGEELLGRVVNPLGQPIDGKGPIETSKTRPIEAAAPGVMDRKSVDEPLQTGIKAIDALVPIG
RGQRELIIGDRQTGKTTVAVDTILNQKDQDMICIYVAIGQKESTVRNTVETFRKHGALENTIVVTAGASDPAPLLYLSPY
AGVAMGEEFMYNGKHVLVIYDDLSKQAVAYRELSLLLRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGGGSLTALPFVE
TQAGDIAAYIPTNVISITDGQIFLQSDLFFSGVRPAINPGLSVSRVGGSAQIKAMKKVAGTLRLDLASFRELEAFSQFGS
DLDKSTQAKLNRGQRTVEVLKQGLHKPMVVEKQVAIIYSLTRGFLDDIPVEDIQRFEEELNIWLESNRNELLTSIRETGN
LPDESEFNDAIDSFKKTFLPSNN
>Mature_502_residues
SINAEEISTLIKQQIENFDSDIEVSDVGTVIEVGDGIARAHGLDNAMAGELLEFSNGVMGLAQNLEESNVGIVILGPYTE
IKEGDEVRRTGRIMQVPVGEELLGRVVNPLGQPIDGKGPIETSKTRPIEAAAPGVMDRKSVDEPLQTGIKAIDALVPIGR
GQRELIIGDRQTGKTTVAVDTILNQKDQDMICIYVAIGQKESTVRNTVETFRKHGALENTIVVTAGASDPAPLLYLSPYA
GVAMGEEFMYNGKHVLVIYDDLSKQAVAYRELSLLLRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGGGSLTALPFVET
QAGDIAAYIPTNVISITDGQIFLQSDLFFSGVRPAINPGLSVSRVGGSAQIKAMKKVAGTLRLDLASFRELEAFSQFGSD
LDKSTQAKLNRGQRTVEVLKQGLHKPMVVEKQVAIIYSLTRGFLDDIPVEDIQRFEEELNIWLESNRNELLTSIRETGNL
PDESEFNDAIDSFKKTFLPSNN

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=488, Percent_Identity=60.0409836065574, Blast_Score=602, Evalue=1e-172,
Organism=Homo sapiens, GI4757810, Length=488, Percent_Identity=60.0409836065574, Blast_Score=602, Evalue=1e-172,
Organism=Homo sapiens, GI19913426, Length=307, Percent_Identity=31.5960912052117, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI19913428, Length=307, Percent_Identity=30.9446254071661, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI32189394, Length=321, Percent_Identity=27.7258566978193, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI19913424, Length=255, Percent_Identity=25.8823529411765, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1790172, Length=510, Percent_Identity=55.8823529411765, Blast_Score=583, Evalue=1e-167,
Organism=Escherichia coli, GI1788251, Length=271, Percent_Identity=32.1033210332103, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1790170, Length=318, Percent_Identity=26.1006289308176, Blast_Score=103, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71988063, Length=507, Percent_Identity=57.5936883629191, Blast_Score=602, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI71988080, Length=507, Percent_Identity=57.5936883629191, Blast_Score=600, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI71988074, Length=507, Percent_Identity=53.6489151873767, Blast_Score=550, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI17510931, Length=383, Percent_Identity=27.6762402088773, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17570191, Length=298, Percent_Identity=29.8657718120805, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI25144756, Length=438, Percent_Identity=24.4292237442922, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=62, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71988068, Length=74, Percent_Identity=39.1891891891892, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6319370, Length=502, Percent_Identity=58.1673306772908, Blast_Score=593, Evalue=1e-170,
Organism=Saccharomyces cerevisiae, GI6319603, Length=304, Percent_Identity=29.6052631578947, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6322581, Length=411, Percent_Identity=26.0340632603406, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24658560, Length=502, Percent_Identity=58.1673306772908, Blast_Score=589, Evalue=1e-168,
Organism=Drosophila melanogaster, GI281361666, Length=301, Percent_Identity=31.2292358803987, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24646341, Length=301, Percent_Identity=31.2292358803987, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI17136796, Length=301, Percent_Identity=31.2292358803987, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24638766, Length=316, Percent_Identity=26.5822784810127, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28574560, Length=426, Percent_Identity=26.056338028169, Blast_Score=89, Evalue=9e-18,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_OCEIH (Q8EM81)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_693899.1
- ProteinModelPortal:   Q8EM81
- SMR:   Q8EM81
- GeneID:   1017925
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB2977
- NMPDR:   fig|221109.1.peg.2980
- HOGENOM:   HBG565875
- OMA:   EMALTLW
- ProtClustDB:   PRK09281
- BioCyc:   OIHE221109:OB2977-MONOMER
- BRENDA:   3.6.3.14
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 54826; Mature: 54695

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSINAEEISTLIKQQIENFDSDIEVSDVGTVIEVGDGIARAHGLDNAMAGELLEFSNGVM
CCCCHHHHHHHHHHHHHCCCCCCEEHHCCCEEECCCCHHHHCCCCHHHHHHHHHHCCCHH
GLAQNLEESNVGIVILGPYTEIKEGDEVRRTGRIMQVPVGEELLGRVVNPLGQPIDGKGP
HHHHCCCCCCCCEEEECCCHHHCCCHHHHHCCCEEECCCCHHHHHHHHHHHCCCCCCCCC
IETSKTRPIEAAAPGVMDRKSVDEPLQTGIKAIDALVPIGRGQRELIIGDRQTGKTTVAV
CCCCCCCCCHHCCCCCCCHHHCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEE
DTILNQKDQDMICIYVAIGQKESTVRNTVETFRKHGALENTIVVTAGASDPAPLLYLSPY
HHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEECCC
AGVAMGEEFMYNGKHVLVIYDDLSKQAVAYRELSLLLRRPPGREAFPGDVFYLHSRLLER
CCCHHCHHHEECCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
AAKLSDAKGGGSLTALPFVETQAGDIAAYIPTNVISITDGQIFLQSDLFFSGVRPAINPG
HHHHCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEECCCHHHCCCCCCCCC
LSVSRVGGSAQIKAMKKVAGTLRLDLASFRELEAFSQFGSDLDKSTQAKLNRGQRTVEVL
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHH
KQGLHKPMVVEKQVAIIYSLTRGFLDDIPVEDIQRFEEELNIWLESNRNELLTSIRETGN
HHHCCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
LPDESEFNDAIDSFKKTFLPSNN
CCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SINAEEISTLIKQQIENFDSDIEVSDVGTVIEVGDGIARAHGLDNAMAGELLEFSNGVM
CCCHHHHHHHHHHHHHCCCCCCEEHHCCCEEECCCCHHHHCCCCHHHHHHHHHHCCCHH
GLAQNLEESNVGIVILGPYTEIKEGDEVRRTGRIMQVPVGEELLGRVVNPLGQPIDGKGP
HHHHCCCCCCCCEEEECCCHHHCCCHHHHHCCCEEECCCCHHHHHHHHHHHCCCCCCCCC
IETSKTRPIEAAAPGVMDRKSVDEPLQTGIKAIDALVPIGRGQRELIIGDRQTGKTTVAV
CCCCCCCCCHHCCCCCCCHHHCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEE
DTILNQKDQDMICIYVAIGQKESTVRNTVETFRKHGALENTIVVTAGASDPAPLLYLSPY
HHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEEECCC
AGVAMGEEFMYNGKHVLVIYDDLSKQAVAYRELSLLLRRPPGREAFPGDVFYLHSRLLER
CCCHHCHHHEECCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
AAKLSDAKGGGSLTALPFVETQAGDIAAYIPTNVISITDGQIFLQSDLFFSGVRPAINPG
HHHHCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEECCCHHHCCCCCCCCC
LSVSRVGGSAQIKAMKKVAGTLRLDLASFRELEAFSQFGSDLDKSTQAKLNRGQRTVEVL
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHH
KQGLHKPMVVEKQVAIIYSLTRGFLDDIPVEDIQRFEEELNIWLESNRNELLTSIRETGN
HHHCCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
LPDESEFNDAIDSFKKTFLPSNN
CCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12235376