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The map label for this gene is nhaC [H]

Identifier: 23100329

GI number: 23100329

Start: 2959522

End: 2960958

Strand: Reverse

Name: nhaC [H]

Synonym: OB2874

Alternate gene names: 23100329

Gene position: 2960958-2959522 (Counterclockwise)

Preceding gene: 23100330

Following gene: 23100327

Centisome position: 81.56

GC content: 40.29

Gene sequence:

>1437_bases
ATGTTTCGAATTAAATCTGAACAAATGCCGTCTTTTCTAGAGGCTATCCTTGTAATCACAGCTATCATCGCTATTATGAG
TGTCAGTATTATCTATTATGAAGCTCCGCCTCATATCCCTTTAACAATTTCACTATTATTGTTAATCGTATATGGAATCA
TTAAAAAGGTCCCTTATGAAAAGTTACAGGAAGGGTTTTCTGAAGGAGCCACTTCTGGAATGGGTGCTGTCTTCCTCTTT
TTTATGATCGGTATTTTGATAGCTGCCTGGATTTATAGTGGAACCATCCCAACTTTGATCTATGCTGGTTTTGAATTAGT
GACCCCACGTTTTTATTATGCGATTGTTTTAATCGTAACCTCTGTGGTTGGTGTTTGTGTAGGGAGTTCTTTGACAACAG
TGGCTACAGTCGGATTGGCTTTTATCGGGATATCGCAGGCTCTCGATATTTCGGTAGCTATCACGGCAGGGGCAATTGTA
TCCGGTGCTTTCTTCGGTGATAAAATGTCACCTATGTCAGATACAACGAATATGGCCTCAAGTATTATGAAGGTCGATTT
GTTTGATCATATACGAAATATGATGTGGACTACAGTACCAGCCTTCCTGATTGGACTGGTGATTTTCGGAATAATATCAC
CGAGTATCTCAACTGCTAATTTCAGTGAAATGGAGTTATATCAGCAAGGGCTTTTAAGTACAGGACTGATTCAATGGTAT
AATGCAGTCATTCCACTTGCTGTCTTAGTTATTTTCTCTATTTTCAAGGCTCCGGCATTATTGGCGCTCACAGCTGGTAC
GATTAGTGCTATCCTTGTCTCGTTTTTTCAAGCTATTCCTTCCGTTGGTGGACTACTCGGAATACTATATGGAGGCTATG
TTTCAGAGACAGGTATTGAACAAATCGATTCTTTGCTAACACGGGGCGGAATGGAGAGTATGTTTTTTACCATTGCACTC
ATTTTGCTTGCATTAGGAATGGGAGGCTTATTGTTTAAGTTAGGGATTGTTCCAAGACTATTTGAATCCGTGGAAAGAAT
GTTACGTTCTGTAAAGTCAGTGATCATCAGTTCGGCTCTAAATGCGATTGGAGTTAACTTGTTGGTAGGGGAACAATATC
TTTCTATTCTTTTAACAACAGAGACGTTCCAGCCGCAATATCAAAAGCTTGGTTTAGCAAATAAAAACCTATCAAGAGTT
GCAGAGGATGCAGGTACAGTAGTTAATCCGCTTGTTCCATGGAGCGTGTGCGGTGTCTTCATTGCAAGTGTTTTAGGTGT
ACCGACTCTAGCGTATTTGCCATTTGCTTTCTTTTGCTTGTTATGCCCAATATTGACGATTCTTTTTGGGATTACTGGGA
AGACGCTGACATATACGGAAGCTGCAGTAGTAAACTCTGTTTCAGATGAATTGGGGGAAGAGAGTAAGATGGGATAG

Upstream 100 bases:

>100_bases
ATAGCCTTTACAAATAAGTTCAAAGCATTAATCGAAAATCCAAGATTACTACTAATAGAACTCCGTTAATCTATCAAATA
AAAAATGAAGGAGATGCATT

Downstream 100 bases:

>100_bases
GTTTTCCATTGTTTTACGAATGAGGTAACTGGTAGTGTGGTCATAGTTGGCTAGTGTGATTCGTTGTTTATACAGTATAT
TAAAAAACGGCTAATTCCTT

Product: Na(+):H(+) antiporter

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MFRIKSEQMPSFLEAILVITAIIAIMSVSIIYYEAPPHIPLTISLLLLIVYGIIKKVPYEKLQEGFSEGATSGMGAVFLF
FMIGILIAAWIYSGTIPTLIYAGFELVTPRFYYAIVLIVTSVVGVCVGSSLTTVATVGLAFIGISQALDISVAITAGAIV
SGAFFGDKMSPMSDTTNMASSIMKVDLFDHIRNMMWTTVPAFLIGLVIFGIISPSISTANFSEMELYQQGLLSTGLIQWY
NAVIPLAVLVIFSIFKAPALLALTAGTISAILVSFFQAIPSVGGLLGILYGGYVSETGIEQIDSLLTRGGMESMFFTIAL
ILLALGMGGLLFKLGIVPRLFESVERMLRSVKSVIISSALNAIGVNLLVGEQYLSILLTTETFQPQYQKLGLANKNLSRV
AEDAGTVVNPLVPWSVCGVFIASVLGVPTLAYLPFAFFCLLCPILTILFGITGKTLTYTEAAVVNSVSDELGEESKMG

Sequences:

>Translated_478_residues
MFRIKSEQMPSFLEAILVITAIIAIMSVSIIYYEAPPHIPLTISLLLLIVYGIIKKVPYEKLQEGFSEGATSGMGAVFLF
FMIGILIAAWIYSGTIPTLIYAGFELVTPRFYYAIVLIVTSVVGVCVGSSLTTVATVGLAFIGISQALDISVAITAGAIV
SGAFFGDKMSPMSDTTNMASSIMKVDLFDHIRNMMWTTVPAFLIGLVIFGIISPSISTANFSEMELYQQGLLSTGLIQWY
NAVIPLAVLVIFSIFKAPALLALTAGTISAILVSFFQAIPSVGGLLGILYGGYVSETGIEQIDSLLTRGGMESMFFTIAL
ILLALGMGGLLFKLGIVPRLFESVERMLRSVKSVIISSALNAIGVNLLVGEQYLSILLTTETFQPQYQKLGLANKNLSRV
AEDAGTVVNPLVPWSVCGVFIASVLGVPTLAYLPFAFFCLLCPILTILFGITGKTLTYTEAAVVNSVSDELGEESKMG
>Mature_478_residues
MFRIKSEQMPSFLEAILVITAIIAIMSVSIIYYEAPPHIPLTISLLLLIVYGIIKKVPYEKLQEGFSEGATSGMGAVFLF
FMIGILIAAWIYSGTIPTLIYAGFELVTPRFYYAIVLIVTSVVGVCVGSSLTTVATVGLAFIGISQALDISVAITAGAIV
SGAFFGDKMSPMSDTTNMASSIMKVDLFDHIRNMMWTTVPAFLIGLVIFGIISPSISTANFSEMELYQQGLLSTGLIQWY
NAVIPLAVLVIFSIFKAPALLALTAGTISAILVSFFQAIPSVGGLLGILYGGYVSETGIEQIDSLLTRGGMESMFFTIAL
ILLALGMGGLLFKLGIVPRLFESVERMLRSVKSVIISSALNAIGVNLLVGEQYLSILLTTETFQPQYQKLGLANKNLSRV
AEDAGTVVNPLVPWSVCGVFIASVLGVPTLAYLPFAFFCLLCPILTILFGITGKTLTYTEAAVVNSVSDELGEESKMG

Specific function: Na(+)/H(+) antiporter. Involved in pH homeostasis and sodium extrusion [H]

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 51151; Mature: 51151

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRIKSEQMPSFLEAILVITAIIAIMSVSIIYYEAPPHIPLTISLLLLIVYGIIKKVPYE
CCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHCCHH
KLQEGFSEGATSGMGAVFLFFMIGILIAAWIYSGTIPTLIYAGFELVTPRFYYAIVLIVT
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
SVVGVCVGSSLTTVATVGLAFIGISQALDISVAITAGAIVSGAFFGDKMSPMSDTTNMAS
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
SIMKVDLFDHIRNMMWTTVPAFLIGLVIFGIISPSISTANFSEMELYQQGLLSTGLIQWY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
NAVIPLAVLVIFSIFKAPALLALTAGTISAILVSFFQAIPSVGGLLGILYGGYVSETGIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
QIDSLLTRGGMESMFFTIALILLALGMGGLLFKLGIVPRLFESVERMLRSVKSVIISSAL
HHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NAIGVNLLVGEQYLSILLTTETFQPQYQKLGLANKNLSRVAEDAGTVVNPLVPWSVCGVF
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHCCHHCCCCHHHHHHHH
IASVLGVPTLAYLPFAFFCLLCPILTILFGITGKTLTYTEAAVVNSVSDELGEESKMG
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFRIKSEQMPSFLEAILVITAIIAIMSVSIIYYEAPPHIPLTISLLLLIVYGIIKKVPYE
CCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHCCHH
KLQEGFSEGATSGMGAVFLFFMIGILIAAWIYSGTIPTLIYAGFELVTPRFYYAIVLIVT
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
SVVGVCVGSSLTTVATVGLAFIGISQALDISVAITAGAIVSGAFFGDKMSPMSDTTNMAS
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
SIMKVDLFDHIRNMMWTTVPAFLIGLVIFGIISPSISTANFSEMELYQQGLLSTGLIQWY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
NAVIPLAVLVIFSIFKAPALLALTAGTISAILVSFFQAIPSVGGLLGILYGGYVSETGIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
QIDSLLTRGGMESMFFTIALILLALGMGGLLFKLGIVPRLFESVERMLRSVKSVIISSAL
HHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NAIGVNLLVGEQYLSILLTTETFQPQYQKLGLANKNLSRVAEDAGTVVNPLVPWSVCGVF
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHCCHHCCCCHHHHHHHH
IASVLGVPTLAYLPFAFFCLLCPILTILFGITGKTLTYTEAAVVNSVSDELGEESKMG
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1660475; 9190799 [H]