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The map label for this gene is frmA [H]

Identifier: 23100256

GI number: 23100256

Start: 2881784

End: 2882908

Strand: Reverse

Name: frmA [H]

Synonym: OB2801

Alternate gene names: 23100256

Gene position: 2882908-2881784 (Counterclockwise)

Preceding gene: 23100258

Following gene: 23100254

Centisome position: 79.41

GC content: 40.44

Gene sequence:

>1125_bases
GTGCAAGTGAAAACAGCTGTTTTACGTACTCAAGGAGCAGATTCACCGTACAAGGAAAGTAAACCTATTAAAATAGAGAC
GTTAGAATTGGATGCTCCTCAGCTTGGTGAAGTATTAATTCAAATAAAAGCTGCAAGTCTCTGTCATTCAGACTTATCCG
TTATTAATGGAAGTCGACCAAGACCTCTTCCAATGGCTCTTGGGCATGAGGCATCCGGTGTGGTTGTTGAAGTTGGAGAA
GGGGTTACATATTTAGAGCCAGGAGATCATATTGTATGTGTGTTTGTACCAAGTTGTGGACATTGTGTACCTTGTAAAGA
AGGTCGTCCGGCATTATGCGAACCAGGTGCAGACTCGAATACTGCTGGAACATTAATTAGTGGTGGCATCCGATTACATG
CTGATGGTGAAGCGATTAATCATCATCTTGGTGTATCTGCGTTTTCAGAATTTGCAGTGGTATCTAGAAATTCCTTAGTA
AAGGTAAAAAAGGATATTCCATTTGAAAAACTCGCATTATTTGGTTGTGCAGTAATAACCGGAGTGGGAGCAGTTGTGAA
TACAGCCAATGTGAAGCTTGGTAGTACAGTTGCAATTGTTGGGCTAGGTGGAATCGGACTCAGTGCTTTACTGGGTGCAG
TAGCTGCAGGTGCCTCCAGAATAATAGCGGTAGATATCAATGAAAACAAACTTAAACAAGCAAAAGAACTAGGAGCTACC
GATGTCTTTAATTCTACAGAAGAAACAGTTATCCAACAAATTAAAGAAGCAACCGATGGCGGTGTAAACTATGCATTTGA
AACAGCCGGTGCTGTCCCAGCAATGGAAGTCGCTTATGGCATTACAAAGCGTGGCGGAACTACAGTGACCACTGGTTTAC
CACATCCAGAACATCAATTTTCATTTCCATATGTGACATTAACTGCTGAGGAGAAGACACTAAAAGGCTCGTATGTTGGT
AGTTGCGTACCTGACCGTGATATTCCAAGATACATGAATTTATTTAAACAAGATCGTCTACCTGTAGATAAATTGATGAC
AGATTTTATTTCTCTAGATGAAATAAACGAAGGGTTTGATAAGTTAGCAAAAGGGGATTCGTCGAGAATTATTATTAAAA
TGTAG

Upstream 100 bases:

>100_bases
TTAAATATGCAGTGAATGGCATGATGAATACAACGTTTTACTCAGATGAAAATTTATTAAAATACTAAAAAAGCTATCCT
GACTCAAGGAGTGGATTGAT

Downstream 100 bases:

>100_bases
TAGAATACAAGAGTTGCTTCGTGAAGGAGTGACTCTTTTTTTGGAGTAAAATCGGGTAGAGGTTAAGGCAGTGGAGGAAG
AAAGCCAAACTAAATGAAGT

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MQVKTAVLRTQGADSPYKESKPIKIETLELDAPQLGEVLIQIKAASLCHSDLSVINGSRPRPLPMALGHEASGVVVEVGE
GVTYLEPGDHIVCVFVPSCGHCVPCKEGRPALCEPGADSNTAGTLISGGIRLHADGEAINHHLGVSAFSEFAVVSRNSLV
KVKKDIPFEKLALFGCAVITGVGAVVNTANVKLGSTVAIVGLGGIGLSALLGAVAAGASRIIAVDINENKLKQAKELGAT
DVFNSTEETVIQQIKEATDGGVNYAFETAGAVPAMEVAYGITKRGGTTVTTGLPHPEHQFSFPYVTLTAEEKTLKGSYVG
SCVPDRDIPRYMNLFKQDRLPVDKLMTDFISLDEINEGFDKLAKGDSSRIIIKM

Sequences:

>Translated_374_residues
MQVKTAVLRTQGADSPYKESKPIKIETLELDAPQLGEVLIQIKAASLCHSDLSVINGSRPRPLPMALGHEASGVVVEVGE
GVTYLEPGDHIVCVFVPSCGHCVPCKEGRPALCEPGADSNTAGTLISGGIRLHADGEAINHHLGVSAFSEFAVVSRNSLV
KVKKDIPFEKLALFGCAVITGVGAVVNTANVKLGSTVAIVGLGGIGLSALLGAVAAGASRIIAVDINENKLKQAKELGAT
DVFNSTEETVIQQIKEATDGGVNYAFETAGAVPAMEVAYGITKRGGTTVTTGLPHPEHQFSFPYVTLTAEEKTLKGSYVG
SCVPDRDIPRYMNLFKQDRLPVDKLMTDFISLDEINEGFDKLAKGDSSRIIIKM
>Mature_374_residues
MQVKTAVLRTQGADSPYKESKPIKIETLELDAPQLGEVLIQIKAASLCHSDLSVINGSRPRPLPMALGHEASGVVVEVGE
GVTYLEPGDHIVCVFVPSCGHCVPCKEGRPALCEPGADSNTAGTLISGGIRLHADGEAINHHLGVSAFSEFAVVSRNSLV
KVKKDIPFEKLALFGCAVITGVGAVVNTANVKLGSTVAIVGLGGIGLSALLGAVAAGASRIIAVDINENKLKQAKELGAT
DVFNSTEETVIQQIKEATDGGVNYAFETAGAVPAMEVAYGITKRGGTTVTTGLPHPEHQFSFPYVTLTAEEKTLKGSYVG
SCVPDRDIPRYMNLFKQDRLPVDKLMTDFISLDEINEGFDKLAKGDSSRIIIKM

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=360, Percent_Identity=41.3888888888889, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI4501933, Length=376, Percent_Identity=40.1595744680851, Blast_Score=265, Evalue=4e-71,
Organism=Homo sapiens, GI4501929, Length=360, Percent_Identity=40.8333333333333, Blast_Score=262, Evalue=3e-70,
Organism=Homo sapiens, GI71565154, Length=363, Percent_Identity=36.3636363636364, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI262073058, Length=376, Percent_Identity=34.3085106382979, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI71743840, Length=360, Percent_Identity=34.7222222222222, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI71565152, Length=384, Percent_Identity=35.9375, Blast_Score=225, Evalue=6e-59,
Organism=Homo sapiens, GI156523966, Length=378, Percent_Identity=35.1851851851852, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI4501939, Length=371, Percent_Identity=35.3099730458221, Blast_Score=211, Evalue=7e-55,
Organism=Homo sapiens, GI156627571, Length=369, Percent_Identity=25.4742547425474, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1786552, Length=362, Percent_Identity=35.6353591160221, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI1788407, Length=332, Percent_Identity=29.5180722891566, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1790045, Length=360, Percent_Identity=25.8333333333333, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI87081918, Length=293, Percent_Identity=33.7883959044369, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI87082125, Length=363, Percent_Identity=25.3443526170799, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1788073, Length=367, Percent_Identity=26.9754768392371, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788075, Length=361, Percent_Identity=25.207756232687, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1787863, Length=226, Percent_Identity=33.1858407079646, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1786518, Length=366, Percent_Identity=24.5901639344262, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI226510992, Length=346, Percent_Identity=24.2774566473988, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786825, Length=263, Percent_Identity=28.8973384030418, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790718, Length=327, Percent_Identity=25.0764525993884, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=365, Percent_Identity=36.986301369863, Blast_Score=241, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI71997431, Length=367, Percent_Identity=37.0572207084469, Blast_Score=237, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI17565904, Length=340, Percent_Identity=37.3529411764706, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17562876, Length=364, Percent_Identity=26.6483516483516, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17562584, Length=370, Percent_Identity=25.9459459459459, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17562878, Length=358, Percent_Identity=26.8156424581006, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17562582, Length=356, Percent_Identity=25.2808988764045, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71988145, Length=375, Percent_Identity=25.0666666666667, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320033, Length=366, Percent_Identity=35.2459016393443, Blast_Score=229, Evalue=6e-61,
Organism=Saccharomyces cerevisiae, GI6323729, Length=371, Percent_Identity=28.0323450134771, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322619, Length=339, Percent_Identity=32.1533923303835, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6319955, Length=339, Percent_Identity=31.858407079646, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6323099, Length=356, Percent_Identity=27.5280898876405, Blast_Score=102, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6324486, Length=353, Percent_Identity=26.9121813031161, Blast_Score=102, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6319621, Length=356, Percent_Identity=27.5280898876405, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6323961, Length=360, Percent_Identity=26.9444444444444, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319258, Length=313, Percent_Identity=28.1150159744409, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319257, Length=356, Percent_Identity=23.5955056179775, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17737895, Length=364, Percent_Identity=37.9120879120879, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI17737897, Length=358, Percent_Identity=30.4469273743017, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17137530, Length=372, Percent_Identity=27.9569892473118, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 39452; Mature: 39452

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVKTAVLRTQGADSPYKESKPIKIETLELDAPQLGEVLIQIKAASLCHSDLSVINGSRP
CCCCCEEHCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
RPLPMALGHEASGVVVEVGEGVTYLEPGDHIVCVFVPSCGHCVPCKEGRPALCEPGADSN
CCCCCCCCCCCCCEEEECCCCEEEECCCCEEEEEEECCCCCEECCCCCCCCCCCCCCCCC
TAGTLISGGIRLHADGEAINHHLGVSAFSEFAVVSRNSLVKVKKDIPFEKLALFGCAVIT
CCCEEEECCEEEEECCHHHHHHCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHH
GVGAVVNTANVKLGSTVAIVGLGGIGLSALLGAVAAGASRIIAVDINENKLKQAKELGAT
HHHHHEEECCEEECCEEEEEEECCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCH
DVFNSTEETVIQQIKEATDGGVNYAFETAGAVPAMEVAYGITKRGGTTVTTGLPHPEHQF
HHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCC
SFPYVTLTAEEKTLKGSYVGSCVPDRDIPRYMNLFKQDRLPVDKLMTDFISLDEINEGFD
CCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
KLAKGDSSRIIIKM
HHHCCCCCEEEEEC
>Mature Secondary Structure
MQVKTAVLRTQGADSPYKESKPIKIETLELDAPQLGEVLIQIKAASLCHSDLSVINGSRP
CCCCCEEHCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
RPLPMALGHEASGVVVEVGEGVTYLEPGDHIVCVFVPSCGHCVPCKEGRPALCEPGADSN
CCCCCCCCCCCCCEEEECCCCEEEECCCCEEEEEEECCCCCEECCCCCCCCCCCCCCCCC
TAGTLISGGIRLHADGEAINHHLGVSAFSEFAVVSRNSLVKVKKDIPFEKLALFGCAVIT
CCCEEEECCEEEEECCHHHHHHCCHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHH
GVGAVVNTANVKLGSTVAIVGLGGIGLSALLGAVAAGASRIIAVDINENKLKQAKELGAT
HHHHHEEECCEEECCEEEEEEECCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCH
DVFNSTEETVIQQIKEATDGGVNYAFETAGAVPAMEVAYGITKRGGTTVTTGLPHPEHQF
HHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCC
SFPYVTLTAEEKTLKGSYVGSCVPDRDIPRYMNLFKQDRLPVDKLMTDFISLDEINEGFD
CCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
KLAKGDSSRIIIKM
HHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]