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The map label for this gene is yhcA [H]

Identifier: 23100224

GI number: 23100224

Start: 2841792

End: 2843324

Strand: Reverse

Name: yhcA [H]

Synonym: OB2769

Alternate gene names: 23100224

Gene position: 2843324-2841792 (Counterclockwise)

Preceding gene: 23100226

Following gene: 23100223

Centisome position: 78.32

GC content: 37.25

Gene sequence:

>1533_bases
ATGACGGATGTAGAATCACTTCATAAAAAACCGCCTTACGGTATGATTGCGATATTATTTATTGGTGCATTCGTTGCAAT
TTTAAACGAGACTTTGCTGAATGTGGCATTGCCATCCATTATGAATGAGTTTGAAGTTAGCCCAACCGCTGTGCAGTGGT
TAACAAATGGTTATATGCTGGTTAATGGTATTTTAATACCTGCGAGTGCATTTTTGATTCAACGCTTTACAAATAAAAGT
TTATTTTTAACGGCAATGTCGTTATTTACAATAGGGACAGTGTTGGCAAGTATATCTCCAACCTTTGCTGTACTGCTTAT
CGCTAGATTAATTCAGGCAGCAGGTTCTGCGGTAATGATGCCATTACTTATGAATGTTATGCTAACTGCATTTCCGATTG
AAAAACGTGGAACTGCGATGGGGACATTCGGTCTTGTAATGGTTGTTGCACCAGCTCTTGGACCAACATTATCAGGTTGG
ATTGTAGAGAATTATGAATGGAGAACTTTATTTGATATTGTTATTCCGATTGCATTACTATCATTAATTATCGGGATATT
TAAGCTGAAAAATGTAACTCCACAACGTGAAATTAAACTTGATGTATTTTCCATTGTTCTATCCAGCTTTGGTTTTGGTG
GATTATTATATGGTTTTAGTTCTGCTGGAGAGCAGGGGTGGAGCAGTCCATATGTATACGGAACAATTATAATTGGTGTC
ATTTCAGTGATTGCATTAGTATTGCGCCAATTAAAAATGGAAGAGCCTATGCTACAGTTCAGGATTTTTAGATATCCAAT
GTTCGCATTATCATCTGCGATTTCGATTGTATTAGCAATGGCATTATTCTCTGGAATGATTTTGCTTCCATTGTATGTGC
AAACAGTTAGAGGATTTACGCCATTTGAAGCTGGATTACTGATGCTGCCTGGCGCACTTGTAATGGGAGTCATGTCTCCG
ATAACCGGAAGACTATTTGATAAGTTTGGTGCACGCACATTAGCGATCCTAGGTTTGCTAATTACGATGACAACCACTTA
CTTTTTCACTCAATTAGATATGGAAACAACGTTTGGACAGATGATGCTTATATTTGCAATACGTAGTTTCGGTATGTCGA
TGGTTATGATGCCTGTAATGACAAATGGTTTAAATCAGTTGCCGATGCATGAAAACCCACATGGTACAGCAATGAATAAT
ACCTTGCAACAAATATCGGGAGCAATTGGCTCAGCACTGCTAATTACCATTATGAATAATCGAACAGAGTCTAAAGCGGA
AGAATTAGCACAATCCGCAATGAATAGTATAGACCCAAGTCAAATGCCATCTGAACAAGCAATGGCGACAATGGAAGCAG
AAATAATGAATCAAGCTATGCTTCAAGGAATTAACTTTTCATTCTTTATTTCCTTATTAATTATGGGAATTGCTTTAGTC
TTATCTCTCTTTATCCGTAGAATTGGCACGGATGGGAAAATGATTACCAAGAAAAAGTTACAAACTCAAAATAAAACGGA
GTATAGTTCTTAA

Upstream 100 bases:

>100_bases
ATATTTATACTAGTAGTCTAGATGAATGAGTAGTTATTCTGTTGATAGAATAATATAACAAACGATAAATTCGATTTGAT
AAAAGAAAGAAGGTATGATG

Downstream 100 bases:

>100_bases
TTAATTTATAAATTTCTTTTGAATGATAGAGCATTGTCACGTCTGTGATAATGCTCTTTTTGCATTGACTTAAATAAAAA
GTTCTGTCTCTACGGTGATA

Product: multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MTDVESLHKKPPYGMIAILFIGAFVAILNETLLNVALPSIMNEFEVSPTAVQWLTNGYMLVNGILIPASAFLIQRFTNKS
LFLTAMSLFTIGTVLASISPTFAVLLIARLIQAAGSAVMMPLLMNVMLTAFPIEKRGTAMGTFGLVMVVAPALGPTLSGW
IVENYEWRTLFDIVIPIALLSLIIGIFKLKNVTPQREIKLDVFSIVLSSFGFGGLLYGFSSAGEQGWSSPYVYGTIIIGV
ISVIALVLRQLKMEEPMLQFRIFRYPMFALSSAISIVLAMALFSGMILLPLYVQTVRGFTPFEAGLLMLPGALVMGVMSP
ITGRLFDKFGARTLAILGLLITMTTTYFFTQLDMETTFGQMMLIFAIRSFGMSMVMMPVMTNGLNQLPMHENPHGTAMNN
TLQQISGAIGSALLITIMNNRTESKAEELAQSAMNSIDPSQMPSEQAMATMEAEIMNQAMLQGINFSFFISLLIMGIALV
LSLFIRRIGTDGKMITKKKLQTQNKTEYSS

Sequences:

>Translated_510_residues
MTDVESLHKKPPYGMIAILFIGAFVAILNETLLNVALPSIMNEFEVSPTAVQWLTNGYMLVNGILIPASAFLIQRFTNKS
LFLTAMSLFTIGTVLASISPTFAVLLIARLIQAAGSAVMMPLLMNVMLTAFPIEKRGTAMGTFGLVMVVAPALGPTLSGW
IVENYEWRTLFDIVIPIALLSLIIGIFKLKNVTPQREIKLDVFSIVLSSFGFGGLLYGFSSAGEQGWSSPYVYGTIIIGV
ISVIALVLRQLKMEEPMLQFRIFRYPMFALSSAISIVLAMALFSGMILLPLYVQTVRGFTPFEAGLLMLPGALVMGVMSP
ITGRLFDKFGARTLAILGLLITMTTTYFFTQLDMETTFGQMMLIFAIRSFGMSMVMMPVMTNGLNQLPMHENPHGTAMNN
TLQQISGAIGSALLITIMNNRTESKAEELAQSAMNSIDPSQMPSEQAMATMEAEIMNQAMLQGINFSFFISLLIMGIALV
LSLFIRRIGTDGKMITKKKLQTQNKTEYSS
>Mature_509_residues
TDVESLHKKPPYGMIAILFIGAFVAILNETLLNVALPSIMNEFEVSPTAVQWLTNGYMLVNGILIPASAFLIQRFTNKSL
FLTAMSLFTIGTVLASISPTFAVLLIARLIQAAGSAVMMPLLMNVMLTAFPIEKRGTAMGTFGLVMVVAPALGPTLSGWI
VENYEWRTLFDIVIPIALLSLIIGIFKLKNVTPQREIKLDVFSIVLSSFGFGGLLYGFSSAGEQGWSSPYVYGTIIIGVI
SVIALVLRQLKMEEPMLQFRIFRYPMFALSSAISIVLAMALFSGMILLPLYVQTVRGFTPFEAGLLMLPGALVMGVMSPI
TGRLFDKFGARTLAILGLLITMTTTYFFTQLDMETTFGQMMLIFAIRSFGMSMVMMPVMTNGLNQLPMHENPHGTAMNNT
LQQISGAIGSALLITIMNNRTESKAEELAQSAMNSIDPSQMPSEQAMATMEAEIMNQAMLQGINFSFFISLLIMGIALVL
SLFIRRIGTDGKMITKKKLQTQNKTEYSS

Specific function: Translocase That Confers Resistance To Substances Of High Hydrophobicity. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=493, Percent_Identity=25.7606490872211, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1788710, Length=460, Percent_Identity=26.304347826087, Blast_Score=158, Evalue=9e-40,
Organism=Escherichia coli, GI87081983, Length=330, Percent_Identity=29.6969696969697, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1790195, Length=412, Percent_Identity=27.4271844660194, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1788392, Length=317, Percent_Identity=30.2839116719243, Blast_Score=105, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6323735, Length=327, Percent_Identity=24.1590214067278, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 55858; Mature: 55727

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
7.6 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
7.5 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDVESLHKKPPYGMIAILFIGAFVAILNETLLNVALPSIMNEFEVSPTAVQWLTNGYML
CCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCEEE
VNGILIPASAFLIQRFTNKSLFLTAMSLFTIGTVLASISPTFAVLLIARLIQAAGSAVMM
EHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHH
PLLMNVMLTAFPIEKRGTAMGTFGLVMVVAPALGPTLSGWIVENYEWRTLFDIVIPIALL
HHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHHHHH
SLIIGIFKLKNVTPQREIKLDVFSIVLSSFGFGGLLYGFSSAGEQGWSSPYVYGTIIIGV
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHH
ISVIALVLRQLKMEEPMLQFRIFRYPMFALSSAISIVLAMALFSGMILLPLYVQTVRGFT
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PFEAGLLMLPGALVMGVMSPITGRLFDKFGARTLAILGLLITMTTTYFFTQLDMETTFGQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MMLIFAIRSFGMSMVMMPVMTNGLNQLPMHENPHGTAMNNTLQQISGAIGSALLITIMNN
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
RTESKAEELAQSAMNSIDPSQMPSEQAMATMEAEIMNQAMLQGINFSFFISLLIMGIALV
CCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LSLFIRRIGTDGKMITKKKLQTQNKTEYSS
HHHHHHHHCCCCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TDVESLHKKPPYGMIAILFIGAFVAILNETLLNVALPSIMNEFEVSPTAVQWLTNGYML
CCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCEEE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HHHHHHHHCCCCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969498 [H]