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The map label for this gene is adhB [H]

Identifier: 23100193

GI number: 23100193

Start: 2808364

End: 2809563

Strand: Reverse

Name: adhB [H]

Synonym: OB2738

Alternate gene names: 23100193

Gene position: 2809563-2808364 (Counterclockwise)

Preceding gene: 23100194

Following gene: 23100192

Centisome position: 77.39

GC content: 38.5

Gene sequence:

>1200_bases
ATGCAAGAGTACGCAGTTTTTCGCACACCAGAAACGATAAATTATGGGCGAAATTCATTTAAAAAAATAGGGATAGAAGC
AGCAGCATGTGGTAATAAGGCGGTTATTATTAGCGATAAAATAATGGAAAATCTGGGGTATGTAAGTGAATGTAGAGATC
TACTTCGCAAGGAAGGAATTGAAAGCGCTATCTATTTAGGTGTGGAATCCGAGCCAACAGATCGATATGTGGAGGAAGCA
TTGCAATTATTAAAGTCTGAACAATGTGATGTTGTTATTTCCCTGGGTGGAGGAAGTTGTATCGATACAGCAAAAGCAAT
TGCAGTGATTGCAACGAATGGTGGCTATATAGGAGATTATATGGGGATGAAGAAATTAGCAGTACTGCCACCTTTACCAC
ATATATCCATTCCGACAACAGCTGGTACTGGATCAGAAGCTACTGATGCTACGATTATTACCAATACAAGTAATAACGTA
AAGATGATGATTAAACAACCAGCATTTATGCCAAATGTTGCTATTGTGGATCCGATATTATCGATATCTTCTCCAAAAAC
TGTTACGGCTGCGACTGGAATTGATGCATTAAGTCATGCAATTGAGGCATATATTTCTCAGAAATCTCAACCGATGACAG
AAATGTTAGCGCTTTCTTCAATGGAGAAAATTGTAAACAGCTTAAAGAGAGCATATGAGAATGGAGAGGATATTTTAGCA
AGAGAAGAAATGTCTCTAGGTTCATTACAAGCAGGTATGTCTTTTACGAACGCATCAGTTTGTCTCGTCCATGGGATGTC
CAGGCCGATAGGAGCCTTGTTCCATGTTCCACATGGTTTTTCCAATGCGATGTTACTTCCCGCTGTGCTGGAATTTAGTA
AAGAACATTGTGTGGAACGACTTGCGGATTTAGGAAGATTTTTTCAACCTGATAATCAGATTGTATCTGATAGAGAGGCA
GCAGATATTGCAGTTGAGTCGGTAAAACAGTTGTGTCTGGAATTAAATATTCCAAACTTAGAAGGATGGGGAATTAAAAA
ATCGGAGTTTCAGCAAGCCATTAGTAAAATGGCAGAAGATGCAATAGCCAGTGGCAGTCCAGGGAATAATCCGAGAGTAC
CAACCAAACAAGAAATAGAGAAACTTTATCAAACTTGTTATAACTATCAATTTTCATCACAAAAGTCGGTAAGTAATTAA

Upstream 100 bases:

>100_bases
CTACACTCTTTGTTTTTAATTATCGGCATAGGAGTCATCATTAGTTGGCATGAATTTTGCATAGTAATGAGTGAACGGAA
AAAAGGGGAGGGAAGAGAAA

Downstream 100 bases:

>100_bases
ACCGTGAACAGGGGGAGAAATGATGGAATTTCTAGGTATGATTGGATTATTGGTATCACTCGTCGTTTTAATTTATCTTA
CCATGAAAGGTGTAAATATC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase II; ADH II [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MQEYAVFRTPETINYGRNSFKKIGIEAAACGNKAVIISDKIMENLGYVSECRDLLRKEGIESAIYLGVESEPTDRYVEEA
LQLLKSEQCDVVISLGGGSCIDTAKAIAVIATNGGYIGDYMGMKKLAVLPPLPHISIPTTAGTGSEATDATIITNTSNNV
KMMIKQPAFMPNVAIVDPILSISSPKTVTAATGIDALSHAIEAYISQKSQPMTEMLALSSMEKIVNSLKRAYENGEDILA
REEMSLGSLQAGMSFTNASVCLVHGMSRPIGALFHVPHGFSNAMLLPAVLEFSKEHCVERLADLGRFFQPDNQIVSDREA
ADIAVESVKQLCLELNIPNLEGWGIKKSEFQQAISKMAEDAIASGSPGNNPRVPTKQEIEKLYQTCYNYQFSSQKSVSN

Sequences:

>Translated_399_residues
MQEYAVFRTPETINYGRNSFKKIGIEAAACGNKAVIISDKIMENLGYVSECRDLLRKEGIESAIYLGVESEPTDRYVEEA
LQLLKSEQCDVVISLGGGSCIDTAKAIAVIATNGGYIGDYMGMKKLAVLPPLPHISIPTTAGTGSEATDATIITNTSNNV
KMMIKQPAFMPNVAIVDPILSISSPKTVTAATGIDALSHAIEAYISQKSQPMTEMLALSSMEKIVNSLKRAYENGEDILA
REEMSLGSLQAGMSFTNASVCLVHGMSRPIGALFHVPHGFSNAMLLPAVLEFSKEHCVERLADLGRFFQPDNQIVSDREA
ADIAVESVKQLCLELNIPNLEGWGIKKSEFQQAISKMAEDAIASGSPGNNPRVPTKQEIEKLYQTCYNYQFSSQKSVSN
>Mature_399_residues
MQEYAVFRTPETINYGRNSFKKIGIEAAACGNKAVIISDKIMENLGYVSECRDLLRKEGIESAIYLGVESEPTDRYVEEA
LQLLKSEQCDVVISLGGGSCIDTAKAIAVIATNGGYIGDYMGMKKLAVLPPLPHISIPTTAGTGSEATDATIITNTSNNV
KMMIKQPAFMPNVAIVDPILSISSPKTVTAATGIDALSHAIEAYISQKSQPMTEMLALSSMEKIVNSLKRAYENGEDILA
REEMSLGSLQAGMSFTNASVCLVHGMSRPIGALFHVPHGFSNAMLLPAVLEFSKEHCVERLADLGRFFQPDNQIVSDREA
ADIAVESVKQLCLELNIPNLEGWGIKKSEFQQAISKMAEDAIASGSPGNNPRVPTKQEIEKLYQTCYNYQFSSQKSVSN

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=404, Percent_Identity=29.4554455445545, Blast_Score=158, Evalue=1e-38,
Organism=Escherichia coli, GI48994951, Length=353, Percent_Identity=38.2436260623229, Blast_Score=235, Evalue=4e-63,
Organism=Escherichia coli, GI1789163, Length=381, Percent_Identity=35.4330708661417, Blast_Score=224, Evalue=6e-60,
Organism=Escherichia coli, GI87082107, Length=385, Percent_Identity=36.3636363636364, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI1787493, Length=408, Percent_Identity=28.921568627451, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1789386, Length=367, Percent_Identity=20.1634877384196, Blast_Score=75, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17537053, Length=431, Percent_Identity=28.0742459396752, Blast_Score=145, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6321181, Length=363, Percent_Identity=37.1900826446281, Blast_Score=220, Evalue=4e-58,
Organism=Drosophila melanogaster, GI24657991, Length=430, Percent_Identity=26.046511627907, Blast_Score=135, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 43245; Mature: 43245

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEYAVFRTPETINYGRNSFKKIGIEAAACGNKAVIISDKIMENLGYVSECRDLLRKEGI
CCCCEEEECCCHHHHCCHHHHHHCCHHCCCCCCEEEEEHHHHHHCCCHHHHHHHHHHCCC
ESAIYLGVESEPTDRYVEEALQLLKSEQCDVVISLGGGSCIDTAKAIAVIATNGGYIGDY
CEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHCCEEEEEEECCCEEHHH
MGMKKLAVLPPLPHISIPTTAGTGSEATDATIITNTSNNVKMMIKQPAFMPNVAIVDPIL
HCHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCHHHHHHHH
SISSPKTVTAATGIDALSHAIEAYISQKSQPMTEMLALSSMEKIVNSLKRAYENGEDILA
HCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
REEMSLGSLQAGMSFTNASVCLVHGMSRPIGALFHVPHGFSNAMLLPAVLEFSKEHCVER
HHHHCHHHHHHCCCCCCCCEEEEECCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
LADLGRFFQPDNQIVSDREAADIAVESVKQLCLELNIPNLEGWGIKKSEFQQAISKMAED
HHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
AIASGSPGNNPRVPTKQEIEKLYQTCYNYQFSSQKSVSN
HHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MQEYAVFRTPETINYGRNSFKKIGIEAAACGNKAVIISDKIMENLGYVSECRDLLRKEGI
CCCCEEEECCCHHHHCCHHHHHHCCHHCCCCCCEEEEEHHHHHHCCCHHHHHHHHHHCCC
ESAIYLGVESEPTDRYVEEALQLLKSEQCDVVISLGGGSCIDTAKAIAVIATNGGYIGDY
CEEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHCCEEEEEEECCCEEHHH
MGMKKLAVLPPLPHISIPTTAGTGSEATDATIITNTSNNVKMMIKQPAFMPNVAIVDPIL
HCHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCHHHHHHHH
SISSPKTVTAATGIDALSHAIEAYISQKSQPMTEMLALSSMEKIVNSLKRAYENGEDILA
HCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
REEMSLGSLQAGMSFTNASVCLVHGMSRPIGALFHVPHGFSNAMLLPAVLEFSKEHCVER
HHHHCHHHHHHCCCCCCCCEEEEECCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
LADLGRFFQPDNQIVSDREAADIAVESVKQLCLELNIPNLEGWGIKKSEFQQAISKMAED
HHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
AIASGSPGNNPRVPTKQEIEKLYQTCYNYQFSSQKSVSN
HHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3584063; 2308827; 2935393 [H]