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The map label for this gene is hxlA [H]

Identifier: 23100152

GI number: 23100152

Start: 2768252

End: 2768797

Strand: Reverse

Name: hxlA [H]

Synonym: OB2697

Alternate gene names: 23100152

Gene position: 2768797-2768252 (Counterclockwise)

Preceding gene: 23100153

Following gene: 23100151

Centisome position: 76.26

GC content: 34.8

Gene sequence:

>546_bases
ATGAAATTACAATTAGCATTGGATCGACTAACACGTGGAGAAAGTATTCGTATATTAGAAAGTGTGAAACAATATGTTGA
TATTATCGAAGTTGGAACTGGGGTAATAAAAGAATATGGAGTCTCTATTATAAAAGAAATAAGAGATTTATATCCTGATA
AAACGATTCTAATGGGGTTCGCAGCTAATCCTATCATTAAAGAAACGCTACAAGTTGCGAAAGAAATGGATGGACAGATG
ATGGTCGATTTGTTAGAAATTCAATCTGCTGATCGAGTAAGAGAGCTATCATTAATTGGTGTAGAATTAGTGAGTCTCCA
TGTAGGAAAAGATAAACAAACAGAAGGGGTTTTTCATACTGATTTATTTTCGTTGATCGAGGGAGTTCCTGTAAAGGTAG
CAGTTGCCGGAGGAATTAATCTGAAAACATTACCAGAAATTACACAACACAAACCAGATATTGTTATTATCGGCAGTGCA
ATTACTGGACAAGATAACCCAGAACTAGTTGCTAAGACAATCAAAAATATGATGCAAGGTAGCTAA

Upstream 100 bases:

>100_bases
TGGTATTACAGGTGATAATGAAGGACTACCGTATTATGAAGATGTCCAAGAACGACTAGGAGAAATAGAGAGAATAGAGC
GGTAATTGAGGTGAGAATTT

Downstream 100 bases:

>100_bases
TCAATCATAGGTCCTGTAAGTGAAAAGAATGTAAAAAGTATGGTGAAGAAGAATGTTTAGGTAAAAAGACTACAGCTTTG
TAGTTATTTGGATTACAATG

Product: D-arabino 3-hexulose 6-phosphate formaldehyde lyase

Products: NA

Alternate protein names: HPS; D-arabino-3-hexulose-6-phosphate formaldehyde lyase; HUMPS [H]

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MKLQLALDRLTRGESIRILESVKQYVDIIEVGTGVIKEYGVSIIKEIRDLYPDKTILMGFAANPIIKETLQVAKEMDGQM
MVDLLEIQSADRVRELSLIGVELVSLHVGKDKQTEGVFHTDLFSLIEGVPVKVAVAGGINLKTLPEITQHKPDIVIIGSA
ITGQDNPELVAKTIKNMMQGS

Sequences:

>Translated_181_residues
MKLQLALDRLTRGESIRILESVKQYVDIIEVGTGVIKEYGVSIIKEIRDLYPDKTILMGFAANPIIKETLQVAKEMDGQM
MVDLLEIQSADRVRELSLIGVELVSLHVGKDKQTEGVFHTDLFSLIEGVPVKVAVAGGINLKTLPEITQHKPDIVIIGSA
ITGQDNPELVAKTIKNMMQGS
>Mature_181_residues
MKLQLALDRLTRGESIRILESVKQYVDIIEVGTGVIKEYGVSIIKEIRDLYPDKTILMGFAANPIIKETLQVAKEMDGQM
MVDLLEIQSADRVRELSLIGVELVSLHVGKDKQTEGVFHTDLFSLIEGVPVKVAVAGGINLKTLPEITQHKPDIVIIGSA
ITGQDNPELVAKTIKNMMQGS

Specific function: Catalyzes the condensation of ribulose 5-phosphate with formaldehyde to form 3-hexulose 6-phosphate. Together with hxlB, may act as a formaldehyde detoxification system [H]

COG id: COG0269

COG function: function code G; 3-hexulose-6-phosphate synthase and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPS/KGPDC family. HPS subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017553
- InterPro:   IPR013785
- InterPro:   IPR001754
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00215 OMPdecase [H]

EC number: =4.1.2.43 [H]

Molecular weight: Translated: 19878; Mature: 19878

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLQLALDRLTRGESIRILESVKQYVDIIEVGTGVIKEYGVSIIKEIRDLYPDKTILMGF
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
AANPIIKETLQVAKEMDGQMMVDLLEIQSADRVRELSLIGVELVSLHVGKDKQTEGVFHT
CCCHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHEEECCCCCCCCCCHHH
DLFSLIEGVPVKVAVAGGINLKTLPEITQHKPDIVIIGSAITGQDNPELVAKTIKNMMQG
HHHHHHCCCCEEEEEECCCCCCCCCHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCC
S
C
>Mature Secondary Structure
MKLQLALDRLTRGESIRILESVKQYVDIIEVGTGVIKEYGVSIIKEIRDLYPDKTILMGF
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
AANPIIKETLQVAKEMDGQMMVDLLEIQSADRVRELSLIGVELVSLHVGKDKQTEGVFHT
CCCHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHEEECCCCCCCCCCHHH
DLFSLIEGVPVKVAVAGGINLKTLPEITQHKPDIVIIGSAITGQDNPELVAKTIKNMMQG
HHHHHHCCCCEEEEEECCCCCCCCCHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7704255; 8969502; 9384377 [H]