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The map label for this gene is est [H]

Identifier: 23099884

GI number: 23099884

Start: 2483410

End: 2484150

Strand: Reverse

Name: est [H]

Synonym: OB2429

Alternate gene names: 23099884

Gene position: 2484150-2483410 (Counterclockwise)

Preceding gene: 23099885

Following gene: 23099883

Centisome position: 68.42

GC content: 33.87

Gene sequence:

>741_bases
ATGAAAATAAAATTACCAGAGCCATTTACATTTGAAGCAGGAGATAAAGCTGTATTATTACTACATGGATTTACCGGTCA
TTCTGCAGACGTACGTATGCTAGGTAGATTTTTGGAGAAAAAAGGGTATACTTCACATGCACCAATTTATAGAGGACATG
GACAACCTCCTGAAGAATTAATTAAAAGTAACCCTGAACAATGGTGGGCAGATGTGGAAGCTGCATATAATCACTTGCAA
GATTTGGGTTATGAAGAAATTGCAGTTGCTGGCCTTTCTTTAGGTGGTGTGTTAGGACTTAAATTAGCTTATTCCAAAAA
TATCAAAGGTATTGTAACGATGTGTTCTCCTATGTTTTTTGATAATGAACAGGAATTGACAAAGGGGTTCCGTCAATTTT
CCACAGAATTTAAACAGCTGGAGAAAAAAGATAAAGAAGTTATCGAAGAAGAAGTAAATCAATTAATGGATCAATCTAAA
GACTTATTTAAGGGTGTAGCTACAACGATTAATGAAGTAAAGACAAATATCGATATGATCTATACTCCGACATTTGTGGT
ACAAGCTAAGAATGACAAGATGATTAATACCGACAGTGCCAATTATATTTATGAAAATGTAGAAGCTTCCAAAAAAGATA
TGAAATGGTATGAAGAGTCTGGTCATGTTATTACGATGGACAAAGAAAAAGATCAGCTTCATGAGGATATTTATCAATTT
CTAGAAAGTTTAGATTGGTAA

Upstream 100 bases:

>100_bases
CGATTCCTTATCACTTATGTGGTAAGGATTTTTTATTTTTACGTTGTATATCCTTGAAGAACGGGTAAAGTAAATAGAGA
CGATAAAAGGAGATAGAGAA

Downstream 100 bases:

>100_bases
CAAACAGGAAAAGAATATTATGAAAGAAGGTGAAAGTATGAAAGAGAAAATAATAAATTATTTTAAAGAATCTGGAACAA
AACCATTATCTGTACAGGAA

Product: carboxylesterase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MKIKLPEPFTFEAGDKAVLLLHGFTGHSADVRMLGRFLEKKGYTSHAPIYRGHGQPPEELIKSNPEQWWADVEAAYNHLQ
DLGYEEIAVAGLSLGGVLGLKLAYSKNIKGIVTMCSPMFFDNEQELTKGFRQFSTEFKQLEKKDKEVIEEEVNQLMDQSK
DLFKGVATTINEVKTNIDMIYTPTFVVQAKNDKMINTDSANYIYENVEASKKDMKWYEESGHVITMDKEKDQLHEDIYQF
LESLDW

Sequences:

>Translated_246_residues
MKIKLPEPFTFEAGDKAVLLLHGFTGHSADVRMLGRFLEKKGYTSHAPIYRGHGQPPEELIKSNPEQWWADVEAAYNHLQ
DLGYEEIAVAGLSLGGVLGLKLAYSKNIKGIVTMCSPMFFDNEQELTKGFRQFSTEFKQLEKKDKEVIEEEVNQLMDQSK
DLFKGVATTINEVKTNIDMIYTPTFVVQAKNDKMINTDSANYIYENVEASKKDMKWYEESGHVITMDKEKDQLHEDIYQF
LESLDW
>Mature_246_residues
MKIKLPEPFTFEAGDKAVLLLHGFTGHSADVRMLGRFLEKKGYTSHAPIYRGHGQPPEELIKSNPEQWWADVEAAYNHLQ
DLGYEEIAVAGLSLGGVLGLKLAYSKNIKGIVTMCSPMFFDNEQELTKGFRQFSTEFKQLEKKDKEVIEEEVNQLMDQSK
DLFKGVATTINEVKTNIDMIYTPTFVVQAKNDKMINTDSANYIYENVEASKKDMKWYEESGHVITMDKEKDQLHEDIYQF
LESLDW

Specific function: Involved in the detoxification of xenobiotics. Shows maximal activity with C6 substrates, with gradually decreasing activity from C8 to C12 substrates. No activity for higher chain length substrates acids rather than long-chain ones [H]

COG id: COG1647

COG function: function code R; Esterase/lipase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lipase/esterase LIP3/BchO family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012354
- InterPro:   IPR001375 [H]

Pfam domain/function: PF00326 Peptidase_S9 [H]

EC number: =3.1.1.1 [H]

Molecular weight: Translated: 28232; Mature: 28232

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKLPEPFTFEAGDKAVLLLHGFTGHSADVRMLGRFLEKKGYTSHAPIYRGHGQPPEEL
CCCCCCCCCEECCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEECCCCCCHHHH
IKSNPEQWWADVEAAYNHLQDLGYEEIAVAGLSLGGVLGLKLAYSKNIKGIVTMCSPMFF
HHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCHHHC
DNEQELTKGFRQFSTEFKQLEKKDKEVIEEEVNQLMDQSKDLFKGVATTINEVKTNIDMI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
YTPTFVVQAKNDKMINTDSANYIYENVEASKKDMKWYEESGHVITMDKEKDQLHEDIYQF
ECCEEEEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHH
LESLDW
HHHCCC
>Mature Secondary Structure
MKIKLPEPFTFEAGDKAVLLLHGFTGHSADVRMLGRFLEKKGYTSHAPIYRGHGQPPEEL
CCCCCCCCCEECCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEECCCCCCHHHH
IKSNPEQWWADVEAAYNHLQDLGYEEIAVAGLSLGGVLGLKLAYSKNIKGIVTMCSPMFF
HHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCHHHC
DNEQELTKGFRQFSTEFKQLEKKDKEVIEEEVNQLMDQSKDLFKGVATTINEVKTNIDMI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
YTPTFVVQAKNDKMINTDSANYIYENVEASKKDMKWYEESGHVITMDKEKDQLHEDIYQF
ECCEEEEEECCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHH
LESLDW
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1369099 [H]