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The map label for this gene is fadN [H]

Identifier: 23099850

GI number: 23099850

Start: 2445806

End: 2448199

Strand: Reverse

Name: fadN [H]

Synonym: OB2395

Alternate gene names: 23099850

Gene position: 2448199-2445806 (Counterclockwise)

Preceding gene: 23099855

Following gene: 23099849

Centisome position: 67.43

GC content: 36.8

Gene sequence:

>2394_bases
GTGACATATTCTATAAAAAGTGCAGCAGTATTAGGATCTGGTGTGATGGGGTCAGGTATTGCAGCTCATTTAGCAAATAA
CGGAATACCAGTAACAATGCTAGATGTTGTGCCAAAGGATTTAACAGATGAAGAAAAGACGAAGGGATTAACTTTAGAAG
ATCAAATAGTAAGAAATAGGATTGCAGAACAAAGTAAAAAGAAATTATTGAAGCAAAAGCCCTCACCAATTACAACGAAG
CAGAGTTTAAATCTAATTCATGTTGGTAACTTAGAAGATGATATTGAGAAGTTAGCTGAAGTGGACTGGATAATCGAAGT
AGTAGTTGAGAATCTTGATATAAAGAAAAAAGTGTTTGCAAACGTCGATAAATATCGAAAAGAGGGTACGATTGTTAGTT
CCAATACATCAGGAATCTCAGTGGAAGCGATGATTGAAGATTGTTCTGAAGATATGAAAAAACACTTCCTGGGGACACAT
TTCTTTAATCCGCCAAGATATTTAAAATTATTGGAAGTTATACCGACAAAACATACTGATCCTAGTGTTCTATCCTTTAT
GAAACAATTTGGTGAAGATGTGTTAGGAAAAGGTGTTGTGGAAGCAAAAGATACACCTAATTTTATTGCTAATCGTATTG
GAACATACGGGTTATTAGTAACTGTGCGTGAAATGCAAAAGGGTGGTTATAGCGTAGGTGAAGTCGATTCTGTTACAGGG
CCAATTATTGGAAGGCCGAAGAGTGCGACATTTCGGACGTTGGATGTTGTAGGACTTGATACATTTCACCATGTTGCGAA
AAATGTCTACGATCAGGTAGATCATGCAGAGGAAAAAGCTGTATTTGAGATACCAGATTTTGTGAATCAAATGATTGAAA
AAGGTTGGATTGGAGCAAAGAAACGTAAAGGATTTTATGAGAAGCAAAAAGACGGAAAAATTTATGAGATTAATCCAGAT
ACATTGGAATTTCAAGAAAGAAAGAAAATAAATTCTGCTGCGGTTGAAATGGCAAAGCAACAAAAAGGTTCTAAACGAAA
ATTGAAAGCGCTTGTAGATGCGAAGGGAGATCGTGCTGGTGACTTAGTTTGGTCAGTACTAAAACCAAGCTTGTTATATT
CTGCAGAGTTACTCGGAGAAATCGCTGATGATATTGTATCGATTGACCAAGCAATGAAATGGGGTTTTGGCTGGGAATTA
GGTCCATTTGAATCGTGGGATGCGATTGGAGTTCGAGATTCTGTAGAACGGATGAAATCAGAAGGAGAAGCTATTCCAAC
TTGGGTGAAGAATATGTTGGATGAAGGCTTTGAAACTTTTTATCAAAAGGATAATGGAAATAATCTTTACTATGATAATG
GCGAGTATAAACAACAGGCCATTAATAATAAAGAAGTTAACATTCGCACATTAAAAGAACAAAAAGGTGTCATTAAAAAA
AATACTGGTGCTAGTTTAATTGATATGGGTGATGGTGTTGCACTTTTAGAGTTCCACTCTCAAAGTAATGCGATCGGATT
AGACATTATTCAAATGGTTAATTTTGCGGTTGAAGAAGTGAATAAGAATTATAAAGGTCTTGTAATAGGGAATCAAGGTA
AGAACTTCTGTGTTGGAGCTAACCTAGCGATGATGTTAATGGAAGCACAGGATGATAATTTCTTTGAACTAGATATGGTA
ATCCGTCAGTTCCAAAATATGACGATGAATATTAAGTATTCCGATCGTCCTGTAGTTGTAGCACCTTTTAATATGACGCT
TGGCGGTGGTGCAGAAGTATCTTTACCTGCAGCAGCTATCCAAGCTTCTCCAGAGACCTATATCGGACTAGTAGAATTTG
GAGTCGGATTAATTCCTGGAGGTGGTGGAACGAAAGAACTTTACTTAAAAGAACTTCGTCATATGCCTAAAGGAATAGAC
TTTGATTTAACTAAGGTTGCAAATAATGTTTTTGAAAAAGTAGCAACGGCTAAAGTTTCTACTTCTGCTGCAGAAGGCAT
TCAAAATGGGTTCTTAAATAGTAACGATAGAATAAGTGCTAACCCAGACCATGTTTTATATGATGCGAAACAAAGAGTTA
TCCGTTTATATGATGGAGGATATAAGAAACCTCAACGTGAGAAAATTCCGGTTGTCGGTGATGCTGGTTACGCTGCCATG
TTAATGGGAGCAAAGTCATTGCAATTTAGTGGATATGCTTCTGCACATGATGTGAAAATTGCAGAAAAATTGGCTTATGT
ATTATCAGGGGGAAGAATTAAAGAAGGTACGGAAATCGATGAGCAAGTAATGCTTGATTTAGAACGTGAGGCATTTTTAA
GTTTAATAGCTGAACCATTGACACAACAGCGTATGCAACACATGTTGGTCAAAGGGAAACCATTGCGTAACTAA

Upstream 100 bases:

>100_bases
TGATTTATAGTTATTTATATAGAAGGATATTTGTATGTCTTTTATTTTTTTACACAAAAATGAATGAGCATTCATTCAAA
TAGGATTGGGGGAGAAATTT

Downstream 100 bases:

>100_bases
GCGATAAAGGGGGATAAAAACGTGAAGGAAGCAGTTATTGTTGCTGGTGCGAGAACACCAGTAGGAAAAGCAAATAAAGG
TTCACTAGCAAATGTTCGTC

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 797; Mature: 796

Protein sequence:

>797_residues
MTYSIKSAAVLGSGVMGSGIAAHLANNGIPVTMLDVVPKDLTDEEKTKGLTLEDQIVRNRIAEQSKKKLLKQKPSPITTK
QSLNLIHVGNLEDDIEKLAEVDWIIEVVVENLDIKKKVFANVDKYRKEGTIVSSNTSGISVEAMIEDCSEDMKKHFLGTH
FFNPPRYLKLLEVIPTKHTDPSVLSFMKQFGEDVLGKGVVEAKDTPNFIANRIGTYGLLVTVREMQKGGYSVGEVDSVTG
PIIGRPKSATFRTLDVVGLDTFHHVAKNVYDQVDHAEEKAVFEIPDFVNQMIEKGWIGAKKRKGFYEKQKDGKIYEINPD
TLEFQERKKINSAAVEMAKQQKGSKRKLKALVDAKGDRAGDLVWSVLKPSLLYSAELLGEIADDIVSIDQAMKWGFGWEL
GPFESWDAIGVRDSVERMKSEGEAIPTWVKNMLDEGFETFYQKDNGNNLYYDNGEYKQQAINNKEVNIRTLKEQKGVIKK
NTGASLIDMGDGVALLEFHSQSNAIGLDIIQMVNFAVEEVNKNYKGLVIGNQGKNFCVGANLAMMLMEAQDDNFFELDMV
IRQFQNMTMNIKYSDRPVVVAPFNMTLGGGAEVSLPAAAIQASPETYIGLVEFGVGLIPGGGGTKELYLKELRHMPKGID
FDLTKVANNVFEKVATAKVSTSAAEGIQNGFLNSNDRISANPDHVLYDAKQRVIRLYDGGYKKPQREKIPVVGDAGYAAM
LMGAKSLQFSGYASAHDVKIAEKLAYVLSGGRIKEGTEIDEQVMLDLEREAFLSLIAEPLTQQRMQHMLVKGKPLRN

Sequences:

>Translated_797_residues
MTYSIKSAAVLGSGVMGSGIAAHLANNGIPVTMLDVVPKDLTDEEKTKGLTLEDQIVRNRIAEQSKKKLLKQKPSPITTK
QSLNLIHVGNLEDDIEKLAEVDWIIEVVVENLDIKKKVFANVDKYRKEGTIVSSNTSGISVEAMIEDCSEDMKKHFLGTH
FFNPPRYLKLLEVIPTKHTDPSVLSFMKQFGEDVLGKGVVEAKDTPNFIANRIGTYGLLVTVREMQKGGYSVGEVDSVTG
PIIGRPKSATFRTLDVVGLDTFHHVAKNVYDQVDHAEEKAVFEIPDFVNQMIEKGWIGAKKRKGFYEKQKDGKIYEINPD
TLEFQERKKINSAAVEMAKQQKGSKRKLKALVDAKGDRAGDLVWSVLKPSLLYSAELLGEIADDIVSIDQAMKWGFGWEL
GPFESWDAIGVRDSVERMKSEGEAIPTWVKNMLDEGFETFYQKDNGNNLYYDNGEYKQQAINNKEVNIRTLKEQKGVIKK
NTGASLIDMGDGVALLEFHSQSNAIGLDIIQMVNFAVEEVNKNYKGLVIGNQGKNFCVGANLAMMLMEAQDDNFFELDMV
IRQFQNMTMNIKYSDRPVVVAPFNMTLGGGAEVSLPAAAIQASPETYIGLVEFGVGLIPGGGGTKELYLKELRHMPKGID
FDLTKVANNVFEKVATAKVSTSAAEGIQNGFLNSNDRISANPDHVLYDAKQRVIRLYDGGYKKPQREKIPVVGDAGYAAM
LMGAKSLQFSGYASAHDVKIAEKLAYVLSGGRIKEGTEIDEQVMLDLEREAFLSLIAEPLTQQRMQHMLVKGKPLRN
>Mature_796_residues
TYSIKSAAVLGSGVMGSGIAAHLANNGIPVTMLDVVPKDLTDEEKTKGLTLEDQIVRNRIAEQSKKKLLKQKPSPITTKQ
SLNLIHVGNLEDDIEKLAEVDWIIEVVVENLDIKKKVFANVDKYRKEGTIVSSNTSGISVEAMIEDCSEDMKKHFLGTHF
FNPPRYLKLLEVIPTKHTDPSVLSFMKQFGEDVLGKGVVEAKDTPNFIANRIGTYGLLVTVREMQKGGYSVGEVDSVTGP
IIGRPKSATFRTLDVVGLDTFHHVAKNVYDQVDHAEEKAVFEIPDFVNQMIEKGWIGAKKRKGFYEKQKDGKIYEINPDT
LEFQERKKINSAAVEMAKQQKGSKRKLKALVDAKGDRAGDLVWSVLKPSLLYSAELLGEIADDIVSIDQAMKWGFGWELG
PFESWDAIGVRDSVERMKSEGEAIPTWVKNMLDEGFETFYQKDNGNNLYYDNGEYKQQAINNKEVNIRTLKEQKGVIKKN
TGASLIDMGDGVALLEFHSQSNAIGLDIIQMVNFAVEEVNKNYKGLVIGNQGKNFCVGANLAMMLMEAQDDNFFELDMVI
RQFQNMTMNIKYSDRPVVVAPFNMTLGGGAEVSLPAAAIQASPETYIGLVEFGVGLIPGGGGTKELYLKELRHMPKGIDF
DLTKVANNVFEKVATAKVSTSAAEGIQNGFLNSNDRISANPDHVLYDAKQRVIRLYDGGYKKPQREKIPVVGDAGYAAML
MGAKSLQFSGYASAHDVKIAEKLAYVLSGGRIKEGTEIDEQVMLDLEREAFLSLIAEPLTQQRMQHMLVKGKPLRN

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=306, Percent_Identity=29.4117647058824, Blast_Score=120, Evalue=7e-27,
Organism=Homo sapiens, GI296179427, Length=323, Percent_Identity=27.8637770897833, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI68989263, Length=436, Percent_Identity=25.6880733944954, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI261878539, Length=436, Percent_Identity=25.6880733944954, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI20127408, Length=321, Percent_Identity=29.595015576324, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI115430219, Length=303, Percent_Identity=25.7425742574257, Blast_Score=76, Evalue=2e-13,
Organism=Escherichia coli, GI1787661, Length=314, Percent_Identity=27.3885350318471, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI1790281, Length=308, Percent_Identity=28.5714285714286, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI1788682, Length=307, Percent_Identity=25.7328990228013, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17553560, Length=311, Percent_Identity=30.8681672025724, Blast_Score=130, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17549919, Length=307, Percent_Identity=31.9218241042345, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17563036, Length=310, Percent_Identity=29.3548387096774, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17508951, Length=417, Percent_Identity=27.5779376498801, Blast_Score=97, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17508953, Length=417, Percent_Identity=27.5779376498801, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17558304, Length=416, Percent_Identity=27.1634615384615, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25144276, Length=299, Percent_Identity=28.0936454849498, Blast_Score=90, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71985923, Length=405, Percent_Identity=24.1975308641975, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71985930, Length=261, Percent_Identity=26.4367816091954, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19921000, Length=463, Percent_Identity=25.2699784017279, Blast_Score=92, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24583077, Length=463, Percent_Identity=25.2699784017279, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24583079, Length=463, Percent_Identity=25.2699784017279, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45549573, Length=268, Percent_Identity=26.1194029850746, Blast_Score=78, Evalue=3e-14,
Organism=Drosophila melanogaster, GI20129993, Length=240, Percent_Identity=27.9166666666667, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =1.1.1.35 [H]

Molecular weight: Translated: 88287; Mature: 88156

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYSIKSAAVLGSGVMGSGIAAHLANNGIPVTMLDVVPKDLTDEEKTKGLTLEDQIVRNR
CCCCCCHHHHHCCCCCCCCHHHHHHCCCCCEEECCCCCCCCCCHHHHCCCCHHHHHHHHH
IAEQSKKKLLKQKPSPITTKQSLNLIHVGNLEDDIEKLAEVDWIIEVVVENLDIKKKVFA
HHHHHHHHHHHCCCCCCCHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
NVDKYRKEGTIVSSNTSGISVEAMIEDCSEDMKKHFLGTHFFNPPRYLKLLEVIPTKHTD
HHHHHHHCCCEEECCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCC
PSVLSFMKQFGEDVLGKGVVEAKDTPNFIANRIGTYGLLVTVREMQKGGYSVGEVDSVTG
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCC
PIIGRPKSATFRTLDVVGLDTFHHVAKNVYDQVDHAEEKAVFEIPDFVNQMIEKGWIGAK
CCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHHHCCCCCH
KRKGFYEKQKDGKIYEINPDTLEFQERKKINSAAVEMAKQQKGSKRKLKALVDAKGDRAG
HHCCCCHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHH
DLVWSVLKPSLLYSAELLGEIADDIVSIDQAMKWGFGWELGPFESWDAIGVRDSVERMKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
EGEAIPTWVKNMLDEGFETFYQKDNGNNLYYDNGEYKQQAINNKEVNIRTLKEQKGVIKK
CCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHCCCCCCEEEEEHHHCCCEEC
NTGASLIDMGDGVALLEFHSQSNAIGLDIIQMVNFAVEEVNKNYKGLVIGNQGKNFCVGA
CCCCCEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEECC
NLAMMLMEAQDDNFFELDMVIRQFQNMTMNIKYSDRPVVVAPFNMTLGGGAEVSLPAAAI
CCEEEEEECCCCCEEHHHHHHHHHCCCEEEEEECCCCEEEEECCEEECCCCCEECCHHHH
QASPETYIGLVEFGVGLIPGGGGTKELYLKELRHMPKGIDFDLTKVANNVFEKVATAKVS
HCCCHHHEEHHHHCCEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
TSAAEGIQNGFLNSNDRISANPDHVLYDAKQRVIRLYDGGYKKPQREKIPVVGDAGYAAM
HHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHEEHHCCCCCCCCCCCCCEECCCCHHHH
LMGAKSLQFSGYASAHDVKIAEKLAYVLSGGRIKEGTEIDEQVMLDLEREAFLSLIAEPL
HHCCHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TQQRMQHMLVKGKPLRN
HHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TYSIKSAAVLGSGVMGSGIAAHLANNGIPVTMLDVVPKDLTDEEKTKGLTLEDQIVRNR
CCCCCHHHHHCCCCCCCCHHHHHHCCCCCEEECCCCCCCCCCHHHHCCCCHHHHHHHHH
IAEQSKKKLLKQKPSPITTKQSLNLIHVGNLEDDIEKLAEVDWIIEVVVENLDIKKKVFA
HHHHHHHHHHHCCCCCCCHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
NVDKYRKEGTIVSSNTSGISVEAMIEDCSEDMKKHFLGTHFFNPPRYLKLLEVIPTKHTD
HHHHHHHCCCEEECCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCC
PSVLSFMKQFGEDVLGKGVVEAKDTPNFIANRIGTYGLLVTVREMQKGGYSVGEVDSVTG
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCC
PIIGRPKSATFRTLDVVGLDTFHHVAKNVYDQVDHAEEKAVFEIPDFVNQMIEKGWIGAK
CCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHHHCCCCCH
KRKGFYEKQKDGKIYEINPDTLEFQERKKINSAAVEMAKQQKGSKRKLKALVDAKGDRAG
HHCCCCHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHH
DLVWSVLKPSLLYSAELLGEIADDIVSIDQAMKWGFGWELGPFESWDAIGVRDSVERMKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
EGEAIPTWVKNMLDEGFETFYQKDNGNNLYYDNGEYKQQAINNKEVNIRTLKEQKGVIKK
CCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHCCCCCCEEEEEHHHCCCEEC
NTGASLIDMGDGVALLEFHSQSNAIGLDIIQMVNFAVEEVNKNYKGLVIGNQGKNFCVGA
CCCCCEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEECC
NLAMMLMEAQDDNFFELDMVIRQFQNMTMNIKYSDRPVVVAPFNMTLGGGAEVSLPAAAI
CCEEEEEECCCCCEEHHHHHHHHHCCCEEEEEECCCCEEEEECCEEECCCCCEECCHHHH
QASPETYIGLVEFGVGLIPGGGGTKELYLKELRHMPKGIDFDLTKVANNVFEKVATAKVS
HCCCHHHEEHHHHCCEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
TSAAEGIQNGFLNSNDRISANPDHVLYDAKQRVIRLYDGGYKKPQREKIPVVGDAGYAAM
HHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHEEHHCCCCCCCCCCCCCEECCCCHHHH
LMGAKSLQFSGYASAHDVKIAEKLAYVLSGGRIKEGTEIDEQVMLDLEREAFLSLIAEPL
HHCCHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TQQRMQHMLVKGKPLRN
HHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]