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The map label for this gene is patB [H]

Identifier: 23099793

GI number: 23099793

Start: 2394775

End: 2395947

Strand: Direct

Name: patB [H]

Synonym: OB2338

Alternate gene names: 23099793

Gene position: 2394775-2395947 (Clockwise)

Preceding gene: 23099791

Following gene: 23099796

Centisome position: 65.96

GC content: 37.08

Gene sequence:

>1173_bases
ATGAGTATTTTTGAAGAAGTTTTTGATAGAAAACAAACTAGATCCGTAAAATGGGATATGGTACAAGAAGTTTTCCAGTC
CAATGATGTGTTGCCAATGTGGGTAGCAGACATGGATTTTAAAGCTCCTGAAGAAGTTAATCAAGCTTTGATAGAACGCG
CAAGACATGGAATTTATGGGTATACCGCAATTGATAGTGATGTAAGTTCAGCTATTATCAATTGGTTAGAACGGAGGCAT
AATTGGTCTATTGATCCTTCCTGGTTATCCTATAGTCCAGGGGTAGTGAACAGTCTACATATGGCGGTTCAAGCATTTAC
AGACCCAGGTGACAATATTTTAATTCAAACACCTGTATATACGCCGTTTTATAATTTGATAAAAGAATTAGATAGAGAAA
TCGTTAAGAACCCGCTCGTTTATGAAGATCAATATTATACCATCGATTTTAATGATATGGAAAAGAAGTTAGCAAGTGGA
ATAAAAGCATTTATCCTTTGTTCTCCACATAATCCTGTTGGTCGGGTTTGGACCAAAGAAGAATTACAAAAAATGGCAGA
CTTATGTTTGCAATATGATGTGATGATCTTTTCCGATGAAATTCATGCAGATTTAGTCTTTCCTGGGGAAAAACATATCC
CTATCGCTTCATTGTCAGAAGAGGTTTCTGATAATACGATTACATGTATGGCACCTTCAAAAACATTTAATTTGGCTGGT
TTAGACGCTTCCTATGTAATTACTTCAAATAAGGAGAACCGTCAAAAGTTGGATAAAGCCTTCCATCGTCAAGGGTTTCA
TAACATGTTAAATACAATGGGAAATACTGCTATGGAAGCAGCTTACCGTCATGGCGATTACTGGTTAGATGAGTTAGTAC
AAGTGTTAGAGCAACATACACAATATGTACGTGAAATGTTTGAAGCCCATGCCCCTGAATTAAAAGTTACACATACGGAG
GGAACGTATCTGCTATGGGTGGATTGTTCTTCACTAGGATTGAATAAACAAGAATTAAAAAAATTCATGATTGAAAAAGC
CAGAGTTGGATTAAATGCCGGTCAGGATTATGGCGTAGAAGGTGATTCGTTTATGCGTATTAACATCGCTTGCCCAAGAG
CGACTTTAGAAGAAGGCATCGAGCGAATTATTACTGCCGTACAATCCAGATAA

Upstream 100 bases:

>100_bases
TAGGCAAGGCGCTTGAACGCTTTGCTTTTTTTTTGCCTTTTTCCCGATATTCTTTGTTATAATAGTAACATTACATTATA
CATAGCTAGGAGGTTTCCCA

Downstream 100 bases:

>100_bases
TCAATTCGAAGAAAATAAAGATGAAGTAAACGTTATTTAAATGGGATATTAGTTTTTTAAATGTGGGTTAAAAATAAGGG
GCTGGACACTGGTATTTACA

Product: aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MSIFEEVFDRKQTRSVKWDMVQEVFQSNDVLPMWVADMDFKAPEEVNQALIERARHGIYGYTAIDSDVSSAIINWLERRH
NWSIDPSWLSYSPGVVNSLHMAVQAFTDPGDNILIQTPVYTPFYNLIKELDREIVKNPLVYEDQYYTIDFNDMEKKLASG
IKAFILCSPHNPVGRVWTKEELQKMADLCLQYDVMIFSDEIHADLVFPGEKHIPIASLSEEVSDNTITCMAPSKTFNLAG
LDASYVITSNKENRQKLDKAFHRQGFHNMLNTMGNTAMEAAYRHGDYWLDELVQVLEQHTQYVREMFEAHAPELKVTHTE
GTYLLWVDCSSLGLNKQELKKFMIEKARVGLNAGQDYGVEGDSFMRINIACPRATLEEGIERIITAVQSR

Sequences:

>Translated_390_residues
MSIFEEVFDRKQTRSVKWDMVQEVFQSNDVLPMWVADMDFKAPEEVNQALIERARHGIYGYTAIDSDVSSAIINWLERRH
NWSIDPSWLSYSPGVVNSLHMAVQAFTDPGDNILIQTPVYTPFYNLIKELDREIVKNPLVYEDQYYTIDFNDMEKKLASG
IKAFILCSPHNPVGRVWTKEELQKMADLCLQYDVMIFSDEIHADLVFPGEKHIPIASLSEEVSDNTITCMAPSKTFNLAG
LDASYVITSNKENRQKLDKAFHRQGFHNMLNTMGNTAMEAAYRHGDYWLDELVQVLEQHTQYVREMFEAHAPELKVTHTE
GTYLLWVDCSSLGLNKQELKKFMIEKARVGLNAGQDYGVEGDSFMRINIACPRATLEEGIERIITAVQSR
>Mature_389_residues
SIFEEVFDRKQTRSVKWDMVQEVFQSNDVLPMWVADMDFKAPEEVNQALIERARHGIYGYTAIDSDVSSAIINWLERRHN
WSIDPSWLSYSPGVVNSLHMAVQAFTDPGDNILIQTPVYTPFYNLIKELDREIVKNPLVYEDQYYTIDFNDMEKKLASGI
KAFILCSPHNPVGRVWTKEELQKMADLCLQYDVMIFSDEIHADLVFPGEKHIPIASLSEEVSDNTITCMAPSKTFNLAGL
DASYVITSNKENRQKLDKAFHRQGFHNMLNTMGNTAMEAAYRHGDYWLDELVQVLEQHTQYVREMFEAHAPELKVTHTEG
TYLLWVDCSSLGLNKQELKKFMIEKARVGLNAGQDYGVEGDSFMRINIACPRATLEEGIERIITAVQSR

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713254, Length=165, Percent_Identity=35.7575757575758, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI56713256, Length=165, Percent_Identity=35.7575757575758, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI95147551, Length=253, Percent_Identity=25.296442687747, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI169881279, Length=253, Percent_Identity=25.296442687747, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI169881281, Length=192, Percent_Identity=26.0416666666667, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4507369, Length=160, Percent_Identity=25.625, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787909, Length=388, Percent_Identity=33.2474226804124, Blast_Score=241, Evalue=7e-65,
Organism=Escherichia coli, GI1787710, Length=255, Percent_Identity=25.0980392156863, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788627, Length=238, Percent_Identity=24.7899159663866, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788722, Length=371, Percent_Identity=22.6415094339623, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786816, Length=307, Percent_Identity=19.5439739413681, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17567663, Length=305, Percent_Identity=25.5737704918033, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71994472, Length=176, Percent_Identity=26.7045454545455, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71994476, Length=176, Percent_Identity=26.7045454545455, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17567369, Length=159, Percent_Identity=25.7861635220126, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6322401, Length=218, Percent_Identity=30.7339449541284, Blast_Score=94, Evalue=3e-20,
Organism=Drosophila melanogaster, GI18859735, Length=378, Percent_Identity=23.5449735449735, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28573069, Length=156, Percent_Identity=30.7692307692308, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24646114, Length=156, Percent_Identity=30.7692307692308, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28573067, Length=156, Percent_Identity=30.7692307692308, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28573065, Length=156, Percent_Identity=30.7692307692308, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44753; Mature: 44622

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIFEEVFDRKQTRSVKWDMVQEVFQSNDVLPMWVADMDFKAPEEVNQALIERARHGIYG
CCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEE
YTAIDSDVSSAIINWLERRHNWSIDPSWLSYSPGVVNSLHMAVQAFTDPGDNILIQTPVY
EEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCC
TPFYNLIKELDREIVKNPLVYEDQYYTIDFNDMEKKLASGIKAFILCSPHNPVGRVWTKE
CHHHHHHHHHHHHHHCCCCEECCCEEEEEHHHHHHHHHCCCEEEEEECCCCCCCCCCCHH
ELQKMADLCLQYDVMIFSDEIHADLVFPGEKHIPIASLSEEVSDNTITCMAPSKTFNLAG
HHHHHHHHHHHHHHEEEECCCCEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCEEEC
LDASYVITSNKENRQKLDKAFHRQGFHNMLNTMGNTAMEAAYRHGDYWLDELVQVLEQHT
CCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHH
QYVREMFEAHAPELKVTHTEGTYLLWVDCSSLGLNKQELKKFMIEKARVGLNAGQDYGVE
HHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
GDSFMRINIACPRATLEEGIERIITAVQSR
CCCEEEEEEECCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SIFEEVFDRKQTRSVKWDMVQEVFQSNDVLPMWVADMDFKAPEEVNQALIERARHGIYG
CHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEE
YTAIDSDVSSAIINWLERRHNWSIDPSWLSYSPGVVNSLHMAVQAFTDPGDNILIQTPVY
EEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCC
TPFYNLIKELDREIVKNPLVYEDQYYTIDFNDMEKKLASGIKAFILCSPHNPVGRVWTKE
CHHHHHHHHHHHHHHCCCCEECCCEEEEEHHHHHHHHHCCCEEEEEECCCCCCCCCCCHH
ELQKMADLCLQYDVMIFSDEIHADLVFPGEKHIPIASLSEEVSDNTITCMAPSKTFNLAG
HHHHHHHHHHHHHHEEEECCCCEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCEEEC
LDASYVITSNKENRQKLDKAFHRQGFHNMLNTMGNTAMEAAYRHGDYWLDELVQVLEQHT
CCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHH
QYVREMFEAHAPELKVTHTEGTYLLWVDCSSLGLNKQELKKFMIEKARVGLNAGQDYGVE
HHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
GDSFMRINIACPRATLEEGIERIITAVQSR
CCCEEEEEEECCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]