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The map label for this gene is uraA [H]

Identifier: 23099748

GI number: 23099748

Start: 2338987

End: 2340246

Strand: Reverse

Name: uraA [H]

Synonym: OB2293

Alternate gene names: 23099748

Gene position: 2340246-2338987 (Counterclockwise)

Preceding gene: 23099749

Following gene: 23099747

Centisome position: 64.46

GC content: 36.67

Gene sequence:

>1260_bases
TTGAAGGATAGAGAAATTCAAGTAGATGAACGTTTACCATTATTACAAAGTTTTCCTTTAAGTTTACAGCATTTATTTGC
TATGTTTGGATCAACAGTTTTAGTGCCAATTTTGTTTGGTGTTGACCCAGCAACGATCTTGTTAATGAATGGTATTGGGA
CATTGTTATATATATTTATTACAAAAGGAAAAATTCCTGCTTACCTAGGATCAAGTTTTGCATTTATATCTCCAGTAACT
ATGGTACTTACAGAAGGTGGAGGGTATGGCGCAGCTTTAGGTGGGTTCTTTGTAGTAGGTTTAGTGCTAGTCATTGTTGG
TTTGATTGTTCGTTATGCTGGAACCAGCTGGATTGATGTTATATTTCCTCCAGCAGCTATGGGGGCAATCGTAGCTGTTA
TTGGATTAGAGTTAGTACCGACAGCTGCTGACATGGCTGGTTTACTACCACAAGCAGATGTACCAAGAGATACTACCGCA
ATTTTGGTATCTTTAATAACTTTGGGTGCAACGATCATTTATTGGGTAACAATGCGCGGGTTTTTGAAAATAATTCCTAT
CTTACTGGGAATTATAACTGGTTATGTTGTCGCTACGATGTTTGGTATTGTAGATTTCAGTGCGGTTAGAGAAGCGTCCT
GGATACAAATGCCAACGTACTATCAAATTGAGTTTAATTGGTCGGATATATTAATCATCTTACCTGCAGCTCTTGTATTA
GTTCCTGAACATATTGGCCATTTGGTAGTTACAGGTAATATCGTGAAAAAAGATTTGGTGAAAGAACCAGGTTTGGATCG
TTCTCTATTCGGAAATGGGTTCTCAACTATGATTTCTAGTTTTCTTGGATCAACACCGAATACCACCTATGGTGAAAATA
TTGGGGTATTAGCAATAAGTAAAGTATATTCCACATGGGTAATTGGAGGAGCTGCGATCATTGCTGTAGTACTTTCTTTC
TGTGGTAAGTTAGCTGCACTTATTTCTTCTATACCTACACCTGTAATGGGAGGGATCTCATTACTACTATTTGGAATAAT
TGCTGTTAGTGGATTGCGTATGTTAGTAGAACAGCAAATTGATTATAGTAAATCACAGAATTTAATTCTGACATGTGTAG
TTCTAGCGATTGGAGTAAGTGGTGCTGCTATTAACGTAGGTTCTGTAGAATTAAAAGGGATGGGATTAGCAACAATTATA
GCAATTGTTGTAAGTTTATTCTTTAAGTTACTCGACGTATTAAAATTATCGAATGAGTAA

Upstream 100 bases:

>100_bases
TCATCGTTATTTGTGTTGATGTTATCTTATACTTTCCCCTGCACCTTGCCAAATTTTTACGGGCAAGGTGTTTTTTATAA
AATAAGGGAGTGTTAGGACA

Downstream 100 bases:

>100_bases
ACCAGGAGATTTTAAATATAGAAAAAACCTGATGAAAAAATCATCAGGTTTTTTTATTGCACCATTGTCGTCTTTAATGC
TACAATAATATAGTTACATC

Product: uracil transporter

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MKDREIQVDERLPLLQSFPLSLQHLFAMFGSTVLVPILFGVDPATILLMNGIGTLLYIFITKGKIPAYLGSSFAFISPVT
MVLTEGGGYGAALGGFFVVGLVLVIVGLIVRYAGTSWIDVIFPPAAMGAIVAVIGLELVPTAADMAGLLPQADVPRDTTA
ILVSLITLGATIIYWVTMRGFLKIIPILLGIITGYVVATMFGIVDFSAVREASWIQMPTYYQIEFNWSDILIILPAALVL
VPEHIGHLVVTGNIVKKDLVKEPGLDRSLFGNGFSTMISSFLGSTPNTTYGENIGVLAISKVYSTWVIGGAAIIAVVLSF
CGKLAALISSIPTPVMGGISLLLFGIIAVSGLRMLVEQQIDYSKSQNLILTCVVLAIGVSGAAINVGSVELKGMGLATII
AIVVSLFFKLLDVLKLSNE

Sequences:

>Translated_419_residues
MKDREIQVDERLPLLQSFPLSLQHLFAMFGSTVLVPILFGVDPATILLMNGIGTLLYIFITKGKIPAYLGSSFAFISPVT
MVLTEGGGYGAALGGFFVVGLVLVIVGLIVRYAGTSWIDVIFPPAAMGAIVAVIGLELVPTAADMAGLLPQADVPRDTTA
ILVSLITLGATIIYWVTMRGFLKIIPILLGIITGYVVATMFGIVDFSAVREASWIQMPTYYQIEFNWSDILIILPAALVL
VPEHIGHLVVTGNIVKKDLVKEPGLDRSLFGNGFSTMISSFLGSTPNTTYGENIGVLAISKVYSTWVIGGAAIIAVVLSF
CGKLAALISSIPTPVMGGISLLLFGIIAVSGLRMLVEQQIDYSKSQNLILTCVVLAIGVSGAAINVGSVELKGMGLATII
AIVVSLFFKLLDVLKLSNE
>Mature_419_residues
MKDREIQVDERLPLLQSFPLSLQHLFAMFGSTVLVPILFGVDPATILLMNGIGTLLYIFITKGKIPAYLGSSFAFISPVT
MVLTEGGGYGAALGGFFVVGLVLVIVGLIVRYAGTSWIDVIFPPAAMGAIVAVIGLELVPTAADMAGLLPQADVPRDTTA
ILVSLITLGATIIYWVTMRGFLKIIPILLGIITGYVVATMFGIVDFSAVREASWIQMPTYYQIEFNWSDILIILPAALVL
VPEHIGHLVVTGNIVKKDLVKEPGLDRSLFGNGFSTMISSFLGSTPNTTYGENIGVLAISKVYSTWVIGGAAIIAVVLSF
CGKLAALISSIPTPVMGGISLLLFGIIAVSGLRMLVEQQIDYSKSQNLILTCVVLAIGVSGAAINVGSVELKGMGLATII
AIVVSLFFKLLDVLKLSNE

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680143, Length=473, Percent_Identity=25.5813953488372, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI44680145, Length=478, Percent_Identity=25.7322175732218, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI44680148, Length=215, Percent_Identity=27.906976744186, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI40316845, Length=215, Percent_Identity=27.906976744186, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1788843, Length=415, Percent_Identity=63.3734939759036, Blast_Score=520, Evalue=1e-149,
Organism=Escherichia coli, GI87081818, Length=420, Percent_Identity=39.7619047619048, Blast_Score=274, Evalue=1e-74,
Organism=Escherichia coli, GI87082181, Length=455, Percent_Identity=25.9340659340659, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1790087, Length=406, Percent_Identity=24.1379310344828, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI87082178, Length=236, Percent_Identity=25.4237288135593, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17558856, Length=172, Percent_Identity=28.4883720930233, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17541904, Length=228, Percent_Identity=24.1228070175439, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 44411; Mature: 44411

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDREIQVDERLPLLQSFPLSLQHLFAMFGSTVLVPILFGVDPATILLMNGIGTLLYIFI
CCCCCCCHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
TKGKIPAYLGSSFAFISPVTMVLTEGGGYGAALGGFFVVGLVLVIVGLIVRYAGTSWIDV
CCCCCCHHHCCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
IFPPAAMGAIVAVIGLELVPTAADMAGLLPQADVPRDTTAILVSLITLGATIIYWVTMRG
ECCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FLKIIPILLGIITGYVVATMFGIVDFSAVREASWIQMPTYYQIEFNWSDILIILPAALVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCEEEEEEECCCHHHHHHHHHHHH
VPEHIGHLVVTGNIVKKDLVKEPGLDRSLFGNGFSTMISSFLGSTPNTTYGENIGVLAIS
HHHHHCCEEEECCHHHHHHHCCCCCCHHHHCCCHHHHHHHHHCCCCCCCCCCCCCHHHHH
KVYSTWVIGGAAIIAVVLSFCGKLAALISSIPTPVMGGISLLLFGIIAVSGLRMLVEQQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYSKSQNLILTCVVLAIGVSGAAINVGSVELKGMGLATIIAIVVSLFFKLLDVLKLSNE
CCCCCCCHHHHHHHHHHCCCCCEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKDREIQVDERLPLLQSFPLSLQHLFAMFGSTVLVPILFGVDPATILLMNGIGTLLYIFI
CCCCCCCHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
TKGKIPAYLGSSFAFISPVTMVLTEGGGYGAALGGFFVVGLVLVIVGLIVRYAGTSWIDV
CCCCCCHHHCCCHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
IFPPAAMGAIVAVIGLELVPTAADMAGLLPQADVPRDTTAILVSLITLGATIIYWVTMRG
ECCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FLKIIPILLGIITGYVVATMFGIVDFSAVREASWIQMPTYYQIEFNWSDILIILPAALVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCEEEEEEECCCHHHHHHHHHHHH
VPEHIGHLVVTGNIVKKDLVKEPGLDRSLFGNGFSTMISSFLGSTPNTTYGENIGVLAIS
HHHHHCCEEEECCHHHHHHHCCCCCCHHHHCCCHHHHHHHHHCCCCCCCCCCCCCHHHHH
KVYSTWVIGGAAIIAVVLSFCGKLAALISSIPTPVMGGISLLLFGIIAVSGLRMLVEQQI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DYSKSQNLILTCVVLAIGVSGAAINVGSVELKGMGLATIIAIVVSLFFKLLDVLKLSNE
CCCCCCCHHHHHHHHHHCCCCCEEECCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]