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The map label for this gene is rocD

Identifier: 23099742

GI number: 23099742

Start: 2329189

End: 2330385

Strand: Reverse

Name: rocD

Synonym: OB2287

Alternate gene names: 23099742

Gene position: 2330385-2329189 (Counterclockwise)

Preceding gene: 23099743

Following gene: 23099741

Centisome position: 64.19

GC content: 36.76

Gene sequence:

>1197_bases
ATGACAATTACATCAACAAATATTATTGAAGAAACTAATTATTATGGTGCTCATAACTATCACCCACTTCCTATAGTTGT
TTCTGAAGCTAATGGCGTATGGGTGAAAGATCCTGAAGGAAATTCCTATATGGATATGTTAAGTGCATATTCAGCGGTGA
ATCAAGGACATCGTCATCCTAAGATTATTGAGGCACTAAAAAATCAAGCTGATAAAGTAACATTGACTTCCCGGGCATTT
CATAATGAATTACTAGGCCCGTGGACAAAACGAATGGCGAAGTTAACGAAGAAAGATAAAGTTTTGCCGATGAATACAGG
TGTGGAGGCTGTTGAGACAGCGATTAAAGCGGCACGACGTTGGGCATACCAAGTGAAGGGAGTTACGGAAAATCAAGCGG
AGATAATTGCTGCTGATGGTAACTTCCACGGACGTACTTTAAATGCAATTTCATTATCAAATGATCCAGATGCTACAAAA
AATTACGGACCGTTTGTTCCCGGAATTAATAAAGTAAGCTATGGAGATATAAATGCAATCGAAAAAGCTATTACAGAAAA
TACTGCCGCCATCATTCTTGAACCCATTCAAGGTGAAGCAGGAATTATTATACCTCCTGAAGGATATTTGAAAAAAGTAA
GAGAACTTTGCTCAGAAAAAAATATATTATTTATAGCAGATGAGGTTCAAACTGGTTTTGCACGGACAGGGAAAATGTTT
GCGTGTGAATGGGAAAATGTAGAACCAGATATCTATGTTATGGGGAAAGCTTTAGGTGGTGGTGTCTTTCCGGTATCTGC
AATTGCAGCTAATAATGAAATTATGGATGTATTTACACCTGGCTCTCATGGCTCTACATTCGGCGGGAATCCATTAGCTT
GTGCTGTATCAATGGCAGCAATTGATGTTATTGAAGAAGAAAACTTAGTTAATAAGTCATTAGAATCAGGGAAATATTTT
GCAGATAAGTTACGAGCGGTTAATTTTGAAGGGATTAAAGAAGTTCGTGCAAGAGGATTATTTATTGGTATGGAATTTCA
CCAACCTGTACGAGAAATTTGTGAAAAATTAAAAGATAAAGGAATCCTATGTAAGGAAACACATGTAAATACGATACGAT
TTGCTCCACCATTAGTAATTACAAAAGATGAAATGGATTGGGCAATACAGCGAATAGAAGAAGTACTTACTAATTAA

Upstream 100 bases:

>100_bases
TTTAAATGGGGTTGTGCTTGATTTTTATTTTAAGGTTGACGTTTCTTGAACTTAATGATAATTCTTAAATATAGAAATAA
TTGAATGAGAGGGGTATTTG

Downstream 100 bases:

>100_bases
TATTGGGGGAGGGAGCAGAGCTCGGTTCCTTCCCTTTATTTATTACAGAAAGGAAATCAACATGAACATATTATTGATGG
TGCGAACTCCATTTATTGAA

Product: ornithine--oxo-acid transaminase

Products: NA

Alternate protein names: OAT; Ornithine--oxo-acid aminotransferase

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MTITSTNIIEETNYYGAHNYHPLPIVVSEANGVWVKDPEGNSYMDMLSAYSAVNQGHRHPKIIEALKNQADKVTLTSRAF
HNELLGPWTKRMAKLTKKDKVLPMNTGVEAVETAIKAARRWAYQVKGVTENQAEIIAADGNFHGRTLNAISLSNDPDATK
NYGPFVPGINKVSYGDINAIEKAITENTAAIILEPIQGEAGIIIPPEGYLKKVRELCSEKNILFIADEVQTGFARTGKMF
ACEWENVEPDIYVMGKALGGGVFPVSAIAANNEIMDVFTPGSHGSTFGGNPLACAVSMAAIDVIEEENLVNKSLESGKYF
ADKLRAVNFEGIKEVRARGLFIGMEFHQPVREICEKLKDKGILCKETHVNTIRFAPPLVITKDEMDWAIQRIEEVLTN

Sequences:

>Translated_398_residues
MTITSTNIIEETNYYGAHNYHPLPIVVSEANGVWVKDPEGNSYMDMLSAYSAVNQGHRHPKIIEALKNQADKVTLTSRAF
HNELLGPWTKRMAKLTKKDKVLPMNTGVEAVETAIKAARRWAYQVKGVTENQAEIIAADGNFHGRTLNAISLSNDPDATK
NYGPFVPGINKVSYGDINAIEKAITENTAAIILEPIQGEAGIIIPPEGYLKKVRELCSEKNILFIADEVQTGFARTGKMF
ACEWENVEPDIYVMGKALGGGVFPVSAIAANNEIMDVFTPGSHGSTFGGNPLACAVSMAAIDVIEEENLVNKSLESGKYF
ADKLRAVNFEGIKEVRARGLFIGMEFHQPVREICEKLKDKGILCKETHVNTIRFAPPLVITKDEMDWAIQRIEEVLTN
>Mature_397_residues
TITSTNIIEETNYYGAHNYHPLPIVVSEANGVWVKDPEGNSYMDMLSAYSAVNQGHRHPKIIEALKNQADKVTLTSRAFH
NELLGPWTKRMAKLTKKDKVLPMNTGVEAVETAIKAARRWAYQVKGVTENQAEIIAADGNFHGRTLNAISLSNDPDATKN
YGPFVPGINKVSYGDINAIEKAITENTAAIILEPIQGEAGIIIPPEGYLKKVRELCSEKNILFIADEVQTGFARTGKMFA
CEWENVEPDIYVMGKALGGGVFPVSAIAANNEIMDVFTPGSHGSTFGGNPLACAVSMAAIDVIEEENLVNKSLESGKYFA
DKLRAVNFEGIKEVRARGLFIGMEFHQPVREICEKLKDKGILCKETHVNTIRFAPPLVITKDEMDWAIQRIEEVLTN

Specific function: Catalyzes the interconversion of ornithine to glutamate semialdehyde

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=400, Percent_Identity=50, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI284507298, Length=300, Percent_Identity=48, Blast_Score=300, Evalue=2e-81,
Organism=Homo sapiens, GI13994255, Length=436, Percent_Identity=30.045871559633, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI37574042, Length=420, Percent_Identity=29.0476190476191, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI226442709, Length=388, Percent_Identity=29.3814432989691, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI226442705, Length=420, Percent_Identity=28.3333333333333, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI24119277, Length=417, Percent_Identity=25.6594724220624, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI188536080, Length=441, Percent_Identity=24.0362811791383, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI38679950, Length=441, Percent_Identity=24.0362811791383, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI38679946, Length=441, Percent_Identity=24.0362811791383, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI145693181, Length=377, Percent_Identity=38.7267904509284, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1788044, Length=379, Percent_Identity=34.8284960422164, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI1789759, Length=379, Percent_Identity=34.5646437994723, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1787560, Length=403, Percent_Identity=32.258064516129, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI1789016, Length=409, Percent_Identity=30.3178484107579, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1786991, Length=395, Percent_Identity=29.620253164557, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI1786349, Length=313, Percent_Identity=27.1565495207668, Blast_Score=114, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI25144271, Length=400, Percent_Identity=49, Blast_Score=413, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI25144274, Length=276, Percent_Identity=45.6521739130435, Blast_Score=260, Evalue=8e-70,
Organism=Caenorhabditis elegans, GI71981843, Length=176, Percent_Identity=52.8409090909091, Blast_Score=207, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI32564660, Length=436, Percent_Identity=30.5045871559633, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71992977, Length=438, Percent_Identity=28.7671232876712, Blast_Score=148, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17541228, Length=425, Percent_Identity=25.1764705882353, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323470, Length=417, Percent_Identity=47.242206235012, Blast_Score=387, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6324432, Length=408, Percent_Identity=28.1862745098039, Blast_Score=192, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6324386, Length=476, Percent_Identity=25.4201680672269, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6321456, Length=372, Percent_Identity=25.5376344086022, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21357415, Length=389, Percent_Identity=50.6426735218509, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI161085790, Length=434, Percent_Identity=31.3364055299539, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI28574759, Length=435, Percent_Identity=31.4942528735632, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI21356575, Length=428, Percent_Identity=29.4392523364486, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI281366494, Length=421, Percent_Identity=24.4655581947743, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24667139, Length=421, Percent_Identity=24.4655581947743, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24667143, Length=421, Percent_Identity=24.4655581947743, Blast_Score=91, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OAT_OCEIH (Q8EP32)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_693208.1
- ProteinModelPortal:   Q8EP32
- SMR:   Q8EP32
- GeneID:   1015890
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB2287
- NMPDR:   fig|221109.1.peg.2284
- HOGENOM:   HBG725944
- OMA:   RHPKIIE
- ProtClustDB:   PRK04073
- BioCyc:   OIHE221109:OB2287-MONOMER
- BRENDA:   2.6.1.13
- GO:   GO:0005737
- HAMAP:   MF_01689
- InterPro:   IPR005814
- InterPro:   IPR010164
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF18
- TIGRFAMs:   TIGR01885

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.13

Molecular weight: Translated: 43839; Mature: 43707

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITSTNIIEETNYYGAHNYHPLPIVVSEANGVWVKDPEGNSYMDMLSAYSAVNQGHRHP
CCCCCCCCEECCCCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHCCCCCH
KIIEALKNQADKVTLTSRAFHNELLGPWTKRMAKLTKKDKVLPMNTGVEAVETAIKAARR
HHHHHHHCCCCEEEEHHHHHHHHHCCHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHH
WAYQVKGVTENQAEIIAADGNFHGRTLNAISLSNDPDATKNYGPFVPGINKVSYGDINAI
HHHEECCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHH
EKAITENTAAIILEPIQGEAGIIIPPEGYLKKVRELCSEKNILFIADEVQTGFARTGKMF
HHHHHCCCEEEEEEECCCCCCEEECCHHHHHHHHHHHCCCCEEEEECCHHHCHHHCCCEE
ACEWENVEPDIYVMGKALGGGVFPVSAIAANNEIMDVFTPGSHGSTFGGNPLACAVSMAA
EEECCCCCCCEEEEEEHHCCCCCCHHEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHH
IDVIEEENLVNKSLESGKYFADKLRAVNFEGIKEVRARGLFIGMEFHQPVREICEKLKDK
HHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCEEEEEEHHHHHHHHHHHHHHHC
GILCKETHVNTIRFAPPLVITKDEMDWAIQRIEEVLTN
CCEEEECCCCEEEECCCEEEECCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TITSTNIIEETNYYGAHNYHPLPIVVSEANGVWVKDPEGNSYMDMLSAYSAVNQGHRHP
CCCCCCCEECCCCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHCCCCCH
KIIEALKNQADKVTLTSRAFHNELLGPWTKRMAKLTKKDKVLPMNTGVEAVETAIKAARR
HHHHHHHCCCCEEEEHHHHHHHHHCCHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHH
WAYQVKGVTENQAEIIAADGNFHGRTLNAISLSNDPDATKNYGPFVPGINKVSYGDINAI
HHHEECCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHH
EKAITENTAAIILEPIQGEAGIIIPPEGYLKKVRELCSEKNILFIADEVQTGFARTGKMF
HHHHHCCCEEEEEEECCCCCCEEECCHHHHHHHHHHHCCCCEEEEECCHHHCHHHCCCEE
ACEWENVEPDIYVMGKALGGGVFPVSAIAANNEIMDVFTPGSHGSTFGGNPLACAVSMAA
EEECCCCCCCEEEEEEHHCCCCCCHHEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHH
IDVIEEENLVNKSLESGKYFADKLRAVNFEGIKEVRARGLFIGMEFHQPVREICEKLKDK
HHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCEEEEEEHHHHHHHHHHHHHHHC
GILCKETHVNTIRFAPPLVITKDEMDWAIQRIEEVLTN
CCEEEECCCCEEEECCCEEEECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376