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The map label for this gene is serA [H]

Identifier: 23099741

GI number: 23099741

Start: 2328183

End: 2329127

Strand: Reverse

Name: serA [H]

Synonym: OB2286

Alternate gene names: 23099741

Gene position: 2329127-2328183 (Counterclockwise)

Preceding gene: 23099742

Following gene: 23099740

Centisome position: 64.15

GC content: 34.71

Gene sequence:

>945_bases
ATGAACATATTATTGATGGTGCGAACTCCATTTATTGAAGCGGTTCCAGACTTTGTAGAAAATTTAAATCGATTAGGTAA
TGTTACTATTTTAGATACGGATAATGGTATCGAGAAAGAGAAACTAAAGCAGGCAGTAAGAGAAGTAGAGGTTATTATAA
CAGCTGTTGTTCAAATTGATAAAGAAATAATTGATGCAGCTCCAAATTTAAAATATATTATGAAGTTTGGAGCTGGTTAC
GATAATATTGATTTTAAGTATGCTAGAGAGAAAGGTATTCCAGTTACAAATACTCCTGGTCAGAATGCAGATGCTGTTGC
AGATCTTGCAATTGGATTAATGCTAGCCACTGCACGTAATATTCCTGCAAAGAATGAGGAATTACGGAATGGGAATTGGG
AATTATCTATGGGAATTGAAATATTTCAAAAGAAATTAGGAATTATCGGATTTGGTGCAATTGGCCAAGCCATTGCACAG
AGGGCGACAGGATTTCAAATGGAAGTCTTAGCTTATGGTACTTTCCAGGATCAAACGATAGCCGATCGTTTAAATGTAGA
ATTTGTAGACCTTAATAAACTCTTGAATGAAAGTGATATTGTAGTTGTTTCTACAACACTTCGCAAAGATAATTATCAGT
TAATTAACGCAAAAACACTAAATGAAATAAAAAAAGATGCCTTGTTTATAAATGTCTCAAGAGGAGCATTAGTAGATGAA
GATGCTTTGTATGAAGCTCTTACAAACGGCAAGATTAAAGGTGCTGGCTTAGATGTATTTGTAGAAGAACCATCCCATCA
TCCTTTGTTAACATTACCGAATACAACGGTAACCCCCCATATTGGCGCTGCTACAAATGAAGCAATAAAACGTACAGGAA
GTGTTGCTTTAGAAAATGTACAACGTTTGAAAAATGACCTTCCTTTGTTGTATGTGGTTAATTAA

Upstream 100 bases:

>100_bases
TGGGCAATACAGCGAATAGAAGAAGTACTTACTAATTAATATTGGGGGAGGGAGCAGAGCTCGGTTCCTTCCCTTTATTT
ATTACAGAAAGGAAATCAAC

Downstream 100 bases:

>100_bases
TAGTAACTGAACAATTTAAGTAGAATGAATAAAAACCGAACTATAAATCAGCTAATGCTGCCTTTATAGTTCGGTTATTT
TGGTTTATTTCGCATGGGCA

Product: glycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MNILLMVRTPFIEAVPDFVENLNRLGNVTILDTDNGIEKEKLKQAVREVEVIITAVVQIDKEIIDAAPNLKYIMKFGAGY
DNIDFKYAREKGIPVTNTPGQNADAVADLAIGLMLATARNIPAKNEELRNGNWELSMGIEIFQKKLGIIGFGAIGQAIAQ
RATGFQMEVLAYGTFQDQTIADRLNVEFVDLNKLLNESDIVVVSTTLRKDNYQLINAKTLNEIKKDALFINVSRGALVDE
DALYEALTNGKIKGAGLDVFVEEPSHHPLLTLPNTTVTPHIGAATNEAIKRTGSVALENVQRLKNDLPLLYVVN

Sequences:

>Translated_314_residues
MNILLMVRTPFIEAVPDFVENLNRLGNVTILDTDNGIEKEKLKQAVREVEVIITAVVQIDKEIIDAAPNLKYIMKFGAGY
DNIDFKYAREKGIPVTNTPGQNADAVADLAIGLMLATARNIPAKNEELRNGNWELSMGIEIFQKKLGIIGFGAIGQAIAQ
RATGFQMEVLAYGTFQDQTIADRLNVEFVDLNKLLNESDIVVVSTTLRKDNYQLINAKTLNEIKKDALFINVSRGALVDE
DALYEALTNGKIKGAGLDVFVEEPSHHPLLTLPNTTVTPHIGAATNEAIKRTGSVALENVQRLKNDLPLLYVVN
>Mature_314_residues
MNILLMVRTPFIEAVPDFVENLNRLGNVTILDTDNGIEKEKLKQAVREVEVIITAVVQIDKEIIDAAPNLKYIMKFGAGY
DNIDFKYAREKGIPVTNTPGQNADAVADLAIGLMLATARNIPAKNEELRNGNWELSMGIEIFQKKLGIIGFGAIGQAIAQ
RATGFQMEVLAYGTFQDQTIADRLNVEFVDLNKLLNESDIVVVSTTLRKDNYQLINAKTLNEIKKDALFINVSRGALVDE
DALYEALTNGKIKGAGLDVFVEEPSHHPLLTLPNTTVTPHIGAATNEAIKRTGSVALENVQRLKNDLPLLYVVN

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=266, Percent_Identity=38.3458646616541, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI23308577, Length=294, Percent_Identity=34.0136054421769, Blast_Score=171, Evalue=7e-43,
Organism=Homo sapiens, GI145580575, Length=296, Percent_Identity=33.1081081081081, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI145580578, Length=296, Percent_Identity=33.1081081081081, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4557499, Length=296, Percent_Identity=33.1081081081081, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4557497, Length=253, Percent_Identity=34.3873517786561, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI61743967, Length=253, Percent_Identity=34.3873517786561, Blast_Score=139, Evalue=3e-33,
Organism=Escherichia coli, GI87082289, Length=261, Percent_Identity=35.2490421455939, Blast_Score=164, Evalue=5e-42,
Organism=Escherichia coli, GI1789279, Length=284, Percent_Identity=33.4507042253521, Blast_Score=140, Evalue=9e-35,
Organism=Escherichia coli, GI1787645, Length=252, Percent_Identity=33.7301587301587, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI87081824, Length=236, Percent_Identity=25.4237288135593, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1788660, Length=258, Percent_Identity=25.5813953488372, Blast_Score=64, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=254, Percent_Identity=34.6456692913386, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI25147481, Length=256, Percent_Identity=29.6875, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324055, Length=253, Percent_Identity=33.201581027668, Blast_Score=140, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6322116, Length=276, Percent_Identity=32.2463768115942, Blast_Score=138, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6320925, Length=276, Percent_Identity=31.1594202898551, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324964, Length=278, Percent_Identity=28.7769784172662, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6325144, Length=167, Percent_Identity=32.9341317365269, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321253, Length=275, Percent_Identity=26.5454545454545, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6324980, Length=170, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28574286, Length=262, Percent_Identity=37.7862595419847, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24585516, Length=291, Percent_Identity=35.3951890034364, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI45552429, Length=285, Percent_Identity=37.1929824561403, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI45551003, Length=285, Percent_Identity=37.1929824561403, Blast_Score=168, Evalue=3e-42,
Organism=Drosophila melanogaster, GI28574284, Length=285, Percent_Identity=37.1929824561403, Blast_Score=168, Evalue=4e-42,
Organism=Drosophila melanogaster, GI24585514, Length=285, Percent_Identity=37.1929824561403, Blast_Score=168, Evalue=4e-42,
Organism=Drosophila melanogaster, GI28574282, Length=285, Percent_Identity=37.1929824561403, Blast_Score=168, Evalue=4e-42,
Organism=Drosophila melanogaster, GI28571528, Length=292, Percent_Identity=34.5890410958904, Blast_Score=151, Evalue=6e-37,
Organism=Drosophila melanogaster, GI19921140, Length=260, Percent_Identity=32.3076923076923, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24646446, Length=267, Percent_Identity=32.2097378277154, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646448, Length=267, Percent_Identity=32.2097378277154, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646452, Length=267, Percent_Identity=32.2097378277154, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646450, Length=267, Percent_Identity=32.2097378277154, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI62472511, Length=267, Percent_Identity=32.2097378277154, Blast_Score=122, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 34542; Mature: 34542

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILLMVRTPFIEAVPDFVENLNRLGNVTILDTDNGIEKEKLKQAVREVEVIITAVVQID
CCEEEEEECCHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
KEIIDAAPNLKYIMKFGAGYDNIDFKYAREKGIPVTNTPGQNADAVADLAIGLMLATARN
HHHHHCCCCHHHHHHHCCCCCCCCEEEHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
IPAKNEELRNGNWELSMGIEIFQKKLGIIGFGAIGQAIAQRATGFQMEVLAYGTFQDQTI
CCCCCHHHCCCCEEEEECHHHHHHHHCEEEEHHHHHHHHHHHCCCEEEEEEECCCCCCHH
ADRLNVEFVDLNKLLNESDIVVVSTTLRKDNYQLINAKTLNEIKKDALFINVSRGALVDE
HHHCCEEEEEHHHHCCCCCEEEEEEEECCCCEEEECHHHHHHHHHCEEEEEECCCCCCCH
DALYEALTNGKIKGAGLDVFVEEPSHHPLLTLPNTTVTPHIGAATNEAIKRTGSVALENV
HHHHHHHHCCEEECCCEEEEEECCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHH
QRLKNDLPLLYVVN
HHHHHCCCEEEEEC
>Mature Secondary Structure
MNILLMVRTPFIEAVPDFVENLNRLGNVTILDTDNGIEKEKLKQAVREVEVIITAVVQID
CCEEEEEECCHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
KEIIDAAPNLKYIMKFGAGYDNIDFKYAREKGIPVTNTPGQNADAVADLAIGLMLATARN
HHHHHCCCCHHHHHHHCCCCCCCCEEEHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
IPAKNEELRNGNWELSMGIEIFQKKLGIIGFGAIGQAIAQRATGFQMEVLAYGTFQDQTI
CCCCCHHHCCCCEEEEECHHHHHHHHCEEEEHHHHHHHHHHHCCCEEEEEEECCCCCCHH
ADRLNVEFVDLNKLLNESDIVVVSTTLRKDNYQLINAKTLNEIKKDALFINVSRGALVDE
HHHCCEEEEEHHHHCCCCCEEEEEEEECCCCEEEECHHHHHHHHHCEEEEEECCCCCCCH
DALYEALTNGKIKGAGLDVFVEEPSHHPLLTLPNTTVTPHIGAATNEAIKRTGSVALENV
HHHHHHHHCCEEECCCEEEEEECCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHH
QRLKNDLPLLYVVN
HHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]