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The map label for this gene is dapL [H]

Identifier: 23099737

GI number: 23099737

Start: 2324555

End: 2325733

Strand: Reverse

Name: dapL [H]

Synonym: OB2282

Alternate gene names: 23099737

Gene position: 2325733-2324555 (Counterclockwise)

Preceding gene: 23099738

Following gene: 23099736

Centisome position: 64.06

GC content: 34.86

Gene sequence:

>1179_bases
ATGCAGTCATTATATAAATCGAATATAGTTCGAAATATGCCACCTTACTTATTTGCTCATATTCAAAAGAAAAAGCAAAA
ACTAATGGAACAGGGAAGCGATGTTATCGACCTAGGTATCGGAGCACCTGATTTACCTCCCCCCTCGTACATAATTGAGG
AATTATCTAAACATATAAAAAATAGACATCTACATCGTTATTCTCCATATCAAGGTATTCCCGAATTAAGGCAAGCTGTA
GCTACTTTTTATCAAGAAAAATACAATGTAACACTGGACCCCGAAGAAGAAATTCTCATTTTGATTGGTAGCAAAGAAGG
ACTCGTTCATTTAATACAGTCCGTTATTAATCCAGGAGATAAAGTGATTTTGCCAGATCCAGGATATCCGGTCTATAAAA
TGGGTGTTCATATGACTCAAGGAAGAGCTGTTTATTTACCGTTAGATAAAAATAAGGAATATAAACCGAATTGGAAAATG
TTAAGTGAGCAAGATAAAGAAGAAGCAAAGCTGTTATTTTTGAATTACCCCAATAATCCAACAGGTGCGACAGCTCAAAA
GGAAACTTTTGTGAAAGCTGTACAAATTGCGAATAAATATAATATCTGTATTGCACATGATGCTGCCTATGATCATGTAA
CATTTTCTGACTATAAATCTCCTAGCCTATTACAAGTAGATGGAGCTAAAAAGGTAGGGGTAGAATTAGGATCATTATCA
AAAAATTTCAATATGACTGGTTGGAGAATTGGATATATTGTAGGAAATTCAAGTGTCATTCAAGCGTTAGCAACATTAAA
AAGTAATATAGATACCAGCCAATTTATACCCGTTCAAATTGCTGCAATAAAAGCTTTAGAGCAAAGTGAAGATGAGATTC
GAACAATTCATCACACAATGGAAAAACGTATGTTAAAAACTTGGAAACTATTAAAGAATGCTGGCTTTGAAGTTAAGAAA
ACCAAAGGGACAATTTTTTTATGGGTGAAAGTTCCAAAGGGATATACCTCAAGCTCATTTACTGAACAAGTTTTGGATCA
AGCACATGTGATTGTAACCCCTGGTTCAGCATTTGGCGAACAAGGTGAAGGATTCTTTAGAATTGCATTAACAGTACCAG
AAGAAAGGTTGATTGAAGCAGTTCAACGTATTGATTCTTGGTTGAATGGAGGAAAGTGA

Upstream 100 bases:

>100_bases
TACCTTTCACATGCTACACTGTGAGTAATTATAAACAAGGCATAGGTTATTGCGTAATGAACATATACTTTAGAAGTAAC
TATTACTCTGGAGGGATCAT

Downstream 100 bases:

>100_bases
TTTGAATCAAAATGGAATTGATTTAAATGCGGCAGAAGCTATTGTAAAAGGATTACGAAGAGAAGAAGTAAAGCATATTT
TTTGTGTTCCGGGTGAAAGT

Product: aspartate aminotransferase

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MQSLYKSNIVRNMPPYLFAHIQKKKQKLMEQGSDVIDLGIGAPDLPPPSYIIEELSKHIKNRHLHRYSPYQGIPELRQAV
ATFYQEKYNVTLDPEEEILILIGSKEGLVHLIQSVINPGDKVILPDPGYPVYKMGVHMTQGRAVYLPLDKNKEYKPNWKM
LSEQDKEEAKLLFLNYPNNPTGATAQKETFVKAVQIANKYNICIAHDAAYDHVTFSDYKSPSLLQVDGAKKVGVELGSLS
KNFNMTGWRIGYIVGNSSVIQALATLKSNIDTSQFIPVQIAAIKALEQSEDEIRTIHHTMEKRMLKTWKLLKNAGFEVKK
TKGTIFLWVKVPKGYTSSSFTEQVLDQAHVIVTPGSAFGEQGEGFFRIALTVPEERLIEAVQRIDSWLNGGK

Sequences:

>Translated_392_residues
MQSLYKSNIVRNMPPYLFAHIQKKKQKLMEQGSDVIDLGIGAPDLPPPSYIIEELSKHIKNRHLHRYSPYQGIPELRQAV
ATFYQEKYNVTLDPEEEILILIGSKEGLVHLIQSVINPGDKVILPDPGYPVYKMGVHMTQGRAVYLPLDKNKEYKPNWKM
LSEQDKEEAKLLFLNYPNNPTGATAQKETFVKAVQIANKYNICIAHDAAYDHVTFSDYKSPSLLQVDGAKKVGVELGSLS
KNFNMTGWRIGYIVGNSSVIQALATLKSNIDTSQFIPVQIAAIKALEQSEDEIRTIHHTMEKRMLKTWKLLKNAGFEVKK
TKGTIFLWVKVPKGYTSSSFTEQVLDQAHVIVTPGSAFGEQGEGFFRIALTVPEERLIEAVQRIDSWLNGGK
>Mature_392_residues
MQSLYKSNIVRNMPPYLFAHIQKKKQKLMEQGSDVIDLGIGAPDLPPPSYIIEELSKHIKNRHLHRYSPYQGIPELRQAV
ATFYQEKYNVTLDPEEEILILIGSKEGLVHLIQSVINPGDKVILPDPGYPVYKMGVHMTQGRAVYLPLDKNKEYKPNWKM
LSEQDKEEAKLLFLNYPNNPTGATAQKETFVKAVQIANKYNICIAHDAAYDHVTFSDYKSPSLLQVDGAKKVGVELGSLS
KNFNMTGWRIGYIVGNSSVIQALATLKSNIDTSQFIPVQIAAIKALEQSEDEIRTIHHTMEKRMLKTWKLLKNAGFEVKK
TKGTIFLWVKVPKGYTSSSFTEQVLDQAHVIVTPGSAFGEQGEGFFRIALTVPEERLIEAVQRIDSWLNGGK

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713254, Length=388, Percent_Identity=27.0618556701031, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI56713256, Length=388, Percent_Identity=27.0618556701031, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI95147551, Length=247, Percent_Identity=27.1255060728745, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI169881279, Length=247, Percent_Identity=27.1255060728745, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI4507369, Length=378, Percent_Identity=23.5449735449735, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI7705897, Length=317, Percent_Identity=24.2902208201893, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI33469970, Length=317, Percent_Identity=24.2902208201893, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI169881281, Length=246, Percent_Identity=22.3577235772358, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1788722, Length=384, Percent_Identity=35.4166666666667, Blast_Score=285, Evalue=4e-78,
Organism=Escherichia coli, GI1786816, Length=364, Percent_Identity=25, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1788627, Length=409, Percent_Identity=26.161369193154, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI1787710, Length=306, Percent_Identity=26.797385620915, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71994472, Length=263, Percent_Identity=26.9961977186312, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71994476, Length=263, Percent_Identity=26.9961977186312, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17567369, Length=262, Percent_Identity=23.2824427480916, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17567663, Length=370, Percent_Identity=24.0540540540541, Blast_Score=99, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6322401, Length=393, Percent_Identity=23.4096692111959, Blast_Score=122, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6320317, Length=360, Percent_Identity=27.5, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323118, Length=353, Percent_Identity=23.7960339943343, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28573069, Length=387, Percent_Identity=24.2894056847545, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24646114, Length=387, Percent_Identity=24.2894056847545, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI28573067, Length=387, Percent_Identity=24.2894056847545, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI28573065, Length=387, Percent_Identity=24.2894056847545, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI18859735, Length=409, Percent_Identity=22.9828850855746, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR019881
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.83 [H]

Molecular weight: Translated: 44186; Mature: 44186

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSLYKSNIVRNMPPYLFAHIQKKKQKLMEQGSDVIDLGIGAPDLPPPSYIIEELSKHIK
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHH
NRHLHRYSPYQGIPELRQAVATFYQEKYNVTLDPEEEILILIGSKEGLVHLIQSVINPGD
HCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCEEEEEECCCCHHHHHHHHHCCCC
KVILPDPGYPVYKMGVHMTQGRAVYLPLDKNKEYKPNWKMLSEQDKEEAKLLFLNYPNNP
EEEECCCCCCEEEECEEEECCCEEEEECCCCCCCCCCHHHHCCCCCCCEEEEEEECCCCC
TGATAQKETFVKAVQIANKYNICIAHDAAYDHVTFSDYKSPSLLQVDGAKKVGVELGSLS
CCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCEEECCCCCCCEEEECCCHHHCEEHHCCC
KNFNMTGWRIGYIVGNSSVIQALATLKSNIDTSQFIPVQIAAIKALEQSEDEIRTIHHTM
CCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHH
EKRMLKTWKLLKNAGFEVKKTKGTIFLWVKVPKGYTSSSFTEQVLDQAHVIVTPGSAFGE
HHHHHHHHHHHHHCCCEEEECCCEEEEEEECCCCCCCHHHHHHHHCCCEEEEECCCCCCC
QGEGFFRIALTVPEERLIEAVQRIDSWLNGGK
CCCCEEEEEEECCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQSLYKSNIVRNMPPYLFAHIQKKKQKLMEQGSDVIDLGIGAPDLPPPSYIIEELSKHIK
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHH
NRHLHRYSPYQGIPELRQAVATFYQEKYNVTLDPEEEILILIGSKEGLVHLIQSVINPGD
HCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEECCCCCEEEEEECCCCHHHHHHHHHCCCC
KVILPDPGYPVYKMGVHMTQGRAVYLPLDKNKEYKPNWKMLSEQDKEEAKLLFLNYPNNP
EEEECCCCCCEEEECEEEECCCEEEEECCCCCCCCCCHHHHCCCCCCCEEEEEEECCCCC
TGATAQKETFVKAVQIANKYNICIAHDAAYDHVTFSDYKSPSLLQVDGAKKVGVELGSLS
CCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCEEECCCCCCCEEEECCCHHHCEEHHCCC
KNFNMTGWRIGYIVGNSSVIQALATLKSNIDTSQFIPVQIAAIKALEQSEDEIRTIHHTM
CCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHH
EKRMLKTWKLLKNAGFEVKKTKGTIFLWVKVPKGYTSSSFTEQVLDQAHVIVTPGSAFGE
HHHHHHHHHHHHHCCCEEEECCCEEEEEEECCCCCCCHHHHHHHHCCCEEEEECCCCCCC
QGEGFFRIALTVPEERLIEAVQRIDSWLNGGK
CCCCEEEEEEECCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA