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The map label for this gene is ung

Identifier: 23099584

GI number: 23099584

Start: 2163785

End: 2164474

Strand: Direct

Name: ung

Synonym: OB2129

Alternate gene names: 23099584

Gene position: 2163785-2164474 (Clockwise)

Preceding gene: 23099583

Following gene: 23099588

Centisome position: 59.6

GC content: 36.38

Gene sequence:

>690_bases
ATGGAAAACCCTTTATATAATGATTGGTCCCTTTTATTAGAGGATGAGTTCAAAAAAGACTACTACCTAAGATTAAGAAG
TTTCTTAAAAAAAGAATATACAGAAGAGAAGATCCATCCCGCTATGGAAGATATTTTTAATGCACTTCATTTTACTCCAT
TTCATAAAGTCAAAGTAGTCATATTGGGGCAAGATCCCTATCACGGTCCGGACCAAGCACATGGATTAAGCTTTTCTGTA
CAACCTGGGATAACCATACCTCCATCTTTAAAAAATATTTTTAAAGAATTAACCCATGAATTTGGTATGAGTATGCCTAC
CCATGGTCATCTTACACATTGGGCTAAACAAGGTGTATTATTATTAAACAATGTATTAACAGTGCGTGAAGGGAAAGCTC
ATTCTCATCGTGGTCAGGGTTGGGAAGTGTTCACAGATAAAGTTATTCAAACACTCAATCAAAAAGATCATCCGGTTGTA
TTTTTACTCTGGGGTGGTGCGGCTCAAAAGAAAGGGGAGCTAATCGACACAAACAAACACATTATCTTAAAAGCTCCTCA
CCCAAGTCCGTTGTCGGCTTATCGTGGATTTTTTGAATCAAATCATTTTTCCAAAGCGAATCAAATTTTACATAAGAATA
ATGTAGAAGAAATTGATTGGACTCTTCCTGAATCCCCATCCCAAGGATAA

Upstream 100 bases:

>100_bases
GACTTATTCGTTCTAAAGGTTTCGAAGAACTTGATAAATATGCGAAAACGCATTTTGCTAATACGCAGAAGGCACAAAAA
TTACTGTAAGGATGATATTA

Downstream 100 bases:

>100_bases
TCAATACGGGAGAATTCGAAATGAGTAGCCGAGGATGAGACAATGAGTAATCATTCTTTTACATCAAAAAGCTAACAAAA
GGGTAAAGTTATCGATGCTA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MENPLYNDWSLLLEDEFKKDYYLRLRSFLKKEYTEEKIHPAMEDIFNALHFTPFHKVKVVILGQDPYHGPDQAHGLSFSV
QPGITIPPSLKNIFKELTHEFGMSMPTHGHLTHWAKQGVLLLNNVLTVREGKAHSHRGQGWEVFTDKVIQTLNQKDHPVV
FLLWGGAAQKKGELIDTNKHIILKAPHPSPLSAYRGFFESNHFSKANQILHKNNVEEIDWTLPESPSQG

Sequences:

>Translated_229_residues
MENPLYNDWSLLLEDEFKKDYYLRLRSFLKKEYTEEKIHPAMEDIFNALHFTPFHKVKVVILGQDPYHGPDQAHGLSFSV
QPGITIPPSLKNIFKELTHEFGMSMPTHGHLTHWAKQGVLLLNNVLTVREGKAHSHRGQGWEVFTDKVIQTLNQKDHPVV
FLLWGGAAQKKGELIDTNKHIILKAPHPSPLSAYRGFFESNHFSKANQILHKNNVEEIDWTLPESPSQG
>Mature_229_residues
MENPLYNDWSLLLEDEFKKDYYLRLRSFLKKEYTEEKIHPAMEDIFNALHFTPFHKVKVVILGQDPYHGPDQAHGLSFSV
QPGITIPPSLKNIFKELTHEFGMSMPTHGHLTHWAKQGVLLLNNVLTVREGKAHSHRGQGWEVFTDKVIQTLNQKDHPVV
FLLWGGAAQKKGELIDTNKHIILKAPHPSPLSAYRGFFESNHFSKANQILHKNNVEEIDWTLPESPSQG

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=214, Percent_Identity=51.8691588785047, Blast_Score=223, Evalue=1e-58,
Organism=Homo sapiens, GI6224979, Length=214, Percent_Identity=51.8691588785047, Blast_Score=222, Evalue=2e-58,
Organism=Escherichia coli, GI1788934, Length=222, Percent_Identity=56.3063063063063, Blast_Score=246, Evalue=7e-67,
Organism=Caenorhabditis elegans, GI17556304, Length=217, Percent_Identity=50.2304147465438, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6323620, Length=233, Percent_Identity=46.7811158798283, Blast_Score=197, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_OCEIH (Q8EPH6)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_693050.1
- ProteinModelPortal:   Q8EPH6
- SMR:   Q8EPH6
- GeneID:   1017699
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB2129
- NMPDR:   fig|221109.1.peg.2127
- HOGENOM:   HBG605450
- OMA:   MLWGNYA
- ProtClustDB:   PRK05254
- BioCyc:   OIHE221109:OB2129-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 26288; Mature: 26288

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 65-65

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENPLYNDWSLLLEDEFKKDYYLRLRSFLKKEYTEEKIHPAMEDIFNALHFTPFHKVKVV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
ILGQDPYHGPDQAHGLSFSVQPGITIPPSLKNIFKELTHEFGMSMPTHGHLTHWAKQGVL
EEECCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCEE
LLNNVLTVREGKAHSHRGQGWEVFTDKVIQTLNQKDHPVVFLLWGGAAQKKGELIDTNKH
EECCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEECCCE
IILKAPHPSPLSAYRGFFESNHFSKANQILHKNNVEEIDWTLPESPSQG
EEEECCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCEECCCCCCCCCC
>Mature Secondary Structure
MENPLYNDWSLLLEDEFKKDYYLRLRSFLKKEYTEEKIHPAMEDIFNALHFTPFHKVKVV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
ILGQDPYHGPDQAHGLSFSVQPGITIPPSLKNIFKELTHEFGMSMPTHGHLTHWAKQGVL
EEECCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCEE
LLNNVLTVREGKAHSHRGQGWEVFTDKVIQTLNQKDHPVVFLLWGGAAQKKGELIDTNKH
EECCEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEECCCE
IILKAPHPSPLSAYRGFFESNHFSKANQILHKNNVEEIDWTLPESPSQG
EEEECCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376