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The map label for this gene is comEB [H]

Identifier: 23099435

GI number: 23099435

Start: 2009301

End: 2009861

Strand: Reverse

Name: comEB [H]

Synonym: OB1980

Alternate gene names: 23099435

Gene position: 2009861-2009301 (Counterclockwise)

Preceding gene: 23099436

Following gene: 23099434

Centisome position: 55.36

GC content: 37.43

Gene sequence:

>561_bases
ATGGAGAGAATTTCATGGGATCAATATTTTATGGCGCAAAGCCATTTACTATCACTAAGAAGTACTTGTACAAGACTTGA
AGTAGGAGCTACTATTGTACGGGATAAGCGAATTATAGCTGGAGGATATAATGGTAGCGTTACTGGAAGTGTACATTGCA
CAGATGAAGGTTGTTATGTCATTGACGGCCATTGTGTCCGTACAGTTCATGCAGAAGCAAATGCGTTATTGCAATGTGCT
AAATTTGGCGTGCCAACTGAAGGTGCAGACGTGTACGTTACTCATTTCCCTTGTTTACAATGCACCAAGCAATTAATTCA
AAGTGGGATAAGAACTGTTTATTATGCTGAAGACTATCATAATCATCCATATGCAATGGAATTATTTACTGAAGCAGGAG
TTAAAACAGTTAAAGTCCCGCTCCATCAGTTATCAATTGATGTAAATGTGGAAGAAAAAGCACAATTTATTCAAGAGATA
ATTGCTAAAATTGATGAAGTATCAGGGAATGATACGGAAATCTCCCGTATTAAAGAAAAAGCAGAGCGCCTATTTAAGTA
G

Upstream 100 bases:

>100_bases
GTATTGGCGAAAAAACCATTGAATCATTAAGAGATTATATTCAAATTCCATAGAGAGAAAAAGCTTTTATAGCAGTGTAA
TAAAAGGAGACGAGTCTGAG

Downstream 100 bases:

>100_bases
GTACATATCGATGAAAGGGTATTGGTATTATGCTGCGATAACAACAGGGGCAGCTATTCTTTTTGTTATTACTAGAGCAG
AATGGCTGCCGCTGTTAATT

Product: late competence protein

Products: dUMP; NH3

Alternate protein names: NA

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MERISWDQYFMAQSHLLSLRSTCTRLEVGATIVRDKRIIAGGYNGSVTGSVHCTDEGCYVIDGHCVRTVHAEANALLQCA
KFGVPTEGADVYVTHFPCLQCTKQLIQSGIRTVYYAEDYHNHPYAMELFTEAGVKTVKVPLHQLSIDVNVEEKAQFIQEI
IAKIDEVSGNDTEISRIKEKAERLFK

Sequences:

>Translated_186_residues
MERISWDQYFMAQSHLLSLRSTCTRLEVGATIVRDKRIIAGGYNGSVTGSVHCTDEGCYVIDGHCVRTVHAEANALLQCA
KFGVPTEGADVYVTHFPCLQCTKQLIQSGIRTVYYAEDYHNHPYAMELFTEAGVKTVKVPLHQLSIDVNVEEKAQFIQEI
IAKIDEVSGNDTEISRIKEKAERLFK
>Mature_186_residues
MERISWDQYFMAQSHLLSLRSTCTRLEVGATIVRDKRIIAGGYNGSVTGSVHCTDEGCYVIDGHCVRTVHAEANALLQCA
KFGVPTEGADVYVTHFPCLQCTKQLIQSGIRTVYYAEDYHNHPYAMELFTEAGVKTVKVPLHQLSIDVNVEEKAQFIQEI
IAKIDEVSGNDTEISRIKEKAERLFK

Specific function: Dispensable for transformability [H]

COG id: COG2131

COG function: function code F; Deoxycytidylate deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI61742819, Length=143, Percent_Identity=35.6643356643357, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI61742821, Length=143, Percent_Identity=35.6643356643357, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321938, Length=140, Percent_Identity=36.4285714285714, Blast_Score=92, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24667298, Length=136, Percent_Identity=38.9705882352941, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24667302, Length=136, Percent_Identity=38.9705882352941, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR013404
- InterPro:   IPR015517
- InterPro:   IPR016193
- InterPro:   IPR016473 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: 3.5.4.12

Molecular weight: Translated: 20870; Mature: 20870

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERISWDQYFMAQSHLLSLRSTCTRLEVGATIVRDKRIIAGGYNGSVTGSVHCTDEGCYV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEECCCCCCEEEEEEECCCCCEE
IDGHCVRTVHAEANALLQCAKFGVPTEGADVYVTHFPCLQCTKQLIQSGIRTVYYAEDYH
ECCCEEEEEHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHCCCEEEEECCCC
NHPYAMELFTEAGVKTVKVPLHQLSIDVNVEEKAQFIQEIIAKIDEVSGNDTEISRIKEK
CCCHHHHHHHHCCCEEEEEEHHHEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AERLFK
HHHHCC
>Mature Secondary Structure
MERISWDQYFMAQSHLLSLRSTCTRLEVGATIVRDKRIIAGGYNGSVTGSVHCTDEGCYV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEECCCCCCEEEEEEECCCCCEE
IDGHCVRTVHAEANALLQCAKFGVPTEGADVYVTHFPCLQCTKQLIQSGIRTVYYAEDYH
ECCCEEEEEHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHCCCEEEEECCCC
NHPYAMELFTEAGVKTVKVPLHQLSIDVNVEEKAQFIQEIIAKIDEVSGNDTEISRIKEK
CCCHHHHHHHHCCCEEEEEEHHHEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AERLFK
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: dCMP; H2O

Specific reaction: dCMP + H2O = dUMP + NH3

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]