Click here to switch to the map view.

The map label for this gene is era

Identifier: 23099406

GI number: 23099406

Start: 1979200

End: 1980102

Strand: Reverse

Name: era

Synonym: OB1951

Alternate gene names: 23099406

Gene position: 1980102-1979200 (Counterclockwise)

Preceding gene: 23099407

Following gene: 23099405

Centisome position: 54.54

GC content: 34.0

Gene sequence:

>903_bases
ATGGAAACAAATTTTAAATCAGGATTTTTATCAATTATTGGTCGCCCTAATGTTGGTAAATCAACTTTTATGAATAAAGT
AATCGGTCAAAAGATTGCAATTATGAGTGATAAAGCGCAGACAACAAGGAACAAAATACAAGGTGTATTTACTACAAATG
ATGCACAAATGATCTTTATCGACACACCAGGTATTCATAAGCCGAAACATCGTCTTGGTGATTTTATGGTTCAAATTGCA
GAAGATACGCTAAATGAAGTCGATAGCATATTATTCATGATAAATGCAGATGAGGGATATGGAAGAGGGGACCAATACAT
TATTGATTTATTGCAAAAGGTTAATAGCCCTGTATTTCTTATTATTAATAAGATTGATTTAATTCACCCTGATCAGCTAT
TACCACTCATTGAAAAGTACAAGTCACTATACGATTTTGAGGAAATTATACCTATATCTGCTCTAGAGGGAAATAATGTC
GACCATTTAGTAGATGTGTTGAAGGAGCATTTGCCGGAAGGTCCTCAATATTATCCGGAGGATCAAGTGACAGATCACCC
AGAACGATTTGTTATATCTGAATTAATACGAGAAAAGGTATTGCATTTAACAAAAGAAGAGGTGCCTCATTCAATTGCAG
TAGTCATTGAGAATATAGAGAAGAATGAAAATGAAAAGTTACTAATTCAAGCGACGATTGTGACGGAAAGAAGTTCTCAA
AAAGGGATATTGATTGGAAAGCAAGGAACCATGTTGAAAAATATTGGAAAACAAGCAAGAAGAGATATTGAAGCACTACT
CGGCTCCAAAGTATATCTAGAGCTATGGATTAAAGTGAAAAAAGACTGGAGAAACAGGCAAAACCAATTACATGAATTTG
GATTTAGAAGTGACGAATATTAA

Upstream 100 bases:

>100_bases
AAAAAAGAAAGTTTTTAAACGTTTTGTCGATTTAATGAAACTGAAATCATTTTATAGTATGATATAAATTAATAAAATTT
AACGTCTCGGAGGATACAAT

Downstream 100 bases:

>100_bases
ACATGGAAATATTTAATACTTATGATTTGATTTAGAAAAGCCATTCTATAAATAAGTTACATTTTCAACCTAATAATTAA
AGAAAGGTGGGGTTTCTTGT

Product: GTP-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
METNFKSGFLSIIGRPNVGKSTFMNKVIGQKIAIMSDKAQTTRNKIQGVFTTNDAQMIFIDTPGIHKPKHRLGDFMVQIA
EDTLNEVDSILFMINADEGYGRGDQYIIDLLQKVNSPVFLIINKIDLIHPDQLLPLIEKYKSLYDFEEIIPISALEGNNV
DHLVDVLKEHLPEGPQYYPEDQVTDHPERFVISELIREKVLHLTKEEVPHSIAVVIENIEKNENEKLLIQATIVTERSSQ
KGILIGKQGTMLKNIGKQARRDIEALLGSKVYLELWIKVKKDWRNRQNQLHEFGFRSDEY

Sequences:

>Translated_300_residues
METNFKSGFLSIIGRPNVGKSTFMNKVIGQKIAIMSDKAQTTRNKIQGVFTTNDAQMIFIDTPGIHKPKHRLGDFMVQIA
EDTLNEVDSILFMINADEGYGRGDQYIIDLLQKVNSPVFLIINKIDLIHPDQLLPLIEKYKSLYDFEEIIPISALEGNNV
DHLVDVLKEHLPEGPQYYPEDQVTDHPERFVISELIREKVLHLTKEEVPHSIAVVIENIEKNENEKLLIQATIVTERSSQ
KGILIGKQGTMLKNIGKQARRDIEALLGSKVYLELWIKVKKDWRNRQNQLHEFGFRSDEY
>Mature_300_residues
METNFKSGFLSIIGRPNVGKSTFMNKVIGQKIAIMSDKAQTTRNKIQGVFTTNDAQMIFIDTPGIHKPKHRLGDFMVQIA
EDTLNEVDSILFMINADEGYGRGDQYIIDLLQKVNSPVFLIINKIDLIHPDQLLPLIEKYKSLYDFEEIIPISALEGNNV
DHLVDVLKEHLPEGPQYYPEDQVTDHPERFVISELIREKVLHLTKEEVPHSIAVVIENIEKNENEKLLIQATIVTERSSQ
KGILIGKQGTMLKNIGKQARRDIEALLGSKVYLELWIKVKKDWRNRQNQLHEFGFRSDEY

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain

Homologues:

Organism=Homo sapiens, GI24307899, Length=331, Percent_Identity=24.1691842900302, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1788919, Length=294, Percent_Identity=39.1156462585034, Blast_Score=234, Evalue=4e-63,
Organism=Escherichia coli, GI87082120, Length=181, Percent_Identity=32.0441988950276, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17532761, Length=141, Percent_Identity=29.0780141843972, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24646434, Length=308, Percent_Identity=25.3246753246753, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ERA_OCEIH (Q8EPY0)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692872.1
- HSSP:   Q9X1F8
- ProteinModelPortal:   Q8EPY0
- SMR:   Q8EPY0
- GeneID:   1018428
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1951
- NMPDR:   fig|221109.1.peg.1951
- HOGENOM:   HBG561652
- OMA:   AKDWQRD
- BioCyc:   OIHE221109:OB1951-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00367
- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- TIGRFAMs:   TIGR00436
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1; SSF54814 KH_prok

EC number: NA

Molecular weight: Translated: 34434; Mature: 34434

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METNFKSGFLSIIGRPNVGKSTFMNKVIGQKIAIMSDKAQTTRNKIQGVFTTNDAQMIFI
CCCCCCCCHHHEECCCCCCHHHHHHHHHHHHHEEECCHHHHHHHHHCEEEEECCCEEEEE
DTPGIHKPKHRLGDFMVQIAEDTLNEVDSILFMINADEGYGRGDQYIIDLLQKVNSPVFL
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHCCCEEE
IINKIDLIHPDQLLPLIEKYKSLYDFEEIIPISALEGNNVDHLVDVLKEHLPEGPQYYPE
EEECCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHCCCCCCCCCC
DQVTDHPERFVISELIREKVLHLTKEEVPHSIAVVIENIEKNENEKLLIQATIVTERSSQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCC
KGILIGKQGTMLKNIGKQARRDIEALLGSKVYLELWIKVKKDWRNRQNQLHEFGFRSDEY
CCEEEECCCHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
METNFKSGFLSIIGRPNVGKSTFMNKVIGQKIAIMSDKAQTTRNKIQGVFTTNDAQMIFI
CCCCCCCCHHHEECCCCCCHHHHHHHHHHHHHEEECCHHHHHHHHHCEEEEECCCEEEEE
DTPGIHKPKHRLGDFMVQIAEDTLNEVDSILFMINADEGYGRGDQYIIDLLQKVNSPVFL
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHCCCEEE
IINKIDLIHPDQLLPLIEKYKSLYDFEEIIPISALEGNNVDHLVDVLKEHLPEGPQYYPE
EEECCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHCCCCCCCCCC
DQVTDHPERFVISELIREKVLHLTKEEVPHSIAVVIENIEKNENEKLLIQATIVTERSSQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEEEEEECCCCC
KGILIGKQGTMLKNIGKQARRDIEALLGSKVYLELWIKVKKDWRNRQNQLHEFGFRSDEY
CCEEEECCCHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12235376