Click here to switch to the map view.

The map label for this gene is xseA

Identifier: 23099334

GI number: 23099334

Start: 1912709

End: 1914076

Strand: Reverse

Name: xseA

Synonym: OB1879

Alternate gene names: 23099334

Gene position: 1914076-1912709 (Counterclockwise)

Preceding gene: 23099335

Following gene: 23099333

Centisome position: 52.72

GC content: 35.16

Gene sequence:

>1368_bases
TTGAAAGATAAATATTTGACGGTAACAGCTTTAACAAAATATGTTAAAAGGAAAATGGATTCTGATCCACATTTGCGGGA
TATTTGGTTACGTGGGGAAATATCAAACTTTAAACACCATAGTCGTGGCCATATGTATCTGACAATTAAAGATGATTCTG
CACGTATTCAGGCGGTAATGTTTGCTTCAAGCAATCGTAAGTTACTTTTTCATCCTGAAAATGGAATGAACGTTCTTATT
CGTGGGGAAATAAGTGTATTTGAAGCTTATGGTCAGTATCAGTTGTATATTCATGAAATGGAGCCTGACGGTATTGGGTC
TTTGTATCAAGCATTTGAACAATTAAAAGAAAGATTACATAAACAAGGTTATTTTGCAGACGAATATAAAAAACCAATTC
CTCGTTATCCAAAAAATATCGCCGTGATTACTTCTCCAACAGGTGCAGCAATTAGGGACATACTAACAACGATGAAACGA
CGTTATCCTTCTGTGAAAATAACGGTTTTTCCAGTACTTGTTCAAGGAAATCAAGCTAAAGCATCCATTGCTCGATCTAT
ACAGCAAGCAGATTCCCTATCGTATGATGTGATTATTGTTGGGAGAGGCGGGGGATCGATTGAAGAATTGTGGAGCTTTA
ATGAAGAAGAAGTTGCAAGAGCAATTTTTGAATCGAAAACACCAATTATATCTGCTGTTGGACATGAAACAGATACCACA
ATAAGTGACTTTGTAGCTGATTTACGTGCACCTACACCAACCGCAGCTGGAGAATTAGCAGTACCTTCCCAGGTTGAACT
TTTGGATAAAATAGAGATTCAAAAAAGACAGTTAGCACGTCTGTTAAAACAATATATTAGTCAGCACGAAACAATACTTC
ATCAACTAAGACAAACCTATGCATTTAAATATCCGCACCAATTAGTAAAGCAAAAAGAACAAGAATTGGATTCAACAATG
GATAACCTTCAACGAAGAATGAAATCAAAGGTTTCTGATGACAAATTAACACATAATCATTTAATAAAAAGATTATCCAG
TCAACATCCACAAAGGGAACTGAGATTAGCAATTGATAAATTACGTCAACTACATTCCCTTCAAAATAAGATGATGAATA
ACTACCTTGAACAACAATCTCAACGGTTATATTCGCAGATAGATAAGTTAAGTTTGGTTAATCCTTTGGAAATTATGAAA
AGAGGATATGCTCTTCCGTATAATGAAGATGGAGCGTTAATTAAATCAGTTAAGCATTTACACATAAATGATACGATTCA
ATTAAGAATTGCAGATGGGGAAGTAACTGGAAAAGTAACAGCAATTAAGGAGGCGAATGAAAATGGCAACGAAGGATCTA
ACGTTTGA

Upstream 100 bases:

>100_bases
AAAGCATCTTACATTACACCGGTTCCACGTGGGGTAGGTCCCATGACGATAACGATGCTGCTAAAAAATACAATTAAAGC
TGCAAAAGGATTGAATGACG

Downstream 100 bases:

>100_bases
ACAAGCCATGGAGAAATTAGAAGGAATCGTTTCTAAATTAGAAGAAGGAGACGTTCCACTTGAAAAAGCGATCGAATATT
ATCAAGAAGGAATGAATCTT

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MKDKYLTVTALTKYVKRKMDSDPHLRDIWLRGEISNFKHHSRGHMYLTIKDDSARIQAVMFASSNRKLLFHPENGMNVLI
RGEISVFEAYGQYQLYIHEMEPDGIGSLYQAFEQLKERLHKQGYFADEYKKPIPRYPKNIAVITSPTGAAIRDILTTMKR
RYPSVKITVFPVLVQGNQAKASIARSIQQADSLSYDVIIVGRGGGSIEELWSFNEEEVARAIFESKTPIISAVGHETDTT
ISDFVADLRAPTPTAAGELAVPSQVELLDKIEIQKRQLARLLKQYISQHETILHQLRQTYAFKYPHQLVKQKEQELDSTM
DNLQRRMKSKVSDDKLTHNHLIKRLSSQHPQRELRLAIDKLRQLHSLQNKMMNNYLEQQSQRLYSQIDKLSLVNPLEIMK
RGYALPYNEDGALIKSVKHLHINDTIQLRIADGEVTGKVTAIKEANENGNEGSNV

Sequences:

>Translated_455_residues
MKDKYLTVTALTKYVKRKMDSDPHLRDIWLRGEISNFKHHSRGHMYLTIKDDSARIQAVMFASSNRKLLFHPENGMNVLI
RGEISVFEAYGQYQLYIHEMEPDGIGSLYQAFEQLKERLHKQGYFADEYKKPIPRYPKNIAVITSPTGAAIRDILTTMKR
RYPSVKITVFPVLVQGNQAKASIARSIQQADSLSYDVIIVGRGGGSIEELWSFNEEEVARAIFESKTPIISAVGHETDTT
ISDFVADLRAPTPTAAGELAVPSQVELLDKIEIQKRQLARLLKQYISQHETILHQLRQTYAFKYPHQLVKQKEQELDSTM
DNLQRRMKSKVSDDKLTHNHLIKRLSSQHPQRELRLAIDKLRQLHSLQNKMMNNYLEQQSQRLYSQIDKLSLVNPLEIMK
RGYALPYNEDGALIKSVKHLHINDTIQLRIADGEVTGKVTAIKEANENGNEGSNV
>Mature_455_residues
MKDKYLTVTALTKYVKRKMDSDPHLRDIWLRGEISNFKHHSRGHMYLTIKDDSARIQAVMFASSNRKLLFHPENGMNVLI
RGEISVFEAYGQYQLYIHEMEPDGIGSLYQAFEQLKERLHKQGYFADEYKKPIPRYPKNIAVITSPTGAAIRDILTTMKR
RYPSVKITVFPVLVQGNQAKASIARSIQQADSLSYDVIIVGRGGGSIEELWSFNEEEVARAIFESKTPIISAVGHETDTT
ISDFVADLRAPTPTAAGELAVPSQVELLDKIEIQKRQLARLLKQYISQHETILHQLRQTYAFKYPHQLVKQKEQELDSTM
DNLQRRMKSKVSDDKLTHNHLIKRLSSQHPQRELRLAIDKLRQLHSLQNKMMNNYLEQQSQRLYSQIDKLSLVNPLEIMK
RGYALPYNEDGALIKSVKHLHINDTIQLRIADGEVTGKVTAIKEANENGNEGSNV

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=443, Percent_Identity=38.3747178329571, Blast_Score=323, Evalue=2e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_OCEIH (Q8EQ44)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692800.1
- GeneID:   1018371
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1879
- NMPDR:   fig|221109.1.peg.1879
- HOGENOM:   HBG634411
- OMA:   ANERREC
- ProtClustDB:   PRK00286
- BioCyc:   OIHE221109:OB1879-MONOMER
- BRENDA:   3.1.11.6
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 52117; Mature: 52117

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDKYLTVTALTKYVKRKMDSDPHLRDIWLRGEISNFKHHSRGHMYLTIKDDSARIQAVM
CCCCEEHHHHHHHHHHHHCCCCCCCEEEEEECCHHCCCCCCCCEEEEEEECCCCEEEEEE
FASSNRKLLFHPENGMNVLIRGEISVFEAYGQYQLYIHEMEPDGIGSLYQAFEQLKERLH
EECCCCEEEEECCCCCEEEEECCHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHH
KQGYFADEYKKPIPRYPKNIAVITSPTGAAIRDILTTMKRRYPSVKITVFPVLVQGNQAK
HCCCCHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEEEEECCCHH
ASIARSIQQADSLSYDVIIVGRGGGSIEELWSFNEEEVARAIFESKTPIISAVGHETDTT
HHHHHHHHHHHCCCEEEEEEECCCCCHHHHHCCCHHHHHHHHHHCCCCEEEECCCCCCCH
ISDFVADLRAPTPTAAGELAVPSQVELLDKIEIQKRQLARLLKQYISQHETILHQLRQTY
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFKYPHQLVKQKEQELDSTMDNLQRRMKSKVSDDKLTHNHLIKRLSSQHPQRELRLAIDK
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
LRQLHSLQNKMMNNYLEQQSQRLYSQIDKLSLVNPLEIMKRGYALPYNEDGALIKSVKHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCHHHHHHHHE
HINDTIQLRIADGEVTGKVTAIKEANENGNEGSNV
EECCEEEEEEECCCCCCEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MKDKYLTVTALTKYVKRKMDSDPHLRDIWLRGEISNFKHHSRGHMYLTIKDDSARIQAVM
CCCCEEHHHHHHHHHHHHCCCCCCCEEEEEECCHHCCCCCCCCEEEEEEECCCCEEEEEE
FASSNRKLLFHPENGMNVLIRGEISVFEAYGQYQLYIHEMEPDGIGSLYQAFEQLKERLH
EECCCCEEEEECCCCCEEEEECCHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHH
KQGYFADEYKKPIPRYPKNIAVITSPTGAAIRDILTTMKRRYPSVKITVFPVLVQGNQAK
HCCCCHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEEEEECCCHH
ASIARSIQQADSLSYDVIIVGRGGGSIEELWSFNEEEVARAIFESKTPIISAVGHETDTT
HHHHHHHHHHHCCCEEEEEEECCCCCHHHHHCCCHHHHHHHHHHCCCCEEEECCCCCCCH
ISDFVADLRAPTPTAAGELAVPSQVELLDKIEIQKRQLARLLKQYISQHETILHQLRQTY
HHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFKYPHQLVKQKEQELDSTMDNLQRRMKSKVSDDKLTHNHLIKRLSSQHPQRELRLAIDK
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
LRQLHSLQNKMMNNYLEQQSQRLYSQIDKLSLVNPLEIMKRGYALPYNEDGALIKSVKHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCHHHHHHHHE
HINDTIQLRIADGEVTGKVTAIKEANENGNEGSNV
EECCEEEEEEECCCCCCEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376