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The map label for this gene is ispA [C]

Identifier: 23099332

GI number: 23099332

Start: 1911617

End: 1912501

Strand: Reverse

Name: ispA [C]

Synonym: OB1877

Alternate gene names: 23099332

Gene position: 1912501-1911617 (Counterclockwise)

Preceding gene: 23099333

Following gene: 23099331

Centisome position: 52.68

GC content: 36.05

Gene sequence:

>885_bases
GTGAATGAAAACTTACAAAGATATTTAGAGATATATCGTGAGAAATTGGAAGCAACATATAATACTTATTTTTCACATTT
AGATATCCCGAATAATTTAAAAGAATCCATGCTATATTCATTAAATGCAGGCGGGAAGCGATTAAGGCCAATATTAATAT
TGGCTAGCTATGAGGTATACGGAAAAACATTAGATAAAGTGATGTCCTCAGCAGTTGCAATAGAAATGATTCATACGTAT
TCACTTATTCATGATGATTTGCCTGCCATGGATGATGATGATTATCGTCGAGGCAAGTTAACAAATCACAAACAATTCAA
TGAAGCAACAGCAATATTGGCTGGAGATGCATTACTAACGTATAGTTTTCAATTAATTAGTTCAGATGACCTACTAACTT
CTGATGAAAAAGTGGAGTTAATACGAATATTATCTGAAGCGAGTGGACCAGCTGGGATGGTCGCTGGTCAAATATTGGAT
ATGGAAGCTGAAAAACAAGCTGTTACACTTGAAGAAATGGAAGAAATTCACGCATTAAAAACTGGAGAGTTAATTCGGTT
TGCAATTATTGCTGGAGCATATCTTGGTGGAGCAACAGACAATCAGTTAAAACACCTTACTGATTATGCTTATTATTTAG
GCTTAATTTTTCAAGTGCAGGACGATATCTTAGACATAACTGGAGATGCGTCGAAGATTGGGAAACCAGTGGGTAGCGAT
GAACTGAATGAAAAAAGCACGTATCCGAAATTATTAGGATTGCAAGGTGCTATCGATCAGAAAAATCTCTATGTTGAAAA
AGCCTACAAAAGTCTACATTTGGCTGGAGCAGAAGATTCTCTGCTCGCTGAATTGACAAAGTATTTCAGTGAGCGTGATC
ATTAG

Upstream 100 bases:

>100_bases
TTTGTAGTGAGAAATTAAATCATGTGCAAGATAAAATGGTTCAGATAATGAATGAACAAGGAGAATTAGAACCTTTTGAT
ATACAGGAGGATTCATCATC

Downstream 100 bases:

>100_bases
AAATGAAAAAGAAAAAAAGAGCTGATGAGTTACTTGTAGAGCGAGAATTGGTTGAGAATATTGATAAAGCCAGAAGGTCT
ATAATGGCCGGGATCGTTTT

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MNENLQRYLEIYREKLEATYNTYFSHLDIPNNLKESMLYSLNAGGKRLRPILILASYEVYGKTLDKVMSSAVAIEMIHTY
SLIHDDLPAMDDDDYRRGKLTNHKQFNEATAILAGDALLTYSFQLISSDDLLTSDEKVELIRILSEASGPAGMVAGQILD
MEAEKQAVTLEEMEEIHALKTGELIRFAIIAGAYLGGATDNQLKHLTDYAYYLGLIFQVQDDILDITGDASKIGKPVGSD
ELNEKSTYPKLLGLQGAIDQKNLYVEKAYKSLHLAGAEDSLLAELTKYFSERDH

Sequences:

>Translated_294_residues
MNENLQRYLEIYREKLEATYNTYFSHLDIPNNLKESMLYSLNAGGKRLRPILILASYEVYGKTLDKVMSSAVAIEMIHTY
SLIHDDLPAMDDDDYRRGKLTNHKQFNEATAILAGDALLTYSFQLISSDDLLTSDEKVELIRILSEASGPAGMVAGQILD
MEAEKQAVTLEEMEEIHALKTGELIRFAIIAGAYLGGATDNQLKHLTDYAYYLGLIFQVQDDILDITGDASKIGKPVGSD
ELNEKSTYPKLLGLQGAIDQKNLYVEKAYKSLHLAGAEDSLLAELTKYFSERDH
>Mature_294_residues
MNENLQRYLEIYREKLEATYNTYFSHLDIPNNLKESMLYSLNAGGKRLRPILILASYEVYGKTLDKVMSSAVAIEMIHTY
SLIHDDLPAMDDDDYRRGKLTNHKQFNEATAILAGDALLTYSFQLISSDDLLTSDEKVELIRILSEASGPAGMVAGQILD
MEAEKQAVTLEEMEEIHALKTGELIRFAIIAGAYLGGATDNQLKHLTDYAYYLGLIFQVQDDILDITGDASKIGKPVGSD
ELNEKSTYPKLLGLQGAIDQKNLYVEKAYKSLHLAGAEDSLLAELTKYFSERDH

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=239, Percent_Identity=32.2175732217573, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1786623, Length=298, Percent_Identity=42.9530201342282, Blast_Score=186, Evalue=1e-48,
Organism=Escherichia coli, GI1789578, Length=215, Percent_Identity=35.3488372093023, Blast_Score=115, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17505681, Length=246, Percent_Identity=27.6422764227642, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24651612, Length=230, Percent_Identity=28.695652173913, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32887; Mature: 32887

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNENLQRYLEIYREKLEATYNTYFSHLDIPNNLKESMLYSLNAGGKRLRPILILASYEVY
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEEEECHHHH
GKTLDKVMSSAVAIEMIHTYSLIHDDLPAMDDDDYRRGKLTNHKQFNEATAILAGDALLT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEE
YSFQLISSDDLLTSDEKVELIRILSEASGPAGMVAGQILDMEAEKQAVTLEEMEEIHALK
EEEEEECCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
TGELIRFAIIAGAYLGGATDNQLKHLTDYAYYLGLIFQVQDDILDITGDASKIGKPVGSD
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCC
ELNEKSTYPKLLGLQGAIDQKNLYVEKAYKSLHLAGAEDSLLAELTKYFSERDH
CCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNENLQRYLEIYREKLEATYNTYFSHLDIPNNLKESMLYSLNAGGKRLRPILILASYEVY
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEEEECHHHH
GKTLDKVMSSAVAIEMIHTYSLIHDDLPAMDDDDYRRGKLTNHKQFNEATAILAGDALLT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEE
YSFQLISSDDLLTSDEKVELIRILSEASGPAGMVAGQILDMEAEKQAVTLEEMEEIHALK
EEEEEECCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
TGELIRFAIIAGAYLGGATDNQLKHLTDYAYYLGLIFQVQDDILDITGDASKIGKPVGSD
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCC
ELNEKSTYPKLLGLQGAIDQKNLYVEKAYKSLHLAGAEDSLLAELTKYFSERDH
CCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]