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The map label for this gene is bfmBAA [H]

Identifier: 23099321

GI number: 23099321

Start: 1897081

End: 1898067

Strand: Reverse

Name: bfmBAA [H]

Synonym: OB1866

Alternate gene names: 23099321

Gene position: 1898067-1897081 (Counterclockwise)

Preceding gene: 23099322

Following gene: 23099320

Centisome position: 52.28

GC content: 38.91

Gene sequence:

>987_bases
ATGACTGAGTCTCAACTAGGAATAAGTAATGATATTGCCTTAGGAATGTATGAAATGATGTTATTGGCAAGAAAATTAGA
TGAGAGAATGTGGCTATTAAATCGTGCCGGGAAAATTCCTTTTGTTATTTCCTGTCAAGGTCAAGAAGCTGCACAAGTCG
GAGCTGCCTTTGCATTAAATCGTACTACGGATTATATTGCTCCTTATTATCGTGATTTAGGAGTTGTATTAGCTTTTGGT
ATGAGTGCACAAGATGTTATGTTATCTGCTTTTGCAAAAGCAGAAGATCCGAATTCTGGTGGAAGACAAATGCCTGGACA
CTTTGGACAAAAGAAAAATAGAATTTTAACTGGTTCTTCACCTGTAACAACCCAATTACCACATGCGGTTGGTGTTGCAT
TAGCGGCAAAAATGGACAAAGAACCTCTGGTATCTTTTGTGACCTTAGGAGAAGGATCATCAAATCAGGGTGATTTTCAT
GAAGGACTTAACTTTGCAGGGGTTCATAAACTTCCTGTAATTACAATGGTTGAAAATAACAAGTATGCTATTTCCGTACC
TTATGACCGCCAAGTGGCAAGTGAAACTATTTCTGAAAGAGCGAACTCCTATGGAATGCCTGGAGTAACAGTGGACGGAA
ATGATCCGGTGGCTGTGTATCAAGCTGTTTCAGAAGCAAGAGACAGGGCTGTAAGAGGAGAAGGGCCAACATTAATTGAA
GCAATTACGTATCGCCTGACAGCACATTCAAGTGATGATGATGATCGGGCATACCGTGAAAAAAATGAAGTTGAAGAAGC
GAAGAAGAAAGATTCAATTATTACATTTGCGACAACTTTAAAAGAAGCTGGAGTACTTAAAGATGAAAAAGAACAAGAAA
TTATGTCTCGTATTGATGAACTTGTAAATGAAGCAACGGATTATGCGGAAAATGCTTCCTATGCAGAACCAGAAGATGCT
TTGCGATATGTGTATGAGGAAGAATAG

Upstream 100 bases:

>100_bases
AAGTATTCATCCACATCCAACATTATCAGAAGTGATCGGTGAAGCTGCATTAGCAGTAGAAGGAAATCAAATTCATGGTT
AATTTAAGGAGGGACAATCA

Downstream 100 bases:

>100_bases
AGAGGAGGAAGAGTTATGCCAGTAATGTCTTATATTCAAGCAATTACTACTGCAATGAAAGAAGAAATGCGTAGAGACAA
AGATGTATTTGTTTTAGGAG

Product: branched-chain alpha-keto acid dehydrogenase E1 alpha chain

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain; BCKDH E1-alpha [H]

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MTESQLGISNDIALGMYEMMLLARKLDERMWLLNRAGKIPFVISCQGQEAAQVGAAFALNRTTDYIAPYYRDLGVVLAFG
MSAQDVMLSAFAKAEDPNSGGRQMPGHFGQKKNRILTGSSPVTTQLPHAVGVALAAKMDKEPLVSFVTLGEGSSNQGDFH
EGLNFAGVHKLPVITMVENNKYAISVPYDRQVASETISERANSYGMPGVTVDGNDPVAVYQAVSEARDRAVRGEGPTLIE
AITYRLTAHSSDDDDRAYREKNEVEEAKKKDSIITFATTLKEAGVLKDEKEQEIMSRIDELVNEATDYAENASYAEPEDA
LRYVYEEE

Sequences:

>Translated_328_residues
MTESQLGISNDIALGMYEMMLLARKLDERMWLLNRAGKIPFVISCQGQEAAQVGAAFALNRTTDYIAPYYRDLGVVLAFG
MSAQDVMLSAFAKAEDPNSGGRQMPGHFGQKKNRILTGSSPVTTQLPHAVGVALAAKMDKEPLVSFVTLGEGSSNQGDFH
EGLNFAGVHKLPVITMVENNKYAISVPYDRQVASETISERANSYGMPGVTVDGNDPVAVYQAVSEARDRAVRGEGPTLIE
AITYRLTAHSSDDDDRAYREKNEVEEAKKKDSIITFATTLKEAGVLKDEKEQEIMSRIDELVNEATDYAENASYAEPEDA
LRYVYEEE
>Mature_327_residues
TESQLGISNDIALGMYEMMLLARKLDERMWLLNRAGKIPFVISCQGQEAAQVGAAFALNRTTDYIAPYYRDLGVVLAFGM
SAQDVMLSAFAKAEDPNSGGRQMPGHFGQKKNRILTGSSPVTTQLPHAVGVALAAKMDKEPLVSFVTLGEGSSNQGDFHE
GLNFAGVHKLPVITMVENNKYAISVPYDRQVASETISERANSYGMPGVTVDGNDPVAVYQAVSEARDRAVRGEGPTLIEA
ITYRLTAHSSDDDDRAYREKNEVEEAKKKDSIITFATTLKEAGVLKDEKEQEIMSRIDELVNEATDYAENASYAEPEDAL
RYVYEEE

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCKDHA family [H]

Homologues:

Organism=Homo sapiens, GI11386135, Length=315, Percent_Identity=37.7777777777778, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI258645172, Length=315, Percent_Identity=37.7777777777778, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI4885543, Length=318, Percent_Identity=28.9308176100629, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI4505685, Length=316, Percent_Identity=29.4303797468354, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI291084742, Length=316, Percent_Identity=29.4303797468354, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI291084744, Length=323, Percent_Identity=28.7925696594427, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI291084757, Length=316, Percent_Identity=26.2658227848101, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI86563357, Length=317, Percent_Identity=39.4321766561514, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI86563355, Length=317, Percent_Identity=39.4321766561514, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17536047, Length=317, Percent_Identity=28.7066246056782, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI32564172, Length=317, Percent_Identity=28.7066246056782, Blast_Score=118, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6321026, Length=326, Percent_Identity=30.6748466257669, Blast_Score=129, Evalue=9e-31,
Organism=Drosophila melanogaster, GI21355903, Length=265, Percent_Identity=34.7169811320755, Blast_Score=158, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24639744, Length=315, Percent_Identity=29.8412698412698, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI28571106, Length=315, Percent_Identity=29.8412698412698, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24639740, Length=315, Percent_Identity=29.8412698412698, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24639748, Length=306, Percent_Identity=30.718954248366, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24639746, Length=271, Percent_Identity=30.9963099630996, Blast_Score=117, Evalue=9e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 36009; Mature: 35878

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESQLGISNDIALGMYEMMLLARKLDERMWLLNRAGKIPFVISCQGQEAAQVGAAFALN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHEEC
RTTDYIAPYYRDLGVVLAFGMSAQDVMLSAFAKAEDPNSGGRQMPGHFGQKKNRILTGSS
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCC
PVTTQLPHAVGVALAAKMDKEPLVSFVTLGEGSSNQGDFHEGLNFAGVHKLPVITMVENN
CCCHHCCHHHHHHHHHHCCCCHHEEEEEECCCCCCCCCHHHCCCCCCCCCCEEEEEEECC
KYAISVPYDRQVASETISERANSYGMPGVTVDGNDPVAVYQAVSEARDRAVRGEGPTLIE
EEEEECCCHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHH
AITYRLTAHSSDDDDRAYREKNEVEEAKKKDSIITFATTLKEAGVLKDEKEQEIMSRIDE
HHHHHHEECCCCCHHHHHHHHHHHHHHHHHCCEEEHHHHHHHCCCCCCHHHHHHHHHHHH
LVNEATDYAENASYAEPEDALRYVYEEE
HHHHHHHHHCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
TESQLGISNDIALGMYEMMLLARKLDERMWLLNRAGKIPFVISCQGQEAAQVGAAFALN
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHEEC
RTTDYIAPYYRDLGVVLAFGMSAQDVMLSAFAKAEDPNSGGRQMPGHFGQKKNRILTGSS
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCC
PVTTQLPHAVGVALAAKMDKEPLVSFVTLGEGSSNQGDFHEGLNFAGVHKLPVITMVENN
CCCHHCCHHHHHHHHHHCCCCHHEEEEEECCCCCCCCCHHHCCCCCCCCCCEEEEEEECC
KYAISVPYDRQVASETISERANSYGMPGVTVDGNDPVAVYQAVSEARDRAVRGEGPTLIE
EEEEECCCHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHH
AITYRLTAHSSDDDDRAYREKNEVEEAKKKDSIITFATTLKEAGVLKDEKEQEIMSRIDE
HHHHHHEECCCCCHHHHHHHHHHHHHHHHHCCEEEHHHHHHHCCCCCCHHHHHHHHHHHH
LVNEATDYAENASYAEPEDALRYVYEEE
HHHHHHHHHCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]