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The map label for this gene is bfmBAB [H]

Identifier: 23099320

GI number: 23099320

Start: 1896082

End: 1897065

Strand: Reverse

Name: bfmBAB [H]

Synonym: OB1865

Alternate gene names: 23099320

Gene position: 1897065-1896082 (Counterclockwise)

Preceding gene: 23099321

Following gene: 23099319

Centisome position: 52.25

GC content: 38.72

Gene sequence:

>984_bases
ATGCCAGTAATGTCTTATATTCAAGCAATTACTACTGCAATGAAAGAAGAAATGCGTAGAGACAAAGATGTATTTGTTTT
AGGAGAAGATGTCGGAAAAAAAGGTGGGGTCTTTAAAGCTACAGATGGCTTATATGAAGAATTTGGCGAAGATCGGGTAT
TAGATACACCTTTAGCAGAATCTGCGATAGCGGGAGTCGCAATTGGTGCAGCTATGTATGGCAAGAGGCCAATTGCGGAA
ATGCAGTTTGCTGATTTTATTATGCCAGCTGTAAATCAGATTATTTCAGAAGCAGCTAAAATACGATATCGTTCAAATAA
TGATTGGAGTGCACCTTTAACGGTAAGAGCGCCATATGGTGGAGGTGTACATGGAGCATTATATCATTCGCAGTCTGTAG
AAGCAGTTTTCGCTAATCAGCCTGGTCTAAAAATTGTTATGCCTTCAACTCCCTATGATGCTAAAGGACTGTTAAAAGCA
GCTATTCGTGATAATGATCCGGTGCTATTTTTTGAGCATAAACGTGCTTATCGTTTGTTGAAAGAAGAAGTACCTGAAGA
CGATTATGTACTACCTATTGGAAAAGCAGACGTTAAACGCGAAGGCGAAGATATTACCGTTATTACGTATGGCTTATGTG
TTCACTTTGCACTTCAAGCAGCTGAAAAGTTAGCTGAAGAAGGTATTGATGTGCATATTTTAGATCTAAGAACAGTGTAT
CCGTTAGACAAAGAGGCAATTCGTGAAGCTGCAAGCAAAACTGGTAAAGTACTTCTAATTACAGAGGATAATAAAGAAGG
TAGCATTATTGGTGAAGTTGCAGCGATAATTTCAGAATCCTGTTTGTTTGATTTAGATGCACCAATTCAACGATTAGCTG
GTCCAGATATACCTGCTATGCCTTATGCGCCAACAATGGAGAAGTACTTTATGGTTAATCCAGATAAAGTAGAAAAAGCA
ATGCGAGAACTCGCAGAATACTAA

Upstream 100 bases:

>100_bases
TGTAAATGAAGCAACGGATTATGCGGAAAATGCTTCCTATGCAGAACCAGAAGATGCTTTGCGATATGTGTATGAGGAAG
AATAGAGAGGAGGAAGAGTT

Downstream 100 bases:

>100_bases
TTGGAGGTATATAGATGTCAGTAGAAAAAATTAACATGCCTCAGTTAGGAGAAAGTGTTACAGAAGGTACGATAAACACT
TGGCTCGTAGCGGTAGGTGA

Product: branched-chain alpha-keto acid dehydrogenase E1 beta chain

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MPVMSYIQAITTAMKEEMRRDKDVFVLGEDVGKKGGVFKATDGLYEEFGEDRVLDTPLAESAIAGVAIGAAMYGKRPIAE
MQFADFIMPAVNQIISEAAKIRYRSNNDWSAPLTVRAPYGGGVHGALYHSQSVEAVFANQPGLKIVMPSTPYDAKGLLKA
AIRDNDPVLFFEHKRAYRLLKEEVPEDDYVLPIGKADVKREGEDITVITYGLCVHFALQAAEKLAEEGIDVHILDLRTVY
PLDKEAIREAASKTGKVLLITEDNKEGSIIGEVAAIISESCLFDLDAPIQRLAGPDIPAMPYAPTMEKYFMVNPDKVEKA
MRELAEY

Sequences:

>Translated_327_residues
MPVMSYIQAITTAMKEEMRRDKDVFVLGEDVGKKGGVFKATDGLYEEFGEDRVLDTPLAESAIAGVAIGAAMYGKRPIAE
MQFADFIMPAVNQIISEAAKIRYRSNNDWSAPLTVRAPYGGGVHGALYHSQSVEAVFANQPGLKIVMPSTPYDAKGLLKA
AIRDNDPVLFFEHKRAYRLLKEEVPEDDYVLPIGKADVKREGEDITVITYGLCVHFALQAAEKLAEEGIDVHILDLRTVY
PLDKEAIREAASKTGKVLLITEDNKEGSIIGEVAAIISESCLFDLDAPIQRLAGPDIPAMPYAPTMEKYFMVNPDKVEKA
MRELAEY
>Mature_326_residues
PVMSYIQAITTAMKEEMRRDKDVFVLGEDVGKKGGVFKATDGLYEEFGEDRVLDTPLAESAIAGVAIGAAMYGKRPIAEM
QFADFIMPAVNQIISEAAKIRYRSNNDWSAPLTVRAPYGGGVHGALYHSQSVEAVFANQPGLKIVMPSTPYDAKGLLKAA
IRDNDPVLFFEHKRAYRLLKEEVPEDDYVLPIGKADVKREGEDITVITYGLCVHFALQAAEKLAEEGIDVHILDLRTVYP
LDKEAIREAASKTGKVLLITEDNKEGSIIGEVAAIISESCLFDLDAPIQRLAGPDIPAMPYAPTMEKYFMVNPDKVEKAM
RELAEY

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=326, Percent_Identity=41.4110429447853, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI34101272, Length=326, Percent_Identity=41.4110429447853, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI156564403, Length=303, Percent_Identity=40.2640264026403, Blast_Score=234, Evalue=7e-62,
Organism=Homo sapiens, GI291084858, Length=303, Percent_Identity=39.6039603960396, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI205277463, Length=276, Percent_Identity=26.0869565217391, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI4507521, Length=276, Percent_Identity=26.0869565217391, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17538422, Length=324, Percent_Identity=41.0493827160494, Blast_Score=250, Evalue=6e-67,
Organism=Caenorhabditis elegans, GI17506935, Length=327, Percent_Identity=42.5076452599388, Blast_Score=250, Evalue=8e-67,
Organism=Saccharomyces cerevisiae, GI6319698, Length=327, Percent_Identity=38.5321100917431, Blast_Score=234, Evalue=2e-62,
Organism=Drosophila melanogaster, GI160714828, Length=326, Percent_Identity=42.0245398773006, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI160714832, Length=326, Percent_Identity=42.0245398773006, Blast_Score=255, Evalue=2e-68,
Organism=Drosophila melanogaster, GI21358145, Length=326, Percent_Identity=38.9570552147239, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24650940, Length=326, Percent_Identity=38.9570552147239, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24650943, Length=90, Percent_Identity=41.1111111111111, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24650945, Length=90, Percent_Identity=41.1111111111111, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 36035; Mature: 35904

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVMSYIQAITTAMKEEMRRDKDVFVLGEDVGKKGGVFKATDGLYEEFGEDRVLDTPLAE
CCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEECCHHHHHHCCCCCCCCCHHH
SAIAGVAIGAAMYGKRPIAEMQFADFIMPAVNQIISEAAKIRYRSNNDWSAPLTVRAPYG
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCEEEECCCC
GGVHGALYHSQSVEAVFANQPGLKIVMPSTPYDAKGLLKAAIRDNDPVLFFEHKRAYRLL
CCCCHHEECCCCCEEEECCCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEECHHHHHHH
KEEVPEDDYVLPIGKADVKREGEDITVITYGLCVHFALQAAEKLAEEGIDVHILDLRTVY
HHHCCCCCEEEECCCHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEC
PLDKEAIREAASKTGKVLLITEDNKEGSIIGEVAAIISESCLFDLDAPIQRLAGPDIPAM
CCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCC
PYAPTMEKYFMVNPDKVEKAMRELAEY
CCCCCCCCEEEECHHHHHHHHHHHHCC
>Mature Secondary Structure 
PVMSYIQAITTAMKEEMRRDKDVFVLGEDVGKKGGVFKATDGLYEEFGEDRVLDTPLAE
CHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEECCHHHHHHCCCCCCCCCHHH
SAIAGVAIGAAMYGKRPIAEMQFADFIMPAVNQIISEAAKIRYRSNNDWSAPLTVRAPYG
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCEEEECCCC
GGVHGALYHSQSVEAVFANQPGLKIVMPSTPYDAKGLLKAAIRDNDPVLFFEHKRAYRLL
CCCCHHEECCCCCEEEECCCCCCEEEECCCCCCHHHHHHHHHCCCCCEEEEECHHHHHHH
KEEVPEDDYVLPIGKADVKREGEDITVITYGLCVHFALQAAEKLAEEGIDVHILDLRTVY
HHHCCCCCEEEECCCHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEC
PLDKEAIREAASKTGKVLLITEDNKEGSIIGEVAAIISESCLFDLDAPIQRLAGPDIPAM
CCCHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCC
PYAPTMEKYFMVNPDKVEKAMRELAEY
CCCCCCCCEEEECHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]