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The map label for this gene is pdp [H]

Identifier: 23099299

GI number: 23099299

Start: 1875948

End: 1877240

Strand: Reverse

Name: pdp [H]

Synonym: OB1844

Alternate gene names: 23099299

Gene position: 1877240-1875948 (Counterclockwise)

Preceding gene: 23099300

Following gene: 23099297

Centisome position: 51.71

GC content: 33.26

Gene sequence:

>1293_bases
ATGAATACGGTAGAAATTATTAATAAGAAAAAATATGGAGAAGTGTTAACTTACGAAGAATTACAGCATGTAATTACTGG
ATATGTAGAAGGAAGTATTCCCGATTATCAAGTATCTTCTCTATTAATGGCAATTTATTTTAATGGATTAACGAATCAGG
AAACATCTGACTTGACTGAAATTATGGTGAATTCCGGAGATCAGATAGATATGTCATTCTTAAATACAATTGTGGTAGAT
AAGCATTCTACAGGTGGTGTAGGAGATAAAGTCAGTCTAATTGTGGCACCAATTATCGCTTCATTAGGTATTCCATTTGC
AAAGATGAGTGGAAGAGGTCTAGGACATACGGGAGGTACAGTAGACAAGTTAGAATCTATTGAAGGATTTCACACAGAAT
TACCATTAGATAAATTTAAAGAACAAGTGAAAGAGCAAGGTATCGCATTAGTTGGACAATCCGGAAACTTAGTACCTGCA
GATAAAAAATTATATGCATTACGTGATGTAACAGGTACAGTGGATTCGATTCCTTTAATTGCTAGCTCTATTATGAGCAA
AAAAATTGCTTCAGGAGCAGATTCGATTGTATTAGATATAAAAGTTGGTAATGGTGCTTTTATGAAAACGGTAGAAGAAG
CTGAAAAACTAGCTACTGCTATGGTTGAAATTGGTAAAAAATTAGATCGTGAAACAGTTGCTGTACTTACAAGAATGGAC
CAGCCTTTAGGAGATGAAATTGGCAATGCGAATGAAGTTATTGAAGCTATAAAATTACTACGGGATAATGATTATAGCAA
AGATATTTATGATGTATCTGTAGAGATTGCTTCACAAATGGTATTGCTTGCGAAAAAAGCTTCAACAATTGAAGAAGCAA
AAAGCTTGGTTTCTGATGTAATTACAAATGGTAAGGCGTATAGTAAATTAGTTGAATTTGTTGAAGCACAAGATGGAAAT
ATAGAAAGTGTGAATGAAATAAAAGCTAATCAATCTATTGATGTATTAAGTGATGAGGAAGGGTACTACGCATCTGTGAA
CACACAATCAATTGGTGAGGCTGCTATGCTACTTGGAGCTGGAAGAGAGACGAAAGAAGATCAGATTGATCATCAAGTAG
GAATAACATTCCATGTTAAATTAGGAGATGCAATTAAAAAAGGAGATAAAATTGCAACCATCCATTCAAATAAACAAAAC
AATGATGAAGTTATTCAAAAGATTAAAAAAGCAATGACATATACTACAGAAGCTGTAGAATCGAAGAATAGCGTAATTAA
AATTATCAAGTAA

Upstream 100 bases:

>100_bases
GATCGAAACAACAGATAAAGTGAGAGAGAGCTTTTTACAATTTGTTCGAAATATCATTCAATCAATGTAATGGTACAAGT
TTGGAGAGGGTGGAGAAATT

Downstream 100 bases:

>100_bases
ATTAGAACATAATTTTGTCCTAACCATATTAAGATAAGAAAAAATAAGAACCTAAATTCTTCTAAACCTTATGTTTTTAT
AAGAGGAATTTTAGGTTTTT

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MNTVEIINKKKYGEVLTYEELQHVITGYVEGSIPDYQVSSLLMAIYFNGLTNQETSDLTEIMVNSGDQIDMSFLNTIVVD
KHSTGGVGDKVSLIVAPIIASLGIPFAKMSGRGLGHTGGTVDKLESIEGFHTELPLDKFKEQVKEQGIALVGQSGNLVPA
DKKLYALRDVTGTVDSIPLIASSIMSKKIASGADSIVLDIKVGNGAFMKTVEEAEKLATAMVEIGKKLDRETVAVLTRMD
QPLGDEIGNANEVIEAIKLLRDNDYSKDIYDVSVEIASQMVLLAKKASTIEEAKSLVSDVITNGKAYSKLVEFVEAQDGN
IESVNEIKANQSIDVLSDEEGYYASVNTQSIGEAAMLLGAGRETKEDQIDHQVGITFHVKLGDAIKKGDKIATIHSNKQN
NDEVIQKIKKAMTYTTEAVESKNSVIKIIK

Sequences:

>Translated_430_residues
MNTVEIINKKKYGEVLTYEELQHVITGYVEGSIPDYQVSSLLMAIYFNGLTNQETSDLTEIMVNSGDQIDMSFLNTIVVD
KHSTGGVGDKVSLIVAPIIASLGIPFAKMSGRGLGHTGGTVDKLESIEGFHTELPLDKFKEQVKEQGIALVGQSGNLVPA
DKKLYALRDVTGTVDSIPLIASSIMSKKIASGADSIVLDIKVGNGAFMKTVEEAEKLATAMVEIGKKLDRETVAVLTRMD
QPLGDEIGNANEVIEAIKLLRDNDYSKDIYDVSVEIASQMVLLAKKASTIEEAKSLVSDVITNGKAYSKLVEFVEAQDGN
IESVNEIKANQSIDVLSDEEGYYASVNTQSIGEAAMLLGAGRETKEDQIDHQVGITFHVKLGDAIKKGDKIATIHSNKQN
NDEVIQKIKKAMTYTTEAVESKNSVIKIIK
>Mature_430_residues
MNTVEIINKKKYGEVLTYEELQHVITGYVEGSIPDYQVSSLLMAIYFNGLTNQETSDLTEIMVNSGDQIDMSFLNTIVVD
KHSTGGVGDKVSLIVAPIIASLGIPFAKMSGRGLGHTGGTVDKLESIEGFHTELPLDKFKEQVKEQGIALVGQSGNLVPA
DKKLYALRDVTGTVDSIPLIASSIMSKKIASGADSIVLDIKVGNGAFMKTVEEAEKLATAMVEIGKKLDRETVAVLTRMD
QPLGDEIGNANEVIEAIKLLRDNDYSKDIYDVSVEIASQMVLLAKKASTIEEAKSLVSDVITNGKAYSKLVEFVEAQDGN
IESVNEIKANQSIDVLSDEEGYYASVNTQSIGEAAMLLGAGRETKEDQIDHQVGITFHVKLGDAIKKGDKIATIHSNKQN
NDEVIQKIKKAMTYTTEAVESKNSVIKIIK

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=407, Percent_Identity=35.3808353808354, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI4503445, Length=407, Percent_Identity=35.3808353808354, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI166158922, Length=407, Percent_Identity=35.3808353808354, Blast_Score=241, Evalue=1e-63,
Organism=Escherichia coli, GI1790842, Length=404, Percent_Identity=41.3366336633663, Blast_Score=307, Evalue=1e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 46563; Mature: 46563

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTVEIINKKKYGEVLTYEELQHVITGYVEGSIPDYQVSSLLMAIYFNGLTNQETSDLTE
CCCHHHHCCHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHH
IMVNSGDQIDMSFLNTIVVDKHSTGGVGDKVSLIVAPIIASLGIPFAKMSGRGLGHTGGT
HHHCCCCEEHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
VDKLESIEGFHTELPLDKFKEQVKEQGIALVGQSGNLVPADKKLYALRDVTGTVDSIPLI
HHHHHHHCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCHHEEHHHCCCCHHHHHHH
ASSIMSKKIASGADSIVLDIKVGNGAFMKTVEEAEKLATAMVEIGKKLDRETVAVLTRMD
HHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QPLGDEIGNANEVIEAIKLLRDNDYSKDIYDVSVEIASQMVLLAKKASTIEEAKSLVSDV
CCCCHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITNGKAYSKLVEFVEAQDGNIESVNEIKANQSIDVLSDEEGYYASVNTQSIGEAAMLLGA
HHCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEECCCCCEEECCCHHHHHHHHHHCC
GRETKEDQIDHQVGITFHVKLGDAIKKGDKIATIHSNKQNNDEVIQKIKKAMTYTTEAVE
CCCCCHHHHHHEECEEEEEEECHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
SKNSVIKIIK
CCCCEEEEEC
>Mature Secondary Structure
MNTVEIINKKKYGEVLTYEELQHVITGYVEGSIPDYQVSSLLMAIYFNGLTNQETSDLTE
CCCHHHHCCHHCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHH
IMVNSGDQIDMSFLNTIVVDKHSTGGVGDKVSLIVAPIIASLGIPFAKMSGRGLGHTGGT
HHHCCCCEEHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCC
VDKLESIEGFHTELPLDKFKEQVKEQGIALVGQSGNLVPADKKLYALRDVTGTVDSIPLI
HHHHHHHCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCHHEEHHHCCCCHHHHHHH
ASSIMSKKIASGADSIVLDIKVGNGAFMKTVEEAEKLATAMVEIGKKLDRETVAVLTRMD
HHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QPLGDEIGNANEVIEAIKLLRDNDYSKDIYDVSVEIASQMVLLAKKASTIEEAKSLVSDV
CCCCHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITNGKAYSKLVEFVEAQDGNIESVNEIKANQSIDVLSDEEGYYASVNTQSIGEAAMLLGA
HHCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEECCCCCEEECCCHHHHHHHHHHCC
GRETKEDQIDHQVGITFHVKLGDAIKKGDKIATIHSNKQNNDEVIQKIKKAMTYTTEAVE
CCCCCHHHHHHEECEEEEEEECHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
SKNSVIKIIK
CCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550462; 8867804; 9384377; 10568751 [H]