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The map label for this gene is lysA [H]

Identifier: 23099288

GI number: 23099288

Start: 1866166

End: 1867473

Strand: Reverse

Name: lysA [H]

Synonym: OB1833

Alternate gene names: 23099288

Gene position: 1867473-1866166 (Counterclockwise)

Preceding gene: 23099289

Following gene: 23099287

Centisome position: 51.44

GC content: 34.94

Gene sequence:

>1308_bases
ATGATAATAGATACTCACCCTTTCACAGTTAATGAAAAAGGACATTTGGAAATAGGCGGTTTGGATACACTTGATTTAGC
AAAGAAATACGGCACTCCTTTGTATGTGTATGACGTTGCACTTATCAGAAATAATGCACGGGCGTTTGTTCAAGCATTTA
CAGAAAAAGGTGTTAAAGGAAAGGTCGCTTATGCTAGTAAAGCTTTTTCTTCTATAGCTATGCTTCAGGTGGCTAAACAA
GAAGGATTATGTCTTGATGTTATATCAGAAGGAGAATTATATACAGCTTTACAAGCTGAGTTCCCAACTGAACGAATACA
TATGCATGGGAATAATAAAAGTATCGAAGAAATTAGAATGGCAGTCGATTATGAAATTGGTTGTATAGTTATTGATAACT
TTCATGATATCGATCTGTTGGAAAAAGTTTTAGAAGAAAAACAAAAACAAATGGATGTTTTAATTCGTGTAACTCCTGGT
GTTGAATCGAAAACACATCAATATATTATGACAGGCAATGAAGACTCTAAGTTTGGATTTGATTTGCAGAATGGACAAGC
TGAACAAGCATTTAAACGTTTACATAATCATCAGCAAATTCGTTTTCAAGGGTTGCACTGTCATATAGGATCTCAAATAT
TCGAAACAAGTGGATTTCAAGTAGCTACAGATTTATTATTTTCAGAACTTGAAAAATGGAATAATAAATACGACTATCAG
CCCAATGTTCTTAATTTAGGCGGAGGTTTTGGAATTCGCTATACAAAAGACGACCAACCACTACCGTTAGATAAATATAT
AAAGAGTATGGCAGATGCTGTACAAACACATGTCAAACAGCTTTCGATGGAAATGCCAGAGATTTGGATTGAGCCTGGCA
GATCGATTGTAGGAAATGCTGGTATTACCTTATATACCATTGGATCAAATAAACAAATACCAGGTATAAGAGAATATTAT
TCAATTGATGGTGGTATGACAGATAATATTAGACCCGCTCTGTATAATGCAGCATATGAAGCGGTTATTGCAAATCATCC
AAAGAATCCCATAGAAAAAGAAGTATCAATTGCCGGTAAATGTTGTGAATCTGGTGACATGCTTATTTGGGATTTACCTG
TACCAGAAATTAATAGTGGTGATGTACTAGCCGTATTTTCAACAGGTGCTTATAGCTATTCTATGGCAAGCCATTATAAC
CGTCTTCCAAATGCAGCTGTAGTATTTGTGGAAAATGGAAGAGATCAATTAGTCGTTAGGCGAGAAACATATCAAGATGT
AGTTCGTAATGATTTATCCTATGAATAA

Upstream 100 bases:

>100_bases
CTTACTTTTTAAGCATCTTGATTTCAACTCACACTTTTGTTTTTTACAGTGTTGTGATAAAGTGTTTTTATTATTTGAAA
TTACGGGGGAAATTAGAATT

Downstream 100 bases:

>100_bases
GAAGTTCTTTATTTATATATTTGACAAGAAGTGATAAAATAGGTGAGAATCTATGATATAAGGAGTTAATAACTATGAAA
ACAGGATATGTTTTAATGGA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MIIDTHPFTVNEKGHLEIGGLDTLDLAKKYGTPLYVYDVALIRNNARAFVQAFTEKGVKGKVAYASKAFSSIAMLQVAKQ
EGLCLDVISEGELYTALQAEFPTERIHMHGNNKSIEEIRMAVDYEIGCIVIDNFHDIDLLEKVLEEKQKQMDVLIRVTPG
VESKTHQYIMTGNEDSKFGFDLQNGQAEQAFKRLHNHQQIRFQGLHCHIGSQIFETSGFQVATDLLFSELEKWNNKYDYQ
PNVLNLGGGFGIRYTKDDQPLPLDKYIKSMADAVQTHVKQLSMEMPEIWIEPGRSIVGNAGITLYTIGSNKQIPGIREYY
SIDGGMTDNIRPALYNAAYEAVIANHPKNPIEKEVSIAGKCCESGDMLIWDLPVPEINSGDVLAVFSTGAYSYSMASHYN
RLPNAAVVFVENGRDQLVVRRETYQDVVRNDLSYE

Sequences:

>Translated_435_residues
MIIDTHPFTVNEKGHLEIGGLDTLDLAKKYGTPLYVYDVALIRNNARAFVQAFTEKGVKGKVAYASKAFSSIAMLQVAKQ
EGLCLDVISEGELYTALQAEFPTERIHMHGNNKSIEEIRMAVDYEIGCIVIDNFHDIDLLEKVLEEKQKQMDVLIRVTPG
VESKTHQYIMTGNEDSKFGFDLQNGQAEQAFKRLHNHQQIRFQGLHCHIGSQIFETSGFQVATDLLFSELEKWNNKYDYQ
PNVLNLGGGFGIRYTKDDQPLPLDKYIKSMADAVQTHVKQLSMEMPEIWIEPGRSIVGNAGITLYTIGSNKQIPGIREYY
SIDGGMTDNIRPALYNAAYEAVIANHPKNPIEKEVSIAGKCCESGDMLIWDLPVPEINSGDVLAVFSTGAYSYSMASHYN
RLPNAAVVFVENGRDQLVVRRETYQDVVRNDLSYE
>Mature_435_residues
MIIDTHPFTVNEKGHLEIGGLDTLDLAKKYGTPLYVYDVALIRNNARAFVQAFTEKGVKGKVAYASKAFSSIAMLQVAKQ
EGLCLDVISEGELYTALQAEFPTERIHMHGNNKSIEEIRMAVDYEIGCIVIDNFHDIDLLEKVLEEKQKQMDVLIRVTPG
VESKTHQYIMTGNEDSKFGFDLQNGQAEQAFKRLHNHQQIRFQGLHCHIGSQIFETSGFQVATDLLFSELEKWNNKYDYQ
PNVLNLGGGFGIRYTKDDQPLPLDKYIKSMADAVQTHVKQLSMEMPEIWIEPGRSIVGNAGITLYTIGSNKQIPGIREYY
SIDGGMTDNIRPALYNAAYEAVIANHPKNPIEKEVSIAGKCCESGDMLIWDLPVPEINSGDVLAVFSTGAYSYSMASHYN
RLPNAAVVFVENGRDQLVVRRETYQDVVRNDLSYE

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=414, Percent_Identity=27.7777777777778, Blast_Score=140, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24586472, Length=349, Percent_Identity=24.6418338108883, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 48877; Mature: 48877

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU ; PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIDTHPFTVNEKGHLEIGGLDTLDLAKKYGTPLYVYDVALIRNNARAFVQAFTEKGVKG
CEECCCCEEECCCCCEEECCCCHHHHHHHHCCCEEEEEEEEHHCCHHHHHHHHHHCCCCC
KVAYASKAFSSIAMLQVAKQEGLCLDVISEGELYTALQAEFPTERIHMHGNNKSIEEIRM
EEHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEECCCCCCEEEEECCCCCHHHHHH
AVDYEIGCIVIDNFHDIDLLEKVLEEKQKQMDVLIRVTPGVESKTHQYIMTGNEDSKFGF
HCCEEEEEEEECCCCCHHHHHHHHHHHHHCEEEEEEECCCCCCCCCEEEEECCCCCCCCC
DLQNGQAEQAFKRLHNHQQIRFQGLHCHIGSQIFETSGFQVATDLLFSELEKWNNKYDYQ
CCCCCCHHHHHHHHCCCCEEEEEEEEEECCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
PNVLNLGGGFGIRYTKDDQPLPLDKYIKSMADAVQTHVKQLSMEMPEIWIEPGRSIVGNA
CCEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHEECCCCEEECCC
GITLYTIGSNKQIPGIREYYSIDGGMTDNIRPALYNAAYEAVIANHPKNPIEKEVSIAGK
CEEEEECCCCCCCCCHHHHEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
CCESGDMLIWDLPVPEINSGDVLAVFSTGAYSYSMASHYNRLPNAAVVFVENGRDQLVVR
CCCCCCEEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCEEEEEEECCCCEEEEE
RETYQDVVRNDLSYE
HHHHHHHHHHCCCCC
>Mature Secondary Structure
MIIDTHPFTVNEKGHLEIGGLDTLDLAKKYGTPLYVYDVALIRNNARAFVQAFTEKGVKG
CEECCCCEEECCCCCEEECCCCHHHHHHHHCCCEEEEEEEEHHCCHHHHHHHHHHCCCCC
KVAYASKAFSSIAMLQVAKQEGLCLDVISEGELYTALQAEFPTERIHMHGNNKSIEEIRM
EEHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEEEECCCCCCEEEEECCCCCHHHHHH
AVDYEIGCIVIDNFHDIDLLEKVLEEKQKQMDVLIRVTPGVESKTHQYIMTGNEDSKFGF
HCCEEEEEEEECCCCCHHHHHHHHHHHHHCEEEEEEECCCCCCCCCEEEEECCCCCCCCC
DLQNGQAEQAFKRLHNHQQIRFQGLHCHIGSQIFETSGFQVATDLLFSELEKWNNKYDYQ
CCCCCCHHHHHHHHCCCCEEEEEEEEEECCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
PNVLNLGGGFGIRYTKDDQPLPLDKYIKSMADAVQTHVKQLSMEMPEIWIEPGRSIVGNA
CCEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHEECCCCEEECCC
GITLYTIGSNKQIPGIREYYSIDGGMTDNIRPALYNAAYEAVIANHPKNPIEKEVSIAGK
CEEEEECCCCCCCCCHHHHEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
CCESGDMLIWDLPVPEINSGDVLAVFSTGAYSYSMASHYNRLPNAAVVFVENGRDQLVVR
CCCCCCEEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCEEEEEEECCCCEEEEE
RETYQDVVRNDLSYE
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2513554; 7934829; 1368705; 8969508; 9384377 [H]