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The map label for this gene is recQ [H]

Identifier: 23099269

GI number: 23099269

Start: 1849719

End: 1851272

Strand: Reverse

Name: recQ [H]

Synonym: OB1814

Alternate gene names: 23099269

Gene position: 1851272-1849719 (Counterclockwise)

Preceding gene: 23099270

Following gene: 23099268

Centisome position: 50.99

GC content: 35.26

Gene sequence:

>1554_bases
ATGGTACAACCCAACGTTAACTTACAGCAAACTCTTAAATATTATTTCCAATATGATAGTTTCCGCCAAGGACAGGAAGA
AATTATTACCGACGTAATGAATGGTAATGATGTTCTGGGAGTGCTGCCAACAGGTTCTGGAAAGTCAATTTGCTATCAGC
TTCCAGCAATTTTACAAGATGGAGTGACAATTGTTGTATCTCCATTAATTTCATTAATGATCGATCAAGTAAAGGAATTA
AAAGCAAAGGGAATTAAAAAGGTTATCGCTTTGAACAGTTTTCTATCTAGAGAAGAAAGGTATAATGTTCTAACTAATCT
AGGGGATTATCGTCTGATATATGTCTCGCCTGAATGGCTTCAGAATGCTTCCTTTGTTCATAAATTGAAACAAATTAATG
TTACATTATTCGTAATTGACGAAGCTCATTGTATATCGCAATGGGGACATGAGTTTCGGCCAGATTACCTGAAACTTCAT
GACATCATTGCTAAACTAGAAAATCCTACTATCTTAGCATTGAGTGCGACCGCAACTCCGGATGTACAAGAAGATATCAT
TCATAGTTTAAATAGATCTCATATAACAAAACATATCTTTCCAATGGATAGAGATAATATCGCTTTTTGTATAGAGACGA
TGGATAGTATAAACGAAAAGAAGGAGCGAATTCAGGAATTAATTCAACAATATCATGTACCAACTCTTATTTATTTTACA
AGTCGATATTTAGCAGAGGAAACTTCTAGGTGGTTATCCTCCATCGTGCCAGACAGAAATATTGCTTATTATCATGGTGG
GATGGAAGCGACCGATCGAGTTCATATTCAACAACAATTTATGAATAACCAGCTAGATGTAATTTGTTGTACAAGTGCTT
TTGGTATGGGAATCAATAAATCCGATATAAGACTTGTTATACATTATCATCTACCATCGCAAATAGAATCCTATATTCAA
GAAGTTGGAAGAGCAGGAAGAGATGGGGAAGAGAGTGTGGCGGTGATCTTATATGCTACTGGTGACTGGATATTACCTAA
ACAAATTATTCAACAAGAACTTCCAATGAAAGAAGATATTTACCGGATGATTGATTGGCTAAAGGGATTATCAAATCAAG
ATCAAAGCACCCTAATTGATGAAGAAGTAATTGCCAATCTACAGATTAGCGAAGTTCAGTGGAGGTTCATACGGTCACAG
CTAGAAAAACATGATATGATAGTGGAAAATCAACTGATTACAGAAGATGTTAATATAGAAAATATAAAGGCTAAAATCAC
GAATCATATAGAAGACCGACTAACCTACAAAGAGAAAAAACTCAAAGAGATGATCCACTGGGTAAATAGTGATCAATGCT
ACCGTGAAAAACTCTACATGCCATTTCAAAACAGCTATCGTCCAAGTATAGGACAATGTTGTAGTAATTGTGGTTTTCAG
TGGAGTAATTGGCAGCCGGAAACAATCATTATTAAATCTCGTGAATCTTTATCGTGGGAAAGTAAATTACAATCTATTTT
TCATATAACCGGGGTAGAACATGAGACAAGATGA

Upstream 100 bases:

>100_bases
TTTCGTCTTCGAGAAATTAAACAATCCGTCGATACGAATATTAGTTATTTTGAAATTAGACTTACTTTAACGTTACTAGG
TACGAATAGGGAGGAAACCA

Downstream 100 bases:

>100_bases
AATCATAAAGCAATTATCCGATAAAGAATTAAGATTTCAATTAGTTTTTTCTCAAATTTTATTTTTAGCTGGAAGTATTT
TATTAAGTTTTATTTTGTTT

Product: ATP-dependent DNA helicase

Products: NA

Alternate protein names: Recombination protein S [H]

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MVQPNVNLQQTLKYYFQYDSFRQGQEEIITDVMNGNDVLGVLPTGSGKSICYQLPAILQDGVTIVVSPLISLMIDQVKEL
KAKGIKKVIALNSFLSREERYNVLTNLGDYRLIYVSPEWLQNASFVHKLKQINVTLFVIDEAHCISQWGHEFRPDYLKLH
DIIAKLENPTILALSATATPDVQEDIIHSLNRSHITKHIFPMDRDNIAFCIETMDSINEKKERIQELIQQYHVPTLIYFT
SRYLAEETSRWLSSIVPDRNIAYYHGGMEATDRVHIQQQFMNNQLDVICCTSAFGMGINKSDIRLVIHYHLPSQIESYIQ
EVGRAGRDGEESVAVILYATGDWILPKQIIQQELPMKEDIYRMIDWLKGLSNQDQSTLIDEEVIANLQISEVQWRFIRSQ
LEKHDMIVENQLITEDVNIENIKAKITNHIEDRLTYKEKKLKEMIHWVNSDQCYREKLYMPFQNSYRPSIGQCCSNCGFQ
WSNWQPETIIIKSRESLSWESKLQSIFHITGVEHETR

Sequences:

>Translated_517_residues
MVQPNVNLQQTLKYYFQYDSFRQGQEEIITDVMNGNDVLGVLPTGSGKSICYQLPAILQDGVTIVVSPLISLMIDQVKEL
KAKGIKKVIALNSFLSREERYNVLTNLGDYRLIYVSPEWLQNASFVHKLKQINVTLFVIDEAHCISQWGHEFRPDYLKLH
DIIAKLENPTILALSATATPDVQEDIIHSLNRSHITKHIFPMDRDNIAFCIETMDSINEKKERIQELIQQYHVPTLIYFT
SRYLAEETSRWLSSIVPDRNIAYYHGGMEATDRVHIQQQFMNNQLDVICCTSAFGMGINKSDIRLVIHYHLPSQIESYIQ
EVGRAGRDGEESVAVILYATGDWILPKQIIQQELPMKEDIYRMIDWLKGLSNQDQSTLIDEEVIANLQISEVQWRFIRSQ
LEKHDMIVENQLITEDVNIENIKAKITNHIEDRLTYKEKKLKEMIHWVNSDQCYREKLYMPFQNSYRPSIGQCCSNCGFQ
WSNWQPETIIIKSRESLSWESKLQSIFHITGVEHETR
>Mature_517_residues
MVQPNVNLQQTLKYYFQYDSFRQGQEEIITDVMNGNDVLGVLPTGSGKSICYQLPAILQDGVTIVVSPLISLMIDQVKEL
KAKGIKKVIALNSFLSREERYNVLTNLGDYRLIYVSPEWLQNASFVHKLKQINVTLFVIDEAHCISQWGHEFRPDYLKLH
DIIAKLENPTILALSATATPDVQEDIIHSLNRSHITKHIFPMDRDNIAFCIETMDSINEKKERIQELIQQYHVPTLIYFT
SRYLAEETSRWLSSIVPDRNIAYYHGGMEATDRVHIQQQFMNNQLDVICCTSAFGMGINKSDIRLVIHYHLPSQIESYIQ
EVGRAGRDGEESVAVILYATGDWILPKQIIQQELPMKEDIYRMIDWLKGLSNQDQSTLIDEEVIANLQISEVQWRFIRSQ
LEKHDMIVENQLITEDVNIENIKAKITNHIEDRLTYKEKKLKEMIHWVNSDQCYREKLYMPFQNSYRPSIGQCCSNCGFQ
WSNWQPETIIIKSRESLSWESKLQSIFHITGVEHETR

Specific function: Probable DNA helicase. Required in synaptic and/or post- synaptic stages of recombination. Probably has overlapping function with recQ (AC O34748). It probably acts to help generate ss-DNA from ds-DNA breaks [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI51242947, Length=362, Percent_Identity=37.292817679558, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI51242943, Length=362, Percent_Identity=37.292817679558, Blast_Score=232, Evalue=7e-61,
Organism=Homo sapiens, GI148612816, Length=362, Percent_Identity=37.292817679558, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI110735439, Length=375, Percent_Identity=36.5333333333333, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI169218196, Length=375, Percent_Identity=36.5333333333333, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI4557365, Length=364, Percent_Identity=36.2637362637363, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI14591902, Length=376, Percent_Identity=33.2446808510638, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI14591904, Length=376, Percent_Identity=33.2446808510638, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI284005309, Length=369, Percent_Identity=34.1463414634146, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI222352149, Length=343, Percent_Identity=23.3236151603499, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI188035877, Length=331, Percent_Identity=22.9607250755287, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI13514831, Length=383, Percent_Identity=20.88772845953, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI7661920, Length=362, Percent_Identity=21.8232044198895, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI48994977, Length=341, Percent_Identity=42.2287390029325, Blast_Score=269, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI25145561, Length=361, Percent_Identity=39.0581717451524, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI71987997, Length=367, Percent_Identity=37.6021798365123, Blast_Score=224, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI71987993, Length=367, Percent_Identity=37.6021798365123, Blast_Score=224, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI32564293, Length=354, Percent_Identity=37.2881355932203, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17552866, Length=333, Percent_Identity=36.6366366366366, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17508543, Length=339, Percent_Identity=23.0088495575221, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI86570094, Length=357, Percent_Identity=24.0896358543417, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71995724, Length=364, Percent_Identity=23.6263736263736, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17507121, Length=364, Percent_Identity=23.3516483516484, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17537549, Length=334, Percent_Identity=22.7544910179641, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17507945, Length=377, Percent_Identity=22.0159151193634, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323844, Length=357, Percent_Identity=36.4145658263305, Blast_Score=217, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6324217, Length=339, Percent_Identity=24.188790560472, Blast_Score=81, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6320449, Length=367, Percent_Identity=20.9809264305177, Blast_Score=80, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6320224, Length=352, Percent_Identity=24.1477272727273, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6325138, Length=256, Percent_Identity=24.21875, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6321360, Length=334, Percent_Identity=25.1497005988024, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24646066, Length=402, Percent_Identity=35.8208955223881, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI21358123, Length=348, Percent_Identity=36.4942528735632, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24664226, Length=367, Percent_Identity=32.1525885558583, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI62472181, Length=367, Percent_Identity=32.1525885558583, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI24664230, Length=367, Percent_Identity=32.1525885558583, Blast_Score=191, Evalue=8e-49,
Organism=Drosophila melanogaster, GI24584994, Length=368, Percent_Identity=24.1847826086957, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21355075, Length=392, Percent_Identity=22.7040816326531, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24662330, Length=407, Percent_Identity=21.8673218673219, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24645031, Length=362, Percent_Identity=22.9281767955801, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24666101, Length=331, Percent_Identity=24.773413897281, Blast_Score=66, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR002464
- InterPro:   IPR004589
- InterPro:   IPR001650
- InterPro:   IPR014021 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 60106; Mature: 60106

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQPNVNLQQTLKYYFQYDSFRQGQEEIITDVMNGNDVLGVLPTGSGKSICYQLPAILQD
CCCCCCCHHHHHHHHHHCCHHCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHC
GVTIVVSPLISLMIDQVKELKAKGIKKVIALNSFLSREERYNVLTNLGDYRLIYVSPEWL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHH
QNASFVHKLKQINVTLFVIDEAHCISQWGHEFRPDYLKLHDIIAKLENPTILALSATATP
HCHHHHHHHHHCCEEEEEEECHHHHHHCCHHCCCHHHHHHHHHHHCCCCEEEEEECCCCC
DVQEDIIHSLNRSHITKHIFPMDRDNIAFCIETMDSINEKKERIQELIQQYHVPTLIYFT
CHHHHHHHHHCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
SRYLAEETSRWLSSIVPDRNIAYYHGGMEATDRVHIQQQFMNNQLDVICCTSAFGMGINK
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEECHHHCCCCCC
SDIRLVIHYHLPSQIESYIQEVGRAGRDGEESVAVILYATGDWILPKQIIQQELPMKEDI
CCEEEEEEECCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCHHHHHHHCCCHHHH
YRMIDWLKGLSNQDQSTLIDEEVIANLQISEVQWRFIRSQLEKHDMIVENQLITEDVNIE
HHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCHH
NIKAKITNHIEDRLTYKEKKLKEMIHWVNSDQCYREKLYMPFQNSYRPSIGQCCSNCGFQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCHHHHHHHCCCC
WSNWQPETIIIKSRESLSWESKLQSIFHITGVEHETR
CCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MVQPNVNLQQTLKYYFQYDSFRQGQEEIITDVMNGNDVLGVLPTGSGKSICYQLPAILQD
CCCCCCCHHHHHHHHHHCCHHCCCHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHC
GVTIVVSPLISLMIDQVKELKAKGIKKVIALNSFLSREERYNVLTNLGDYRLIYVSPEWL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHH
QNASFVHKLKQINVTLFVIDEAHCISQWGHEFRPDYLKLHDIIAKLENPTILALSATATP
HCHHHHHHHHHCCEEEEEEECHHHHHHCCHHCCCHHHHHHHHHHHCCCCEEEEEECCCCC
DVQEDIIHSLNRSHITKHIFPMDRDNIAFCIETMDSINEKKERIQELIQQYHVPTLIYFT
CHHHHHHHHHCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
SRYLAEETSRWLSSIVPDRNIAYYHGGMEATDRVHIQQQFMNNQLDVICCTSAFGMGINK
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEECHHHCCCCCC
SDIRLVIHYHLPSQIESYIQEVGRAGRDGEESVAVILYATGDWILPKQIIQQELPMKEDI
CCEEEEEEECCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCHHHHHHHCCCHHHH
YRMIDWLKGLSNQDQSTLIDEEVIANLQISEVQWRFIRSQLEKHDMIVENQLITEDVNIE
HHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCHH
NIKAKITNHIEDRLTYKEKKLKEMIHWVNSDQCYREKLYMPFQNSYRPSIGQCCSNCGFQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCHHHHHHHCCCC
WSNWQPETIIIKSRESLSWESKLQSIFHITGVEHETR
CCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377; 9642195 [H]