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The map label for this gene is ubiE

Identifier: 23099244

GI number: 23099244

Start: 1826019

End: 1826735

Strand: Reverse

Name: ubiE

Synonym: OB1789

Alternate gene names: 23099244

Gene position: 1826735-1826019 (Counterclockwise)

Preceding gene: 23099245

Following gene: 23099243

Centisome position: 50.32

GC content: 35.01

Gene sequence:

>717_bases
ATGGGGAAACCATCATCAAAAGAAGAGCGAGTGCATCATGTTTTTGAAAATATCTATTCCAAATATGATTCCATGAATTC
GATTATATCATTTCAACGTCACAAATCTTGGCGTAAAGATACAATGAAACGCATGAATGTACAAGCAGGAGAAACTGCTT
TAGATGTATGTTGTGGAACAGGGGATTGGTCAATTTCGCTTTCAGAAGCGGTTGGGCAAACAGGAAAAGTAATCGGCCTT
GATTTTAGTAAAAACATGCTCTCGATTGCAAAACAAAAAAAACAGGACTTGCAATTAAATCAACTAGAACTAGTTCACGG
TAATGCGATGGAATTACCTTATGAGGAAAATAGTTTTGATTATGTTACCATTGGATTTGGTTTACGTAATGTGCCGGATT
ATATGACGGTTTTAGAAGAAATGTATCGAGTTGTGAAGCCTGGTGGTAAAGTGGTATGTATTGAAACATCTCAACCTACC
TTAATTGGCTATCGACAAGCATATTACTTTTATTTCAAATTTATAATGCCGATATTAGGTAAATTAATCGCCAAGAGCTA
TAAAGAATATTCTTGGTTACAAGAATCAGCAAAAGATTTCCCGGGGAAAAAAGAATTAAAGGAAATGTTTTTAAATGCTG
GTTTCGATAAAGTAGAAATGAAAAGTTATACAGGTGGAGTTGCTGCAATGCATATGGGCTTTAAAGCATCTCAATAG

Upstream 100 bases:

>100_bases
AAACATTATCAAATCAAACTGCATTTATCACTCATTATATTCAAGATCAACAAAACGATAATGTTAAAATCTCGACTAGA
CTTTAGAGGAAGTGTATTTA

Downstream 100 bases:

>100_bases
TACGTAGAATTGTAAAAGGTAAAATAAGGTGACTTACATGAAACTACCAAAAATTTATGGCTTTTTAAAGAAAGATATGG
AAAGTATAGAATCTGCATTA

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MGKPSSKEERVHHVFENIYSKYDSMNSIISFQRHKSWRKDTMKRMNVQAGETALDVCCGTGDWSISLSEAVGQTGKVIGL
DFSKNMLSIAKQKKQDLQLNQLELVHGNAMELPYEENSFDYVTIGFGLRNVPDYMTVLEEMYRVVKPGGKVVCIETSQPT
LIGYRQAYYFYFKFIMPILGKLIAKSYKEYSWLQESAKDFPGKKELKEMFLNAGFDKVEMKSYTGGVAAMHMGFKASQ

Sequences:

>Translated_238_residues
MGKPSSKEERVHHVFENIYSKYDSMNSIISFQRHKSWRKDTMKRMNVQAGETALDVCCGTGDWSISLSEAVGQTGKVIGL
DFSKNMLSIAKQKKQDLQLNQLELVHGNAMELPYEENSFDYVTIGFGLRNVPDYMTVLEEMYRVVKPGGKVVCIETSQPT
LIGYRQAYYFYFKFIMPILGKLIAKSYKEYSWLQESAKDFPGKKELKEMFLNAGFDKVEMKSYTGGVAAMHMGFKASQ
>Mature_237_residues
GKPSSKEERVHHVFENIYSKYDSMNSIISFQRHKSWRKDTMKRMNVQAGETALDVCCGTGDWSISLSEAVGQTGKVIGLD
FSKNMLSIAKQKKQDLQLNQLELVHGNAMELPYEENSFDYVTIGFGLRNVPDYMTVLEEMYRVVKPGGKVVCIETSQPTL
IGYRQAYYFYFKFIMPILGKLIAKSYKEYSWLQESAKDFPGKKELKEMFLNAGFDKVEMKSYTGGVAAMHMGFKASQ

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2)

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family

Homologues:

Organism=Homo sapiens, GI116063536, Length=272, Percent_Identity=34.1911764705882, Blast_Score=150, Evalue=8e-37,
Organism=Escherichia coli, GI48994983, Length=230, Percent_Identity=40, Blast_Score=189, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17557039, Length=236, Percent_Identity=33.8983050847458, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6323526, Length=248, Percent_Identity=29.8387096774194, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24641702, Length=247, Percent_Identity=32.3886639676113, Blast_Score=143, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIE_OCEIH (Q8CWG0)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692710.1
- ProteinModelPortal:   Q8CWG0
- SMR:   Q8CWG0
- GeneID:   1018283
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1789
- NMPDR:   fig|221109.1.peg.1790
- HOGENOM:   HBG559580
- OMA:   FDVYTIA
- ProtClustDB:   PRK00216
- BioCyc:   OIHE221109:OB1789-MONOMER
- HAMAP:   MF_01813
- InterPro:   IPR014122
- InterPro:   IPR004033
- PANTHER:   PTHR10108:SF24
- TIGRFAMs:   TIGR02752
- TIGRFAMs:   TIGR01934

Pfam domain/function: PF01209 Ubie_methyltran

EC number: 2.1.1.-

Molecular weight: Translated: 27166; Mature: 27034

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: PS01183 UBIE_1; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKPSSKEERVHHVFENIYSKYDSMNSIISFQRHKSWRKDTMKRMNVQAGETALDVCCGT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEECC
GDWSISLSEAVGQTGKVIGLDFSKNMLSIAKQKKQDLQLNQLELVHGNAMELPYEENSFD
CCCEEEHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEECCCEEECCCCCCCCC
YVTIGFGLRNVPDYMTVLEEMYRVVKPGGKVVCIETSQPTLIGYRQAYYFYFKFIMPILG
EEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
KLIAKSYKEYSWLQESAKDFPGKKELKEMFLNAGFDKVEMKSYTGGVAAMHMGFKASQ
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEHHHHCCCHHHHHCCCCCCC
>Mature Secondary Structure 
GKPSSKEERVHHVFENIYSKYDSMNSIISFQRHKSWRKDTMKRMNVQAGETALDVCCGT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEECC
GDWSISLSEAVGQTGKVIGLDFSKNMLSIAKQKKQDLQLNQLELVHGNAMELPYEENSFD
CCCEEEHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEECCCEEECCCCCCCCC
YVTIGFGLRNVPDYMTVLEEMYRVVKPGGKVVCIETSQPTLIGYRQAYYFYFKFIMPILG
EEEECCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
KLIAKSYKEYSWLQESAKDFPGKKELKEMFLNAGFDKVEMKSYTGGVAAMHMGFKASQ
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEHHHHCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376