Click here to switch to the map view.

The map label for this gene is folE2 [H]

Identifier: 23099143

GI number: 23099143

Start: 1727117

End: 1728043

Strand: Reverse

Name: folE2 [H]

Synonym: OB1688

Alternate gene names: 23099143

Gene position: 1728043-1727117 (Counterclockwise)

Preceding gene: 23099144

Following gene: 23099142

Centisome position: 47.6

GC content: 34.74

Gene sequence:

>927_bases
ATGCAACAAATGAAATCAATGCCGAAAAAACAACTTCCGCCTAAGGAAGAACGACATAAATTATTCGGTTCTGTGCCACC
AAAAGAAAGAACGAAACCAATTGAAAAAAATAAAATGGCAGATCTACAAAATACCAAAAGAGACTTTTTATTTAAATTAG
ATGCAGTTGGAATTTCAAATGTTAAATATCCTGTTATTATTCACAGTGATTTAGCACCAAAAGAACAAACAAGTATTGGT
ACATTTGAATTTTCATCTAGTATTCCTACAATGTCCAAGGGTACGAATATGAGTCGTTTCATGGAGTTACTTCAAGAATA
TAGTTCTAGTGGGATGAATGTTTCTATATCAGAATTAAAACGATTCACAAAAGAGCTTTCTGGGAAATTAGAACAGAAAG
ACGCAACTATAGAAGTTAGCTTCCCATGGTTTTTTGAACGTAAAGGTCCAGAATCCCAATCCGCTGGTATGAATCACGCA
GATGCAAAATTATCCGTGACCTATGATAGTAATTCTGGATTCAGTATAGACGTTTCTTTATCAGCTTGGATTACAACATT
ATGTCCATGTTCAAAGGAAATTAGTGAATATAGCGCGCATAACCAAAGAGGTAATGTTACGCTAGAAGCTACTTTAGTAG
AAGATTTTGACGAAGCTAAAATTGATTGGAAATTGGCATTATTAGAAGCTGCAGAAAGTAATGCAAGTGCAAGACTCCAT
CCTGTGCTTAAAAGGACCGATGAAAAAATGGTAACAGAACAAGCATATGAAAATCCACGTTTTGTTGAAGATATGGTTCG
TCTCATTGCAGCAGATTTATATGAAATGCCATTTGTGAGTAAATTTCACGTTTCTTGTCGTAACGAAGAATCCATTCATA
TGCATGACGCAATTGCATCAATAACATACGATAAAAGCTCCGAATAA

Upstream 100 bases:

>100_bases
TTGAATAATTGTTTTCTATTCAGTATACTAAACCCTAGTCAATATGTTTGACTTCATACGATAAAAACAGCACTTCTTTG
CTAGGAAAGGGTGTTTCACC

Downstream 100 bases:

>100_bases
AGGAGATTATTTCATGAAATTTATTTTTATCGGACTAATAAAATTTTATCGAAGCGCTATTAGCCCCTTCACTCCTTCTA
GTTGTCGTTTTTATCCAACT

Product: putative GTP cyclohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MQQMKSMPKKQLPPKEERHKLFGSVPPKERTKPIEKNKMADLQNTKRDFLFKLDAVGISNVKYPVIIHSDLAPKEQTSIG
TFEFSSSIPTMSKGTNMSRFMELLQEYSSSGMNVSISELKRFTKELSGKLEQKDATIEVSFPWFFERKGPESQSAGMNHA
DAKLSVTYDSNSGFSIDVSLSAWITTLCPCSKEISEYSAHNQRGNVTLEATLVEDFDEAKIDWKLALLEAAESNASARLH
PVLKRTDEKMVTEQAYENPRFVEDMVRLIAADLYEMPFVSKFHVSCRNEESIHMHDAIASITYDKSSE

Sequences:

>Translated_308_residues
MQQMKSMPKKQLPPKEERHKLFGSVPPKERTKPIEKNKMADLQNTKRDFLFKLDAVGISNVKYPVIIHSDLAPKEQTSIG
TFEFSSSIPTMSKGTNMSRFMELLQEYSSSGMNVSISELKRFTKELSGKLEQKDATIEVSFPWFFERKGPESQSAGMNHA
DAKLSVTYDSNSGFSIDVSLSAWITTLCPCSKEISEYSAHNQRGNVTLEATLVEDFDEAKIDWKLALLEAAESNASARLH
PVLKRTDEKMVTEQAYENPRFVEDMVRLIAADLYEMPFVSKFHVSCRNEESIHMHDAIASITYDKSSE
>Mature_308_residues
MQQMKSMPKKQLPPKEERHKLFGSVPPKERTKPIEKNKMADLQNTKRDFLFKLDAVGISNVKYPVIIHSDLAPKEQTSIG
TFEFSSSIPTMSKGTNMSRFMELLQEYSSSGMNVSISELKRFTKELSGKLEQKDATIEVSFPWFFERKGPESQSAGMNHA
DAKLSVTYDSNSGFSIDVSLSAWITTLCPCSKEISEYSAHNQRGNVTLEATLVEDFDEAKIDWKLALLEAAESNASARLH
PVLKRTDEKMVTEQAYENPRFVEDMVRLIAADLYEMPFVSKFHVSCRNEESIHMHDAIASITYDKSSE

Specific function: Converts GTP to 7,8-dihydroneopterin triphosphate [H]

COG id: COG1469

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase IV family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022838
- InterPro:   IPR003801
- InterPro:   IPR002042 [H]

Pfam domain/function: PF02649 DUF198 [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 34882; Mature: 34882

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQMKSMPKKQLPPKEERHKLFGSVPPKERTKPIEKNKMADLQNTKRDFLFKLDAVGISN
CCHHHCCCHHCCCCHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHHEEEEECCCCCC
VKYPVIIHSDLAPKEQTSIGTFEFSSSIPTMSKGTNMSRFMELLQEYSSSGMNVSISELK
CEEEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHH
RFTKELSGKLEQKDATIEVSFPWFFERKGPESQSAGMNHADAKLSVTYDSNSGFSIDVSL
HHHHHHCCCCCCCCCEEEEECCEEECCCCCCHHHCCCCCCCCEEEEEEECCCCEEEEEEH
SAWITTLCPCSKEISEYSAHNQRGNVTLEATLVEDFDEAKIDWKLALLEAAESNASARLH
HHHHHHHCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCEEEEEEEHHHCCCCCCCHH
PVLKRTDEKMVTEQAYENPRFVEDMVRLIAADLYEMPFVSKFHVSCRNEESIHMHDAIAS
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEHHHHHHH
ITYDKSSE
EECCCCCC
>Mature Secondary Structure
MQQMKSMPKKQLPPKEERHKLFGSVPPKERTKPIEKNKMADLQNTKRDFLFKLDAVGISN
CCHHHCCCHHCCCCHHHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHHHHEEEEECCCCCC
VKYPVIIHSDLAPKEQTSIGTFEFSSSIPTMSKGTNMSRFMELLQEYSSSGMNVSISELK
CEEEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEHHHHH
RFTKELSGKLEQKDATIEVSFPWFFERKGPESQSAGMNHADAKLSVTYDSNSGFSIDVSL
HHHHHHCCCCCCCCCEEEEECCEEECCCCCCHHHCCCCCCCCEEEEEEECCCCEEEEEEH
SAWITTLCPCSKEISEYSAHNQRGNVTLEATLVEDFDEAKIDWKLALLEAAESNASARLH
HHHHHHHCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCEEEEEEEHHHCCCCCCCHH
PVLKRTDEKMVTEQAYENPRFVEDMVRLIAADLYEMPFVSKFHVSCRNEESIHMHDAIAS
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEHHHHHHH
ITYDKSSE
EECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]