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The map label for this gene is lytS

Identifier: 23099097

GI number: 23099097

Start: 1681944

End: 1683701

Strand: Reverse

Name: lytS

Synonym: OB1642

Alternate gene names: 23099097

Gene position: 1683701-1681944 (Counterclockwise)

Preceding gene: 23099098

Following gene: 23099096

Centisome position: 46.38

GC content: 35.1

Gene sequence:

>1758_bases
TTGATAGAACTAACGATAGTCTTATTCCAACGTATTGGTTTGTTATTATTAATGGCTTTTATCTTAACGAGAATACCTCG
ATTTCGTTCATTGCTAGATAAAGATATTACGTTAAAAACAGTTATCTATCATTCTCTTATATTTGGATTAATAAGTATTA
TTGGAGCACATGTTGGAGTTGTTATGATAGGTAATGAGTTAATCATGCAAGCTTGGATTATAAATGTTGCAGAAAATGAA
GTCTTAATAGGGTTTAGTATCGTTGTTGTGATGATTGCCGGACTACTTGGCGGACCATTTTTAGGATTAGGCACAGGAAT
GGTTGCCGGCTTATATATCATTTTTTTAGGTGGCGGAGGATGGGTTGCAAATAGTTTGATTAATCCTTTAGCTGGCTTAT
TAACTGGATGGGCTGGTCAATTCTTTTCAGATGATCGAGTAATGTCCCCCAATAAAGCACTCTTTATCGGGATATTCCCC
CCTGTTTTACATATGGGATTATTACTTATTATGCTGCCTGACCAACAAATTGGTGTGCAAATTGTAAATACAATCGGTAT
TCCCTTAGTAGTTACTAACTCGATTGCACTGACTATTTTTACGATGATGATACGTTTAGCCTTAAATGAAACAGAACAAG
AGGCTGCTTTAGAGACTAATCGCGCTTTAACAATTGCCGAGAAGGCACTTCCTTTGCTAAGTGAAGAACCAGGTACAATG
AATGCTCGTAAGATGGCTAAGTTACTTTTTAAAGAATTAGATATTGCTGCTATATCGATTACAAACCGAACAACAGTATT
AAGCCACGTCGGATTAGGAGATGATCATCATCAACCTGGTGAGCCATTAAAAATGCGACTTTCTAAAAAAGCAGTTAAAG
ATGGGAGAATACAGATTGCTTATCATCAAAGTGATATCCAATGTGGTGTAGAAAATTGTAAGCTAAAGACAGCCATCATG
GTACCTATATACCGATCAGGCGAAGTAATCGGTTTAATTAATCTATATTACCGACATTCACAACAAATAACAGCAGTCGA
AATAACGTTAGCAAAAGGTTTAGGAACAATTATTTCCAATCAAATAAGCGGACTTGAAGCAGAAAAAATGAAGAAATTAC
TAAAGGAAGCTAAAATGCGTAACTTACAAGCCCAAATAAACCCTCATTTTCTGTTCAATACATTTCATTTAATTCATAGC
CTATTACGGGTAGATGCAGAAAAAGCAAGACACATTCTCGTACAATTAAGTCAGTTTATGAGAGCAAATTTAAAGATTGC
AAGTGAATCCCTTGTTCCGCTTCATAAAGAACTGGAACATTTGCAAGCATATTTAGAAATCGTTCAAGCTCGATTTCCGG
ATCAAATATCGACTTCTATTCATGTAGACGATTATTTGTTAGATATCGAAATTCCACCAGCCACCCTACAACCTCTTGTC
GAAAATAGCATTCAGCATGGTTTATCTCTGTCTACATCTAAAGGGATACTTACCATCAATATAACGAAGACAGATAATAA
TGTCTCGATTGTATTATTGGATAATGGGCAAGGTTTTGAAGAAAAGTTACTTCCAATACTGGGGAAAAAACCATTACATC
AAAATGAAAATAAAGGGAATGGAATTGCACTGTATAATATAAACCAACGCTTAATAAGTTTATTAGGAGAAGATAGTCAA
CTTCATATTCAAAATACAGACAAAGGAAGCATGGTCCAATTTATACTACCATATCGTAACTGTAAGAAAATCATGTGA

Upstream 100 bases:

>100_bases
TAGCTTGTATTGTTGGTTCTTTTCTAGACTCAAATGGTGATCGTGGAAATTATCAAGAAATGTTAATAAGGATTCACACC
AGGATTGGAGTGAATAAATC

Downstream 100 bases:

>100_bases
TCATGCAATAAAATTGAGGAGGTGTATATATTGAAAATTCATATCATGATTGCAGAAGATGAACGATTAGCAAGAGAGGA
GCTTATGTATCTTTTGCAAC

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 585; Mature: 585

Protein sequence:

>585_residues
MIELTIVLFQRIGLLLLMAFILTRIPRFRSLLDKDITLKTVIYHSLIFGLISIIGAHVGVVMIGNELIMQAWIINVAENE
VLIGFSIVVVMIAGLLGGPFLGLGTGMVAGLYIIFLGGGGWVANSLINPLAGLLTGWAGQFFSDDRVMSPNKALFIGIFP
PVLHMGLLLIMLPDQQIGVQIVNTIGIPLVVTNSIALTIFTMMIRLALNETEQEAALETNRALTIAEKALPLLSEEPGTM
NARKMAKLLFKELDIAAISITNRTTVLSHVGLGDDHHQPGEPLKMRLSKKAVKDGRIQIAYHQSDIQCGVENCKLKTAIM
VPIYRSGEVIGLINLYYRHSQQITAVEITLAKGLGTIISNQISGLEAEKMKKLLKEAKMRNLQAQINPHFLFNTFHLIHS
LLRVDAEKARHILVQLSQFMRANLKIASESLVPLHKELEHLQAYLEIVQARFPDQISTSIHVDDYLLDIEIPPATLQPLV
ENSIQHGLSLSTSKGILTINITKTDNNVSIVLLDNGQGFEEKLLPILGKKPLHQNENKGNGIALYNINQRLISLLGEDSQ
LHIQNTDKGSMVQFILPYRNCKKIM

Sequences:

>Translated_585_residues
MIELTIVLFQRIGLLLLMAFILTRIPRFRSLLDKDITLKTVIYHSLIFGLISIIGAHVGVVMIGNELIMQAWIINVAENE
VLIGFSIVVVMIAGLLGGPFLGLGTGMVAGLYIIFLGGGGWVANSLINPLAGLLTGWAGQFFSDDRVMSPNKALFIGIFP
PVLHMGLLLIMLPDQQIGVQIVNTIGIPLVVTNSIALTIFTMMIRLALNETEQEAALETNRALTIAEKALPLLSEEPGTM
NARKMAKLLFKELDIAAISITNRTTVLSHVGLGDDHHQPGEPLKMRLSKKAVKDGRIQIAYHQSDIQCGVENCKLKTAIM
VPIYRSGEVIGLINLYYRHSQQITAVEITLAKGLGTIISNQISGLEAEKMKKLLKEAKMRNLQAQINPHFLFNTFHLIHS
LLRVDAEKARHILVQLSQFMRANLKIASESLVPLHKELEHLQAYLEIVQARFPDQISTSIHVDDYLLDIEIPPATLQPLV
ENSIQHGLSLSTSKGILTINITKTDNNVSIVLLDNGQGFEEKLLPILGKKPLHQNENKGNGIALYNINQRLISLLGEDSQ
LHIQNTDKGSMVQFILPYRNCKKIM
>Mature_585_residues
MIELTIVLFQRIGLLLLMAFILTRIPRFRSLLDKDITLKTVIYHSLIFGLISIIGAHVGVVMIGNELIMQAWIINVAENE
VLIGFSIVVVMIAGLLGGPFLGLGTGMVAGLYIIFLGGGGWVANSLINPLAGLLTGWAGQFFSDDRVMSPNKALFIGIFP
PVLHMGLLLIMLPDQQIGVQIVNTIGIPLVVTNSIALTIFTMMIRLALNETEQEAALETNRALTIAEKALPLLSEEPGTM
NARKMAKLLFKELDIAAISITNRTTVLSHVGLGDDHHQPGEPLKMRLSKKAVKDGRIQIAYHQSDIQCGVENCKLKTAIM
VPIYRSGEVIGLINLYYRHSQQITAVEITLAKGLGTIISNQISGLEAEKMKKLLKEAKMRNLQAQINPHFLFNTFHLIHS
LLRVDAEKARHILVQLSQFMRANLKIASESLVPLHKELEHLQAYLEIVQARFPDQISTSIHVDDYLLDIEIPPATLQPLV
ENSIQHGLSLSTSKGILTINITKTDNNVSIVLLDNGQGFEEKLLPILGKKPLHQNENKGNGIALYNINQRLISLLGEDSQ
LHIQNTDKGSMVQFILPYRNCKKIM

Specific function: Member of the two-component regulatory system lytS/lytT that probably regulates genes involved in cell wall metabolism

COG id: COG3275

COG function: function code T; Putative regulator of cell autolysis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain

Homologues:

Organism=Escherichia coli, GI1788723, Length=580, Percent_Identity=30, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI1788446, Length=588, Percent_Identity=27.891156462585, Blast_Score=219, Evalue=5e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LYTS_OCEIH (Q8EQQ2)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692563.1
- ProteinModelPortal:   Q8EQQ2
- SMR:   Q8EQQ2
- GeneID:   1018137
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1642
- NMPDR:   fig|221109.1.peg.1644
- HOGENOM:   HBG724694
- OMA:   NSIQHGL
- ProtClustDB:   CLSK2462074
- BioCyc:   OIHE221109:OB1642-MONOMER
- BRENDA:   2.7.13.3
- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR010559
- InterPro:   IPR011620
- Gene3D:   G3DSA:3.30.565.10
- SMART:   SM00065
- SMART:   SM00387

Pfam domain/function: PF07694 5TM-5TMR_LYT; PF02518 HATPase_c; PF06580 His_kinase; SSF55874 ATP_bd_ATPase

EC number: =2.7.13.3

Molecular weight: Translated: 64671; Mature: 64671

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xf0c5968)-; HASH(0xe8b0fd4)-; HASH(0xeb28638)-; HASH(0xf1fab9c)-; HASH(0xc65705c)-; HASH(0xe759874)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELTIVLFQRIGLLLLMAFILTRIPRFRSLLDKDITLKTVIYHSLIFGLISIIGAHVGV
CEEEHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCE
VMIGNELIMQAWIINVAENEVLIGFSIVVVMIAGLLGGPFLGLGTGMVAGLYIIFLGGGG
EEECHHHHHHHHHEEECCCCEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEEEECCCH
WVANSLINPLAGLLTGWAGQFFSDDRVMSPNKALFIGIFPPVLHMGLLLIMLPDQQIGVQ
HHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCEEEEEECHHHHHHHEEEEECCCCHHCHH
IVNTIGIPLVVTNSIALTIFTMMIRLALNETEQEAALETNRALTIAEKALPLLSEEPGTM
HHHHCCCCEEEECHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEHHHHCHHHCCCCCCC
NARKMAKLLFKELDIAAISITNRTTVLSHVGLGDDHHQPGEPLKMRLSKKAVKDGRIQIA
CHHHHHHHHHHHCCEEEEEECCCCEEEHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEE
YHQSDIQCGVENCKLKTAIMVPIYRSGEVIGLINLYYRHSQQITAVEITLAKGLGTIISN
EECCCCCCCCCCCEEEEEEEEEEECCCCEEEEEEHHHHCCCCEEEEEEEEHHHHHHHHHH
QISGLEAEKMKKLLKEAKMRNLQAQINPHFLFNTFHLIHSLLRVDAEKARHILVQLSQFM
HHCCCCHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RANLKIASESLVPLHKELEHLQAYLEIVQARFPDQISTSIHVDDYLLDIEIPPATLQPLV
HCCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHCCEEEECEEEEEEECCCHHHHHHH
ENSIQHGLSLSTSKGILTINITKTDNNVSIVLLDNGQGFEEKLLPILGKKPLHQNENKGN
HHHHHHCCCEECCCCEEEEEEEECCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCC
GIALYNINQRLISLLGEDSQLHIQNTDKGSMVQFILPYRNCKKIM
EEEEEECHHHHHHHHCCCCEEEEEECCCCCEEEEEECHHHHHCCH
>Mature Secondary Structure
MIELTIVLFQRIGLLLLMAFILTRIPRFRSLLDKDITLKTVIYHSLIFGLISIIGAHVGV
CEEEHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCE
VMIGNELIMQAWIINVAENEVLIGFSIVVVMIAGLLGGPFLGLGTGMVAGLYIIFLGGGG
EEECHHHHHHHHHEEECCCCEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEEEECCCH
WVANSLINPLAGLLTGWAGQFFSDDRVMSPNKALFIGIFPPVLHMGLLLIMLPDQQIGVQ
HHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCEEEEEECHHHHHHHEEEEECCCCHHCHH
IVNTIGIPLVVTNSIALTIFTMMIRLALNETEQEAALETNRALTIAEKALPLLSEEPGTM
HHHHCCCCEEEECHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEHHHHCHHHCCCCCCC
NARKMAKLLFKELDIAAISITNRTTVLSHVGLGDDHHQPGEPLKMRLSKKAVKDGRIQIA
CHHHHHHHHHHHCCEEEEEECCCCEEEHCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEE
YHQSDIQCGVENCKLKTAIMVPIYRSGEVIGLINLYYRHSQQITAVEITLAKGLGTIISN
EECCCCCCCCCCCEEEEEEEEEEECCCCEEEEEEHHHHCCCCEEEEEEEEHHHHHHHHHH
QISGLEAEKMKKLLKEAKMRNLQAQINPHFLFNTFHLIHSLLRVDAEKARHILVQLSQFM
HHCCCCHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RANLKIASESLVPLHKELEHLQAYLEIVQARFPDQISTSIHVDDYLLDIEIPPATLQPLV
HCCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHCCEEEECEEEEEEECCCHHHHHHH
ENSIQHGLSLSTSKGILTINITKTDNNVSIVLLDNGQGFEEKLLPILGKKPLHQNENKGN
HHHHHHCCCEECCCCEEEEEEEECCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCC
GIALYNINQRLISLLGEDSQLHIQNTDKGSMVQFILPYRNCKKIM
EEEEEECHHHHHHHHCCCCEEEEEECCCCCEEEEEECHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12235376