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The map label for this gene is uppS

Identifier: 23099045

GI number: 23099045

Start: 1626076

End: 1626834

Strand: Direct

Name: uppS

Synonym: OB1590

Alternate gene names: 23099045

Gene position: 1626076-1626834 (Clockwise)

Preceding gene: 23099044

Following gene: 23099046

Centisome position: 44.79

GC content: 35.18

Gene sequence:

>759_bases
ATGTCTATCAAAATTCCTTTTTTATCAAAACAAGTAAAAGAAACGGAACTAGAAGATTGGGATAACATACCCAGTCATAT
TGCTATCATAATGGATGGAAACGGTCGTTGGGCACAAAAACGAGGGTTACCTAGGATTGCTGGACACAGAGAAGGCGTCT
CTACTGTTAATCGAATCGTCAAAACCGCTGTCAATGCAAATGTAAAAGTATTAACACTTTACACATTTTCAACAGAGAAC
TGGAAACGGCCAAAATCTGAAGTGGATTTTATTTTAAAATTACCAAAAGAGTTCCTGCATGTATATTTACCAGGTTTAAT
AGAAAATAATGTTCGTGTACAAACAATTGGTGATTTTAATGCAGTACCTAAGCATACACAGGATGCGATAGAATATGCAA
TGGAGAAAACAAAGGACAACGATGGTTTAGTACTTAATTTTGCGCTAAACTATGGAAGTAGGTATGAAATCATACATGCA
GTAAAACAAATAGTGCAAAAAACAAAAGCATCTGAACTAGACGTAGAACAATTGGATGAAAGCTATTTTGAAAAACATCT
ATTTACGAATGGTTTATCTGATCCAGATTTATTAATTCGTACTGGAGGAGAGTACCGTTTAAGTAACTTTATGCTTTGGC
AGCTTGCTTATACGGAATTTTGGTTTACGGAAAAGCTCTGGCCGGAATTTGATGAAGATACATTTCATCAAGCGTTGATG
GAATATCAACAACGAAAAAGGAGATACGGAGGTATATAA

Upstream 100 bases:

>100_bases
TCATTTACAATATTTAATTGGCATGGTCATGCCTTTCATACCTTTTTCTTCAAGTTAGAAAGAAAGGTTTGTGAATTAAC
AACCATTCGGGGGACGGATT

Downstream 100 bases:

>100_bases
GGTGATGATTTCTTAATGAAACAAAGAACAATTACAGCATTACTTGCACTATTAATCTTTGTCCCATTCATCCTTATCGG
TGGACTTCCATTTATGGTAT

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MSIKIPFLSKQVKETELEDWDNIPSHIAIIMDGNGRWAQKRGLPRIAGHREGVSTVNRIVKTAVNANVKVLTLYTFSTEN
WKRPKSEVDFILKLPKEFLHVYLPGLIENNVRVQTIGDFNAVPKHTQDAIEYAMEKTKDNDGLVLNFALNYGSRYEIIHA
VKQIVQKTKASELDVEQLDESYFEKHLFTNGLSDPDLLIRTGGEYRLSNFMLWQLAYTEFWFTEKLWPEFDEDTFHQALM
EYQQRKRRYGGI

Sequences:

>Translated_252_residues
MSIKIPFLSKQVKETELEDWDNIPSHIAIIMDGNGRWAQKRGLPRIAGHREGVSTVNRIVKTAVNANVKVLTLYTFSTEN
WKRPKSEVDFILKLPKEFLHVYLPGLIENNVRVQTIGDFNAVPKHTQDAIEYAMEKTKDNDGLVLNFALNYGSRYEIIHA
VKQIVQKTKASELDVEQLDESYFEKHLFTNGLSDPDLLIRTGGEYRLSNFMLWQLAYTEFWFTEKLWPEFDEDTFHQALM
EYQQRKRRYGGI
>Mature_251_residues
SIKIPFLSKQVKETELEDWDNIPSHIAIIMDGNGRWAQKRGLPRIAGHREGVSTVNRIVKTAVNANVKVLTLYTFSTENW
KRPKSEVDFILKLPKEFLHVYLPGLIENNVRVQTIGDFNAVPKHTQDAIEYAMEKTKDNDGLVLNFALNYGSRYEIIHAV
KQIVQKTKASELDVEQLDESYFEKHLFTNGLSDPDLLIRTGGEYRLSNFMLWQLAYTEFWFTEKLWPEFDEDTFHQALME
YQQRKRRYGGI

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=245, Percent_Identity=34.6938775510204, Blast_Score=158, Evalue=4e-39,
Organism=Homo sapiens, GI45580742, Length=245, Percent_Identity=34.6938775510204, Blast_Score=158, Evalue=4e-39,
Organism=Escherichia coli, GI1786371, Length=226, Percent_Identity=45.1327433628319, Blast_Score=216, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI71993029, Length=226, Percent_Identity=32.7433628318584, Blast_Score=131, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6319474, Length=228, Percent_Identity=35.5263157894737, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6323748, Length=229, Percent_Identity=32.3144104803493, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI18857969, Length=225, Percent_Identity=35.1111111111111, Blast_Score=147, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_OCEIH (Q8EQU9)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692511.1
- ProteinModelPortal:   Q8EQU9
- SMR:   Q8EQU9
- GeneID:   1017978
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1590
- NMPDR:   fig|221109.1.peg.1592
- HOGENOM:   HBG627837
- OMA:   ACMERGV
- BioCyc:   OIHE221109:OB1590-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 29389; Mature: 29258

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 32-32

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKIPFLSKQVKETELEDWDNIPSHIAIIMDGNGRWAQKRGLPRIAGHREGVSTVNRIV
CEEECCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHCCCCCCCCCCCHHHHHHHHH
KTAVNANVKVLTLYTFSTENWKRPKSEVDFILKLPKEFLHVYLPGLIENNVRVQTIGDFN
HHHHCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
AVPKHTQDAIEYAMEKTKDNDGLVLNFALNYGSRYEIIHAVKQIVQKTKASELDVEQLDE
CCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
SYFEKHLFTNGLSDPDLLIRTGGEYRLSNFMLWQLAYTEFWFTEKLWPEFDEDTFHQALM
HHHHHHHHHCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
EYQQRKRRYGGI
HHHHHHHHCCCC
>Mature Secondary Structure 
SIKIPFLSKQVKETELEDWDNIPSHIAIIMDGNGRWAQKRGLPRIAGHREGVSTVNRIV
EEECCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHCCCCCCCCCCCHHHHHHHHH
KTAVNANVKVLTLYTFSTENWKRPKSEVDFILKLPKEFLHVYLPGLIENNVRVQTIGDFN
HHHHCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
AVPKHTQDAIEYAMEKTKDNDGLVLNFALNYGSRYEIIHAVKQIVQKTKASELDVEQLDE
CCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH
SYFEKHLFTNGLSDPDLLIRTGGEYRLSNFMLWQLAYTEFWFTEKLWPEFDEDTFHQALM
HHHHHHHHHCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
EYQQRKRRYGGI
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376