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The map label for this gene is prpC [H]

Identifier: 23098963

GI number: 23098963

Start: 1552178

End: 1552942

Strand: Direct

Name: prpC [H]

Synonym: OB1508

Alternate gene names: 23098963

Gene position: 1552178-1552942 (Clockwise)

Preceding gene: 23098962

Following gene: 23098964

Centisome position: 42.75

GC content: 38.3

Gene sequence:

>765_bases
GTGGAAGGACATTTTCTTACAGACCGCGGTAAGGTTCGAAATCATAATGAAGATGCTGGTGGATTGTTTTACAATAAAAG
TAATCAACTAATTGCAATTATTGCAGATGGTATGGGCGGTCACCAAGCGGGTGATGTTGCCAGCAAGTTAGCAACGGAAA
GTATTAAACAAAAATGGTTAGAAACTGACCACTTGGGCGGTCCGGAACAAGTGGAAGGCTGGTTAAAAGAAGCAGTTCAA
CAAACGAATCAGCATATATTTAAAAAATCACAGGAAGATAAACGTTGTGAAGGAATGGGGACAACTGTAGTTATTGCTGT
TGCATTAGAGGAATATGTAACGATTGCTCATGTTGGAGATAGCCGCTGTTATCTATTGAATGAAGATGGCTTCCAACAAG
TAACCGAGGATCATTCTTTTGTAAATGAATTAGTTCGTATTGGGCAAATTTCTGAAGATGATGCTGAAATACACCCTCGT
AAAAATGTGATTCTACGTGCGTTAGGAACGGATAATCAGGTCAATGTAGATTTAAAAACATTAACATGGCAAAAAAATGA
TCGATTATTATTGTGCTCGGATGGGTTATCGGATAAGGTAACTGAACACGAGCTAGCTGACTTTACAGATTCTACTAAGG
ATATTGAAGTAATTGGTAATGAACTGATTCAGTTAGCAAATAATCGGGGAGGAGAAGATAATATTTCTCTAATATTAATT
GTCCATCCTGATAGTGCTGAGGAGGCAGGTGAGCCTGTTGAATAA

Upstream 100 bases:

>100_bases
GATAATTTCGTTTTGTTATTGGTAAATTTGTGCAATACTTGATGTAAAGATAGTTAATTATGATTATAATGAAATAAAAT
TGGAGATAGGGGGGGAACAA

Downstream 100 bases:

>100_bases
AGGAGAACTGCTGAATGAACGCTATAAGATAATTAAGAAGATTGGCGGAGGCGGAATGGCCAACGTCTATCTTGCCCGAG
ATACAATACTAGAACGTGAT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MEGHFLTDRGKVRNHNEDAGGLFYNKSNQLIAIIADGMGGHQAGDVASKLATESIKQKWLETDHLGGPEQVEGWLKEAVQ
QTNQHIFKKSQEDKRCEGMGTTVVIAVALEEYVTIAHVGDSRCYLLNEDGFQQVTEDHSFVNELVRIGQISEDDAEIHPR
KNVILRALGTDNQVNVDLKTLTWQKNDRLLLCSDGLSDKVTEHELADFTDSTKDIEVIGNELIQLANNRGGEDNISLILI
VHPDSAEEAGEPVE

Sequences:

>Translated_254_residues
MEGHFLTDRGKVRNHNEDAGGLFYNKSNQLIAIIADGMGGHQAGDVASKLATESIKQKWLETDHLGGPEQVEGWLKEAVQ
QTNQHIFKKSQEDKRCEGMGTTVVIAVALEEYVTIAHVGDSRCYLLNEDGFQQVTEDHSFVNELVRIGQISEDDAEIHPR
KNVILRALGTDNQVNVDLKTLTWQKNDRLLLCSDGLSDKVTEHELADFTDSTKDIEVIGNELIQLANNRGGEDNISLILI
VHPDSAEEAGEPVE
>Mature_254_residues
MEGHFLTDRGKVRNHNEDAGGLFYNKSNQLIAIIADGMGGHQAGDVASKLATESIKQKWLETDHLGGPEQVEGWLKEAVQ
QTNQHIFKKSQEDKRCEGMGTTVVIAVALEEYVTIAHVGDSRCYLLNEDGFQQVTEDHSFVNELVRIGQISEDDAEIHPR
KNVILRALGTDNQVNVDLKTLTWQKNDRLLLCSDGLSDKVTEHELADFTDSTKDIEVIGNELIQLANNRGGEDNISLILI
VHPDSAEEAGEPVE

Specific function: Protein phosphatase that dephosphorylates prkC and fusA (elongation factor G). PrpC and prkC are cotranscribed, which suggests that they form a functional couple in vivo, prpC's primary role being possibly to counter the action of prkC. May be involved in

COG id: COG0631

COG function: function code T; Serine/threonine protein phosphatase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PP2C-like domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015655
- InterPro:   IPR001932
- InterPro:   IPR014045 [H]

Pfam domain/function: PF00481 PP2C [H]

EC number: =3.1.3.16 [H]

Molecular weight: Translated: 28139; Mature: 28139

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGHFLTDRGKVRNHNEDAGGLFYNKSNQLIAIIADGMGGHQAGDVASKLATESIKQKWL
CCCCEECCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
ETDHLGGPEQVEGWLKEAVQQTNQHIFKKSQEDKRCEGMGTTVVIAVALEEYVTIAHVGD
HHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCEEEEEEHHHHEEEEEECC
SRCYLLNEDGFQQVTEDHSFVNELVRIGQISEDDAEIHPRKNVILRALGTDNQVNVDLKT
CEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEE
LTWQKNDRLLLCSDGLSDKVTEHELADFTDSTKDIEVIGNELIQLANNRGGEDNISLILI
EEEECCCCEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEE
VHPDSAEEAGEPVE
ECCCCHHCCCCCCC
>Mature Secondary Structure
MEGHFLTDRGKVRNHNEDAGGLFYNKSNQLIAIIADGMGGHQAGDVASKLATESIKQKWL
CCCCEECCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
ETDHLGGPEQVEGWLKEAVQQTNQHIFKKSQEDKRCEGMGTTVVIAVALEEYVTIAHVGD
HHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCEEEEEEHHHHEEEEEECC
SRCYLLNEDGFQQVTEDHSFVNELVRIGQISEDDAEIHPRKNVILRALGTDNQVNVDLKT
CEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEE
LTWQKNDRLLLCSDGLSDKVTEHELADFTDSTKDIEVIGNELIQLANNRGGEDNISLILI
EEEECCCCEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEE
VHPDSAEEAGEPVE
ECCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]