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The map label for this gene is coaBC [H]

Identifier: 23098959

GI number: 23098959

Start: 1546149

End: 1547357

Strand: Direct

Name: coaBC [H]

Synonym: OB1504

Alternate gene names: 23098959

Gene position: 1546149-1547357 (Clockwise)

Preceding gene: 23098958

Following gene: 23098960

Centisome position: 42.59

GC content: 37.3

Gene sequence:

>1209_bases
ATGCTACAAAACAAGAAAATTTTACTTGGTGTCTCCGGTGGGATAGCTGTATATAAGGCTTGTGGTCTGGCAAGTAAACT
AACTCAAGCAGGTGCAGAAGTCAGAGTGATAATGACAGAAAGCGCACAAGAATTTGTTTCACCGCTAACTTTTCAAGCAT
TGACTAGAAATCCAGTGTATACAGACACATTTGATGAAAAAAATCCGAAAAAAATAGCACATATTGATATAGCTGATTGG
GCGGATATTGCCATTATTGCTCCAGCTACAGCAAATATTATTAGCAAACTGGCTAGTGGACAAGCAGACGATATGCTCTC
AACTACTATGTTAGCGACACAGGCAGAAGTCTATATAGCGCCTGCAATGAATGTACATATGTATGCTCATCCAGCCGTCA
TGAATAATATGAAACAACTTGAATCTTGGGGATATCACTTTATTGAACCGGGTGCAGGTTATTTAGCATGTGGTTATGTT
GGTAAAGGGAGACTAGAAGAACCTGAAGAGATTGTATCTGTTATCCAAAGACATGTATCAAAACAACAATATTTACATGG
GAAGAAAATCCTTATTTCTGCAGGTCCTACACGAGAAACCGTAGATCCTGTCCGTTTTTTCTCCAATCGTTCATCGGGGA
AAATGGGATTTGCCTTGGCAGAAGCAGCCGCAAATCTAGGGGCTGAAGTTACACTTGTTTCAGGTCCGGTAAGTTTACAA
ACTAATCATCCTAATATTAATCGAATCGATATAACCTCTGCTCAAGAGATGTACGATGAGATTACAAGTCGGTTTGACCA
TCAAGATATAGTAATTAAATCAGCAGCGGTTGCTGATTATCGTCCTAAATTCATGCATCAAGGAAAGATGAAGAAAAAGG
ATAGAGATTATACAATTGAAATGGAAAGAACAAAAGATATATTAGCAACACTAGGTGAGCAGAAGAGACATCAATTTTTA
GTAGGGTTTGCTGCTGAAACAGATACACCGATTGAATACGGATTAGGAAAGCTAGATCGTAAAAATTTAGATGCAATTGT
AGTAAACGATATTAGTTCAGATGGTGCAGGTTTTGAGGGAGACACGAATATTGTTACGTATATTAATAAGAAAAAACAGC
AAAAATCAATTCATCAAGCAACAAAATCAGATATAGCTTATCAATTATTTGAATTAATTTCCCAAGACTTAAAGGATGAT
GACCGTTGA

Upstream 100 bases:

>100_bases
GTTCCTGTTCTAAGTATCGTTAATACTTTTGAAAAGCGATTGTTCGTATTATATGTTATAAATAAATTAGAAGGATCGGA
TAGTTGAAGGGGGTAGAGTC

Downstream 100 bases:

>100_bases
ATATAGCTAGTGTTATTGTGGATGTGCCATCTAGTTCAACAAATCAAACATTCGATTATTGTATTCCTGAACAGTTTCAG
GGGGTTATCCAAAAGGGGAT

Product: pantothenate metabolism

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MLQNKKILLGVSGGIAVYKACGLASKLTQAGAEVRVIMTESAQEFVSPLTFQALTRNPVYTDTFDEKNPKKIAHIDIADW
ADIAIIAPATANIISKLASGQADDMLSTTMLATQAEVYIAPAMNVHMYAHPAVMNNMKQLESWGYHFIEPGAGYLACGYV
GKGRLEEPEEIVSVIQRHVSKQQYLHGKKILISAGPTRETVDPVRFFSNRSSGKMGFALAEAAANLGAEVTLVSGPVSLQ
TNHPNINRIDITSAQEMYDEITSRFDHQDIVIKSAAVADYRPKFMHQGKMKKKDRDYTIEMERTKDILATLGEQKRHQFL
VGFAAETDTPIEYGLGKLDRKNLDAIVVNDISSDGAGFEGDTNIVTYINKKKQQKSIHQATKSDIAYQLFELISQDLKDD
DR

Sequences:

>Translated_402_residues
MLQNKKILLGVSGGIAVYKACGLASKLTQAGAEVRVIMTESAQEFVSPLTFQALTRNPVYTDTFDEKNPKKIAHIDIADW
ADIAIIAPATANIISKLASGQADDMLSTTMLATQAEVYIAPAMNVHMYAHPAVMNNMKQLESWGYHFIEPGAGYLACGYV
GKGRLEEPEEIVSVIQRHVSKQQYLHGKKILISAGPTRETVDPVRFFSNRSSGKMGFALAEAAANLGAEVTLVSGPVSLQ
TNHPNINRIDITSAQEMYDEITSRFDHQDIVIKSAAVADYRPKFMHQGKMKKKDRDYTIEMERTKDILATLGEQKRHQFL
VGFAAETDTPIEYGLGKLDRKNLDAIVVNDISSDGAGFEGDTNIVTYINKKKQQKSIHQATKSDIAYQLFELISQDLKDD
DR
>Mature_402_residues
MLQNKKILLGVSGGIAVYKACGLASKLTQAGAEVRVIMTESAQEFVSPLTFQALTRNPVYTDTFDEKNPKKIAHIDIADW
ADIAIIAPATANIISKLASGQADDMLSTTMLATQAEVYIAPAMNVHMYAHPAVMNNMKQLESWGYHFIEPGAGYLACGYV
GKGRLEEPEEIVSVIQRHVSKQQYLHGKKILISAGPTRETVDPVRFFSNRSSGKMGFALAEAAANLGAEVTLVSGPVSLQ
TNHPNINRIDITSAQEMYDEITSRFDHQDIVIKSAAVADYRPKFMHQGKMKKKDRDYTIEMERTKDILATLGEQKRHQFL
VGFAAETDTPIEYGLGKLDRKNLDAIVVNDISSDGAGFEGDTNIVTYINKKKQQKSIHQATKSDIAYQLFELISQDLKDD
DR

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=189, Percent_Identity=35.978835978836, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI87082301, Length=366, Percent_Identity=46.448087431694, Blast_Score=296, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17560194, Length=190, Percent_Identity=33.1578947368421, Blast_Score=88, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6322762, Length=193, Percent_Identity=31.0880829015544, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24657262, Length=187, Percent_Identity=29.9465240641711, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44417; Mature: 44417

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQNKKILLGVSGGIAVYKACGLASKLTQAGAEVRVIMTESAQEFVSPLTFQALTRNPVY
CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHCCHHHHHHCCCCCC
TDTFDEKNPKKIAHIDIADWADIAIIAPATANIISKLASGQADDMLSTTMLATQAEVYIA
CCCCCCCCCCEEEEEECCCCCCEEEECCCHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEE
PAMNVHMYAHPAVMNNMKQLESWGYHFIEPGAGYLACGYVGKGRLEEPEEIVSVIQRHVS
ECCEEEEEECHHHHHHHHHHHHCCCEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHH
KQQYLHGKKILISAGPTRETVDPVRFFSNRSSGKMGFALAEAAANLGAEVTLVSGPVSLQ
HHHHHCCCEEEEECCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEECCEEEE
TNHPNINRIDITSAQEMYDEITSRFDHQDIVIKSAAVADYRPKFMHQGKMKKKDRDYTIE
ECCCCCCEEECCCHHHHHHHHHHHCCCCCEEEEEHHHHCCCHHHHHCCCCCCCCCCEEEE
MERTKDILATLGEQKRHQFLVGFAAETDTPIEYGLGKLDRKNLDAIVVNDISSDGAGFEG
EHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHCCCCCCCCCCCEEEEECCCCCCCCCCC
DTNIVTYINKKKQQKSIHQATKSDIAYQLFELISQDLKDDDR
CCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLQNKKILLGVSGGIAVYKACGLASKLTQAGAEVRVIMTESAQEFVSPLTFQALTRNPVY
CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHCCHHHHHHCCCCCC
TDTFDEKNPKKIAHIDIADWADIAIIAPATANIISKLASGQADDMLSTTMLATQAEVYIA
CCCCCCCCCCEEEEEECCCCCCEEEECCCHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEE
PAMNVHMYAHPAVMNNMKQLESWGYHFIEPGAGYLACGYVGKGRLEEPEEIVSVIQRHVS
ECCEEEEEECHHHHHHHHHHHHCCCEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHH
KQQYLHGKKILISAGPTRETVDPVRFFSNRSSGKMGFALAEAAANLGAEVTLVSGPVSLQ
HHHHHCCCEEEEECCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEECCEEEE
TNHPNINRIDITSAQEMYDEITSRFDHQDIVIKSAAVADYRPKFMHQGKMKKKDRDYTIE
ECCCCCCEEECCCHHHHHHHHHHHCCCCCEEEEEHHHHCCCHHHHHCCCCCCCCCCEEEE
MERTKDILATLGEQKRHQFLVGFAAETDTPIEYGLGKLDRKNLDAIVVNDISSDGAGFEG
EHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHCCCCCCCCCCCEEEEECCCCCCCCCCC
DTNIVTYINKKKQQKSIHQATKSDIAYQLFELISQDLKDDDR
CCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]