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The map label for this gene is pyrD

Identifier: 23098948

GI number: 23098948

Start: 1535091

End: 1536005

Strand: Direct

Name: pyrD

Synonym: OB1493

Alternate gene names: 23098948

Gene position: 1535091-1536005 (Clockwise)

Preceding gene: 23098947

Following gene: 23098949

Centisome position: 42.28

GC content: 38.36

Gene sequence:

>915_bases
ATGAATCTGTCAGTAAAATTACCAGGATTAAACTTAAAAAATCCGATCATGCCGGCATCTGGTTGTTTTGGGTTTGGAAA
AGAATACAGTGAGTATTATGATTTAAGTCTTTTAGGTGGAGTAATGATGAAAGCAGCCACTCAATTTGAAAGATTAGGTA
ATCCAACTCCACGTGTCGCAGAAACTAGTGCAGGAATGTTAAATGCAATAGGTCTTCAAAATCCAGGAGTCCAACAAATA
ATTGACCATGAAGTGCCGCGACTTGCAAAATACGATACATCCATTATTGCAAATATTGCTGGTAGTTCTATTGAGGAATA
TGAGTTTGTAGCAGCTTCATTTAACCAAACAACAGATGTAGACGCACTTGAATTAAATATTTCTTGTCCAAATGTAAAAG
AAGGTGGAATTCAATTTGGTACAGACCCTTTCATGGCAAAAAAGGTGACGGAAGTAGTAAAGAAAGCAAGTAACAAGCCT
GTATATGTAAAGCTTTCACCAAATGTGCATAATATTGTCGAGATGGCAAAAGCCGTAGAAGAAGCTGGTGCAGATGGGCT
ATCGATGATTAACACATTGACAGGAATGAAAATTCATCTACCATCACGTAAACCGTTAATCGCCAATAAAACCGGTGGAC
TGTCTGGTCCTGCAATAAAGCCGGTTGCTATTCGTATGATATATGAAGTAAGGCAACAAGTTTCGATTCCGATTATCGGG
ATGGGTGGCATCACTAGCGCGGAAGATGTTTTAGAGTATCTAATAGCTGGGGCTGATGCTGTTGCGGTCGGTACTGCGAA
TTTTCAAAATCCATTTGTTTGTGTAGATATAATAAATGAGTTACCAGAAGTATTGGAGCAGTATGGATTTAATTCAATAG
AAGATGTTATCGAAAAAAGGGGGATTACGGTATGA

Upstream 100 bases:

>100_bases
GCGTAGGTGCATGCATGGCCTGTGTATTGCCTACCGTGGATAATCATTATAAAAAAATCTGTAGTGAAGGACCAGTTTTT
GTTGCTGAGGAGGTGGTCCT

Downstream 100 bases:

>100_bases
CCATGTTTGTAGCACTAGATTTTCCTGATTGGAAACAAACAGAGGCATTTCTATATAAAAATGAATTGCAAGGTGTTCCT
GTTAAAGTTGGTATGGAACT

Product: dihydroorotase dehydrogenase

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MNLSVKLPGLNLKNPIMPASGCFGFGKEYSEYYDLSLLGGVMMKAATQFERLGNPTPRVAETSAGMLNAIGLQNPGVQQI
IDHEVPRLAKYDTSIIANIAGSSIEEYEFVAASFNQTTDVDALELNISCPNVKEGGIQFGTDPFMAKKVTEVVKKASNKP
VYVKLSPNVHNIVEMAKAVEEAGADGLSMINTLTGMKIHLPSRKPLIANKTGGLSGPAIKPVAIRMIYEVRQQVSIPIIG
MGGITSAEDVLEYLIAGADAVAVGTANFQNPFVCVDIINELPEVLEQYGFNSIEDVIEKRGITV

Sequences:

>Translated_304_residues
MNLSVKLPGLNLKNPIMPASGCFGFGKEYSEYYDLSLLGGVMMKAATQFERLGNPTPRVAETSAGMLNAIGLQNPGVQQI
IDHEVPRLAKYDTSIIANIAGSSIEEYEFVAASFNQTTDVDALELNISCPNVKEGGIQFGTDPFMAKKVTEVVKKASNKP
VYVKLSPNVHNIVEMAKAVEEAGADGLSMINTLTGMKIHLPSRKPLIANKTGGLSGPAIKPVAIRMIYEVRQQVSIPIIG
MGGITSAEDVLEYLIAGADAVAVGTANFQNPFVCVDIINELPEVLEQYGFNSIEDVIEKRGITV
>Mature_304_residues
MNLSVKLPGLNLKNPIMPASGCFGFGKEYSEYYDLSLLGGVMMKAATQFERLGNPTPRVAETSAGMLNAIGLQNPGVQQI
IDHEVPRLAKYDTSIIANIAGSSIEEYEFVAASFNQTTDVDALELNISCPNVKEGGIQFGTDPFMAKKVTEVVKKASNKP
VYVKLSPNVHNIVEMAKAVEEAGADGLSMINTLTGMKIHLPSRKPLIANKTGGLSGPAIKPVAIRMIYEVRQQVSIPIIG
MGGITSAEDVLEYLIAGADAVAVGTANFQNPFVCVDIINELPEVLEQYGFNSIEDVIEKRGITV

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI119943098, Length=185, Percent_Identity=35.6756756756757, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI45006951, Length=318, Percent_Identity=26.7295597484277, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI87082059, Length=321, Percent_Identity=29.595015576324, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71984108, Length=176, Percent_Identity=31.8181818181818, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17509475, Length=322, Percent_Identity=26.7080745341615, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6322633, Length=305, Percent_Identity=31.1475409836066, Blast_Score=111, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24640763, Length=204, Percent_Identity=33.3333333333333, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI18858217, Length=204, Percent_Identity=33.3333333333333, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI281361352, Length=320, Percent_Identity=28.4375, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17137316, Length=320, Percent_Identity=28.4375, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_OCEIH (Q8CWG1)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_692414.1
- ProteinModelPortal:   Q8CWG1
- SMR:   Q8CWG1
- GeneID:   1017751
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1493
- NMPDR:   fig|221109.1.peg.1495
- HOGENOM:   HBG472415
- OMA:   NSIGLQN
- BioCyc:   OIHE221109:OB1493-MONOMER
- BRENDA:   1.3.3.1
- GO:   GO:0005737
- HAMAP:   MF_00224_B
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01037

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.3.1

Molecular weight: Translated: 32604; Mature: 32604

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLSVKLPGLNLKNPIMPASGCFGFGKEYSEYYDLSLLGGVMMKAATQFERLGNPTPRVA
CCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
ETSAGMLNAIGLQNPGVQQIIDHEVPRLAKYDTSIIANIAGSSIEEYEFVAASFNQTTDV
HHCCCHHHHCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCC
DALELNISCPNVKEGGIQFGTDPFMAKKVTEVVKKASNKPVYVKLSPNVHNIVEMAKAVE
CEEEEEEECCCCCCCCEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHH
EAGADGLSMINTLTGMKIHLPSRKPLIANKTGGLSGPAIKPVAIRMIYEVRQQVSIPIIG
HHCCCHHHHHHHHCCCEEECCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
MGGITSAEDVLEYLIAGADAVAVGTANFQNPFVCVDIINELPEVLEQYGFNSIEDVIEKR
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHC
GITV
CCCC
>Mature Secondary Structure
MNLSVKLPGLNLKNPIMPASGCFGFGKEYSEYYDLSLLGGVMMKAATQFERLGNPTPRVA
CCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
ETSAGMLNAIGLQNPGVQQIIDHEVPRLAKYDTSIIANIAGSSIEEYEFVAASFNQTTDV
HHCCCHHHHCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCC
DALELNISCPNVKEGGIQFGTDPFMAKKVTEVVKKASNKPVYVKLSPNVHNIVEMAKAVE
CEEEEEEECCCCCCCCEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHH
EAGADGLSMINTLTGMKIHLPSRKPLIANKTGGLSGPAIKPVAIRMIYEVRQQVSIPIIG
HHCCCHHHHHHHHCCCEEECCCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEE
MGGITSAEDVLEYLIAGADAVAVGTANFQNPFVCVDIINELPEVLEQYGFNSIEDVIEKR
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHC
GITV
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376