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The map label for this gene is metC [H]

Identifier: 23098564

GI number: 23098564

Start: 1162035

End: 1163168

Strand: Direct

Name: metC [H]

Synonym: OB1109

Alternate gene names: 23098564

Gene position: 1162035-1163168 (Clockwise)

Preceding gene: 23098563

Following gene: 23098565

Centisome position: 32.01

GC content: 37.57

Gene sequence:

>1134_bases
ATGAGAGATAAGACAAAAATGATACATGGTGGAATTACTTCAGATGAACGTACTGGAGCAGTAAATGTCCCGATATATCA
AGTAAGCACATATAAACAAGATGCTCCAGGAGAACACCGTGGTTACGAGTATTCTCGTACGGGAAATCCTACTAGACATG
CACTCGAAACTGTAATTGCCGAATTAGAAGAAGGGAATGCTGGCTTTGCTTTTGGATCAGGAATGGCTGCCATTACTTCG
ATTATGATGTTATTGGAATCCGGAGATCATGTCATCATGACAGATGATGTCTACGGCGGATCTTACCGATTAATGACTAA
AGTGTTGAATCAGTATAATATAGAGCATACTTTTATTGATACAAGTTCAGAGGAATCTGTGATCAATGCGATTAAACCAA
ATACAAAAGCGATTTATGTAGAAACACCAACTAATCCGTTGTTGAAAATTACAGATATTAAGGAAATATCAACGATTGCG
CAAAAACATAATCTTTTACTAATTGTAGATAACACTTTTGCAACTCCCTATTGGCAAAAACCACTAACAATGGGTGCAGA
TATTGTATTGCATAGTGCTACGAAGTATATTGGTGGACATAGTGATGTTGTTGCGGGATTAGTGGCAGTGAAATCCAATG
AATTAGCGGAACGGATTCATTTTATACAAAACTCTGTAGGAGCAGTACTTGGCCCACAAGACTCATGGCTCTTACAACGT
GGAATTAAAACCTTAGCAATTCGTATGGAAGCTATTGAGCAAAACACGAAAAAACTAATTGCTTATTTAGAACAGAATCC
AAGAGTAGAAAAAATATATTATCCTGGACTAGAAAATCATCCAGGACACCATATTGCCAAACAACAAGCATCCGGGTTTG
GTGGAATGGTATCGATAGATGTAGGAAGTGGCGACCTTGCAGATAAAATTTTAAGCAAAGTAGAATTTTTTACACTGGCA
GAAAGTCTTGGTGCCATTGAAAGTTTGATATCGATTCCTGCCAAAATGACACATGCCTCTATACCTGCTGACCGTAGACA
AGAACTTGGTATTACTGACGGATTAATTCGTTTATCGGTTGGTATTGAAGATATAGATGACCTTATTGACGATTTAGAAA
AATCGATGCAGTAA

Upstream 100 bases:

>100_bases
CAGGAACGACAATTGTTACTATTCTTCCTGATGGAAGTGATCGCTATTTAAGTAAACAGATTTATAATGTGTCAAAGCAA
TTGTAAAGGAGTTTGGAGAG

Downstream 100 bases:

>100_bases
GTAAGATAAAGGACTATTTCCTATATGGAAATAGTCTTTTTTTTGTTGTCTAGGAAATTAAAAAATTTGGGGGCTGTGGA
TAAACAACTAAGTTAATAAG

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: Gamma-cystathionase; Homocysteine gamma-lyase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MRDKTKMIHGGITSDERTGAVNVPIYQVSTYKQDAPGEHRGYEYSRTGNPTRHALETVIAELEEGNAGFAFGSGMAAITS
IMMLLESGDHVIMTDDVYGGSYRLMTKVLNQYNIEHTFIDTSSEESVINAIKPNTKAIYVETPTNPLLKITDIKEISTIA
QKHNLLLIVDNTFATPYWQKPLTMGADIVLHSATKYIGGHSDVVAGLVAVKSNELAERIHFIQNSVGAVLGPQDSWLLQR
GIKTLAIRMEAIEQNTKKLIAYLEQNPRVEKIYYPGLENHPGHHIAKQQASGFGGMVSIDVGSGDLADKILSKVEFFTLA
ESLGAIESLISIPAKMTHASIPADRRQELGITDGLIRLSVGIEDIDDLIDDLEKSMQ

Sequences:

>Translated_377_residues
MRDKTKMIHGGITSDERTGAVNVPIYQVSTYKQDAPGEHRGYEYSRTGNPTRHALETVIAELEEGNAGFAFGSGMAAITS
IMMLLESGDHVIMTDDVYGGSYRLMTKVLNQYNIEHTFIDTSSEESVINAIKPNTKAIYVETPTNPLLKITDIKEISTIA
QKHNLLLIVDNTFATPYWQKPLTMGADIVLHSATKYIGGHSDVVAGLVAVKSNELAERIHFIQNSVGAVLGPQDSWLLQR
GIKTLAIRMEAIEQNTKKLIAYLEQNPRVEKIYYPGLENHPGHHIAKQQASGFGGMVSIDVGSGDLADKILSKVEFFTLA
ESLGAIESLISIPAKMTHASIPADRRQELGITDGLIRLSVGIEDIDDLIDDLEKSMQ
>Mature_377_residues
MRDKTKMIHGGITSDERTGAVNVPIYQVSTYKQDAPGEHRGYEYSRTGNPTRHALETVIAELEEGNAGFAFGSGMAAITS
IMMLLESGDHVIMTDDVYGGSYRLMTKVLNQYNIEHTFIDTSSEESVINAIKPNTKAIYVETPTNPLLKITDIKEISTIA
QKHNLLLIVDNTFATPYWQKPLTMGADIVLHSATKYIGGHSDVVAGLVAVKSNELAERIHFIQNSVGAVLGPQDSWLLQR
GIKTLAIRMEAIEQNTKKLIAYLEQNPRVEKIYYPGLENHPGHHIAKQQASGFGGMVSIDVGSGDLADKILSKVEFFTLA
ESLGAIESLISIPAKMTHASIPADRRQELGITDGLIRLSVGIEDIDDLIDDLEKSMQ

Specific function: Catalyzes the conversion of cystathionine to cysteine, and homocysteine to sulfide [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=360, Percent_Identity=48.3333333333333, Blast_Score=349, Evalue=2e-96,
Organism=Homo sapiens, GI299473759, Length=360, Percent_Identity=43.8888888888889, Blast_Score=296, Evalue=3e-80,
Organism=Homo sapiens, GI25453487, Length=359, Percent_Identity=42.6183844011142, Blast_Score=282, Evalue=4e-76,
Organism=Escherichia coli, GI1790375, Length=378, Percent_Identity=41.005291005291, Blast_Score=302, Evalue=3e-83,
Organism=Escherichia coli, GI1789383, Length=393, Percent_Identity=29.7709923664122, Blast_Score=171, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17538055, Length=345, Percent_Identity=47.8260869565217, Blast_Score=332, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI17560056, Length=345, Percent_Identity=45.2173913043478, Blast_Score=324, Evalue=6e-89,
Organism=Caenorhabditis elegans, GI71980708, Length=370, Percent_Identity=39.1891891891892, Blast_Score=277, Evalue=5e-75,
Organism=Saccharomyces cerevisiae, GI6319307, Length=383, Percent_Identity=44.3864229765013, Blast_Score=323, Evalue=3e-89,
Organism=Saccharomyces cerevisiae, GI6321254, Length=402, Percent_Identity=34.3283582089552, Blast_Score=219, Evalue=7e-58,
Organism=Saccharomyces cerevisiae, GI6323333, Length=410, Percent_Identity=33.6585365853659, Blast_Score=179, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6321170, Length=317, Percent_Identity=32.4921135646688, Blast_Score=172, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6321904, Length=391, Percent_Identity=29.923273657289, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6322590, Length=352, Percent_Identity=24.7159090909091, Blast_Score=93, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6323557, Length=336, Percent_Identity=24.702380952381, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6322970, Length=337, Percent_Identity=24.3323442136499, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19922554, Length=378, Percent_Identity=48.9417989417989, Blast_Score=384, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.1; =4.4.1.2 [H]

Molecular weight: Translated: 41348; Mature: 41348

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDKTKMIHGGITSDERTGAVNVPIYQVSTYKQDAPGEHRGYEYSRTGNPTRHALETVIA
CCCCCCEEECCCCCCCCCCEEECEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
ELEEGNAGFAFGSGMAAITSIMMLLESGDHVIMTDDVYGGSYRLMTKVLNQYNIEHTFID
HHHCCCCCEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEC
TSSEESVINAIKPNTKAIYVETPTNPLLKITDIKEISTIAQKHNLLLIVDNTFATPYWQK
CCCCHHHHHHCCCCCEEEEEECCCCCCEEEECHHHHHHHHHHCCEEEEEECCCCCCCCCC
PLTMGADIVLHSATKYIGGHSDVVAGLVAVKSNELAERIHFIQNSVGAVLGPQDSWLLQR
CCCCCCHHEEEHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCEECCCHHHHHHH
GIKTLAIRMEAIEQNTKKLIAYLEQNPRVEKIYYPGLENHPGHHIAKQQASGFGGMVSID
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCEEEEE
VGSGDLADKILSKVEFFTLAESLGAIESLISIPAKMTHASIPADRRQELGITDGLIRLSV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHCCCCCCEEEEEC
GIEDIDDLIDDLEKSMQ
CHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRDKTKMIHGGITSDERTGAVNVPIYQVSTYKQDAPGEHRGYEYSRTGNPTRHALETVIA
CCCCCCEEECCCCCCCCCCEEECEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
ELEEGNAGFAFGSGMAAITSIMMLLESGDHVIMTDDVYGGSYRLMTKVLNQYNIEHTFID
HHHCCCCCEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEC
TSSEESVINAIKPNTKAIYVETPTNPLLKITDIKEISTIAQKHNLLLIVDNTFATPYWQK
CCCCHHHHHHCCCCCEEEEEECCCCCCEEEECHHHHHHHHHHCCEEEEEECCCCCCCCCC
PLTMGADIVLHSATKYIGGHSDVVAGLVAVKSNELAERIHFIQNSVGAVLGPQDSWLLQR
CCCCCCHHEEEHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCEECCCHHHHHHH
GIKTLAIRMEAIEQNTKKLIAYLEQNPRVEKIYYPGLENHPGHHIAKQQASGFGGMVSID
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCEEEEE
VGSGDLADKILSKVEFFTLAESLGAIESLISIPAKMTHASIPADRRQELGITDGLIRLSV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHCCCCCCEEEEEC
GIEDIDDLIDDLEKSMQ
CHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377 [H]