Click here to switch to the map view.

The map label for this gene is pbuX [H]

Identifier: 23098517

GI number: 23098517

Start: 1104747

End: 1106051

Strand: Direct

Name: pbuX [H]

Synonym: OB1062

Alternate gene names: 23098517

Gene position: 1104747-1106051 (Clockwise)

Preceding gene: 23098516

Following gene: 23098518

Centisome position: 30.43

GC content: 36.4

Gene sequence:

>1305_bases
ATGAAGATCGCAGCTCTGGGATTTCAACATGTATTAGCAATGTATGCAGGAGCCATTTTAGTACCATTAATTGTTGGGGA
AGCGCTTGGGCTAACAGTTGAACAATTAACATATCTTGTAGCCATCGATATCTTTATGTGTGGTATTGCTACACTATTTC
AAGTTATGAATAATCGTTTCTTTGGTATTGGTTTGCCAGTAGTATTAGGATGTACATTTACAGCAGTTGCACCAATGATT
GCCATTGGTGGGCAATATGGGATAACTGCTATCTATGGAGCGATTATTGTTTCAGGTATATTTGTAGTTCTAATTAGTGG
ATTTTTCGGCAAACTTGTTCGATTTTTCCCACCAGTTGTAACTGGCTCAGTAGTAACCATCATTGGTATTACTCTAATTC
CAGTCGCTATTAACAATCTTGGCGGTGGACAAGGTGCAAGTGACTTTGGTTCATTAGCAAATATTTCACTTGGATTTGGC
ACATTATTATTTATTATACTTATGTATCGCTTTACAACTGGATTTTTACGCTCCATATCTATTTTAATTGGATTAGCTAT
AGGTACAATTATTGCTAGTTTCATGGGAAGAGTTGATTTTACGGCAGTTGCAGATGCGTCTTACTTCCATATGATTCAAC
CTTTTTATTTTGGGACTCCGACCTTTGAATGGCCGGCAATTATTACAATGATATTAGTTGCGATGGTATCGTTAGTGGAA
TCTACCGGAGTATATTTTGCTTTAGGGGATATCACAGATAAGAAATTAAAAGAGAAAGATTTAACGAAAGGATATCGTGC
AGAAGGGTTGGCCATTTTACTAGGTGGGATATTTAATGCTTTACAATATACAGCATTTTCTCAAAACGTTGGTTTAATTC
AAATGACTGGCGTGAAAAAATTAAGAGTAATTGTTGTTGCGGGTATCATGTTGATTGCTTTAGGATTAATACCAAAAATA
GCAGCACTTACTACAATTATTCCAACAGCTGTATTAGGAGGGGCAATGGTAGCAATGTTTGGTATGGTCATTGCTCAAGG
GATCAAGATGCTTAGTGCAGTAATTAGCGACTCGCATGAAAATTCTATGATCATTGCATGCTCCGTTGGGATGGGCTTAG
GTGTTACAGTTGTCCCAGAACTATTTGCACAAATTCCGAATAGTTTACAAATATTAACGAGTAATGGAATTGTAGCAGGT
AGCGTAACTGCAATAGTATTAAATATATTATTTCATATGTTACCACAGCGTTCTAAAAAACAACAAACAACTGATAGCAG
AGAGTTAGCAGAGGATATTGTTTAA

Upstream 100 bases:

>100_bases
GAAAACAGCTAAGAGATAAAGGTATTCGAGTAGAATCTTTAGCCATAGTAGAATCATTATCGGATGGAACAGTAAGGTTT
AAAGAGGAGGCTCGTATATA

Downstream 100 bases:

>100_bases
TAAAAGATTCATTTCAAGGAAGAGGATATTATGCTGTAGGAGCATAATATCCTCTTTTCTTCGTTGTCTAGGAAATTATA
AAATTTTGGGTCTGTGGATA

Product: xanthine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MKIAALGFQHVLAMYAGAILVPLIVGEALGLTVEQLTYLVAIDIFMCGIATLFQVMNNRFFGIGLPVVLGCTFTAVAPMI
AIGGQYGITAIYGAIIVSGIFVVLISGFFGKLVRFFPPVVTGSVVTIIGITLIPVAINNLGGGQGASDFGSLANISLGFG
TLLFIILMYRFTTGFLRSISILIGLAIGTIIASFMGRVDFTAVADASYFHMIQPFYFGTPTFEWPAIITMILVAMVSLVE
STGVYFALGDITDKKLKEKDLTKGYRAEGLAILLGGIFNALQYTAFSQNVGLIQMTGVKKLRVIVVAGIMLIALGLIPKI
AALTTIIPTAVLGGAMVAMFGMVIAQGIKMLSAVISDSHENSMIIACSVGMGLGVTVVPELFAQIPNSLQILTSNGIVAG
SVTAIVLNILFHMLPQRSKKQQTTDSRELAEDIV

Sequences:

>Translated_434_residues
MKIAALGFQHVLAMYAGAILVPLIVGEALGLTVEQLTYLVAIDIFMCGIATLFQVMNNRFFGIGLPVVLGCTFTAVAPMI
AIGGQYGITAIYGAIIVSGIFVVLISGFFGKLVRFFPPVVTGSVVTIIGITLIPVAINNLGGGQGASDFGSLANISLGFG
TLLFIILMYRFTTGFLRSISILIGLAIGTIIASFMGRVDFTAVADASYFHMIQPFYFGTPTFEWPAIITMILVAMVSLVE
STGVYFALGDITDKKLKEKDLTKGYRAEGLAILLGGIFNALQYTAFSQNVGLIQMTGVKKLRVIVVAGIMLIALGLIPKI
AALTTIIPTAVLGGAMVAMFGMVIAQGIKMLSAVISDSHENSMIIACSVGMGLGVTVVPELFAQIPNSLQILTSNGIVAG
SVTAIVLNILFHMLPQRSKKQQTTDSRELAEDIV
>Mature_434_residues
MKIAALGFQHVLAMYAGAILVPLIVGEALGLTVEQLTYLVAIDIFMCGIATLFQVMNNRFFGIGLPVVLGCTFTAVAPMI
AIGGQYGITAIYGAIIVSGIFVVLISGFFGKLVRFFPPVVTGSVVTIIGITLIPVAINNLGGGQGASDFGSLANISLGFG
TLLFIILMYRFTTGFLRSISILIGLAIGTIIASFMGRVDFTAVADASYFHMIQPFYFGTPTFEWPAIITMILVAMVSLVE
STGVYFALGDITDKKLKEKDLTKGYRAEGLAILLGGIFNALQYTAFSQNVGLIQMTGVKKLRVIVVAGIMLIALGLIPKI
AALTTIIPTAVLGGAMVAMFGMVIAQGIKMLSAVISDSHENSMIIACSVGMGLGVTVVPELFAQIPNSLQILTSNGIVAG
SVTAIVLNILFHMLPQRSKKQQTTDSRELAEDIV

Specific function: Transport of xanthine in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=428, Percent_Identity=26.6355140186916, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI44680143, Length=432, Percent_Identity=26.1574074074074, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI44680148, Length=223, Percent_Identity=28.6995515695067, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI40316845, Length=223, Percent_Identity=28.6995515695067, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI87082181, Length=431, Percent_Identity=40.1392111368909, Blast_Score=328, Evalue=5e-91,
Organism=Escherichia coli, GI1790087, Length=421, Percent_Identity=34.4418052256532, Blast_Score=194, Evalue=8e-51,
Organism=Escherichia coli, GI87082178, Length=448, Percent_Identity=33.0357142857143, Blast_Score=181, Evalue=9e-47,
Organism=Escherichia coli, GI87081818, Length=393, Percent_Identity=29.5165394402036, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1788843, Length=378, Percent_Identity=29.6296296296296, Blast_Score=116, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17558856, Length=196, Percent_Identity=31.1224489795918, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17542262, Length=430, Percent_Identity=22.3255813953488, Blast_Score=65, Evalue=1e-10,
Organism=Drosophila melanogaster, GI21356175, Length=416, Percent_Identity=26.6826923076923, Blast_Score=101, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 45839; Mature: 45839

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HCCCHHHHHHHHCC
>Mature Secondary Structure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HCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9098051; 9384377 [H]