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The map label for this gene is xpt

Identifier: 23098516

GI number: 23098516

Start: 1104163

End: 1104747

Strand: Direct

Name: xpt

Synonym: OB1061

Alternate gene names: 23098516

Gene position: 1104163-1104747 (Clockwise)

Preceding gene: 23098515

Following gene: 23098517

Centisome position: 30.41

GC content: 34.87

Gene sequence:

>585_bases
ATGGAGTTACTAAAGAATAAAATCATCGAAGAAGGAAGAGTGTTGTCGGATACTGTGTTAAAGGTTGATTCTTTTCTAAA
TCATCAAGTAGACCCTAAATTAATGAAGCAAGTTGGAGAAGAATTTGCAAAAAAATTTAGAAATACTGGAATTACAAAAA
TATTAACCATTGAATCTTCAGGAATTGCACCTGCAACAATGACAGGTTTGGAGTTAGACGTTCCAGTAATTTTTGCAAGA
AAAAGAAAATCGCTCACACTAACCGATCATCTTTTTACTGCGGAAGTATACTCCTATACAAAAAAGACATCGAATGAAAT
TTCTGTTTCAAAAGATTTTCTCCATGAAGACGATATTGTCTTAGTTATGGATGATTTCTTAGCAAATGGCCAAGCAGCCT
TAGGTCTATTAGAAATAGCGAAACAAGCGAAAGCGACAGTAGTGGGTGTAGGTATTGTAATCGAAAAAGGTTTTCAAACT
GGCGGAAAACAGCTAAGAGATAAAGGTATTCGAGTAGAATCTTTAGCCATAGTAGAATCATTATCGGATGGAACAGTAAG
GTTTAAAGAGGAGGCTCGTATATAA

Upstream 100 bases:

>100_bases
CAAAGACTATCGTTTTTAAATTTTCGACATTTCAAGCTCGGAAATCTGCTTTTTTATAGGCGGATTTTCGAGCTTTTTAT
ATTTTAGGAGGAATGGAAGC

Downstream 100 bases:

>100_bases
TGAAGATCGCAGCTCTGGGATTTCAACATGTATTAGCAATGTATGCAGGAGCCATTTTAGTACCATTAATTGTTGGGGAA
GCGCTTGGGCTAACAGTTGA

Product: xanthine phosphoribosyltransferase

Products: NA

Alternate protein names: XPRTase

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MELLKNKIIEEGRVLSDTVLKVDSFLNHQVDPKLMKQVGEEFAKKFRNTGITKILTIESSGIAPATMTGLELDVPVIFAR
KRKSLTLTDHLFTAEVYSYTKKTSNEISVSKDFLHEDDIVLVMDDFLANGQAALGLLEIAKQAKATVVGVGIVIEKGFQT
GGKQLRDKGIRVESLAIVESLSDGTVRFKEEARI

Sequences:

>Translated_194_residues
MELLKNKIIEEGRVLSDTVLKVDSFLNHQVDPKLMKQVGEEFAKKFRNTGITKILTIESSGIAPATMTGLELDVPVIFAR
KRKSLTLTDHLFTAEVYSYTKKTSNEISVSKDFLHEDDIVLVMDDFLANGQAALGLLEIAKQAKATVVGVGIVIEKGFQT
GGKQLRDKGIRVESLAIVESLSDGTVRFKEEARI
>Mature_194_residues
MELLKNKIIEEGRVLSDTVLKVDSFLNHQVDPKLMKQVGEEFAKKFRNTGITKILTIESSGIAPATMTGLELDVPVIFAR
KRKSLTLTDHLFTAEVYSYTKKTSNEISVSKDFLHEDDIVLVMDDFLANGQAALGLLEIAKQAKATVVGVGIVIEKGFQT
GGKQLRDKGIRVESLAIVESLSDGTVRFKEEARI

Specific function: Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. XPT subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XPT_OCEIH (Q8CUP6)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_691982.1
- HSSP:   P42085
- ProteinModelPortal:   Q8CUP6
- SMR:   Q8CUP6
- GeneID:   1016938
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB1061
- NMPDR:   fig|221109.1.peg.1062
- HOGENOM:   HBG288993
- OMA:   ATVYSFT
- ProtClustDB:   PRK09219
- BioCyc:   OIHE221109:OB1061-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01184
- InterPro:   IPR000836
- InterPro:   IPR010079
- TIGRFAMs:   TIGR01744

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.22

Molecular weight: Translated: 21409; Mature: 21409

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 20-20 BINDING 27-27 BINDING 156-156

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELLKNKIIEEGRVLSDTVLKVDSFLNHQVDPKLMKQVGEEFAKKFRNTGITKILTIESS
CCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECC
GIAPATMTGLELDVPVIFARKRKSLTLTDHLFTAEVYSYTKKTSNEISVSKDFLHEDDIV
CCCCCEECCCEECCCEEEECCCCCEEEHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEE
LVMDDFLANGQAALGLLEIAKQAKATVVGVGIVIEKGFQTGGKQLRDKGIRVESLAIVES
EEEECHHCCCHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCHHHHHCCCEEHHHHHHHH
LSDGTVRFKEEARI
CCCCCEEEHHCCCC
>Mature Secondary Structure
MELLKNKIIEEGRVLSDTVLKVDSFLNHQVDPKLMKQVGEEFAKKFRNTGITKILTIESS
CCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECC
GIAPATMTGLELDVPVIFARKRKSLTLTDHLFTAEVYSYTKKTSNEISVSKDFLHEDDIV
CCCCCEECCCEECCCEEEECCCCCEEEHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEE
LVMDDFLANGQAALGLLEIAKQAKATVVGVGIVIEKGFQTGGKQLRDKGIRVESLAIVES
EEEECHHCCCHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCHHHHHCCCEEHHHHHHHH
LSDGTVRFKEEARI
CCCCCEEEHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376