Click here to switch to the map view.

The map label for this gene is hbd [H]

Identifier: 23098452

GI number: 23098452

Start: 1041383

End: 1042306

Strand: Direct

Name: hbd [H]

Synonym: OB0997

Alternate gene names: 23098452

Gene position: 1041383-1042306 (Clockwise)

Preceding gene: 23098451

Following gene: 23098453

Centisome position: 28.68

GC content: 37.88

Gene sequence:

>924_bases
ATGAAGAAAGTAGCTGTTATTGGTACAGGAGTAATTGGTAATGGATGGATTACTCGTTTTCTTGCAAACGGGTGTGAAGT
TGTAGCTCATGATCCTGCACCAGGGGCAAAAGAAAGAACAATACAAGCAATCGAGAATGCTTGGGAATCAGTAGAACAAT
TAGGATTAAAAGAAGGTGCATCCAAAGATTCTCTTACTTTTGTGGATAGTATTGAAGAAGCGGTTAAAGATGCAGATTTA
ATTCAAGAAAGTGTACCAGAACGATATGAATTAAAACACGGCGTACTTAAAGAAATTGATCGTTTTGCACATTCGAATAC
AATTATTGGATCTAGTACTTCTGGAATTAAGCCAACAGACTTACAAATAGGCTTAAATCATCCGGAACGTTTAGTAGTAG
CTCATCCATTCAATCCAGTTTATCTACTTCCACTCGTAGAAATCGTTGGTGGAGAGGCAACAACAAAAGAAATTACGAAT
AGGGCATCGGTATATTATGAATCTTTACAAATGAAACCTATGGTAATTGAAAAAGAAATTGAAGGATTTGTAGCAGACCG
TTTAATGGAGGCACTTTGGCGTGAAGCATTGCATCTGGTAAATGACGGTATCGCGACAACCGAAGAAGTAGATAAAGCAA
TTACTTATGGCGCTGGTTTACGTTGGGCGCAAATGGGACCATTTATGACGTTCCATTTAGCTGGAGGAAATGCAGGCATG
AGACATATGCTAGAACAATTCGGACCAGCATTAAAATTACCTTGGACGAAACTAGAAGCACCGGAGTTAACAGATGAATT
AAAAGAACGTGTTATTCAAGGCTGTGAAACACATGCTAATGATCGGTCTGTCGAAGAGTTAGAGAAAAAGAGAAATGAAT
TTTTAGTAAAACTTATTGATCTTGTCGAAGATTATTGGCCATAA

Upstream 100 bases:

>100_bases
AAGCGGTAAATCAATTACATGCAAATAATATAGAAATAATGACTCCTCAAGAAGCAAGAGAGGCTTATAACTTAAGAGGT
AAATAAAGGGGAAATCCAAA

Downstream 100 bases:

>100_bases
GAGGTGACATGAAAAGATGGATAGAATGTTTAACTTCAAATCAGAAGTAAAACCAGAATGGGTAGATTATAACGGTCATA
TGAATGATGCCGCATATGCT

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MKKVAVIGTGVIGNGWITRFLANGCEVVAHDPAPGAKERTIQAIENAWESVEQLGLKEGASKDSLTFVDSIEEAVKDADL
IQESVPERYELKHGVLKEIDRFAHSNTIIGSSTSGIKPTDLQIGLNHPERLVVAHPFNPVYLLPLVEIVGGEATTKEITN
RASVYYESLQMKPMVIEKEIEGFVADRLMEALWREALHLVNDGIATTEEVDKAITYGAGLRWAQMGPFMTFHLAGGNAGM
RHMLEQFGPALKLPWTKLEAPELTDELKERVIQGCETHANDRSVEELEKKRNEFLVKLIDLVEDYWP

Sequences:

>Translated_307_residues
MKKVAVIGTGVIGNGWITRFLANGCEVVAHDPAPGAKERTIQAIENAWESVEQLGLKEGASKDSLTFVDSIEEAVKDADL
IQESVPERYELKHGVLKEIDRFAHSNTIIGSSTSGIKPTDLQIGLNHPERLVVAHPFNPVYLLPLVEIVGGEATTKEITN
RASVYYESLQMKPMVIEKEIEGFVADRLMEALWREALHLVNDGIATTEEVDKAITYGAGLRWAQMGPFMTFHLAGGNAGM
RHMLEQFGPALKLPWTKLEAPELTDELKERVIQGCETHANDRSVEELEKKRNEFLVKLIDLVEDYWP
>Mature_307_residues
MKKVAVIGTGVIGNGWITRFLANGCEVVAHDPAPGAKERTIQAIENAWESVEQLGLKEGASKDSLTFVDSIEEAVKDADL
IQESVPERYELKHGVLKEIDRFAHSNTIIGSSTSGIKPTDLQIGLNHPERLVVAHPFNPVYLLPLVEIVGGEATTKEITN
RASVYYESLQMKPMVIEKEIEGFVADRLMEALWREALHLVNDGIATTEEVDKAITYGAGLRWAQMGPFMTFHLAGGNAGM
RHMLEQFGPALKLPWTKLEAPELTDELKERVIQGCETHANDRSVEELEKKRNEFLVKLIDLVEDYWP

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=322, Percent_Identity=32.6086956521739, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI296179429, Length=237, Percent_Identity=29.535864978903, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI296179427, Length=254, Percent_Identity=27.9527559055118, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI20127408, Length=215, Percent_Identity=26.5116279069767, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI68989263, Length=264, Percent_Identity=26.1363636363636, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI261878539, Length=264, Percent_Identity=26.1363636363636, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1787661, Length=238, Percent_Identity=28.1512605042017, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790281, Length=157, Percent_Identity=29.9363057324841, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788682, Length=136, Percent_Identity=30.1470588235294, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI193203623, Length=277, Percent_Identity=30.6859205776173, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI115533614, Length=286, Percent_Identity=30.7692307692308, Blast_Score=114, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17553560, Length=279, Percent_Identity=29.3906810035842, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17549919, Length=238, Percent_Identity=29.8319327731092, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17508953, Length=215, Percent_Identity=29.3023255813954, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25144276, Length=215, Percent_Identity=29.3023255813954, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17508951, Length=215, Percent_Identity=29.3023255813954, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17563036, Length=242, Percent_Identity=26.0330578512397, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17558304, Length=220, Percent_Identity=28.1818181818182, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI71985930, Length=235, Percent_Identity=26.3829787234043, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71985923, Length=238, Percent_Identity=24.3697478991597, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45549573, Length=306, Percent_Identity=31.3725490196078, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI20129993, Length=313, Percent_Identity=30.0319488817891, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI19921000, Length=212, Percent_Identity=27.3584905660377, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24583077, Length=212, Percent_Identity=27.3584905660377, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24583079, Length=212, Percent_Identity=27.3584905660377, Blast_Score=81, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 34183; Mature: 34183

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVAVIGTGVIGNGWITRFLANGCEVVAHDPAPGAKERTIQAIENAWESVEQLGLKEGA
CCCEEEEECCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
SKDSLTFVDSIEEAVKDADLIQESVPERYELKHGVLKEIDRFAHSNTIIGSSTSGIKPTD
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCC
LQIGLNHPERLVVAHPFNPVYLLPLVEIVGGEATTKEITNRASVYYESLQMKPMVIEKEI
EEECCCCCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHH
EGFVADRLMEALWREALHLVNDGIATTEEVDKAITYGAGLRWAQMGPFMTFHLAGGNAGM
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHCCCEEEEEEECCCHHH
RHMLEQFGPALKLPWTKLEAPELTDELKERVIQGCETHANDRSVEELEKKRNEFLVKLID
HHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LVEDYWP
HHHHHCC
>Mature Secondary Structure
MKKVAVIGTGVIGNGWITRFLANGCEVVAHDPAPGAKERTIQAIENAWESVEQLGLKEGA
CCCEEEEECCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
SKDSLTFVDSIEEAVKDADLIQESVPERYELKHGVLKEIDRFAHSNTIIGSSTSGIKPTD
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCC
LQIGLNHPERLVVAHPFNPVYLLPLVEIVGGEATTKEITNRASVYYESLQMKPMVIEKEI
EEECCCCCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHH
EGFVADRLMEALWREALHLVNDGIATTEEVDKAITYGAGLRWAQMGPFMTFHLAGGNAGM
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHCCCEEEEEEECCCHHH
RHMLEQFGPALKLPWTKLEAPELTDELKERVIQGCETHANDRSVEELEKKRNEFLVKLID
HHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
LVEDYWP
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA