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The map label for this gene is kynU [H]

Identifier: 23098211

GI number: 23098211

Start: 805209

End: 806483

Strand: Reverse

Name: kynU [H]

Synonym: OB0756

Alternate gene names: 23098211

Gene position: 806483-805209 (Counterclockwise)

Preceding gene: 23098224

Following gene: 23098210

Centisome position: 22.21

GC content: 38.9

Gene sequence:

>1275_bases
ATGGTTAAAAAATACACTAGATCGCATGCGCAGGAAATGGATGAACAGGACGAATTGAAACAGTTCCGTAGTGAATTTCA
TCTTAAAAATGAAAGCATTTACATGGATGGGAATTCATTAGGTTTAATGTCTAAAAGGGCAGAAAACGCACTACATAACA
TAATTGACTCTTGGAAGAAATATGGCATCGACGGTTGGATGGAAGGAGATCATCCGTGGTACTATCTGTCTGAACATCTA
GGTGAAAAGATGTCAGTCCTAGTTGGTGGAAAAAAAGATGAAGTTATTGCGACCGGTTCTACAACGATTAATTTACATCA
GCTTGTATCAACTTTTTTTCAGCCGGAAGGAAAGCGGACAAAGATTTTAGCAGATGCATTAACGTTTCCAAGTGATATTT
ATGCATTGAAGGCACAATTACAATTAAAAGGGTATGATGAATCCCATTTGGTACAGGTGCAGAGTGAGGATGGAAATCTG
TTAAACGAGGAACACCTTATTGAAGCGATGACAGATGATATTGCGCTGATCGTGCTTCCAAGTGTTCTATACCGGAGTGG
ACAAATTCTTGATATGGAACGACTTACAAGGGAGGCCCATAAACGCAATATTAAAATTGGTTTTGATTTATGCCATTCAA
TTGGGTCTATTCCACATGACCTTCATAAATGGGGTGTTGATTTTGCCTTCTGGTGCACCTACAAACATCTAAACGGAGGA
CCGGGTAGTGTTGCAGGTTTATTTTTACATGAAAAACATTTTGGTGTTGCACCTGGACTGGCGGGATGGTTCAGTTCTGC
TAAGGATAAGCAATTTGACATGGAACATACCTTAACACACGCTAATAATGCCGGGGCTTTTCAAATTGGAACACCTCATC
TTTTTAGTGTGGCACCTCTGATTGGATCACTAGATTTATTTCATGAAGCCGGAATTGAAAAAGTACGTAAAAAATCACTC
GCGCTAACGGACTATTTAATGGAGTTAATTAAACATGAACTCGATGGGCATGGCGTAGTGATCTGTAATCCGGAAAATCA
TATACAACGCGGCGGTCACGTATATGTCGAACATCCTGAAGCTGCTCGAATATGTAAAGCATTAAAAATGAAAAAGGTTA
TCCCGGATTTCAGAACCCCTAGCGGCATTCGCCTAGCACCTGTTGCTTTATATAATACATTTGAAGATGTTTATGATTGC
GTACAAATTTTTAAAACGATTATGGAAGATGAATTATATAAGCAATTTGAAAATGTAAGGGAGGTTGTTTCCTAA

Upstream 100 bases:

>100_bases
TGACATTATGTCATTGACACTATGTCAGTTATTAAATATAATTTAACCATACAATAAATAAACAATTCAAGTTAAAAATT
ATAGTTCCAGGGGGAAACAT

Downstream 100 bases:

>100_bases
ATGGGTGTATGGATTGATATTTCGCAACCGATAAATAATAATTTAGCTTGTTGGCCGGGGGATCAATCATTTCATTTTCA
TACACCGGTAACGAAGGAAA

Product: kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MVKKYTRSHAQEMDEQDELKQFRSEFHLKNESIYMDGNSLGLMSKRAENALHNIIDSWKKYGIDGWMEGDHPWYYLSEHL
GEKMSVLVGGKKDEVIATGSTTINLHQLVSTFFQPEGKRTKILADALTFPSDIYALKAQLQLKGYDESHLVQVQSEDGNL
LNEEHLIEAMTDDIALIVLPSVLYRSGQILDMERLTREAHKRNIKIGFDLCHSIGSIPHDLHKWGVDFAFWCTYKHLNGG
PGSVAGLFLHEKHFGVAPGLAGWFSSAKDKQFDMEHTLTHANNAGAFQIGTPHLFSVAPLIGSLDLFHEAGIEKVRKKSL
ALTDYLMELIKHELDGHGVVICNPENHIQRGGHVYVEHPEAARICKALKMKKVIPDFRTPSGIRLAPVALYNTFEDVYDC
VQIFKTIMEDELYKQFENVREVVS

Sequences:

>Translated_424_residues
MVKKYTRSHAQEMDEQDELKQFRSEFHLKNESIYMDGNSLGLMSKRAENALHNIIDSWKKYGIDGWMEGDHPWYYLSEHL
GEKMSVLVGGKKDEVIATGSTTINLHQLVSTFFQPEGKRTKILADALTFPSDIYALKAQLQLKGYDESHLVQVQSEDGNL
LNEEHLIEAMTDDIALIVLPSVLYRSGQILDMERLTREAHKRNIKIGFDLCHSIGSIPHDLHKWGVDFAFWCTYKHLNGG
PGSVAGLFLHEKHFGVAPGLAGWFSSAKDKQFDMEHTLTHANNAGAFQIGTPHLFSVAPLIGSLDLFHEAGIEKVRKKSL
ALTDYLMELIKHELDGHGVVICNPENHIQRGGHVYVEHPEAARICKALKMKKVIPDFRTPSGIRLAPVALYNTFEDVYDC
VQIFKTIMEDELYKQFENVREVVS
>Mature_424_residues
MVKKYTRSHAQEMDEQDELKQFRSEFHLKNESIYMDGNSLGLMSKRAENALHNIIDSWKKYGIDGWMEGDHPWYYLSEHL
GEKMSVLVGGKKDEVIATGSTTINLHQLVSTFFQPEGKRTKILADALTFPSDIYALKAQLQLKGYDESHLVQVQSEDGNL
LNEEHLIEAMTDDIALIVLPSVLYRSGQILDMERLTREAHKRNIKIGFDLCHSIGSIPHDLHKWGVDFAFWCTYKHLNGG
PGSVAGLFLHEKHFGVAPGLAGWFSSAKDKQFDMEHTLTHANNAGAFQIGTPHLFSVAPLIGSLDLFHEAGIEKVRKKSL
ALTDYLMELIKHELDGHGVVICNPENHIQRGGHVYVEHPEAARICKALKMKKVIPDFRTPSGIRLAPVALYNTFEDVYDC
VQIFKTIMEDELYKQFENVREVVS

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=430, Percent_Identity=35.3488372093023, Blast_Score=246, Evalue=4e-65,
Organism=Homo sapiens, GI74101437, Length=278, Percent_Identity=36.3309352517986, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17550466, Length=429, Percent_Identity=33.3333333333333, Blast_Score=250, Evalue=9e-67,
Organism=Saccharomyces cerevisiae, GI6323261, Length=414, Percent_Identity=34.7826086956522, Blast_Score=233, Evalue=6e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 48028; Mature: 48028

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKKYTRSHAQEMDEQDELKQFRSEFHLKNESIYMDGNSLGLMSKRAENALHNIIDSWKK
CCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
YGIDGWMEGDHPWYYLSEHLGEKMSVLVGGKKDEVIATGSTTINLHQLVSTFFQPEGKRT
CCCCCEECCCCCEEHHHHHCCCCEEEEECCCCCCEEECCCCEEEHHHHHHHHHCCCCCCH
KILADALTFPSDIYALKAQLQLKGYDESHLVQVQSEDGNLLNEEHLIEAMTDDIALIVLP
HHHHHHHCCCHHHHHHHHEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHCCHHHHHHH
SVLYRSGQILDMERLTREAHKRNIKIGFDLCHSIGSIPHDLHKWGVDFAFWCTYKHLNGG
HHHHCCCCEECHHHHHHHHHHCCCEEHHHHHHHHCCCCHHHHHHCCCEEEEEEEHHCCCC
PGSVAGLFLHEKHFGVAPGLAGWFSSAKDKQFDMEHTLTHANNAGAFQIGTPHLFSVAPL
CCCCEEEEEECCCCCCCCCHHHHHCCCCCCCCCHHHHHHCCCCCCEEEECCCHHHHHHHH
IGSLDLFHEAGIEKVRKKSLALTDYLMELIKHELDGHGVVICNPENHIQRGGHVYVEHPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHCCCEEEEECCH
AARICKALKMKKVIPDFRTPSGIRLAPVALYNTFEDVYDCVQIFKTIMEDELYKQFENVR
HHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVVS
HHHC
>Mature Secondary Structure
MVKKYTRSHAQEMDEQDELKQFRSEFHLKNESIYMDGNSLGLMSKRAENALHNIIDSWKK
CCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
YGIDGWMEGDHPWYYLSEHLGEKMSVLVGGKKDEVIATGSTTINLHQLVSTFFQPEGKRT
CCCCCEECCCCCEEHHHHHCCCCEEEEECCCCCCEEECCCCEEEHHHHHHHHHCCCCCCH
KILADALTFPSDIYALKAQLQLKGYDESHLVQVQSEDGNLLNEEHLIEAMTDDIALIVLP
HHHHHHHCCCHHHHHHHHEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHCCHHHHHHH
SVLYRSGQILDMERLTREAHKRNIKIGFDLCHSIGSIPHDLHKWGVDFAFWCTYKHLNGG
HHHHCCCCEECHHHHHHHHHHCCCEEHHHHHHHHCCCCHHHHHHCCCEEEEEEEHHCCCC
PGSVAGLFLHEKHFGVAPGLAGWFSSAKDKQFDMEHTLTHANNAGAFQIGTPHLFSVAPL
CCCCEEEEEECCCCCCCCCHHHHHCCCCCCCCCHHHHHHCCCCCCEEEECCCHHHHHHHH
IGSLDLFHEAGIEKVRKKSLALTDYLMELIKHELDGHGVVICNPENHIQRGGHVYVEHPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHCCCEEEEECCH
AARICKALKMKKVIPDFRTPSGIRLAPVALYNTFEDVYDCVQIFKTIMEDELYKQFENVR
HHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVVS
HHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA