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The map label for this gene is msrA [H]

Identifier: 23098189

GI number: 23098189

Start: 782777

End: 783298

Strand: Reverse

Name: msrA [H]

Synonym: OB0734

Alternate gene names: 23098189

Gene position: 783298-782777 (Counterclockwise)

Preceding gene: 23098209

Following gene: 23098188

Centisome position: 21.58

GC content: 36.4

Gene sequence:

>522_bases
ATGACATTACAAAAAGCAACATTTGCAGGAGGATGTTTCTGGTGCATGGTTAAGCCTTTTGATCAATGGGACGGCGTTCA
TCAGGTTATATCTGGATATACTGGTGGAAAAGTTATAAACCCTACTTATGAACAAGTAAAAAAAGGTAATACTGGACATT
ATGAAGCTGTTGAAATTACATATGATGATGCAATCATCGATTATAATACGATACTCGATTTATATTGGAAGCAAATAGAC
CCAACTGATGATGGTGGTCAATTCCAGGATCGAGGAGAACAATATCGAGCTGCGATTTTTTATCATACGAAAGAACAATG
GGGATTAGCTGAAGCCTCGAAAGAAGAACTTGCAACTAGCGGACGTTTTTCGAAACCAATTGTAACAGAGATTAAACCAG
CCACTCCTTTTTATCCGGCTGAAGAATATCATCAAGATTTTTATAAAAAGAATAAAGAAGAATATGAAGAAGATCGAGCC
AAATCTGGTAGAGATGAGTTTATTGAAGATAACTGGGAGTAA

Upstream 100 bases:

>100_bases
CAAACGGTTCTTCCATACTGTCACCCAATCTTTGATTGTGTTATATTAAGTTTATTCTACTAAAATAGTAACGGTTTGAA
AATAATTAAGGAGGTATATG

Downstream 100 bases:

>100_bases
TTCATAAAGTTAACTATCATTATAAGATCTTGTGTAAGAATGTGATTGTTGCTTTGTTTGTTTTTCATTACAGACGACGC
TTTTTAGCAGGATGACTTCA

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 173; Mature: 172

Protein sequence:

>173_residues
MTLQKATFAGGCFWCMVKPFDQWDGVHQVISGYTGGKVINPTYEQVKKGNTGHYEAVEITYDDAIIDYNTILDLYWKQID
PTDDGGQFQDRGEQYRAAIFYHTKEQWGLAEASKEELATSGRFSKPIVTEIKPATPFYPAEEYHQDFYKKNKEEYEEDRA
KSGRDEFIEDNWE

Sequences:

>Translated_173_residues
MTLQKATFAGGCFWCMVKPFDQWDGVHQVISGYTGGKVINPTYEQVKKGNTGHYEAVEITYDDAIIDYNTILDLYWKQID
PTDDGGQFQDRGEQYRAAIFYHTKEQWGLAEASKEELATSGRFSKPIVTEIKPATPFYPAEEYHQDFYKKNKEEYEEDRA
KSGRDEFIEDNWE
>Mature_172_residues
TLQKATFAGGCFWCMVKPFDQWDGVHQVISGYTGGKVINPTYEQVKKGNTGHYEAVEITYDDAIIDYNTILDLYWKQIDP
TDDGGQFQDRGEQYRAAIFYHTKEQWGLAEASKEELATSGRFSKPIVTEIKPATPFYPAEEYHQDFYKKNKEEYEEDRAK
SGRDEFIEDNWE

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=154, Percent_Identity=37.012987012987, Blast_Score=100, Evalue=5e-22,
Organism=Homo sapiens, GI208609995, Length=154, Percent_Identity=37.012987012987, Blast_Score=100, Evalue=6e-22,
Organism=Homo sapiens, GI208609993, Length=107, Percent_Identity=36.4485981308411, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=44.078947368421, Blast_Score=123, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17533973, Length=151, Percent_Identity=34.4370860927152, Blast_Score=80, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6320881, Length=157, Percent_Identity=31.2101910828025, Blast_Score=75, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24664627, Length=147, Percent_Identity=38.0952380952381, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24664631, Length=147, Percent_Identity=36.0544217687075, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45553131, Length=137, Percent_Identity=37.956204379562, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 20096; Mature: 19965

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLQKATFAGGCFWCMVKPFDQWDGVHQVISGYTGGKVINPTYEQVKKGNTGHYEAVEIT
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCEEECCCHHHHHCCCCCCEEEEEEE
YDDAIIDYNTILDLYWKQIDPTDDGGQFQDRGEQYRAAIFYHTKEQWGLAEASKEELATS
ECCEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHEEEEEEEECHHHCCCHHHHHHHHHHC
GRFSKPIVTEIKPATPFYPAEEYHQDFYKKNKEEYEEDRAKSGRDEFIEDNWE
CCCCCCCHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCHHHCCCCC
>Mature Secondary Structure 
TLQKATFAGGCFWCMVKPFDQWDGVHQVISGYTGGKVINPTYEQVKKGNTGHYEAVEIT
CCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCEEECCCHHHHHCCCCCCEEEEEEE
YDDAIIDYNTILDLYWKQIDPTDDGGQFQDRGEQYRAAIFYHTKEQWGLAEASKEELATS
ECCEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHEEEEEEEECHHHCCCHHHHHHHHHHC
GRFSKPIVTEIKPATPFYPAEEYHQDFYKKNKEEYEEDRAKSGRDEFIEDNWE
CCCCCCCHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]