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The map label for this gene is msrA [H]

Identifier: 23098154

GI number: 23098154

Start: 738436

End: 739896

Strand: Direct

Name: msrA [H]

Synonym: OB0699

Alternate gene names: 23098154

Gene position: 738436-739896 (Clockwise)

Preceding gene: 23098153

Following gene: 23098155

Centisome position: 20.34

GC content: 35.04

Gene sequence:

>1461_bases
ATGGAAAGAATTAGTTTTGAATTAGAAAATATTGAATTAACTTATTTAGATAAAGAAATTTTAAAAATTGACCGTTTAGC
CATCCATCAATTTGATCGTATTGGTATTGTCGGAAAGAATGGATCGGGAAAAAGCAGCTTATTAAAGTTACTTGCTGGAA
AAATCAAACCAAATAAAGGCATTGTGCACCAACACGCAAGTTATGCCTATTTCGAACAAATGGAAGCCCCTGATTTACAT
TTAACCGGAAATGAAGATCCTGCTTTGCTAGGAAAATTGCATGTTCCCTCTCAATTAGATTCCATAAGTGGAGGGGAGCA
AACTCGTTTGAAATTAACACAACTTTTATCAGAGTATCGTGAAGCTTTATTTATTGATGAGCCAACGACGCATCTAGATC
AAGACGGAGTGGCATTTATACAATCTGAACTGGAATATTATTATGGTGCACTAGTATTAGTAAGTCATGATCGTACTTTA
CTAGATCAATTAGTATCGACCATTTGGGAAATTCATGATGGCAGTGTTTTTGTTTATGCAGGTAATTATACGGAATACGA
AAAACAGAAACAGCTTGAGTTCGAGCAACAACAAGAAGCTCATTATCAATATGTAAAGGAAAAGTCTCGTTTAGAAAAAG
CTGCTGATCAAAAGCGTTCAAAGGCAACTAAAATGATGAAAGGTGATAAAGCAAATGTTCGGGCAAAAGAAGGGGTTAAT
CGGATGTTTGCAACAAAGTCAAAAGATGCTACGCAAAAAGCGATGCAAAAAAGTGCTAAAGCTATTGAAAAACGAATAGA
TCAATTAGAGGAAGTTAGAGCTCCTGAATCAAGCAACCCAATAAACTTCTATAAGTCAAAAGCACTGGACTTGCACAATA
AATTTCCGATTATAGGTGACCAATTAACGTTACAAGCAGGAGATAAAGTCTTATTGGAAGAAGCAAGATTTCAATTTCCG
CTTGGTGAAAATATAGCAATTACCGGTGGGAATGGAGTAGGAAAAAGTTCATTACTTCAGCACATTGTACAACGCGGGCA
TGCTTTGGACATTTCGCCTAAAGTTACATTTGGCTATTTTCAACAGCTAGGTTATCAGAGAGAGATTAATGAGACTGTGC
TGGAATTTTTGCAAAAACGAACAGAATATGAGGAAGGATTTTTAAGAAGTGTACTTCATTCTATGTATTTCTCTGGAAAT
GACTTAAGAAAAAAGTTGAATCAACTAAGTGGAGGAGAATCAATACGACTCCAATTAAGCTATTTATTTCTAGGGAAATT
TCATATTTTAATACTGGATGAACCAACAAATTTCTTAGATATTCCTACCATCCAGGCTCTTGAGAATTTCTTTCATGCAT
ACCCTGGGACGATTGTATTTGTTTCGCATGACCAAACATTTATTAATCAGGTTGCAACTAAGCAATTTGTGATTCAAAAC
AAGAAGTTATATGAAGTATAA

Upstream 100 bases:

>100_bases
TTTGATCATTACGAGCTTGTCTTAATTAACCATTTAATCAAGCTCGTATCGATGAACTAGCTATCGATACGAAGTAAATT
TATTTCGGAGGTAGCTATCA

Downstream 100 bases:

>100_bases
TAGAAACTAAAATGCGATAGGTTGAAATTTATGAAAATTATACTCCAAAATAATTTTTCAACCAAGACAGAGCTTTATAT
GATGAAAATAGTTAACCGAT

Product: erythromycin resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MERISFELENIELTYLDKEILKIDRLAIHQFDRIGIVGKNGSGKSSLLKLLAGKIKPNKGIVHQHASYAYFEQMEAPDLH
LTGNEDPALLGKLHVPSQLDSISGGEQTRLKLTQLLSEYREALFIDEPTTHLDQDGVAFIQSELEYYYGALVLVSHDRTL
LDQLVSTIWEIHDGSVFVYAGNYTEYEKQKQLEFEQQQEAHYQYVKEKSRLEKAADQKRSKATKMMKGDKANVRAKEGVN
RMFATKSKDATQKAMQKSAKAIEKRIDQLEEVRAPESSNPINFYKSKALDLHNKFPIIGDQLTLQAGDKVLLEEARFQFP
LGENIAITGGNGVGKSSLLQHIVQRGHALDISPKVTFGYFQQLGYQREINETVLEFLQKRTEYEEGFLRSVLHSMYFSGN
DLRKKLNQLSGGESIRLQLSYLFLGKFHILILDEPTNFLDIPTIQALENFFHAYPGTIVFVSHDQTFINQVATKQFVIQN
KKLYEV

Sequences:

>Translated_486_residues
MERISFELENIELTYLDKEILKIDRLAIHQFDRIGIVGKNGSGKSSLLKLLAGKIKPNKGIVHQHASYAYFEQMEAPDLH
LTGNEDPALLGKLHVPSQLDSISGGEQTRLKLTQLLSEYREALFIDEPTTHLDQDGVAFIQSELEYYYGALVLVSHDRTL
LDQLVSTIWEIHDGSVFVYAGNYTEYEKQKQLEFEQQQEAHYQYVKEKSRLEKAADQKRSKATKMMKGDKANVRAKEGVN
RMFATKSKDATQKAMQKSAKAIEKRIDQLEEVRAPESSNPINFYKSKALDLHNKFPIIGDQLTLQAGDKVLLEEARFQFP
LGENIAITGGNGVGKSSLLQHIVQRGHALDISPKVTFGYFQQLGYQREINETVLEFLQKRTEYEEGFLRSVLHSMYFSGN
DLRKKLNQLSGGESIRLQLSYLFLGKFHILILDEPTNFLDIPTIQALENFFHAYPGTIVFVSHDQTFINQVATKQFVIQN
KKLYEV
>Mature_486_residues
MERISFELENIELTYLDKEILKIDRLAIHQFDRIGIVGKNGSGKSSLLKLLAGKIKPNKGIVHQHASYAYFEQMEAPDLH
LTGNEDPALLGKLHVPSQLDSISGGEQTRLKLTQLLSEYREALFIDEPTTHLDQDGVAFIQSELEYYYGALVLVSHDRTL
LDQLVSTIWEIHDGSVFVYAGNYTEYEKQKQLEFEQQQEAHYQYVKEKSRLEKAADQKRSKATKMMKGDKANVRAKEGVN
RMFATKSKDATQKAMQKSAKAIEKRIDQLEEVRAPESSNPINFYKSKALDLHNKFPIIGDQLTLQAGDKVLLEEARFQFP
LGENIAITGGNGVGKSSLLQHIVQRGHALDISPKVTFGYFQQLGYQREINETVLEFLQKRTEYEEGFLRSVLHSMYFSGN
DLRKKLNQLSGGESIRLQLSYLFLGKFHILILDEPTNFLDIPTIQALENFFHAYPGTIVFVSHDQTFINQVATKQFVIQN
KKLYEV

Specific function: Confers resistance to 14-membered ring macrolides (like erythromycin) and to B streptogramins, by acting as an ATP- dependent efflux pump [H]

COG id: COG0488

COG function: function code R; ATPase components of ABC transporters with duplicated ATPase domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Homo sapiens, GI10947137, Length=541, Percent_Identity=24.9537892791128, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI27881506, Length=541, Percent_Identity=24.9537892791128, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI10947135, Length=412, Percent_Identity=26.4563106796117, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI69354671, Length=412, Percent_Identity=26.4563106796117, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI148612853, Length=403, Percent_Identity=26.7990074441687, Blast_Score=115, Evalue=1e-25,
Organism=Escherichia coli, GI1789751, Length=521, Percent_Identity=28.7907869481766, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1787041, Length=522, Percent_Identity=27.0114942528736, Blast_Score=165, Evalue=6e-42,
Organism=Escherichia coli, GI2367384, Length=391, Percent_Identity=30.690537084399, Blast_Score=155, Evalue=7e-39,
Organism=Escherichia coli, GI1787182, Length=415, Percent_Identity=27.4698795180723, Blast_Score=132, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17559834, Length=397, Percent_Identity=29.7229219143577, Blast_Score=139, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17555318, Length=396, Percent_Identity=26.7676767676768, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17553372, Length=401, Percent_Identity=25.6857855361596, Blast_Score=116, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320874, Length=400, Percent_Identity=26, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6321121, Length=394, Percent_Identity=26.9035532994924, Blast_Score=116, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6324314, Length=183, Percent_Identity=30.0546448087432, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6325030, Length=213, Percent_Identity=29.1079812206573, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323278, Length=173, Percent_Identity=26.0115606936416, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24641342, Length=401, Percent_Identity=27.930174563591, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24666836, Length=403, Percent_Identity=27.5434243176179, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24642252, Length=411, Percent_Identity=25.7907542579075, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI18859989, Length=411, Percent_Identity=25.7907542579075, Blast_Score=119, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593
- InterPro:   IPR000014 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 55442; Mature: 55442

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERISFELENIELTYLDKEILKIDRLAIHQFDRIGIVGKNGSGKSSLLKLLAGKIKPNKG
CCCCEEEEECEEEEEECHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHCCCCCCC
IVHQHASYAYFEQMEAPDLHLTGNEDPALLGKLHVPSQLDSISGGEQTRLKLTQLLSEYR
CHHCCCHHHHHHHCCCCCEEEECCCCCCEEEEECCCHHHHCCCCCCHHHHHHHHHHHHHH
EALFIDEPTTHLDQDGVAFIQSELEYYYGALVLVSHDRTLLDQLVSTIWEIHDGSVFVYA
HHEECCCCCCCCCCCHHHHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEE
GNYTEYEKQKQLEFEQQQEAHYQYVKEKSRLEKAADQKRSKATKMMKGDKANVRAKEGVN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
RMFATKSKDATQKAMQKSAKAIEKRIDQLEEVRAPESSNPINFYKSKALDLHNKFPIIGD
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCC
QLTLQAGDKVLLEEARFQFPLGENIAITGGNGVGKSSLLQHIVQRGHALDISPKVTFGYF
EEEECCCCHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCCEECCCCCCHHHHH
QQLGYQREINETVLEFLQKRTEYEEGFLRSVLHSMYFSGNDLRKKLNQLSGGESIRLQLS
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEE
YLFLGKFHILILDEPTNFLDIPTIQALENFFHAYPGTIVFVSHDQTFINQVATKQFVIQN
EEEECEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHCC
KKLYEV
CHHCCC
>Mature Secondary Structure
MERISFELENIELTYLDKEILKIDRLAIHQFDRIGIVGKNGSGKSSLLKLLAGKIKPNKG
CCCCEEEEECEEEEEECHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHCCCCCCC
IVHQHASYAYFEQMEAPDLHLTGNEDPALLGKLHVPSQLDSISGGEQTRLKLTQLLSEYR
CHHCCCHHHHHHHCCCCCEEEECCCCCCEEEEECCCHHHHCCCCCCHHHHHHHHHHHHHH
EALFIDEPTTHLDQDGVAFIQSELEYYYGALVLVSHDRTLLDQLVSTIWEIHDGSVFVYA
HHEECCCCCCCCCCCHHHHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEE
GNYTEYEKQKQLEFEQQQEAHYQYVKEKSRLEKAADQKRSKATKMMKGDKANVRAKEGVN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
RMFATKSKDATQKAMQKSAKAIEKRIDQLEEVRAPESSNPINFYKSKALDLHNKFPIIGD
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCC
QLTLQAGDKVLLEEARFQFPLGENIAITGGNGVGKSSLLQHIVQRGHALDISPKVTFGYF
EEEECCCCHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCCEECCCCCCHHHHH
QQLGYQREINETVLEFLQKRTEYEEGFLRSVLHSMYFSGNDLRKKLNQLSGGESIRLQLS
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEE
YLFLGKFHILILDEPTNFLDIPTIQALENFFHAYPGTIVFVSHDQTFINQVATKQFVIQN
EEEECEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHCC
KKLYEV
CHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2233255 [H]