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The map label for this gene is ycsA [H]

Identifier: 23098116

GI number: 23098116

Start: 696807

End: 697868

Strand: Direct

Name: ycsA [H]

Synonym: OB0661

Alternate gene names: 23098116

Gene position: 696807-697868 (Clockwise)

Preceding gene: 23098115

Following gene: 23098118

Centisome position: 19.19

GC content: 36.72

Gene sequence:

>1062_bases
ATGAAAAATTTTAAAATTGCTAACATTCCGGGTGATGGAATTGGAAAAGAAGTTGTACCTGCAGCAGCAAATGTTTTAAA
AGCTATAGCAGCTATTCATGGAGGTTTAAGATTCGAATTTACTGAATTTCCGTGGAGCTGCGAATATTATATGGAGCACG
GTAAAATGATGCCGGAGGATGGATTAGAGATAATAAAGGATTATAATGCAATCTTTTTAGGAGCAGTCGGTAATATAGAA
CTTGTGCCTGATCATATTTCCTTGTGGGGACTTTTAATCAAGTTTCGCCGAGAATTTGAACAAGTTATTAACTATAGACC
TGCAAAAGTACTTCCTGGAGTGAAATCAAAGATAGTAAATCCAAAAGATTTTGATCTTATAGTTGTTCGAGAAAATAGTG
AAGGTGAGTATAGCGAAGTTGGCGGCAGAATTTTTCGAGGGGAAGATGAAATAGCCATTCAGAATAGCATCTTTTCCAGA
AGAGGAACGGAACGAGTTATGCGATTTGCTTTCGAACTAGCTGCTAAACGTAAAAAACATGTAACTAGTGCAACAAAATC
CAATGGTATTTTTCATTCCATGCCATTTTGGGATGAAGTATTTAAAGATGTTTCAAGAGATTATTCAACCATTGAAACGG
ATTCCCAACATATTGATGCGTTGGCTGCCTTCTTTGTAACGAATCCAGAAAGATTTGATGTTATTGTTGCTAGTAATTTA
TTTGGGGATGTATTAAGTGATTTAGGTGCGGCTATCATGGGAAGTGTAGGAGTTGCACCGGCAGCAAACATTAATGTTAA
TGGCAAGTATCCTTCTATGTTTGAACCAGTTCATGGATCTGCTCCGGATATTATTGGGAAGAATATTGCTAATCCAATCG
GACAAATTTGGACGGCGAAATTAATGTTAGATCATTTTGGAGAAGAAGAGTTAGGCAGTCTGTTATTAGATGTGATTGAA
AATACTACAAATAAAGGAATTTTGACTCCAGACATCGGTGGAAAGCATACAACTTCAGAGGTGACAGAAGAAATTATTGA
AGGATTAAAGGCGCGATTCTAA

Upstream 100 bases:

>100_bases
AATTAAAATATTTCATTGATTGGAAAAATACATTCAATTATACTTTAACCATAATGAGATCGAGTAAACGTCAGATATTA
AAGACATAAGGAGAATAATG

Downstream 100 bases:

>100_bases
TCGGATAATCGTGCGGGTTTTTTATCAAATTTTTACAAACGATGAGTAAATTAGCGCAAAAAGACTGGAATAAGTGTGGT
AAGATAACCATTTTTATTCC

Product: tartrate dehydrogenase

Products: NA

Alternate protein names: TDH; D-malate dehydrogenase [decarboxylating] [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MKNFKIANIPGDGIGKEVVPAAANVLKAIAAIHGGLRFEFTEFPWSCEYYMEHGKMMPEDGLEIIKDYNAIFLGAVGNIE
LVPDHISLWGLLIKFRREFEQVINYRPAKVLPGVKSKIVNPKDFDLIVVRENSEGEYSEVGGRIFRGEDEIAIQNSIFSR
RGTERVMRFAFELAAKRKKHVTSATKSNGIFHSMPFWDEVFKDVSRDYSTIETDSQHIDALAAFFVTNPERFDVIVASNL
FGDVLSDLGAAIMGSVGVAPAANINVNGKYPSMFEPVHGSAPDIIGKNIANPIGQIWTAKLMLDHFGEEELGSLLLDVIE
NTTNKGILTPDIGGKHTTSEVTEEIIEGLKARF

Sequences:

>Translated_353_residues
MKNFKIANIPGDGIGKEVVPAAANVLKAIAAIHGGLRFEFTEFPWSCEYYMEHGKMMPEDGLEIIKDYNAIFLGAVGNIE
LVPDHISLWGLLIKFRREFEQVINYRPAKVLPGVKSKIVNPKDFDLIVVRENSEGEYSEVGGRIFRGEDEIAIQNSIFSR
RGTERVMRFAFELAAKRKKHVTSATKSNGIFHSMPFWDEVFKDVSRDYSTIETDSQHIDALAAFFVTNPERFDVIVASNL
FGDVLSDLGAAIMGSVGVAPAANINVNGKYPSMFEPVHGSAPDIIGKNIANPIGQIWTAKLMLDHFGEEELGSLLLDVIE
NTTNKGILTPDIGGKHTTSEVTEEIIEGLKARF
>Mature_353_residues
MKNFKIANIPGDGIGKEVVPAAANVLKAIAAIHGGLRFEFTEFPWSCEYYMEHGKMMPEDGLEIIKDYNAIFLGAVGNIE
LVPDHISLWGLLIKFRREFEQVINYRPAKVLPGVKSKIVNPKDFDLIVVRENSEGEYSEVGGRIFRGEDEIAIQNSIFSR
RGTERVMRFAFELAAKRKKHVTSATKSNGIFHSMPFWDEVFKDVSRDYSTIETDSQHIDALAAFFVTNPERFDVIVASNL
FGDVLSDLGAAIMGSVGVAPAANINVNGKYPSMFEPVHGSAPDIIGKNIANPIGQIWTAKLMLDHFGEEELGSLLLDVIE
NTTNKGILTPDIGGKHTTSEVTEEIIEGLKARF

Specific function: Unknown

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=345, Percent_Identity=32.463768115942, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI28178816, Length=351, Percent_Identity=28.7749287749288, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI4758582, Length=349, Percent_Identity=29.512893982808, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI28178821, Length=354, Percent_Identity=28.2485875706215, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI28178838, Length=307, Percent_Identity=28.9902280130293, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI28178819, Length=198, Percent_Identity=28.2828282828283, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1788101, Length=357, Percent_Identity=53.5014005602241, Blast_Score=380, Evalue=1e-107,
Organism=Escherichia coli, GI87081683, Length=341, Percent_Identity=34.8973607038123, Blast_Score=191, Evalue=6e-50,
Organism=Escherichia coli, GI1787381, Length=379, Percent_Identity=28.2321899736148, Blast_Score=120, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17550882, Length=353, Percent_Identity=29.4617563739377, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71986051, Length=352, Percent_Identity=29.8295454545455, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17505779, Length=347, Percent_Identity=26.8011527377522, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI25144293, Length=344, Percent_Identity=26.7441860465116, Blast_Score=117, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6322097, Length=368, Percent_Identity=34.7826086956522, Blast_Score=189, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6319830, Length=361, Percent_Identity=30.4709141274238, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324291, Length=356, Percent_Identity=31.1797752808989, Blast_Score=143, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6324709, Length=356, Percent_Identity=32.0224719101124, Blast_Score=140, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24643270, Length=353, Percent_Identity=32.0113314447592, Blast_Score=158, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24643268, Length=353, Percent_Identity=32.0113314447592, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI24661184, Length=357, Percent_Identity=30.812324929972, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI161078639, Length=347, Percent_Identity=29.6829971181556, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI161078635, Length=347, Percent_Identity=29.6829971181556, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI161078633, Length=347, Percent_Identity=29.6829971181556, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24650122, Length=347, Percent_Identity=29.6829971181556, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI161078637, Length=347, Percent_Identity=29.6829971181556, Blast_Score=139, Evalue=2e-33,
Organism=Drosophila melanogaster, GI281362242, Length=354, Percent_Identity=28.2485875706215, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24648872, Length=354, Percent_Identity=28.2485875706215, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI20130355, Length=352, Percent_Identity=24.7159090909091, Blast_Score=101, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR011829 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.93; =4.1.1.73; =1.1.1.83 [H]

Molecular weight: Translated: 39062; Mature: 39062

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNFKIANIPGDGIGKEVVPAAANVLKAIAAIHGGLRFEFTEFPWSCEYYMEHGKMMPED
CCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHCCCCCCHH
GLEIIKDYNAIFLGAVGNIELVPDHISLWGLLIKFRREFEQVINYRPAKVLPGVKSKIVN
HHHHHHHCCEEEEECCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHCCC
PKDFDLIVVRENSEGEYSEVGGRIFRGEDEIAIQNSIFSRRGTERVMRFAFELAAKRKKH
CCCCEEEEEEECCCCCHHHHCCEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
VTSATKSNGIFHSMPFWDEVFKDVSRDYSTIETDSQHIDALAAFFVTNPERFDVIVASNL
HHHHHHCCCCEECCCCHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHCCCCCEEEEEEHHH
FGDVLSDLGAAIMGSVGVAPAANINVNGKYPSMFEPVHGSAPDIIGKNIANPIGQIWTAK
HHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LMLDHFGEEELGSLLLDVIENTTNKGILTPDIGGKHTTSEVTEEIIEGLKARF
HHHHHCCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKNFKIANIPGDGIGKEVVPAAANVLKAIAAIHGGLRFEFTEFPWSCEYYMEHGKMMPED
CCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHCCCCCCHH
GLEIIKDYNAIFLGAVGNIELVPDHISLWGLLIKFRREFEQVINYRPAKVLPGVKSKIVN
HHHHHHHCCEEEEECCCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHCCC
PKDFDLIVVRENSEGEYSEVGGRIFRGEDEIAIQNSIFSRRGTERVMRFAFELAAKRKKH
CCCCEEEEEEECCCCCHHHHCCEEECCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
VTSATKSNGIFHSMPFWDEVFKDVSRDYSTIETDSQHIDALAAFFVTNPERFDVIVASNL
HHHHHHCCCCEECCCCHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHCCCCCEEEEEEHHH
FGDVLSDLGAAIMGSVGVAPAANINVNGKYPSMFEPVHGSAPDIIGKNIANPIGQIWTAK
HHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LMLDHFGEEELGSLLLDVIENTTNKGILTPDIGGKHTTSEVTEEIIEGLKARF
HHHHHCCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 10568751 [H]