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The map label for this gene is rsbRA [H]

Identifier: 23098079

GI number: 23098079

Start: 652243

End: 653112

Strand: Direct

Name: rsbRA [H]

Synonym: OB0624

Alternate gene names: 23098079

Gene position: 652243-653112 (Clockwise)

Preceding gene: 23098078

Following gene: 23098080

Centisome position: 17.97

GC content: 35.63

Gene sequence:

>870_bases
ATGAAACGAGGGTTTAGAGAGCTCCTTATAGAGAACAGTGATTCCATTGTTGAAAATTGGCTAGCAGAAATTAACTCATT
AAAGACAGGTAATTATACTGCGACTATATCAGACGAATTGTATGAAAGTACAAATCGAGAGTTTGTCAATGTGATATTTA
CAAGTATTCGTAATCAAGGTTCGTCTAAGGAAGTAGAAGATTTTTCTGAAAAGATCATAAATCTAGGATGGCCGTTGAGT
TATTTAACAGATGGACTACAGGTGTTTCGAAGAGTGTCAACAGAGTATTTACTTAGTCAATCCGAAGTAATTGATTCTAA
CCAATTCTCAATGATTTTATCTAGTGTTGATGAGTGGGTGGAGCCTCTTATTCGCCAGTTAGTGAATGAATACTCTGGCA
GCTGGGAGAATATTCTGTCGTTGCAACGTGTTGCTTTACAAGAATTATCTGCCCCACTGATTCCTGTTATGGAAGGTATT
ACGGTAATGCCTTTAATTGGAACGATTGATACAGAAAGAGCAAAGTTAATTATGGAGAATCTTCTGGAAGGTACGATAAA
ACACAATTCAGAGGTTGTATTAATAGATATTACAGGTGTTCCGGTAGTTGATACGATGGTTGCACATCATATTATTCAAG
CTGCGGAAGCCGTTCGATTAATTGGTTCTACATGTATTTTAGTTGGAATTCGTCCTGAAATTGCTCAAACAATTGTAAAC
TTAGGAATTGATTTAAGTAATTTCCCAACACAGAGTTCATTGAAAAAAGGATTTACGAAAGCATTAGAACTTACTGGACG
TGAGGTTATAGATTTAAAAAATCGCGAGTCTGATATTGAAGGAATCATAAATTCCTTGAAAGGAGAATAA

Upstream 100 bases:

>100_bases
ATACATAATAATTTGTGTATTTTAATTGCACAAAATCACATTAAATGTAACAATATGTCTAAATTTTAATTTAAATTATT
TTGGTGGAGGTAGAGAAAGC

Downstream 100 bases:

>100_bases
GTATATGCGCATTCCAATTTTAAAGCTTCATAACTACTTACTTATCTCTATTCAAACAGAAATAGACGACCAAACAGCAA
TTCAATTTCAAGAGGATTTA

Product: positive regulator of sigma-B activity

Products: NA

Alternate protein names: Stressosome protein rsbRA [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MKRGFRELLIENSDSIVENWLAEINSLKTGNYTATISDELYESTNREFVNVIFTSIRNQGSSKEVEDFSEKIINLGWPLS
YLTDGLQVFRRVSTEYLLSQSEVIDSNQFSMILSSVDEWVEPLIRQLVNEYSGSWENILSLQRVALQELSAPLIPVMEGI
TVMPLIGTIDTERAKLIMENLLEGTIKHNSEVVLIDITGVPVVDTMVAHHIIQAAEAVRLIGSTCILVGIRPEIAQTIVN
LGIDLSNFPTQSSLKKGFTKALELTGREVIDLKNRESDIEGIINSLKGE

Sequences:

>Translated_289_residues
MKRGFRELLIENSDSIVENWLAEINSLKTGNYTATISDELYESTNREFVNVIFTSIRNQGSSKEVEDFSEKIINLGWPLS
YLTDGLQVFRRVSTEYLLSQSEVIDSNQFSMILSSVDEWVEPLIRQLVNEYSGSWENILSLQRVALQELSAPLIPVMEGI
TVMPLIGTIDTERAKLIMENLLEGTIKHNSEVVLIDITGVPVVDTMVAHHIIQAAEAVRLIGSTCILVGIRPEIAQTIVN
LGIDLSNFPTQSSLKKGFTKALELTGREVIDLKNRESDIEGIINSLKGE
>Mature_289_residues
MKRGFRELLIENSDSIVENWLAEINSLKTGNYTATISDELYESTNREFVNVIFTSIRNQGSSKEVEDFSEKIINLGWPLS
YLTDGLQVFRRVSTEYLLSQSEVIDSNQFSMILSSVDEWVEPLIRQLVNEYSGSWENILSLQRVALQELSAPLIPVMEGI
TVMPLIGTIDTERAKLIMENLLEGTIKHNSEVVLIDITGVPVVDTMVAHHIIQAAEAVRLIGSTCILVGIRPEIAQTIVN
LGIDLSNFPTQSSLKKGFTKALELTGREVIDLKNRESDIEGIINSLKGE

Specific function: Negative regulator of sigma-B activity. Non- phosphorylated rsbS binds to rsbT, preventing its association with rsbU. Requires any one of rsbRA, rsbRB, rsbRC or rsbRD to sequester rsbT. When rsbS and the rsbR paralog(s) are phosphorylated, they release rs

COG id: COG1366

COG function: function code T; Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 STAS domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014792
- InterPro:   IPR002645 [H]

Pfam domain/function: PF08678 Rsbr_N; PF01740 STAS [H]

EC number: NA

Molecular weight: Translated: 32267; Mature: 32267

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: PS50801 STAS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRGFRELLIENSDSIVENWLAEINSLKTGNYTATISDELYESTNREFVNVIFTSIRNQG
CCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCC
SSKEVEDFSEKIINLGWPLSYLTDGLQVFRRVSTEYLLSQSEVIDSNQFSMILSSVDEWV
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
EPLIRQLVNEYSGSWENILSLQRVALQELSAPLIPVMEGITVMPLIGTIDTERAKLIMEN
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHCCCCHHHHHHHHHH
LLEGTIKHNSEVVLIDITGVPVVDTMVAHHIIQAAEAVRLIGSTCILVGIRPEIAQTIVN
HHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHEEEECCHHHHHHHHH
LGIDLSNFPTQSSLKKGFTKALELTGREVIDLKNRESDIEGIINSLKGE
HCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MKRGFRELLIENSDSIVENWLAEINSLKTGNYTATISDELYESTNREFVNVIFTSIRNQG
CCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCC
SSKEVEDFSEKIINLGWPLSYLTDGLQVFRRVSTEYLLSQSEVIDSNQFSMILSSVDEWV
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
EPLIRQLVNEYSGSWENILSLQRVALQELSAPLIPVMEGITVMPLIGTIDTERAKLIMEN
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHCCCCHHHHHHHHHH
LLEGTIKHNSEVVLIDITGVPVVDTMVAHHIIQAAEAVRLIGSTCILVGIRPEIAQTIVN
HHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHEEEECCHHHHHHHHH
LGIDLSNFPTQSSLKKGFTKALELTGREVIDLKNRESDIEGIINSLKGE
HCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8002610; 9384377; 11157946; 10329124 [H]