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The map label for this gene is 23097682

Identifier: 23097682

GI number: 23097682

Start: 248696

End: 249805

Strand: Direct

Name: 23097682

Synonym: OB0227

Alternate gene names: NA

Gene position: 248696-249805 (Clockwise)

Preceding gene: 23097681

Following gene: 23097683

Centisome position: 6.85

GC content: 39.1

Gene sequence:

>1110_bases
TTGAGTAAGAGACAATTGACCGTTAAAGTGCCAGGCAAACTAATGATTGCTGGAGAGTTCGCTGTATTAGAACCTTATCA
AAAACTTGCAGTAATGGCAGTTAATCGATACGTGTATGCAACCATAACAGACGCAGAAAATTATACATTGTCTCTAGAAG
ACTTTGGGTTACATGATATTGCTTGGTCTTACCAAACGGGAACTGTAAATATAGAATCGGACGATGAGCGATTTTCTTTT
GTGAAGGATGCTATCTACATTACATGTACGTATTTAGAAGAAAAAAGCATAGGAATCCCTTCTTTTCATTTGTCTACTCG
AAGTGAGTTGGATGATGCTTCCGGTGTGAAATACGGTCTAGGGTCAAGTGCCGCTATTGTAACATCTGTTGTATCGGCAA
TTCTTCGTTTTGTTGCTCCACGTTACGCAACGAAGGAAATTATTTTTCGGTTAGCGGCGTTGTCTCATGTCTGTACACAA
GGTAATGGATCTGGTGCCGATATTGCAGCTTCCACATATGGTGGTTTTCGACAATATAGTTCGTTTCAAGCAGATTGGTT
ATTGAATACATATAAGAATGCTTCAACGATATCTGAAGTTGTAGATATGGAGTGGAAGTATTATCAATCAGAAAATATTC
GCATACCTGATTTTCTAAACGTCTGTGTAGGTTGGACAGGTACTGCTGCATCAACAAAGAACCTTGTCCAACAGATTCGT
TTATTAAAAGTAAGTGATTCAGATGCATATGAACATTTTCTACAAAGTAGTAAAGAAGCGGTCGGCCTATTTTTAGATGG
AATGAATAGCGAGAACCTTTCTATGTTAATGGACGGAGTAAGAAAAAATAGACAAGCATTAGCACACGTAGGACAAAAAG
CTAAAACACCAATTGAAACATCGATGCTGACAAAATTATGTGACCTTGCTGAACAGTTAGGTGGTGCTGGGAAACCATCA
GGTGCTGGTGGAGGCGATTGTGGTATTGCATTTATGTACTCTAAAGATCAAGCAGAGAATCTTTTTCATGCTTGGGCAGA
AGTCGGAATCAAGCCCCTAACATTACAGCCTTCATTAGAAGGTGAGCAAGTTGTAATCGAAGAGGAATAA

Upstream 100 bases:

>100_bases
GTCGAAAGTGAAGCAAAGACTTGAACAGATTATGGGTGTCGAGGATGTAATCGTTAGTAAGCCAGGAAAAGGAATAAGCT
ATTTGTAGGGGTTGGAAAAG

Downstream 100 bases:

>100_bases
AAAAATTTAAAAAAGACATTCCAACGATAGTATGTGGATGTCTTTTTACCCTTTTTTTATCTCTTTATGATATTTTTTCA
TAATCATTCATTAGTTGGTC

Product: phosphomevalonate kinase

Products: ADP; (R)-5-diphosphomevalonate

Alternate protein names: Mevalonate Kinase; Isopentenyl-Diphosphate Delta-Isomerase; LOW QUALITY PROTEIN Phosphomevalonate Kinase

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MSKRQLTVKVPGKLMIAGEFAVLEPYQKLAVMAVNRYVYATITDAENYTLSLEDFGLHDIAWSYQTGTVNIESDDERFSF
VKDAIYITCTYLEEKSIGIPSFHLSTRSELDDASGVKYGLGSSAAIVTSVVSAILRFVAPRYATKEIIFRLAALSHVCTQ
GNGSGADIAASTYGGFRQYSSFQADWLLNTYKNASTISEVVDMEWKYYQSENIRIPDFLNVCVGWTGTAASTKNLVQQIR
LLKVSDSDAYEHFLQSSKEAVGLFLDGMNSENLSMLMDGVRKNRQALAHVGQKAKTPIETSMLTKLCDLAEQLGGAGKPS
GAGGGDCGIAFMYSKDQAENLFHAWAEVGIKPLTLQPSLEGEQVVIEEE

Sequences:

>Translated_369_residues
MSKRQLTVKVPGKLMIAGEFAVLEPYQKLAVMAVNRYVYATITDAENYTLSLEDFGLHDIAWSYQTGTVNIESDDERFSF
VKDAIYITCTYLEEKSIGIPSFHLSTRSELDDASGVKYGLGSSAAIVTSVVSAILRFVAPRYATKEIIFRLAALSHVCTQ
GNGSGADIAASTYGGFRQYSSFQADWLLNTYKNASTISEVVDMEWKYYQSENIRIPDFLNVCVGWTGTAASTKNLVQQIR
LLKVSDSDAYEHFLQSSKEAVGLFLDGMNSENLSMLMDGVRKNRQALAHVGQKAKTPIETSMLTKLCDLAEQLGGAGKPS
GAGGGDCGIAFMYSKDQAENLFHAWAEVGIKPLTLQPSLEGEQVVIEEE
>Mature_368_residues
SKRQLTVKVPGKLMIAGEFAVLEPYQKLAVMAVNRYVYATITDAENYTLSLEDFGLHDIAWSYQTGTVNIESDDERFSFV
KDAIYITCTYLEEKSIGIPSFHLSTRSELDDASGVKYGLGSSAAIVTSVVSAILRFVAPRYATKEIIFRLAALSHVCTQG
NGSGADIAASTYGGFRQYSSFQADWLLNTYKNASTISEVVDMEWKYYQSENIRIPDFLNVCVGWTGTAASTKNLVQQIRL
LKVSDSDAYEHFLQSSKEAVGLFLDGMNSENLSMLMDGVRKNRQALAHVGQKAKTPIETSMLTKLCDLAEQLGGAGKPSG
AGGGDCGIAFMYSKDQAENLFHAWAEVGIKPLTLQPSLEGEQVVIEEE

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.7.4.2

Molecular weight: Translated: 40441; Mature: 40310

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKRQLTVKVPGKLMIAGEFAVLEPYQKLAVMAVNRYVYATITDAENYTLSLEDFGLHDI
CCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHCEEEEEEEECCCCCEEEEECCCCCCE
AWSYQTGTVNIESDDERFSFVKDAIYITCTYLEEKSIGIPSFHLSTRSELDDASGVKYGL
EEEEECCEEEECCCCHHHHHHHHCEEEEEEEEECCCCCCCCEECCCHHCCCCCCCCEECC
GSSAAIVTSVVSAILRFVAPRYATKEIIFRLAALSHVCTQGNGSGADIAASTYGGFRQYS
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHC
SFQADWLLNTYKNASTISEVVDMEWKYYQSENIRIPDFLNVCVGWTGTAASTKNLVQQIR
CCCHHHHHHHHCCHHHHHHHHHCCCEEECCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHH
LLKVSDSDAYEHFLQSSKEAVGLFLDGMNSENLSMLMDGVRKNRQALAHVGQKAKTPIET
HEEECCCHHHHHHHHCCHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
SMLTKLCDLAEQLGGAGKPSGAGGGDCGIAFMYSKDQAENLFHAWAEVGIKPLTLQPSLE
HHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCEEEEECCCCC
GEQVVIEEE
CCEEEEECC
>Mature Secondary Structure 
SKRQLTVKVPGKLMIAGEFAVLEPYQKLAVMAVNRYVYATITDAENYTLSLEDFGLHDI
CCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHCEEEEEEEECCCCCEEEEECCCCCCE
AWSYQTGTVNIESDDERFSFVKDAIYITCTYLEEKSIGIPSFHLSTRSELDDASGVKYGL
EEEEECCEEEECCCCHHHHHHHHCEEEEEEEEECCCCCCCCEECCCHHCCCCCCCCEECC
GSSAAIVTSVVSAILRFVAPRYATKEIIFRLAALSHVCTQGNGSGADIAASTYGGFRQYS
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHC
SFQADWLLNTYKNASTISEVVDMEWKYYQSENIRIPDFLNVCVGWTGTAASTKNLVQQIR
CCCHHHHHHHHCCHHHHHHHHHCCCEEECCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHH
LLKVSDSDAYEHFLQSSKEAVGLFLDGMNSENLSMLMDGVRKNRQALAHVGQKAKTPIET
HEEECCCHHHHHHHHCCHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
SMLTKLCDLAEQLGGAGKPSGAGGGDCGIAFMYSKDQAENLFHAWAEVGIKPLTLQPSLE
HHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCEEEEECCCCC
GEQVVIEEE
CCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; (R)-5-phosphomevalonate

Specific reaction: ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA