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The map label for this gene is sul [H]

Identifier: 23097540

GI number: 23097540

Start: 87477

End: 88298

Strand: Direct

Name: sul [H]

Synonym: OB0085

Alternate gene names: 23097540

Gene position: 87477-88298 (Clockwise)

Preceding gene: 23097539

Following gene: 23097541

Centisome position: 2.41

GC content: 37.83

Gene sequence:

>822_bases
TTGAATATTCGAACGAAGAAACGAACATTAAATGTTTCTAAACGAACACATATCATGGGCATACTAAATGTAACTCCGGA
TTCTTTTTCAGATGGAGGGAACTATTCAACTGTTAATAAAGCTGTCGACCAAGCTTTGCAATTAGAAAAGCAAGGGGCGG
ATATGATTGATATAGGAGGAGAATCGACACGACCAGGCTACACTCCAATCTCTGCCGAAGAGGAGTTGAATCGAATTATT
CCAGTTATTCGAATCCTTAAAGACAAATTAAGTATTCCGATATCGGTGGATACGTTTAAAGCAGAGACAGCTAGAAAAGT
GTTAGAAGCAGGAGCAGATATGATCAATGATATATGGGGAGCAAAAAAGGATCCAGATATGGCGAAGGTTGTAGCAGAAT
ATAATGTTCCAATTATTTTAATGCATAATCGTAAAGAAGAAGATTATAGTGATTTCATGGAAGACGTAAAATCCGATTTA
TTGGAAAGTATTCAAATTGCAAAAGATGCAGGGATTAGCGAGGATAACATTATTATTGATCCTGGTGTAGGTTTTGCAAA
AAGCATGGAACAGAATATGGAAGTAGTACGAGAGTTACATCAATTAGTTAATCTAGGTTATCCGGTACTATTAGCCACTT
CACGTAAAAGGTTTATTGGACATGTATTAGATGTACCTGCAGCTGATCGTGATGTTGGTACTGCTGCTACTACAGTAATT
GGAGTACAGCAAGGAGCTCATATAGTACGAGTGCATAATGTACATATCAATGCAGAAGCTGCCAAGGTCGCAGATGCTAT
CTATGGGAAAAGGAGTCTTTAG

Upstream 100 bases:

>100_bases
ATTGGTCAGCTCTTTTTTGTTTATGGTGGTGCTTCCGTTCTGTGAGTAGTTATTGTACGATGAAAGAATAGATTATGTAA
GAAAAGAGGTAGGCGATAAG

Downstream 100 bases:

>100_bases
GAATGGATAAAATCATTATAAAACAAATGCAATTTTATGGTTATCATGGACTTTTTCCAGAAGAAAATAAACTAGGACAA
CGGTTTAATGTAGATCTTGA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MNIRTKKRTLNVSKRTHIMGILNVTPDSFSDGGNYSTVNKAVDQALQLEKQGADMIDIGGESTRPGYTPISAEEELNRII
PVIRILKDKLSIPISVDTFKAETARKVLEAGADMINDIWGAKKDPDMAKVVAEYNVPIILMHNRKEEDYSDFMEDVKSDL
LESIQIAKDAGISEDNIIIDPGVGFAKSMEQNMEVVRELHQLVNLGYPVLLATSRKRFIGHVLDVPAADRDVGTAATTVI
GVQQGAHIVRVHNVHINAEAAKVADAIYGKRSL

Sequences:

>Translated_273_residues
MNIRTKKRTLNVSKRTHIMGILNVTPDSFSDGGNYSTVNKAVDQALQLEKQGADMIDIGGESTRPGYTPISAEEELNRII
PVIRILKDKLSIPISVDTFKAETARKVLEAGADMINDIWGAKKDPDMAKVVAEYNVPIILMHNRKEEDYSDFMEDVKSDL
LESIQIAKDAGISEDNIIIDPGVGFAKSMEQNMEVVRELHQLVNLGYPVLLATSRKRFIGHVLDVPAADRDVGTAATTVI
GVQQGAHIVRVHNVHINAEAAKVADAIYGKRSL
>Mature_273_residues
MNIRTKKRTLNVSKRTHIMGILNVTPDSFSDGGNYSTVNKAVDQALQLEKQGADMIDIGGESTRPGYTPISAEEELNRII
PVIRILKDKLSIPISVDTFKAETARKVLEAGADMINDIWGAKKDPDMAKVVAEYNVPIILMHNRKEEDYSDFMEDVKSDL
LESIQIAKDAGISEDNIIIDPGVGFAKSMEQNMEVVRELHQLVNLGYPVLLATSRKRFIGHVLDVPAADRDVGTAATTVI
GVQQGAHIVRVHNVHINAEAAKVADAIYGKRSL

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=273, Percent_Identity=39.1941391941392, Blast_Score=202, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6324073, Length=317, Percent_Identity=33.1230283911672, Blast_Score=159, Evalue=4e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 29998; Mature: 29998

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIRTKKRTLNVSKRTHIMGILNVTPDSFSDGGNYSTVNKAVDQALQLEKQGADMIDIGG
CCCCCCHHEECCCHHEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCC
ESTRPGYTPISAEEELNRIIPVIRILKDKLSIPISVDTFKAETARKVLEAGADMINDIWG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHC
AKKDPDMAKVVAEYNVPIILMHNRKEEDYSDFMEDVKSDLLESIQIAKDAGISEDNIIID
CCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
PGVGFAKSMEQNMEVVRELHQLVNLGYPVLLATSRKRFIGHVLDVPAADRDVGTAATTVI
CCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCCCCCCCCHHHHHHE
GVQQGAHIVRVHNVHINAEAAKVADAIYGKRSL
ECCCCCEEEEEEEEEECCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNIRTKKRTLNVSKRTHIMGILNVTPDSFSDGGNYSTVNKAVDQALQLEKQGADMIDIGG
CCCCCCHHEECCCHHEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEECCC
ESTRPGYTPISAEEELNRIIPVIRILKDKLSIPISVDTFKAETARKVLEAGADMINDIWG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHC
AKKDPDMAKVVAEYNVPIILMHNRKEEDYSDFMEDVKSDLLESIQIAKDAGISEDNIIID
CCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
PGVGFAKSMEQNMEVVRELHQLVNLGYPVLLATSRKRFIGHVLDVPAADRDVGTAATTVI
CCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCCCCCCCCHHHHHHE
GVQQGAHIVRVHNVHINAEAAKVADAIYGKRSL
ECCCCCEEEEEEEEEECCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2123867; 7584024; 9384377 [H]