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The map label for this gene is tmk

Identifier: 23097491

GI number: 23097491

Start: 38894

End: 39571

Strand: Direct

Name: tmk

Synonym: OB0036

Alternate gene names: 23097491

Gene position: 38894-39571 (Clockwise)

Preceding gene: 23097490

Following gene: 23097492

Centisome position: 1.07

GC content: 35.84

Gene sequence:

>678_bases
ATGGCTGGTTTGTTTATTACATTTGAAGGTGGAGAAGGTGCTGGAAAGACAACAGTTATCCAACATATCTTCCAAAAATT
AATTGCTCAAGGGATTGATGTTATTCAAACAAGAGAACCCGGAGGAATAAAAATATCGGAGAAAATTCGAAGTATTATAC
ATGATCCAGAACATCTGGAAATGGAAGAAAGAACGGAAGCTCTATTATATGCAGCTGCTAGAAGACAGCATTTAGTGGAG
AAAGTGTTTCCCGCTTTGGAACAAGGAAAAGTGGTGCTCTGTGATCGCTTTGTAGATAGTAGCTTAGCATATCAAGGTTA
TGCTAGAGGATTAGGAATAGATGAAGTTTATGCAATTAATCATTTTGTAATTCAAGATTGCATGCCTGATTTAACACTTT
TTTTCGATATAGAACCAAAAAAGGGATTAGAACGCATAGCGGCGAATAAAAATAGAGAAAGAAACCGATTAGATCTAGAA
AATATGCAGTTTCATGAAGCAGTTTATGAAGGATATCAAAAAGTGATTGCTCGTTTCCCTGAGCGGATAAAGACGATTCA
AGCGGAACAAGCATTAGAGGCAGTGGAACAGGATACCATGGAGATAATCAGTTCTTTTTTAAATGAAAAAGAAAAGGGTG
GTAACAATGAAATTAATTATTACGGTGATTCAAGATAA

Upstream 100 bases:

>100_bases
GCGCATATTACAAAGATTCAGCTTTTGATTCAACAAGGAGTAACCATTCAGCAACGGGAAGAAGGAATACGTATATATAG
GAAGGCATGAGACACAATAT

Downstream 100 bases:

>100_bases
GGATTCAAACCGACTTGTTAATGCATTAGGAGAACAAAATTTTAAGACAACAAAACTAGCAACCACAGGTGGATTTTTAA
AAGAAGGAAATACGACGTTA

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MAGLFITFEGGEGAGKTTVIQHIFQKLIAQGIDVIQTREPGGIKISEKIRSIIHDPEHLEMEERTEALLYAAARRQHLVE
KVFPALEQGKVVLCDRFVDSSLAYQGYARGLGIDEVYAINHFVIQDCMPDLTLFFDIEPKKGLERIAANKNRERNRLDLE
NMQFHEAVYEGYQKVIARFPERIKTIQAEQALEAVEQDTMEIISSFLNEKEKGGNNEINYYGDSR

Sequences:

>Translated_225_residues
MAGLFITFEGGEGAGKTTVIQHIFQKLIAQGIDVIQTREPGGIKISEKIRSIIHDPEHLEMEERTEALLYAAARRQHLVE
KVFPALEQGKVVLCDRFVDSSLAYQGYARGLGIDEVYAINHFVIQDCMPDLTLFFDIEPKKGLERIAANKNRERNRLDLE
NMQFHEAVYEGYQKVIARFPERIKTIQAEQALEAVEQDTMEIISSFLNEKEKGGNNEINYYGDSR
>Mature_224_residues
AGLFITFEGGEGAGKTTVIQHIFQKLIAQGIDVIQTREPGGIKISEKIRSIIHDPEHLEMEERTEALLYAAARRQHLVEK
VFPALEQGKVVLCDRFVDSSLAYQGYARGLGIDEVYAINHFVIQDCMPDLTLFFDIEPKKGLERIAANKNRERNRLDLEN
MQFHEAVYEGYQKVIARFPERIKTIQAEQALEAVEQDTMEIISSFLNEKEKGGNNEINYYGDSR

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=214, Percent_Identity=37.3831775700935, Blast_Score=113, Evalue=9e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_OCEIH (Q8EU53)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_690957.1
- ProteinModelPortal:   Q8EU53
- GeneID:   1015078
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB0036
- NMPDR:   fig|221109.1.peg.36
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- ProtClustDB:   PRK00698
- BioCyc:   OIHE221109:OB0036-MONOMER
- BRENDA:   2.7.4.9
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 25650; Mature: 25518

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGLFITFEGGEGAGKTTVIQHIFQKLIAQGIDVIQTREPGGIKISEKIRSIIHDPEHLE
CCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCHHEECCCCCCCCHHHHHHHHHCCCHHCC
MEERTEALLYAAARRQHLVEKVFPALEQGKVVLCDRFVDSSLAYQGYARGLGIDEVYAIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHCCCCCHHHHHHH
HFVIQDCMPDLTLFFDIEPKKGLERIAANKNRERNRLDLENMQFHEAVYEGYQKVIARFP
HHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ERIKTIQAEQALEAVEQDTMEIISSFLNEKEKGGNNEINYYGDSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
AGLFITFEGGEGAGKTTVIQHIFQKLIAQGIDVIQTREPGGIKISEKIRSIIHDPEHLE
CCEEEEEECCCCCCHHHHHHHHHHHHHHCCCHHEECCCCCCCCHHHHHHHHHCCCHHCC
MEERTEALLYAAARRQHLVEKVFPALEQGKVVLCDRFVDSSLAYQGYARGLGIDEVYAIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHCCCCCHHHHHHH
HFVIQDCMPDLTLFFDIEPKKGLERIAANKNRERNRLDLENMQFHEAVYEGYQKVIARFP
HHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ERIKTIQAEQALEAVEQDTMEIISSFLNEKEKGGNNEINYYGDSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376