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The map label for this gene is gyrA [H]

Identifier: 23097462

GI number: 23097462

Start: 7123

End: 9636

Strand: Direct

Name: gyrA [H]

Synonym: OB0007

Alternate gene names: 23097462

Gene position: 7123-9636 (Clockwise)

Preceding gene: 23097461

Following gene: 23097463

Centisome position: 0.2

GC content: 38.5

Gene sequence:

>2514_bases
ATGGCAGATATAAATCGTCCGAGAGTATCGGAAATTAATATTAGTAATGAGATGCGTACGTCATTCCTCGATTATGCGAT
GAGTGTAATTGTAGCTCGTGCATTACCAGATGTGCGTGACGGAATGAAACCAGTTCATCGTCGTATTCTATATGCGATGA
ACGACTTAGGTATGCATTCAGATAAAGCATATAAGAAGTCAGCTCGTATTGTTGGTGAAGTTATTGGTAAATATCACCCA
CATGGTGATTCCGCAGTATACGAAACGATGGTACGTATGGCGCAAACTTTTAGCTATCGATATATGTTAGTCGATGGACA
CGGAAACTTCGGATCCGTAGATGGTGACTCAGCAGCAGCTATGCGTTATACAGAAGCTAGAATGTCCAAAATTTCCATGG
AATTACTCCGTGATATTAATAAAGACACGATCGATTATCAAGATAACTATGACGGTACAGAAAGAGAGCCTGTTGTATTT
CCAGCACGTTTTCCAAATTTACTTGTAAATGGTACATCTGGGATTGCAGTTGGTATGGCGACGAATATCCCCCCTCATCA
TTTAGGGGAGACGATTGATGCTGTACTGGCTATTAGTCAAAATCCTGACATTACGATAGACGAAATAATGGAAAATCATC
TTCCAGGTCCTGATTTTCCAACTGCTGGTCAAATATTAGGCCGGAGCGGTATTCGAAAAGCATATGAGACTGGTAAAGGA
TCTATTACCATTCGTGCGAAGTTAAATATCGAACAAGGTAAAAATGATAAAGAAACAATTATTGTCACAGAATTACCTTA
TCAAGTTAACAAAGCAAAACTGATTGAAAAAATTGCAGAATTAGTTCGTGATAAGAAAGTAGAAGGTATCACTGATCTTC
GCGATGAATCTGACCGTAATGGAATGCGAATTGTAATTGAATTACGACGTGATGCAAATGCGAATGTTGTACTTAATAAT
TTATATAAGCATACGTCCCTACAAACTACATTTGGCATCAATATGCTGGCACTTGTAGATGGGCAACCAAGAGTACTTAA
TATAAAGCAATGTCTTAGCTACTACTTAGAGCATCAAAAAGTCATCATAAAACGTCGTACGCAATTTGAATTAAATAAGG
CAGAGGCACGTGCACATATTTTAGAGGGTCTACGTATAGCACTGGATCACTTGGATGAGGTAATTGAGTTAATCCGTAGT
TCTAAAACAGCTGATATTGCTCGCGAAGGTTTAATGGAACGATTTAAATTAAGTGAGAAACAAGCACAAGCTATCTTGGA
TATGCGTCTTCAACGTTTAACGGGATTAGAGCGAGAGAAAATTGAAGATGAATATAAAGAGCTGCAGGCTTTGATTGAAG
AATTAAAAGCAATTTTAGCGGATGAAGAAAAAGTATTAGAGATTATCCGTGAAGAATTAACGGAGATTAAAGAAAAGTAT
AAAGAAGATCGAAGAACAGAAATCGTAGCAGGTGGCGCAGGATTCTTTGAAGATGAAGATCTTATCCCAGAAGAAAATAT
CGTCATAACGTTAACTCATCAAGGTTATATCAAACGATTACCTGCATCTACGTACCGCACACAAAAACGTGGGGGACGTG
GAATACAAGGTATGGGTACTAACGAGGATGATTTTGTAGAACATTTAGTATCTACATCTACACATGATACGATCCTCTTC
TTTACCAACAAAGGGAAGGTTTATAAGGCGAAAGGGTATGAAATTCCGGAGTTCAGCCGAACTGCGAAAGGCATACCAAT
TATTAATCTTCTTCAAGTGGAAAAAGGGGAATGGGTGAATGCTGTTATATCCGTTAATCAATTTGATGAAGAAGCGTACC
TATTCTTTACGACCAAACACGGAATTGCAAAACGTACATCTCTTGAGAAATTCCGTAATATCCGTAAAGGTGGATTAATT
GCAGTCGGCCTTCGAGAAGAAGATGAATTAATATCCGTTCGTCTGACAGATGGACAAAAAGAAATGATGATAGCAACGAA
GAACGGTTATCTCATTCGTTTTGAAGAAACACAGATTCGTTCGATGGGACGAACGGCTGCAGGTGTTAAAGGGATTTCTT
TACGAGGCGATGATGTCGTCGTTTCCATGGAAATTATTGAACCAGGATCTAAAATTCTTCACGTTACCAACAAAGGATTC
GGTAAACAAACCGATGAATCAGAATACCGTCGTATTAATCGTGGTGGTAAAGGGGTATTTACTTGTAAACTCGATGAAAA
GACGGGAAATGTTGTTGCAGTTAAGGCAGTAAATGGTGACGAAGACTTAATGTTAATTACCATTGCCGGTGTATTAATCC
GAATACAAGTGCAGGACATATCACAAACAGGTAGAAATACAAAAGGGGTTCACTTAATTCGATTGCAGGATGGTGAAGAA
GTAGCTACAGTTACTCGTATCGAAAAAGATGATGAAGAAGATGTCGAGGATATTGAAGTAGTAGAAGGAGAAACAACGGA
TCCATCAACAGAGACAAACGAAGATAAGGAATAA

Upstream 100 bases:

>100_bases
TTAGACATTTAACCATGTCCAAATATGAATGATTAGATAGAAGATCGATTGAAGGAAATCACTAAGTTAGTGTGCTTAGT
GATTGGGAGGTAATGAAAGA

Downstream 100 bases:

>100_bases
TTAATGGTGCTGTCTCTTATTTTGATAGAGGCAGCACTTCCATATTGTCTATCTTAGGGGGAAATGTTATATGAAAATGA
AGACTTCACATCTCATGCCT

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 837; Mature: 836

Protein sequence:

>837_residues
MADINRPRVSEINISNEMRTSFLDYAMSVIVARALPDVRDGMKPVHRRILYAMNDLGMHSDKAYKKSARIVGEVIGKYHP
HGDSAVYETMVRMAQTFSYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMELLRDINKDTIDYQDNYDGTEREPVVF
PARFPNLLVNGTSGIAVGMATNIPPHHLGETIDAVLAISQNPDITIDEIMENHLPGPDFPTAGQILGRSGIRKAYETGKG
SITIRAKLNIEQGKNDKETIIVTELPYQVNKAKLIEKIAELVRDKKVEGITDLRDESDRNGMRIVIELRRDANANVVLNN
LYKHTSLQTTFGINMLALVDGQPRVLNIKQCLSYYLEHQKVIIKRRTQFELNKAEARAHILEGLRIALDHLDEVIELIRS
SKTADIAREGLMERFKLSEKQAQAILDMRLQRLTGLEREKIEDEYKELQALIEELKAILADEEKVLEIIREELTEIKEKY
KEDRRTEIVAGGAGFFEDEDLIPEENIVITLTHQGYIKRLPASTYRTQKRGGRGIQGMGTNEDDFVEHLVSTSTHDTILF
FTNKGKVYKAKGYEIPEFSRTAKGIPIINLLQVEKGEWVNAVISVNQFDEEAYLFFTTKHGIAKRTSLEKFRNIRKGGLI
AVGLREEDELISVRLTDGQKEMMIATKNGYLIRFEETQIRSMGRTAAGVKGISLRGDDVVVSMEIIEPGSKILHVTNKGF
GKQTDESEYRRINRGGKGVFTCKLDEKTGNVVAVKAVNGDEDLMLITIAGVLIRIQVQDISQTGRNTKGVHLIRLQDGEE
VATVTRIEKDDEEDVEDIEVVEGETTDPSTETNEDKE

Sequences:

>Translated_837_residues
MADINRPRVSEINISNEMRTSFLDYAMSVIVARALPDVRDGMKPVHRRILYAMNDLGMHSDKAYKKSARIVGEVIGKYHP
HGDSAVYETMVRMAQTFSYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMELLRDINKDTIDYQDNYDGTEREPVVF
PARFPNLLVNGTSGIAVGMATNIPPHHLGETIDAVLAISQNPDITIDEIMENHLPGPDFPTAGQILGRSGIRKAYETGKG
SITIRAKLNIEQGKNDKETIIVTELPYQVNKAKLIEKIAELVRDKKVEGITDLRDESDRNGMRIVIELRRDANANVVLNN
LYKHTSLQTTFGINMLALVDGQPRVLNIKQCLSYYLEHQKVIIKRRTQFELNKAEARAHILEGLRIALDHLDEVIELIRS
SKTADIAREGLMERFKLSEKQAQAILDMRLQRLTGLEREKIEDEYKELQALIEELKAILADEEKVLEIIREELTEIKEKY
KEDRRTEIVAGGAGFFEDEDLIPEENIVITLTHQGYIKRLPASTYRTQKRGGRGIQGMGTNEDDFVEHLVSTSTHDTILF
FTNKGKVYKAKGYEIPEFSRTAKGIPIINLLQVEKGEWVNAVISVNQFDEEAYLFFTTKHGIAKRTSLEKFRNIRKGGLI
AVGLREEDELISVRLTDGQKEMMIATKNGYLIRFEETQIRSMGRTAAGVKGISLRGDDVVVSMEIIEPGSKILHVTNKGF
GKQTDESEYRRINRGGKGVFTCKLDEKTGNVVAVKAVNGDEDLMLITIAGVLIRIQVQDISQTGRNTKGVHLIRLQDGEE
VATVTRIEKDDEEDVEDIEVVEGETTDPSTETNEDKE
>Mature_836_residues
ADINRPRVSEINISNEMRTSFLDYAMSVIVARALPDVRDGMKPVHRRILYAMNDLGMHSDKAYKKSARIVGEVIGKYHPH
GDSAVYETMVRMAQTFSYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMELLRDINKDTIDYQDNYDGTEREPVVFP
ARFPNLLVNGTSGIAVGMATNIPPHHLGETIDAVLAISQNPDITIDEIMENHLPGPDFPTAGQILGRSGIRKAYETGKGS
ITIRAKLNIEQGKNDKETIIVTELPYQVNKAKLIEKIAELVRDKKVEGITDLRDESDRNGMRIVIELRRDANANVVLNNL
YKHTSLQTTFGINMLALVDGQPRVLNIKQCLSYYLEHQKVIIKRRTQFELNKAEARAHILEGLRIALDHLDEVIELIRSS
KTADIAREGLMERFKLSEKQAQAILDMRLQRLTGLEREKIEDEYKELQALIEELKAILADEEKVLEIIREELTEIKEKYK
EDRRTEIVAGGAGFFEDEDLIPEENIVITLTHQGYIKRLPASTYRTQKRGGRGIQGMGTNEDDFVEHLVSTSTHDTILFF
TNKGKVYKAKGYEIPEFSRTAKGIPIINLLQVEKGEWVNAVISVNQFDEEAYLFFTTKHGIAKRTSLEKFRNIRKGGLIA
VGLREEDELISVRLTDGQKEMMIATKNGYLIRFEETQIRSMGRTAAGVKGISLRGDDVVVSMEIIEPGSKILHVTNKGFG
KQTDESEYRRINRGGKGVFTCKLDEKTGNVVAVKAVNGDEDLMLITIAGVLIRIQVQDISQTGRNTKGVHLIRLQDGEEV
ATVTRIEKDDEEDVEDIEVVEGETTDPSTETNEDKE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=428, Percent_Identity=24.7663551401869, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI19913406, Length=322, Percent_Identity=25.4658385093168, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1788562, Length=876, Percent_Identity=50.9132420091324, Blast_Score=864, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=734, Percent_Identity=36.1035422343324, Blast_Score=447, Evalue=1e-126,
Organism=Caenorhabditis elegans, GI212645845, Length=500, Percent_Identity=23.6, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17535065, Length=354, Percent_Identity=25.7062146892655, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=193, Percent_Identity=29.5336787564767, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136538, Length=367, Percent_Identity=24.2506811989101, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 94301; Mature: 94170

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADINRPRVSEINISNEMRTSFLDYAMSVIVARALPDVRDGMKPVHRRILYAMNDLGMHS
CCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCC
DKAYKKSARIVGEVIGKYHPHGDSAVYETMVRMAQTFSYRYMLVDGHGNFGSVDGDSAAA
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHHH
MRYTEARMSKISMELLRDINKDTIDYQDNYDGTEREPVVFPARFPNLLVNGTSGIAVGMA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEECCCCEEEEEE
TNIPPHHLGETIDAVLAISQNPDITIDEIMENHLPGPDFPTAGQILGRSGIRKAYETGKG
CCCCHHHHHHHHHHHEEECCCCCEEHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCC
SITIRAKLNIEQGKNDKETIIVTELPYQVNKAKLIEKIAELVRDKKVEGITDLRDESDRN
CEEEEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCC
GMRIVIELRRDANANVVLNNLYKHTSLQTTFGINMLALVDGQPRVLNIKQCLSYYLEHQK
CCEEEEEEECCCCCCEEEHHHHHHCCCEEEECCEEEEEECCCCCEEEHHHHHHHHHHHHH
VIIKRRTQFELNKAEARAHILEGLRIALDHLDEVIELIRSSKTADIAREGLMERFKLSEK
HEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHH
QAQAILDMRLQRLTGLEREKIEDEYKELQALIEELKAILADEEKVLEIIREELTEIKEKY
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
KEDRRTEIVAGGAGFFEDEDLIPEENIVITLTHQGYIKRLPASTYRTQKRGGRGIQGMGT
HHCCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCHHHHCCCHHHHHHHCCCCCCCCCCC
NEDDFVEHLVSTSTHDTILFFTNKGKVYKAKGYEIPEFSRTAKGIPIINLLQVEKGEWVN
CHHHHHHHHHCCCCCCEEEEEECCCEEEEECCCCCCCHHHHCCCCCEEEEEEECCCCEEE
AVISVNQFDEEAYLFFTTKHGIAKRTSLEKFRNIRKGGLIAVGLREEDELISVRLTDGQK
EEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCC
EMMIATKNGYLIRFEETQIRSMGRTAAGVKGISLRGDDVVVSMEIIEPGSKILHVTNKGF
EEEEEECCCEEEEEEHHHHHHCCCHHCCCCEEEECCCCEEEEEEEECCCCEEEEEECCCC
GKQTDESEYRRINRGGKGVFTCKLDEKTGNVVAVKAVNGDEDLMLITIAGVLIRIQVQDI
CCCCCHHHHHHHCCCCCEEEEEEECCCCCCEEEEEEECCCCCEEEEEEECEEEEEEEEHH
SQTGRNTKGVHLIRLQDGEEVATVTRIEKDDEEDVEDIEVVEGETTDPSTETNEDKE
HHCCCCCCCEEEEEECCCCCEEHHHHCCCCCCCCCCHHEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ADINRPRVSEINISNEMRTSFLDYAMSVIVARALPDVRDGMKPVHRRILYAMNDLGMHS
CCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCC
DKAYKKSARIVGEVIGKYHPHGDSAVYETMVRMAQTFSYRYMLVDGHGNFGSVDGDSAAA
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHHH
MRYTEARMSKISMELLRDINKDTIDYQDNYDGTEREPVVFPARFPNLLVNGTSGIAVGMA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEECCCCEEEEEE
TNIPPHHLGETIDAVLAISQNPDITIDEIMENHLPGPDFPTAGQILGRSGIRKAYETGKG
CCCCHHHHHHHHHHHEEECCCCCEEHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCC
SITIRAKLNIEQGKNDKETIIVTELPYQVNKAKLIEKIAELVRDKKVEGITDLRDESDRN
CEEEEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCHHHCCCCCCC
GMRIVIELRRDANANVVLNNLYKHTSLQTTFGINMLALVDGQPRVLNIKQCLSYYLEHQK
CCEEEEEEECCCCCCEEEHHHHHHCCCEEEECCEEEEEECCCCCEEEHHHHHHHHHHHHH
VIIKRRTQFELNKAEARAHILEGLRIALDHLDEVIELIRSSKTADIAREGLMERFKLSEK
HEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHH
QAQAILDMRLQRLTGLEREKIEDEYKELQALIEELKAILADEEKVLEIIREELTEIKEKY
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
KEDRRTEIVAGGAGFFEDEDLIPEENIVITLTHQGYIKRLPASTYRTQKRGGRGIQGMGT
HHCCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCHHHHCCCHHHHHHHCCCCCCCCCCC
NEDDFVEHLVSTSTHDTILFFTNKGKVYKAKGYEIPEFSRTAKGIPIINLLQVEKGEWVN
CHHHHHHHHHCCCCCCEEEEEECCCEEEEECCCCCCCHHHHCCCCCEEEEEEECCCCEEE
AVISVNQFDEEAYLFFTTKHGIAKRTSLEKFRNIRKGGLIAVGLREEDELISVRLTDGQK
EEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCCCC
EMMIATKNGYLIRFEETQIRSMGRTAAGVKGISLRGDDVVVSMEIIEPGSKILHVTNKGF
EEEEEECCCEEEEEEHHHHHHCCCHHCCCCEEEECCCCEEEEEEEECCCCEEEEEECCCC
GKQTDESEYRRINRGGKGVFTCKLDEKTGNVVAVKAVNGDEDLMLITIAGVLIRIQVQDI
CCCCCHHHHHHHCCCCCEEEEEEECCCCCCEEEEEEECCCCCEEEEEEECEEEEEEEEHH
SQTGRNTKGVHLIRLQDGEEVATVTRIEKDDEEDVEDIEVVEGETTDPSTETNEDKE
HHCCCCCCCEEEEEECCCCCEEHHHHCCCCCCCCCCHHEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2987847; 7584024; 9384377 [H]